Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…The correlation of CSF β2M with P-tau (proportion = 25.4%, P < 0.001) and T-tau (proportion = 26.7%, P < 0.001) was partially mediated by GFAP in total participants, reproduced in late-life individuals. Furthermore, the astrocyte cascade also partially mediated the pathological relationship between CSF β2M and tau pathology (β2M → GFAP → YKL-40 → P-tau/T-tau, IE: 0.424—0.435, all P < 0.001). …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

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Drp1–associated genes implicated in sepsis survival by Marissa D. Pokharel, Marissa D. Pokharel, Anlin Feng, Anlin Feng, Ying Liang, Ying Liang, Wenli Ma, Wenli Ma, Saurabh Aggarwal, Hoshang Unwalla, Stephen M. Black, Stephen M. Black, Stephen M. Black, Ting Wang, Ting Wang, Ting Wang

“…Sepsis is a severe and life-threatening medical syndrome that can lead to organ failure and death. …”
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Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) by Laura Howells, Kim S. Thomas, Miriam Santer, Ingrid Muller, Kate Greenwell, Amanda Roberts, Hywel C. Williams, Jane Harvey, Stephanie J. Lax, Natasha K. Rogers, Tracey H. Sach, Sandra Lawton, Mary Steele, Katy Sivyer, Julie Hooper, Amina Ahmed, Sylvia Wilczynska, Sinead Langan, Paul Leighton

“…Key lessons in developing an implementation strategy include 1) start implementation work early 2) maintain flexibility to explore multiple routes to implementation 3) use secondary data sources 4) balance theory with practicalities 5) consider longer-term maintenance beyond the life of the research project. Conclusion Implementation planning is a key stage of the research process that is often not adequately resourced. …”
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Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D by Lihua Wang, Siyu Wang, Jason A. Anema, Vaha A. Moghaddam, Yanli Lu, Shiow Lin, E. Warwick Daw, Allison L. Kuipers, Iva Miljkovic, Michael Brent, Gary J. Patti, Bharat Thygarajan, Joseph M. Zmuda, Michael A. Province, Ping An

“…To identify novel genetic loci for THR change over time (ΔTHR), we conducted genome-wide association study (GWAS) and genome-wide linkage scan (GWLS) among nondiabetic Europeans from the Long Life Family Study (n = 1,384). Subjects with diabetes or on dyslipidemia medications were excluded. …”
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Analysis of Prognostis Factors and Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease by Yiming XU, Honghua SHEN, Jingbo DU, Lei REN

“…All patients completed aerobic exercise of different intensity for 20 weeks, and postoperative life quality, treatment, and survival time of the patients were followed up for 2 years. …”
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Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

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Preliminary Data on <i>Silybum marianum</i> Metabolites: Comprehensive Characterization, Antioxidant, Antidiabetic, Antimicrobial Activities, LC-MS/MS Profiling, and Predicted ADME... by Sabrina Lekmine, Ouided Benslama, Mohammad Shamsul Ola, Nabil Touzout, Hamza Moussa, Hichem Tahraoui, Haroun Hafsa, Jie Zhang, Abdeltif Amrane

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Prediction of outpatient rehabilitation patient preferences and optimization of graded diagnosis and treatment based on XGBoost machine learning algorithm by Xuehui Fan, Ruixue Ye, Yan Gao, Kaiwen Xue, Zeyu Zhang, Jing Xu, Jingpu Zhao, Jun Feng, Yulong Wang

“…BackgroundThe Department of Rehabilitation Medicine is key to improving patients’ quality of life. Driven by chronic diseases and an aging population, there is a need to enhance the efficiency and resource allocation of outpatient facilities. …”
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Good-Quality mHealth Apps for Endometriosis Care: Systematic Search by Diksha Sirohi, Cecilia HM Ng, Niranjan Bidargaddi, Helen Slater, Melissa Parker, M Louise Hull, Rebecca O'Hara

“…ConclusionsAlthough time and geographical location can influence the search results, we identified 6 “good-quality” endometriosis mHealth apps that can be recommended to the endometriosis community. mHealth apps designed for community use should evaluate their effectiveness on user’s endometriosis knowledge, self-recommended management strategies, pain self-efficacy, user satisfaction, and user quality of life. Digital technology should be leveraged to develop mHealth apps for clinicians that contribute to continued medical education and assist clinical decision-making in endometriosis management. …”
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Assessment of the general population knowledge about the emergence of Nipah virus outbreak in Bangladesh: A nationwide cross-sectional study by Mobin Ibne Mokbul, Shuvajit Saha, Samiha Nahar Tuli, Fatema Binte Nur, A.M. Khairul Islam, Tariful Islam, Shirsho Shreyan, Alok Bijoy Bhadra, Golam Dastageer Prince, Irfath Sharmin Eva, Mustari Nailah Tabassum, Ferdous Wahid, Md Irfan Bin Kayes, Nazim Hassan Ziad, Mohammad Delwer Hossain Hawlader

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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

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Computational analysis of heat transfer and fluid flow characteristics in a diamond microchannel heat sink with orthogonal ribs by Liang Du, Wenbo Hu, Ningkang Deng, Zhaoyang Zhang, Hongxing Wang

“…Effective thermal management technologies ensure that electronic equipment operates under optimal conditions, extends its service life, improves system integration and reliability, and ensures compliance with industry regulations and standards. …”
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Improving future fish consumption: A case study on developing fish products for preschool children by Hui Jia, Zdeněk Fuka, Jan Hora, Magdalena Marešová, Věra Adámková, Koushik Roy, Jan Mraz

“…Microbiological analysis confirmed all products met European (EU) standards with Listeria monocytogenes levels (0 before product left producer, <10 CFU/g during 3-week shelf-life), ensuring safety. Nutritional assessments highlighted balanced protein (14.3–17.2 g/100 g) and varied fat contents (6.6–18.3 g/100 g), with salt levels (1.54–1.7 g/100 g) significantly lower than traditional smoked products, aligning with healthier standards for children. …”
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Security and religion in democratizing Tunisia: re-enacting surveillance through religious narratives and gendered dynamics by Fabrizio Leonardo Cuccu, Alessandra Bonci

“…By inquiring about their everyday work, our aim is to highlight how “national security delineates individual experience” (Ochs, 2011: 3), how the national discourse on security is reproduced in day-to-day life and how in turn, these everyday practices shape the security apparatus. …”
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Indication of frailty transitions on 2-year adverse health outcomes among older Chinese inpatients: Insight from a multicenter prospective cohort study. by Miao Yu, Jiaqi Ding, Xinjuan Wu, Xianxiu Wen, Jingfen Jin, Hui Wang, Dongmei Lv, Shengxiu Zhao, Jing Jiao, Tao Xu

“…The outcome variables included mortality, falls, hospital readmissions, and Health-Related Quality of Life (HRQoL). Cox proportional hazard regression, generalized linear models and linear regression was used to examine the association between frailty transitions and adverse health outcomes.…”
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance by Hyunjeong Kim, Marienela Y. Heredia, Xiao Chen, Maisha Ahmed, Mohammad Qasim, Tracy L. Callender, Aaron D. Hernday, Jason M. Rauceo

“…ABSTRACT The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. …”
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Usability and Usefulness of a Symptom Management Coaching System for Patients With Cancer Treated With Immune Checkpoint Inhibitors: Comparative Mixed Methods Study by Savannah Lucia Caterina Glaser, Itske Fraterman, Noah van Brummelen, Valentina Tibollo, Laura Maria Del Campo, Henk Mallo, Sofie Wilgenhof, Szymon Wilk, Vitali Gisko, Vadzim Khadakou, Ronald Cornet, Manuel Ottaviano, Stephanie Medlock

“…A prototype of the eHealth tool Cancer Patients Better Life Experience (CAPABLE) was developed to facilitate symptom management, aimed at patients with melanoma and renal cell carcinoma treated with immunotherapy. …”
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Effects of open-skill exercise on executive functions in children and adolescents: a systematic review and meta-analysis by Shunding Hu, Peng Shi, Ziyun Zhang, Xiaosu Feng, Kai Zhang, Kai Zhang, Kai Zhang, Teng Jin

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The effect of pressurized intraperitoneal aerosolized chemotherapy on the surgical treatment outcomes of ovarian cancer with peritoneal carcinomatosis by A. S. Dzasochov, A. A. Kostin, V. L. Astashov, A. B. Turiev, A. D. Uskov, M. A. Andreeva

“…To study the surgical safety profile of PIPAC, all adverse events of a surgical profile were recorded at each hospitalization. The duration of life without relapse was estimated as the main outcome, the median relapse-free survival was the main indicator. …”
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