Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab by Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu

“…Immunostaining showed that a high proportion of the tumor cells were positive for expression of programmed death-ligand 1 (PD-L1). The patient received stereotactic radiotherapy for the brain metastases, followed by administration of pembrolizumab. …”
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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…Growing evidence stresses on the PPARγ ligand-dependent dysregulation as a key molecular initiating event (MIE) for this adverse effect. …”
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Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling by Suguru Saito, Duo‐Yao Cao, Tomohiro Shibata, Yan Liu, Aoi Otagiri‐Hoshi, Xiaojiang Cui, Kenneth E. Bernstein

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Amphiphilic Ruthenium(II) Terpyridine Sensitizers with Long Alkyl Chain Substituted β-Diketonato Ligands: An Efficient Coadsorbent-Free Dye-Sensitized Solar Cells by Ashraful Islam, Surya Prakash Singh, Masatoshi Yanagida, Mohammad Rezaul Karim, Liyuan Han

“…These complexes exhibit a broad metal-to-ligand charge transfer absorption band over the whole visible range extending up to 950 nm. …”
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Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions by Husham M. Mubark, Israa N. Witwit, Hussein A. Ali Salman, Mohauman M. Al Rufaie

Subjects: “…azo ligand…”
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Comparative efficacy of programmed death ligand 1 inhibition and chemotherapy in advanced gastric or gastroesophageal junction cancer with combined positive score – a meta-analysis by Zakari Shaibu, Fumeng Yang, Liu Ting, Lily Dzidula, Amina Elmi Yusuf, Zhi-hong Chen, Wei Zhu

“…Immune checkpoint inhibitors, particularly targeting programmed cell death ligand-1 (PD-L1), have emerged as promising agents to enhance patient outcomes. …”
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Allosteric coupling between G‐protein binding and extracellular ligand binding sites in GPR52 revealed by 19F‐NMR and cryo‐electron microscopy by Yanliu Fan, Xi Lin, Benxun Pan, Bo Chen, Dongsheng Liu, Kurt Wüthrich, Fei Xu

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P-selectin glycoprotein ligand-1 is diversely expressed in the primary tumour and venous thrombus of clear cell renal cancer and correlates with poor overall survival by Rafał Pęksa, Sumit Sharma, Michał Kunc, Marta Popęda, Le Qu, Mikołaj Frankiewicz, Marcin Folwarski, Piotr Radziszewski, Łukasz Zapała

Subjects: “…p-selectin glycoprotein ligand-1…”
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Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes by Rayees Ahmad Shiekh, Maqsood Ahmad Malik, Shaeel Ahmed Al-Thabaiti, Mohmmad Younus Wani, Arshid Nabi

“…2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide ligand with a series of transition metal complexes has been synthesized via two routes: microwave irradiation and conventional heating method. …”
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Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells by David Schnittker, Karen Kwofie, Ali Ashkar, Bernardo Trigatti, Carl D. Richards

“…The results suggest that OSM is able to synergize with TLR-4 ligands to induce proinflammatory responses by HAoAFs and HAoSMCs, supporting the notion that OSM regulation of these cells contributes to the pathogenesis of atherosclerosis.…”
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Structural Characterization of B-DNA d(CGTGAATTCACG)₂ in Complex with the Specific Minor Groove Binding Fluorescent Marker Hoechst 33342 by Hristina Sbirkova-Dimitrova, Rusi Rusew, Hristo Gerginov, Annie Heroux, Boris L. Shivachev

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Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis by Yuanke Li, Ruiying Liu, Zhen Zhao

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Exploring the Role of C-C Motif Chemokine Ligand-2 Single Nucleotide Polymorphism in Pulmonary Tuberculosis: A Genetic Association Study from North India by Sanjay K. Biswas, Mayank Mittal, Ekata Sinha, Vandana Singh, Nidhi Arela, Bharat Bajaj, Pramod K. Tiwari, Vishwa M. Katoch, Keshar K. Mohanty

“…The C-C motif chemokine ligand-2 (CCL2) was evidenced to be associated with tuberculosis susceptibility in some ethnic groups. …”
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Novel Computational Methodologies for Structural Modeling of Spacious Ligand Binding Sites of G-Protein-Coupled Receptors: Development and Application to Human Leukotriene B4 Receptor by Yoko Ishino, Takanori Harada

“…The core idea of the method is that a molecular dynamics simulation is used to calculate average 3D coordinates of all atoms of a GPCR protein against heat fluctuation on the picosecond or nanosecond time scale, and then evolutionary computation including receptor-ligand docking simulations functions to determine the rotation angle of each helix of a GPCR protein as a movement on a longer time scale. …”
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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analysis by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

“…The receptor-ligand complex of Nymphaea lotus was compared with known inhibitors. …”
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Synthesis, Biological, and Quantum Chemical Studies of Zn(II) and Ni(II) Mixed-Ligand Complexes Derived from N,N-Disubstituted Dithiocarbamate and Benzoic Acid by Anthony C. Ekennia, Damian C. Onwudiwe, Aderoju A. Osowole, Lukman O. Olasunkanmi, Eno E. Ebenso

“…Some mixed-ligand complexes of Zn(II) and Ni(II) derived from the sodium salt of N-alkyl-N-phenyl dithiocarbamate and benzoic acid have been prepared. …”
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Fas Ligand DNA Enhances a Vaccination Effect by Coadministered DNA Encoding a Tumor Antigen through Augmenting Production of Antibody against the Tumor Antigen by Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

“…Interaction of Fas and Fas ligand (FasL) plays an important role in the regulation of immune responses by inducing apoptosis of activated cells; however, a possible role of FasL in DNA vaccination has not been well understood. …”
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Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biological Application by Madhumita Hazra, Tanushree Dolai, Akhil Pandey, Subrata Kumar Dey, Animesh Patra

“…Moreover, the antioxidant study of the ligand and complexes is evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assays, which demonstrate that the complexes are of higher antioxidant activity than free ligand.…”
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Heavy metal (Pb, Ni, Cd) elimination from water and wastewater using an antibacterial modified cellulose filter paper as an efficient filtration membrane technology: A portable fil... by Milad Kazemnejadi

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Solvent extraction of uranium from an acidic medium for the front-end of nuclear fuel cycle: from mechanisms understanding to innovative process design by Giusti, Fabrice, Guerinoni, Elise, Lemire, David, Thimotée, Marine, Arrachart, Guilhem, Dourdain, Sandrine, Pellet-Rostaing, Stéphane

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