Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…City officials undertook the construction of attributes worthy of a Roman provincial capital: a powerful city wall, remarkable monumental decorations, large public spaces devoted to civic and economic life, circulation routes, water supply and drainage networks, etc. …”
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Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…However, cardiac complications are still the main cause of death in patients with thalassaemia.Conclusion Data gathered into the registry can be used to understand the progression of the disorder, to monitor iron overload management and to improve the outcomes of treatment, to enhance preventive strategies, reduce healthcare burden and improve the quality of life. Sustainability of the Malaysian Thalassaemia Registry is important for surveillance of thalassaemia management in the country and help the national health authorities to develop more effective policies.…”
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…The limited number of established targets further restricts the identification of novel antibiotics to treat life-threatening MDR infections caused by Staphylococcus aureus strains. …”
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Open-source code for analysis of the lifetime total physical activity questionnaire (LTPAQ) by Coral Sánchez-Martín, Javier Leal-Martín, Timo Rantalainen, Irene Rodríguez-Gómez, Luis M. Alegre, Ignacio Ara

“…By facilitating the processing of physical activity data from this questionnaire, our tool is expected to encourage its application in epidemiological studies and foster new insights into the impact of lifestyle from a life course perspective, ultimately playing a crucial role in shaping public health policies and enhancing clinical practice.…”
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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…Introduction In Australia, while paediatric intensive care unit (PICU) mortality has dropped to 2.2%, one in three survivors experience long-term neurodevelopmental impairment, limiting their life-course opportunities. Unlike other high-risk paediatric populations, standardised routine neurodevelopmental follow-up of PICU survivors is rare, and there is limited knowledge regarding the best methods. …”
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Pengaruh Edible Coating Berbasis Kitosan, Ekstrak Aloe Vera Dengan Penambahan Pektin Jeruk Terhadap Masa Simpan Buah Pir Potong by Muryeti Muryeti, Koulan Sadida

“…Quality tests were then carried out, including weight loss, pH, vitamin C content, total dissolved solids and organoleptics.The results showed that edible coatings significantly reduced weight loss, maintained total soluble solid, pH, vitamin C content, and organoleptic quality, extending the shelf life of sliced pears compared to untreated pears (control). …”
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Evaluasi TKTI Puri Saron Hotel Seminyak dengan Framework Cobit 5 by Norsa Yudhi Arso, Made Wisnu Antara Kesiman, Dewa Gede Hendra Divayana

“…The findings of the analysis are centered on the COBIT Process, specifically the domains (EDM04) IT Resources, (APO01) Consistency Management, (APO03) IT Architecture, (APO04) IT Innovation, (APO07) Resource Management, (BAI04) Balancing Flows and Future Needs , (BAI09) Company Assets, (BAI10) Configuration Management, (DSS01) Operations Management, (DSS03) Managing Company Life Cycle Problems, and ( The process of planning, assessing and adjusting Puri Saron Hotel Seminyak for a better direction, and most of the domain activities have been executed, policies and norms have been written, and communication has improved. …”
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Pengaruh Pesan Keagamaan Dalam Nadham Maulid Al-Dhiyâ’ Al-Lâmi’ Terhadap Jamaah Majelis Taklim Al-Hidayat Gampong Peulanggahan Banda Aceh; Kajian Ritual Effect by Syarifuddin, Cut Masthura Rahmatillah, Abd Razak, Rahma Salbiah

“…The findings are as follows: First, the content includes messages of monotheism, praise for the Prophet, nobility, lineage, praises for the birth, and prophetic history; second, the religious impact on the lives of the congregation and the Acehnese community includes increased faith, love for the Prophet, adherence to Allah’s Sharia and the Prophet’s Sunnah, blessed life, improved morals, psychological therapy, and strengthened social relationships; third, the ritual art of reciting Nadham Maulid Al-Dhiyâ’ Al-Lâmi’ can be preserved due to the attraction to the familial network of the Prophet known as Ahlul Bait, as well as the traditional Hadrah music تركز هذه الدراسة على تحليل الرسائل الدينية في الطقوس القرائية لنظم مولد الضياء اللامع، وتأثيره على جماعة مجلس التعليم الهدى والمجتمع، وكذلك دوافع واستراتيجيات الحفاظ عليه باستخدام نهج تأثير الطقوس. …”
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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

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Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

“…Summary: Metastatic dissemination is driven by genetic, biochemical, and biophysical cues that favor the distant colonization of organs and the formation of life-threatening secondary tumors. We have previously demonstrated that endothelial cells (ECs) actively remodel during extravasation by enwrapping arrested tumor cells (TCs) and extruding them from the vascular lumen while maintaining perfusion. …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…IntroductionRheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients’ ability to carry out daily activities, mental health, and life expectancy. Current treatments for RA are limited in terms of duration, efficacy, and adverse effects. …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…Compared with healthy controls (HC; n = 59), voxel-based and brain-wide volumetric changes and their associations with stressful life events (SLE) were tested. These stratified associations were validated using two large population-based cohorts (the ABCD study; n = 1680, 11.92 ± 0.62 years; and UK Biobank, n = 20547, 55.38 ± 7.43 years). …”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.MethodsThe randomized controlled trials (RCTs) investigating the efficacy of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in Alzheimer’s disease (AD) were systematically searched across PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. …”
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Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution) by V. T. Ivashkin, V. V. Fomin, O. N. Tkacheva, O. S. Medvedev, E. A. Poluektova, D. I. Abdulganieva, S. R. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, M. S. Zharkova, O. Yu. Zolnikova, K. V. Ivashkin, I. L. Kliaritskaia, N. V. Korochanskaya, S. N. Mammaev, R. V. Maslennikov, R. G. Myazin, M. V. Perekalina, A. V. Povtoreyko, A. I. Ulyanin, M. V. Fadeeva, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin

“…Optimization of approaches to the diagnosis and treatment of SIBO, the development of domestic gas analyzers, increasing the awareness of physicians in all regions of the Russian Federation, as well as the development and optimization of clinical recommendations appear to be necessary measures to increase the effectiveness of medical care, the duration and quality of life of the Russian population. These goals can be achieved within the framework of Federal programs under the supervision of specialized reference centers of the Ministry of Health of the Russian Federation.…”
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Impacts of the COVID-19 pandemic on access to sexual and reproductive health services for women and gender-diverse people with disabilities in Canada: a qualitative study by Meredith Evans, Alexandra Rego, Nkem Ogbonna, Kate Welsh, Sidrah K. Zafar, Lucy C. Barker, Anne Berndl, Janice Du Mont, Yona Lunsky, Amy McPherson, Lesley A. Tarasoff, Ashley Vandermorris, Hilary K. Brown

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Faecal microbiota transplantation for patients with diabetes type 1 and severe gastrointestinal neuropathy (FADIGAS): a randomised, double-blinded, placebo-controlled trialResearch... by Katrine Lundby Høyer, Simon Mark Dahl Baunwall, Ditte Smed Kornum, Mette Winther Klinge, Asbjørn Mohr Drewes, Knud Bonnet Yderstræde, Louise Bruun Thingholm, Martin Steen Mortensen, Susan Mikkelsen, Christian Erikstrup, Christian Lodberg Hvas, Klaus Krogh

“…Secondary endpoints included gastrointestinal symptoms and quality of life assessed four weeks after treatment. Public trial registration, ClinicalTrials.gov NCT04749030. …”
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Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study by Satoshi Kubota, Ai Sato, Manami Hosokawa, Yosuke Okubo, Shohei Takayama, Atsuko Kaneko, Yasuho Shimada, Yuki Asano, Yoshihiko Sato, Masanori Yamazaki, Mitsuhisa Komatsu

“…The ratings from questionnaires assessing treatment burden, satisfaction, and quality of life remained unchanged. The MiniMed 770G HCL system improved glycemic control and optimized insulin delivery, particularly in patients with high implementation rates.…”
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Effect of retirement on the body mass index in China: a nationwide study based on the regression discontinuity design by Jiarun Mi, Xueyan Han, Hanchao Cheng, Zhaoyang Pan, Jian Guo, Hailu Zhu, Qi Wang, Yicong Wang, Yuanli Liu, Congyi Zheng, Xin Wang, Xue Cao, Zhen Hu, Yixin Tian, Zengwu Wang, Tianjia Guan

“…Abstract Introduction Retirement represents a significant life transition and is associated with individual health outcomes. …”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Such advancements would modify treatment and nutritional strategies, allowing a more secure, effective, and long life.…”
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