Advanced mutant receptor activator of nuclear factor kappa‐Β ligand development with low affinity for osteoprotegerin by Yuria Jang, Yongjin Cho, Youngjong Ko, Yeonhee Moon, Chang‐Moon Lee, Wonbong Lim

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Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action by Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec

“…Here, we present synthesis, physicochemical characterization, biological effects, and mechanisms of action of four new analogs of conventional cisplatin, namely, cis-Pt(II) complexes containing either methyl or ethyl pyrazole N-donor ligands and chlorido or iodido ligands. It is noteworthy that while chlorido complexes display activity in a variety of cancer cell lines comparable to cisplatin, iodido complexes are considerably more potent due to their enhanced hydrophobicity and consequently enhanced cellular accumulation. …”
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Synthesis of Poly(hydroxamic Acid)-Poly(amidoxime) Chelating Ligands for Removal of Metals from Industrial Wastewater by M. R. Lutfor, M. Y. Mashitah

“…Synthesis of poly(hydroxamic acid)-poly(amidoxime) chelating ligands were carried out from poly(methyl acrylate-co-acrylonitrile) grafted sago starch and hydroxylamine in alkaline medium. …”
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The algebraic extended atom-type graph-based model for precise ligand–receptor binding affinity prediction by Farjana Tasnim Mukta, Md Masud Rana, Avery Meyer, Sally Ellingson, Duc D. Nguyen

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Stability Constants of Mixed Ligand Complexes of Cu(II) and Ni(II) with Some Amino Acids and Phosphates by Aruna Adam, Suman Verma, Gita Seth

“…The binary and ternary metal complexes of Cu(II) & Ni(II) with some amino acids (leucine, isoleucine & serine) as primary ligand and pyrophosphate (PP), adenosine-5´-triphosphate (ATP), as secondary ligand have been studied potentiometrically at 35 °C and a constant ionic strength (1.0 mol dm-3 KNO3). …”
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PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors by Elisabetta Benedetti, Renato Galzio, Barbara D'Angelo, Maria Paola Cerù, Annamaria Cimini

“…Among malignant neuroepithelial tumors, with regard to PPAR ligands, the most extensively studied were tumors of astrocytic origin and neuroblastoma. …”
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Assessing the role of Chemokine (C–C motif) ligand 14 in AKI: a European consensus meeting by Jay L. Koyner, Christian Arndt, Jaume Baldira Martinez de Irujo, Sílvia Coelho, Manuel Garcia-Montesinos de la Peña, Luca di Girolamo, Michael Joannidis, Pablo Jorge-Monjas, Christian Koch, Steven Lobaz, Alain Meyer, Marlies Ostermann, Nicoletta Pertica, John R. Prowle, Jon Silversides, Alexander Zarbock, Jorge Echeverri, Kai Harenski, Lui G. Forni

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Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands by Christiana A. Mitsopoulou, Constantinos Dagas

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Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration by Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda

“…Aim: Evaluate the selective cytotoxic effect of the palindromic sequence RWQWRWQWR and its analogues obtained by replacement of L-amino acids by D-amino acids or the functionalization by adding the RGD (integrin ligand motif) to the peptide. Methods: Peptides were obtained by SPPS, characterized by RP-HPLC and ESI-QTOF and its biological activity was evaluated using MTT assays. …”
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Exploring the Potential of Oxalyldihydrazide-Derived Schiff Bases as Versatile Ligands: Synthesis, Structural Characterization, and Magnetic Properties by Ernesto Costa-Villén, Marina Ortiz, Pedro Sitjar, Cristina Puigjaner, Mohamed Salah El Fallah

“…Schiff bases constitute a broad and well-established class of ligands widely utilized in coordination chemistry. …”
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Synthesis of a One-Dimensional Coordination Polymer of Nickel(II) Complex with a β-Oxodithioester Ligand by Ricardo Rosas-Reyes, Yasmi Reyes-Ortega, T. Jesus Morales-Juarez, Virginia Gómez-Vidales, Ivan García-Orozco

“…Bis-[methyl-1-hydroxy-1-cyclopentene-2-dithiocarboxylate-O,S]nickel(II) 1 was prepared starting from methyl 2-hydroxycyclopent-1-encarbodithioate ligand (CPDT) and Ni(II), and catena-[(μ2-4,4′-Bipyril)-bis-(methyl-2-hydroxy-1-cyclopentene-2-dithiocarboxylate-O,S)]nickel(ΙΙ) 2 was prepared in good yields from 1 plus 4,4′-bipyridyl (bpy) by shish-kebab methodology. …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels expressed in nervous and non-nervous system tissue important for memory, movement, and sensory processes. …”
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Synthetic, Structural, and Biochemical Studies of Organotin(IV) With Schiff Bases Having Nitrogen and Sulphur Donor Ligands

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Selective Phenome Growth Adapted NK Model: A Novel Landscape to Represent Aptamer Ligand Binding by Andrew Brian Kinghorn, Julian Alexander Tanner

“…Comparison to empirical aptamer microarray data shows that our theoretical fitness landscapes more accurately represent aptamer ligand binding than other theoretical models. These improved fitness landscapes have potential for the computational analysis and optimisation of other complex systems.…”
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Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase by Wen-Ping Liu, Tao Xue, Yangchun Li, Ruoyu Cui

“…With the reaction between Cu(NO3)2·3H2O and 4-(2′,3′-dicarboxylphenoxy) benzoic acid (H3L), a semirigid trichromatic acid ligand, in the presence of N-donor co-ligand 1,2-bis(4-pyridyl) ethylene (bpe), two novel mixed-ligand coordination polymers (CPs), i.e., [Cu(H2L)2(bpe)(H2O)2]bpe·(H2O)4 (1) and [Cu3(L)2(bpe)3(H2O)4]·(H2O)6 (2), have been created under different solvent systems. …”
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Balancing CIK Cell Cancer Immunotherapy and PPAR Ligands: One Potential Therapeutic Application for CNS Malignancies by Kira Vordermark, JingJing Pu, Amit Sharma, Jarek Maciacyzk, Ingo G. H. Schmidt‐Wolf

“…Equally important are the hints suggesting peroxisome proliferator‐activated receptors (PPARs) ligands being co‐expressed in the central nervous system (CNS). …”
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Photophysical and Electrochemical Studies of Multinuclear Complexes of Iron(II) with Acetate and Extended Conjugated N-Donor Ligands by Norbani Abdullah, Suhana Mohd Said, Anita Marlina, Muhamad Faris Roslan, Afiq Azil, Abdul Rahman Nordin

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Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors by Steingrimur Stefansson, Lára A. Stefansson, Suk-won Chung, Kevin Ko, Hena H. Kwon, Saeyoung Nate Ahn

“…Biomolecular detections performed on carbon nanotube field-effect transistors (CNT-FETs) frequently use reactive pyrenes as an anchor to tether bioactive ligands to the hydrophobic nanotubes. In this paper, we explore the possibility of directly using bioactive aromatic compounds themselves as CNT-FET ligands. …”
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The PPARδ Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells by Jordan Clark, Rania Nasrallah, Richard L. Hébert

“…These results show that a PPARδ ligand inhibits growth but does not affect anisomycin-apoptosis in a mouse IMCD cell line. …”
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Ligand-Activated Peroxisome Proliferator-Activated Receptor β/δ Facilitates Cell Proliferation in Human Cholesteatoma Keratinocytes by Chen Zhang, Yang-Wenyi Liu, Zhangcai Chi, Bing Chen

“…We found that the expression of PPAR β/δ was significantly upregulated in cholesteatoma and ligand-activated PPAR β/δ markedly promoted the proliferation of cholesteatoma keratinocytes. …”
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