Synthesis and crystal structure of [Sr(urea)(NO3)2]n by Aysanem Bektursinova, Zulfiya Djumanazarova, Zamira Uzakbergenova, Jamshid Ashurov, Akram A Khan, Shakhnoza Kadirova, Batirbay Torambetov

“…The nitrate anions act as bidentate ligands, displaying both terminal and bridging coordination modes. …”
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Therapeutic Implications of PPARγ in Cardiovascular Diseases by Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro

“…Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis.…”
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Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy by Eugenia Hovsepian, Federico Penas, Gerardo A. Mirkin, Nora B. Goren

“…The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. …”
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Synthesis, Spectroscopic Characterization and Preliminary Antimicrobial Studies of Mn(II) and Cu(II) Complexes of two Thiolates; S,S’-(2,6-Diaminopyridine-3,5-diyl) Dibenzenecarbot... by P. O. Ukoha, C.U. Alioke, N.L> Obasi, K.F. Chah

“…The IR spectral studies indicate that the ligands coordinated through the carbonyl oxygen, the sulphur atom and also with the amino group in DBCT. …”
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Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines by Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Lothar Hennig, Joachim Sieler, Steffen Blaurock, Lothar Beyer

“…Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. …”
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Therapeutic Potential of Retinoid X Receptor Modulators for the Treatment of the Metabolic Syndrome by Jane A. Pinaire, Anne Reifel-Miller

“…This review examines and compares the effects of four RXR-selective ligands: LGD1069, LG100268, AGN194204, and LG101506, a selective RXR modulator. …”
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Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation by Yonghyeok Kim, Seon Jeong Baek, Eun-Kyung Yoon, Minhee Choi, Jung-Hoon Kim, Kyungtae Kim, Chi Hoon Park, Byung Il Lee

“…To expand the chemical space for VHL ligands, we conducted fragment screening using VHL–ELOB–ELOC (VBC) proteins. …”
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Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases by Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin

“…The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. …”
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CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration by Jing Hu, Qian Ji, Fei Chen, Xiaoqin Gong, Chuansheng Chen, Kaijun Zhang, Ye Hua, Jinlei Wang, Rongkun Li, Xu Wang, Chunhua Dai, Ye Tian

“…CXCR2 is a G-protein-coupled receptor that mediates the migration of neutrophils by combining with its ligands. Compared with observations in liver and lung tissues, we found that CXCR2 and its ligands, including CXCL1, CXCL2, CXCL3, and CXCL5, were all significantly upregulated in irradiated intestinal tissues. …”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…Among neuroepithelial cancers, NB is the most studied tumor as far as PPAR ligands are concerned. PPAR ligands are endowed with antitumoral effects, mainly acting on cancer stem cells, and constitute a possible add-on therapy to antiblastic drugs, in particular for NB with unfavourable prognosis. …”
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Proinflammatory Stimuli Enhance Phagocytosis of Apoptotic Cells by Neutrophil Granulocytes by Lars Hellberg, Sabrina Fuchs, Christoph Gericke, Arup Sarkar, Martina Behnen, Werner Solbach, Tamás Laskay

“…We observed that exposure to ligands of TLR2 (Malp2, Pam3CSK4), TLR4 (LPS), TLR7/TLR8 (R848), and TLR9 (ODN 2006) led to increased phagocytosis of apoptotic cells by neutrophils. …”
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Chemogenomics for steroid hormone receptors (NR3) by Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk

“…Although several NR3 ligands such as glucocorticoids are invaluable drugs, this family is only partially explored, for example, in autoimmune diseases and neurodegeneration, but may hold therapeutic potential in new areas. …”
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Synthesis of Platinum Complexes from N-Benzyl-2-Aminoethanethiol Derivatives by Mauro Vieira de Almeida, Laura Lúcia C. de Oliviera, Eloi Teixeira Cesar, Marcus Vinícius N. de Souza

“…Twelve new platinum(II) complexes, analogs of cisplatin, containing a 2-aminoethanethiol N-substituted by several benzyl groups have been prepared and characterized in good yields. The ligands were obtained by reaction between 2-aminoethanethiol hydrochloride and different benzyl halides…”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…Since D11 reduces the acquisition of pathogenic features induced by CD36 ligands, it could support the generation of therapeutic proteins targeting CD36.…”
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Liquid-Liquid Extraction of Transition Metal Cations by Glyoximes and Their Macrocyclic Glyoxime Ether Derivatives by Nazan Karapinar, Emin Karapinar, Emine Ozcan

“…Crown ether groups having ligands (L3, L4) carry especially Na+ cation from aqueous phase to organic phase. …”
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Synthesis and crystal structures of 4,4′-methylenebis(2,6-diethylaniline) and 4,4′-methylenebis(3-chloro-2,6-diethylaniline) by Daniil E. Smirnov, Oleg S. Morozov, Ekaterina S. Afanasyeva, Viktor V. Avdeev

“…Consequently, despite their chemical similarity, it is the precise structural data that enables us to explain their differing reactivity and opens up the possibility of evaluating steric properties for the development of new materials and ligands.…”
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Cobalt and Nickel Complexes Bearing 2-(2-pyridyl)-Benzimidazole: Synthesis and Ethylene Oligomerization by Jian-Long Du, Li-Jun-Li

“…A series of cobalt and nickel complexes MLX2 (M=Co or Ni, X=Cl) bearing 2-(2-pyridyl)benzimidazole ligands were synthesized. Treatment of the complexes with methylaluminoxane (MAO) leads to active catalysts for ethylene oligomerization. …”
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Synthesis of Furo[3,2-b]pyrrole-5-carboxhydrazides and Their Cu, CO and Ni Complexes by Renata Gašparová, Ján Titiš, Filip Kraic

“…Carboxhydrazides 3 were used as ligands for synthesis of Cu, Co, and Ni complexes 4.…”
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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model by Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek

“…This work paves the way for the development of ligands targeting multiple xenobiotic nuclear receptors. …”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis, breast cancer, type II diabetes, malaria, measles and sickle cell disease were revealed through docking of GCâMS identified phyto-compound ligands with candidate disease proteins. Of the 242 ligands, three dimensional structures of 47 compounds had to be drawn using ChemSketch and the remaining structures were retrieved from PubChem and docked with the active sites of candidate proteins. …”
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