Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice by Yan Yang, Wenting Zhang, Xiaohui Wu, Jing Wu, Chengjun Sun, Feihong Luo, Zhou Pei

Get full text

Patient and public involvement in the design and protocol development for a platform randomised trial to evaluate diagnostic tests to optimise antimicrobial therapy (PROTECT) [vers... by Sammy Ainsworth, Cherry-Ann Waldron, Sarah Jones, Julie Carman, Martina Svobodova, Graham Prestwich, Margaret Ogden, Melanie Gager, Liza Keating

“…Identification and recruitment of public contributors via working with existing public involvement groups across the UK enabled the trial team to involve public members with varied life experiences and from diverse backgrounds. This project was a good practice example of how public involvement groups and practitioners across the UK can work together to deliver public involvement that is inclusive of relevant groups.…”
Get full text

Plasma-enhanced upcycling of mixed plastic waste over La0.6Ca0.4FeO3−δ nano spheres for co-producing hydrogen and high-value carbon by Guoxing Chen, Xiao Yu, Aasir Rashid, Chanchan Li, Marc Widenmeyer, Lina Liu, Bowen Liu, Yi Wang, Gert Homm, Emanuel Ionescu, Tao Shao, Anke Weidenkaff

“…The addition of La0.6Ca0.4FeO3−δ nano spheres as a pre-catalyst further enhanced hydrogen yield by 1.8 times while facilitating the production of value-added carbon nanotube composite materials. A life-cycle assessment demonstrated that recycling mixed plastic waste via this method significantly reduces CO₂ emissions compared to conventional thermal pyrolysis. …”
Get full text

US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers by Kun Zhou, Holger Strunk, Dobromir Dimitrov, Joan Vidal-Jove, Maria A. Gonzalez-Carmona, Markus Essler, Chengbin Jin, Zhechuan Mei, Hui Zhu, Milka Marinova

“…The underutilized yet promising USgHIFU exhibits the potential to enhance patients’ quality of life by alleviating cancer-related pain. Experts in the field should evaluate this treatment option be evaluated by experts in this field, with this consensus paper potentially serving as a guiding resource for the medical community.Conclusions: US-guided HIFU for advanced pancreatic cancer addresses treatment goals, available options, success rates, and limitations. …”
Get full text

Optimasi Formula Produk Mi Basah Terfortifikasi Bubuk Spirulina Platensis L. Menggunakan D-Optimal Mixture Design by Hendrix Yulis Setyawan, Eka Wahyu Belianna, Lana Izzatul Afifal, Devi Dwi Damayanti, Dhea Aura Bening Shafira, Karlina Wijayanti

“…Abstract The productive life of Indonesian people encourages the consumption of cheap and practical instant noodles, with 3.8% consuming them more than once a day. …”
Get full text

Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism by Yang Yang, Yang Yang, Qing Hong, Qing Hong, Xuehong Zhang, Zhenmin Liu, Zhenmin Liu

Get full text

Self-assessed depressive symptoms in adolescents comparing two Swedish cohorts born 15 years apart by Carl Wikberg, Pia Augustsson, Marcus Praetorius Björk, Tord Ivarsson, Gudny Sveinsdottir, Eiríkur Örn Arnarson, W. Edward Craighead, Ina Marteinsdottir, Josefine Lilja

Get full text

Psychological well-being and academic performance of Ukrainian medical students under the burden of war: a cross-sectional study by Mykhaylo Korda, Arkadii Shulhai, Oksana Shevchuk, Oleksandra Shulhai, Anna-Mariia Shulhai, Anna-Mariia Shulhai

“…Living and studying facing the war has a crucial influence on medical students’ education and daily life. The study aimed to determine the psychological well-being and academic achievements of Ukrainian medical students who lived in the rear areas after the 18 months of the Russian–Ukrainian war.MethodsThe cross-sectional study was conducted at I.Ya. …”
Get full text

Persistently high concentrations of β-hydroxybutyrate affect hepatic SOD2 expression and blood SOD activity in high-yielding dairy cows by Dominika Grzybowska, Katarzyna Żarczyńska, Przemysław Sobiech, Paweł Brym, Dawid Tobolski

Get full text

Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…Abstract Background Anxiety disorders in older adults have become a prominent public health problem due to their concomitant chronic conditions, reduced quality of life and even death. However, fewer studies have been conducted on differences in anxiety among older individuals in different aged-care models, and the interactive relationship between the influencing factors on anxiety remains unclear. …”
Get full text

Nursing of a patient with sudden deafness using Orem self-care mode combined with Traditional Chinese medicine interventions (Orem自理模式联合中医疗法应用于1例突发性聋患者的护理体会)... by SONG Bo (宋波), MEI Xueting (梅雪婷), PEI Xiaolu (裴晓璐), WANG Junge (王俊阁), AI Jianwei (艾建伟), YAN Xinyu (闫新宇), HAN Jinshuai (韩金帅)

“…In response to the problems of affected quality of life, easy occurrence of adverse emotions, and decreased self-care ability of the patient, the Orem self-care mode was used to guide the nursing practice. …”
Get full text

The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study by Banafsheh Darvishi Teli, Meysam Behzadifar, Mania Beiranvand, Aziz Rezapour, Seyed Jafar Ehsanzadeh, Samad Azari, Ahad Bakhtiari, Payam Haghighatfard, Mariano Martini, Maryam Saran, Masoud Behzadifar

“…Comprehensive policies addressing both medical and non-medical expenses are necessary to improve patients’ quality of life and lessen the financial challenges associated with breast cancer in Iran.…”
Get full text

Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…Diabetic wound infections caused by conventional antibiotic-resistant <i>Staphylococcus aureus</i> strains are fast emerging, leading to life-threatening situations (e.g., high costs, morbidity, and mortality) associated with delayed healing and chronic inflammation. …”
Get full text

Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

Get full text

Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial by Andreas Blomqvist, Maria Bäck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma

“…Although the 1-year survival rate after the first diagnosis is high, physical inactivity and sedentary behavior are associated with increased mortality and negatively impact the health-related quality of life (HR-QoL). ObjectiveWe tested the recruitment frequency, implementation fidelity, and feasibility of outcomes of the Activity Coach app that was developed using an existing mobile health (mHealth) tool, Optilogg, to support older adults with HF to be more physically active and less sedentary. …”
Get full text

Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

“…The resulting top 10 research questions cover multiple themes, i.e. prediction of disease progression, development of novel tools, mechanistic insights, improved diagnostics, therapeutic integration of multi‐omics techniques, assessment of impact on daily life, expanding treatment avenues, optimal study designs, effect of lifestyle interventions, and data utilization using FAIR principles. …”
Get full text

Psychological factors affecting post-treatment follow-up care in breast cancer patients attending healthcare centers in western Mazandaran (2021-2022) by Zahra Fotokian, Sobhan Rahimi Esbo, Zahra Jannat Alipour, Ali Pourhabib, Fatemeh Ghaffari, Mojtaba Qanbari Qalesari, Shahrbanoo Keyhanian, Mohsen Vakili Sadeghi

“…Background & Aim: Post-treatment follow-up care for breast cancer is crucial in reducing mortality rates, minimizing treatment costs, and enhancing patients' quality of life. This study aims to identify the psychosocial factors affecting post-treatment follow-up care in breast cancer patients. …”
Get full text

Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy by S. Rossi, R. Maisto, C. Gesualdo, M. C. Trotta, F. Ferraraccio, M. K. Kaneva, S. J. Getting, E. Surace, F. Testa, F. Simonelli, P. Grieco, F. Merlino, M. Perretti, M. D’Amico, C. Di Filippo

Get full text

A Sustainable Approach: Repurposing Red Beetroot Peels for Innovative Meringue Products by Oana Emilia Constantin, Florina Stoica, Silvia Lazăr (Mistrianu), Doina Georgeta Andronoiu, Mihaela Turturică, Nicoleta Stănciuc, Roxana Nicoleta Rațu, Constantin Croitoru, Gabriela Râpeanu

Get full text

The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Future research and new therapies may enhance outcomes and reduce health care costs, improving patient quality of life.…”
Get full text