Clinical outcomes of endocrine and other disorders induced by immune checkpoint inhibitors in Japanese patients by Yuichiro Iwamoto, Tomohiko Kimura, Kazunori Dan, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…We evaluated the occurrence of Grade 3 or higher irAEs and the life expectancy and treatment efficacy after ICI administration. …”
Get full text

SAlexNet: Superimposed AlexNet using residual attention mechanism for accurate and efficient automatic primary brain tumor detection and classification by Qurat-ul-ain Chaudhary, Shahzad Ahmad Qureshi, Touseef Sadiq, Anila Usman, Ambreen Khawar, Syed Taimoor Hussain Shah, Aziz ul Rehman

“…It is one of the most aggressive tumors, leading to a short life expectancy. However, the classification of brain tumors is a challenging task due to the heterogeneity, complexity, and variability of brain tumors. …”
Get full text

Non-medical treatment for late age-related macular degeneration by A.K. Drakon, A.G. Kurguzova, V.M. Sheludchenko, N.B. Korchazhkina

“…Moreover, the number of these patients will increase growth as life expectancy increases. It is estimated that late AMD accounts for half of blindness and low vision cases in European countries. …”
Get full text

Hubungan Jumlah Paritas dengan Usia Menopause by Hadya Gorga, Putri Sri Lasmini, Arni Amir

“…Currently, the number of women of menopausal age increases as the increase in life expectancy. The study of menopause is very important, especially related to the consequences that will occur after the menopause such as cardiovascular disease and osteoporosis. …”
Get full text

Long-term Patency and Complications of Endovascular and Surgical Revascularization for Takayasu Arteritis by Jiyoung Shin, Ara Cho, Ahram Han, Sanghyun Ahn, Sangil Min, Seung-Kee Min

“…As TAK predominantly affects young female with a longer life expectancy than those with atherosclerotic diseases, assessing the specific long-term outcomes of TAK treatment is important. …”
Get full text

Prevalence of Diabetes and Cardiovascular Comorbidity in the Canadian Community Health Survey 20022003 by Frank Mo, Lisa M. Pogany, Felix C.K. Li, Howard Morrison

“…Diabetes mellitus is a major risk factor for heart disease (heart attack, angina, and heart failure), stroke, and hypertension, which shorten the average life expectancy. The main objective of this study was to describe the prevalence of heart disease, hypertension, and stroke among Canadians with diabetes compared to those without diabetes in the Canadian general population aged 12 years and over. …”
Get full text

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice by Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault

“…Abstract Background Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therapeutic interventions, the underlying mechanisms precipitating the progression of PAD to CLTI remain elusive. …”
Get full text

Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats by Doreen Enyang, Mubo A. Sonibare, Armelle D. Tchamgoue, Lauve R. Y. Tchokouaha, Fanta S. Yadang, Gael N. Nfor, Christelle W. Kom, Patrick D. H. Betote, Cedric F. Tchinda, Steveng S. K. Tiogo, Gabriel A. Agbor

“…Antiretroviral therapy (ART) has revolutionized the lives of people living with HIV/AIDS by overall improving their quality of life and increasing life expectancy. However, ART-associated hepatotoxicity and metabolic disorders in HIV/AIDS patients are growing concerns to clinicians, especially due to the long-term use of the drugs. …”
Get full text

A study protocol for individualized prognostic counselling in the palliative phase by Boyd Noël van den Besselaar, A. Sewnaik, M. C. Dorr, A. Hoesseini, J. A. Hardillo, R. J. Baatenburg de Jong, M.P.J. Offerman

“…Unfortunately, predicting individual life expectancy in this phase is particularly challenging, as physicians and patients tend to overestimate survival. …”
Get full text

The effect of bacterial overgrowth syndrome and bacterial translocation on the course of liver cirrhosis by M. S. Zharkova, M. V. Mayevskaya, V. T. Ivashkin

“…To determine the effect of bacterial overgrowth syndrome and translocation of bacterial DNA in ascitic fluid on morbidity in liver cirrhosis (LC) and long-term life expectancy.Material and methods. Overall 42 LC patients were included to original study (Child-Pugh class A – 15 patients, class B – 10, class C – 17). …”
Get full text

Understanding Loneliness in an Aging Population of San Vito de Coto Brus, Costa Rica by Nicholas Leahy, Melissa Rallo, Lillianna Pedersen, Christine Wan, Hima Konduru, Shania Bailey, Alexis Vetack, Wendel Mora, Shailvi Gupta, Carlos Faerron Guzmán

“…Introduction: As trends in life expectancy continue to improve, the burden of loneliness in geriatric populations on a global scale is increasing. …”
Get full text

Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know by Emanuela De Bellis, Danilo Donnarumma, Adele Zarrella, Salvatore Maria Mazzeo, Annarita Pagano, Valentina Manzo, Ines Mazza, Francesco Sabbatino, Graziamaria Corbi, Pasquale Pagliano, Amelia Filippelli, Valeria Conti

“…Highly active antiretroviral therapy has led to a significant increase in the life expectancy of people living with HIV. The trade-off is that HIV-infected patients often suffer from comorbidities that require additional treatment, increasing the risk of Drug-Drug Interactions (DDIs), the clinical relevance of which has often not been determined during registration trials of the drugs involved. …”
Get full text

Application of GUHA data mining method in cohort data to explore paths associated with premature death: a 29-year follow-up study by Lily Nosraty, Esko Turunen, Saila Kyrönlahti, Clas-Håkan Nygård, Prakash KC, Subas Neupane

“…Premature death was defined as a death occurring earlier than the age- and sex-specific actuarial life expectancy indicated by life tables for 1981, as the baseline, with the threshold period of nine months. …”
Get full text

Microbial phenolic metabolites are associated with better frontal lobe cognition by Inés Domínguez-López, Isabella Parilli-Moser, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Cinta Valls-Pedret, Zenaida Vázquez-Ruiz, Olga Castañer, Ramon Estruch, Emili Ros, Rosa M. Lamuela-Raventós

“…With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. …”
Get full text

Implementasi Self Organizing Maps untuk Pengelompokan Kabupaten/Kota Berdasarkan Indeks Pembangunan Manusia by Dwi Marisa Midyanti, Syamsul Bahri

“…In 2022, the four HDI indicators changed to Life Expectancy at Birth (UHH), Years of School Expectation (HLS), Average Years of Schooling (RLS), and Annual Capita Spending. …”
Get full text

Relationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers by María Isabel Pastor-Orduña, Federico Palomar-Llatas, David Palomar-Albert, María Teresa Murillo-Llorente, Ignacio Ventura, Francisco Tomás-Aguirre, Marcelino Pérez-Bermejo

“…In addition, a positive correlation was found between Barthel Score and survival, suggesting that patients with greater functional independence have a longer life expectancy. On the other hand, the negative correlation between total lymphocyte count and survival suggests that lymphocytopenia may be a marker of adaptive immunosuppression. …”
Get full text

Initial Diagnostic Strategies for Helicobacter Pylori in Patients With Bleeding Peptic Ulcers Undergoing Endoscopy: A Cost-Effectiveness Analysis by Michael G. Artin, Josephine Soddano, Sheila D. Rustgi, Zainab Aziz, Francesca Lim, Jeong Yun Yang, Myles A. Ingram, John T. Nathanson, John Y. Kao, Chin Hur

“…Model outcomes included hospitalizations for rebleeds, number needed to treat to avoid another hospitalization, life expectancy, total cost, quality-adjusted life years, and incremental cost-effectiveness ratios. …”
Get full text

The Lived Experience of Adult Cancer Survivors After Hematopoietic Stem Cell Transplantation: A Qualitative Study From Saudi Arabia by Almutairi H, Aboshaiqah A, Alzahrani M, Almutairi AF, Salam M

“…Hamdan Almutairi,1,2 Ahmad Aboshaiqah,2 Mohsen Alzahrani,3 Adel F Almutairi,4 Mahmoud Salam5 1Transfusion Medicine Services, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 2College of Nursing, King Saud University, Riyadh, Saudi Arabia; 3Division of Hematology and Stem Cell Transplant, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 4King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 5Alice Ramez Chagoury School of Nursing, Lebanese American University, Byblos, LebanonCorrespondence: Hamdan Almutairi, Transfusion Medicine Services, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, Tel +966503414140, Email MotairiH@mngha.med.sa Mahmoud Salam, Alice Ramez Chagoury School of Nursing, Lebanese American University, Byblos, Lebanon, Tel +96170054397, Email mahmoud.salam@lau.edu.lbBackground: Hematopoietic stem cell transplantation (HSCT) is a high-intensity treatment with the potential to extend the life expectancy of some patients with cancer. The aim of this study is to explore the lived experience of cancer survivors who underwent HSCT from Saudi Arabia.Material And Methods: This study adopted a qualitative descriptive research design using semi-structured in-depth face-to-face interviews. …”
Get full text

Trends and distribution patterns of infant mortality and maternal HIV positivity in South Africa: A decade review (2007 - 2016) by M Makhele, N Ledibane, H Ramatsoma, A Musekiwa

“…We recommend the use of disability-adjusted life expectancy in SA to measure population health and introduce robust data sets that can better inform policy. …”
Get full text

IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers by Sunita Mathur, John Muscedere, David M Maslove, Miranda Hunt, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Michelle Tryon, Natasha Arianne Jawa, Michaela Hanley, Robin Westphal, Afolasade Fakolade

“…Survivors of critical illness will be eligible if: age ≥18 years, life expectancy ≥6 months and high risk for PICS. We define high risk as ICU stay ≥4 days or involving 1+ of mechanical ventilation, tracheostomy, delirium or lack of access to a primary care physician (PCP). 20 ICU survivor-primary caregiver dyads will be enrolled (n=10 dyads per group) and randomised 1:1 to the intervention versus control group. …”
Get full text