Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study by Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

“… BackgroundGastrointestinal bleeding (GIB) is a severe and potentially life-threatening complication in patients with acute myocardial infarction (AMI), significantly affecting prognosis during hospitalization. …”
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Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity by Yazhou Bao, Qian Zhang, Hai Zhu, Yong Pei, Yaning Zhao, Yixin Li, Peiyun Ji, Dandan Du, Hao Peng, Guangyuan Xu, Xiaodan Wang, Zhiyuan Yin, Gan Ai, Xiangxiu Liang, Daolong Dou

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Experimental study on freeze-thaw damage characteristics and mechanical properties of fractured rock mass of surface mine slope in cold region by Sen TIAN, Ying ZHAO, Hu SI, Chun ZHU, Quangui LI

“…Especially in northwest China, the landslides in surface mines occur frequently due to the complicated topographical and geological structures, harsh climate and environment, as well as long-term engineering disturbance, which seriously threaten miner’s life and property safety. From the perspective of macro-micro damage evolution of characteristic slope rock masses, this study conducted the freeze-thaw test, the frost heave force evolution test, and the uniaxial compression test of fractured rock masses in the potential landslide area, based on the actual engineering geological and environmental characteristics of high-steep rock slope at an surface mine in Xinjiang province. …”
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Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review by Siligato R, Gembillo G, De Giorgi A, Di Maria A, Scichilone LM, Capone M, Vinci FM, Nicoletti S, Bondanelli M, Malaventura C, Storari A, Santoro D, Dionisi S, Fabbian F

“…Health care professionals need to improve their knowledge about the relationship between FT and renal disease; there is a paucity of data regarding the effects of FT on different outcomes, although this nonmedical risk factor can negatively influence kidney health and quality of life. Further studies involving different professionals able to consider environmental, physical and emotional risk factors are needed. …”
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Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization by Yeon-Su Gwak, Seo-Yeon Kim, Chae-Eon Woo, Kihyuk Shin, Eunjeong Son, Jin-Woo Kim, Sung-Jin Kim, Tae-Jin Song, Hae Ryoun Park, Kihun Kim, Dai Sik Ko, Yun Hak Kim

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Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine sett... by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

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NDVI Estimation Throughout the Whole Growth Period of Multi-Crops Using RGB Images and Deep Learning by Jianliang Wang, Chen Chen, Jiacheng Wang, Zhaosheng Yao, Ying Wang, Yuanyuan Zhao, Yi Sun, Fei Wu, Dongwei Han, Guanshuo Yang, Xinyu Liu, Chengming Sun, Tao Liu

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Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study by Marat Fudim, Muhammad Shahzeb Khan, Dominik Linz, JoAnn Lindenfeld, Calum MacRae, Nina Kimmeskamp-Kirschbaum, Michaela Meyer, Thomas Mondritzki, Hanna Tinel, Wilfried Dinh, Robert J. Mentz

“…The study was terminated early based on new and unexpected preclinical findings from a chronic animal toxicology study in monkeys in which evidence of increased vascular inflammation was observed, leading to a no longer favorable risk-benefit balance for the intended long-term (i.e., life-long) treatment of heart failure patients. Comparable adverse events were not encountered in REMOTE-HF. …”
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Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies by Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song

“…IntroductionPremenstrual dysphoric disorder (PMDD) is a cyclical mood disorder that severely affects the daily life of women of reproductive age. Most of the medications being used clinically have limitations such as low efficacy, side effects, and high cost, so there is an urgent need to discover safer and more effective medications. …”
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Desarrollo de la nueva guía canadiense de diseño y gestión de infraestructura vial 2011: un resumen del estado de la práctica canadiense Development of the new 2011 canadian paveme... by Susan L Tighe, Norman W. McLeod, Marta Juhasz

“…There will be 15 chapters in the new guide ranging from discussions on the principles of asset management, to data requirements, sustainability, maintenance, materials, low and high volume road design and life cycle analysis of pavement designs. The draft 2011 PADMG has been submitted and the project will be completed by September 2011.…”
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The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

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Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area by Gloria Omaira Bautista, Axel Kroeger, Nelly Rosero Castillo, Eduardo Gabriel Osorio Sanchez, Dianne Sofía Gonzales Escobar, Rafael Olarte, Sonia Diaz Monsalve

“…They all had stressful life events recently, with economic hardship being the most significant one, especially among migrants. …”
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Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice by Xiuxiu Wu, Tianyi Guo, Biao Li, Shuai Han, Zuomin Hu, Yi Luo, Dandan Qin, Yaping Zhou, Feijun Luo, Qinlu Lin

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Riesgo y vulnerabilidad de los profesionales de la salud ante la pandemia de COVID-19 by Diana L. Reartes-Peñafiel, Clara Juárez-Ramírez, Hortensia Reyes-Morales, Gaudencio Gutiérrez-Alba, José A. Muños-Hernández

“…Methods: Three emergent categories were inferentially analyzed based on some constructivist grounded theory assumptions: a) harm reduction strategies used, b) perception of own vulnerability to SARS-CoV-2 and c) impact on personal life. Results: Perceptions of risk and vulnerability are two interdependent domains constructed from lived experience of health care professionals, meanings were developed as negative attributes were socially assigned: the cause of the infection was unknown, but it was a dangerous virus that caused the deaths of colleagues. …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Finally, RNA stability experiments confirmed CKB, RRM2, NME1, PKM, and UXS1 as specific metabolic target genes affected by NC/IGF2BP3, displaying reduced RNA half-life post IGF2BP3 downregulation. Conclusion Our study suggest that NC may exert its anti-HCC effects by downregulating IGF2BP3, inhibiting the m6A modification levels of metabolic-related genes, thereby reducing their stability and expression. …”
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Effects of rocky desertification on soil bacterial community in alpine grasslands of the Qinghai-Tibet Plateau by Shan Li, Shan Li, Huakun Zhou, Wenying Wang, Haze Ade, Haze Ade, Zhonghua Zhang, Li Ma, Zhen Wang, Qiang Zhang, Jingjing Wei, Jingjing Wei, Hongye Su, Hongye Su, Ruimin Qin, Ruimin Qin, Zhengchen Shi, Zhengchen Shi, Xue Hu, Xue Hu, Faliang Wu

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The relationship between social support and depression among older adults with hypertension in urban communities: mediating effects of coping styles by Dan Li, Jin-Hua Jie, Hong Li, Xue-Mei Xia, Yilin Zhang, Yilin Zhang, Yan Yang, Yan Yang, Jianjun Xiang, Jianjun Xiang, Jianjun Xiang, Hai-Lin Zhuang

“…Interventions to reduce depression in this population should focus on enhancing social support (across objective, subjective, and utilization aspects) and promoting positive coping strategies, thus strengthening psychological resilience and improving overall health and quality of life for older adults with hypertension.…”
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Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot stu... by Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Sahar K. Hegazy, Maha M. Maher, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa

“…Clinical remission was defined as a PMS of less than 2 and the absence of any single sub score greater than 1.Primary outcomeDecreased PMS and improved quality of life.Secondary outcomeChange in the level of measured biomarkers.ResultsCompared to the placebo group (n = 24), the atorvastatin group (n = 23) exhibited a significant decrease in the level of IL-6 (p = 0.001), S1P (p = 0.0001), TNF-α (p = 0.003), NO (p = 0.0001), CRP (p = 0.015), ESR (p = 0.012), PMS (p = 0.013), and fecal calprotectin (p = 0.0003), and improved SF-36 (p = 0.006). …”
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Impact of the initiation of isCGM soon after type 1 diabetes mellitus diagnosis in adults on glycemic indices and fear of hypoglycemia: a randomized controlled trial by Jerzy Hohendorff, Jerzy Hohendorff, Agata Grzelka-Wozniak, Marta Wrobel, Michal Kania, Michal Kania, Lidia Lapinska, Dominika Rokicka, Dorota Stoltny, Irina Kowalska, Krzysztof Strojek, Dorota Zozulinska-Ziolkiewicz, Maciej T. Malecki, Maciej T. Malecki

“…BackgroundContinuous glucose monitoring (CGM) improves glycemic control and quality of life. Data on glycemic indices and fear of hypoglycemia (FoH) in newly diagnosed T1DM patients are limited.AimTo assess the impact of initiating intermittently scanned CGM (isCGM) within 1–6 months of diagnosis on glycemic control and FoH in adults with T1DM.Subjects and methodsAfter wearing a blinded sensor for 14 days, participants were randomized (1:1) to either isCGM (intervention) or self-monitoring blood glucose (SMBG) with glucometers and blinded CGM (control). …”
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Visual analysis of traditional Chinese medicine nursing research on post-stroke sleep disorders based on CiteSpace (基于CiteSpace的脑卒中后睡眠障碍中医护理研究可视化分析)... by GAO Ziqi (高子琪), LIAO Ruoyi (廖若夷), YU Yanlan (余艳兰), SI Huijie (佀惠婕), LIU Bin (刘彬), GUO Yuan (郭元)

“…Conclusion TCM nursing intervention for sleep disorders after stroke has achieved good results, which can significantly improve the sleep quality of patients, promote the outcome of the disease, and improve the quality of life of patients. (目的 使用CiteSpace工具对卒中后睡眠障碍进行分析, 为今后的临床护理和相关研究提供一定的帮助和参考。…”
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