Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…We also determined the half-life and Gibbs free energy of the complex of TBP with the АВСА9 promoter. …”
Get full text

Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…The Bcl-2/Bad expression area ratio in 10-week-old animals was twice as high as in 18-week-old animals, which indicates the presence of conditions for blocking apoptosis in the liver of younger db/db mice. At the 18th week of life, db/db mice displayed an almost threefold increase in the expression area of the Bad protein against the background of an unchanged expression of the Bcl-2 protein. …”
Get full text

Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health by O.E. Dorofieieva, K.S. Yarymbash, O.A. Glinyana, Yu.V. Syomych, I.T. Skrypchenko

“…Mine-blast injuries of the shin cause impairments at the structural level, but the majority of impairments in patients were found at the level of function, activity, and participation, which significantly affected their quality of life.…”
Get full text

LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation by Jun Liu, Xiang Li, Peng Yang, Yufeng He, Weilong Hong, Yawei Feng, Zhiqiang Ye

“…Abstract Background Acute respiratory distress syndrome (ARDS) is a life-threatening and heterogeneous disorder leading to lung injury. …”
Get full text

Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…Key epidemiological indicators were extracted, including prevalence, incidence, mortality, and disability-adjusted life-years (DALYs). Temporal trends were quantified through estimated annual percentage changes (EAPCs) in age-standardized rates of prevalence (ASPR), incidence (ASIR), mortality (ASDR), and DALYs across the study period. …”
Get full text

Connective tissue disease-associated interstitial lung disease – A multicenter observational study from India by Sham Santhanam, Pravin Patil, Mohit Goyal, C B Mithun, Parthajit Das, Kavitha Mohanasundaram, Neeraj Jain, Vijaya Prasanna, Keerthi Talari, Himanshu Pathak, Parshant Aggarwal, Deepika Ponnuru, Vikram Raj Jain, Sharath Kumar

“…More than a third of the patients had PH. In the real-life scenario, we noticed hesitancy among the treating doctors in using MTX in RA-ILD. …”
Get full text

Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system by Jingrong Yang, Mengfan You, Jingxin Wang, Rongfei Sun, Lili Han, Xiaonan Liu, Kaibin Niu, Kaidi Xing, Juanping Sun, Wenge Su, Yifei Wang

“…BackgroundArrhythmias are prevalent cardiac disorders with significant impacts on patient quality of life and mortality. Amiodarone, a class III antiarrhythmic agent, is widely used to manage both atrial and ventricular arrhythmias due to its efficacy in prolonging the cardiac action potential and its multiple antiarrhythmic properties. …”
Get full text

Two new strains of Streptomyces with metabolic potential for biological control of pear black spot disease by Yi-Huang Chen, Jia-Xing Zhang, Yan Min, Yang Liu, Jian-Ming Wang, Lin-Quan Bai, Xiao-Xia Luo

Get full text

Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18 by Kunyu Li, Yize Song, Yekai Fan, Hui Zhang, Mingxing Chu, Yufang Liu

“…These findings lay the foundation for further elucidation of the molecular mechanisms underlying muscle growth and development across different life stages of goats. Additionally, it could be a potential molecular marker for improving muscle production in goats.…”
Get full text

Optimal Vase Solution for <i>Gerbera hybrida</i> Cut Flower Keeping Fresh by Activating SA and Cytokinin Signaling and Scavenging Reactive Oxygen Species by Chaoshui Xia, Yiyang Cao, Weixin Gan, Huifeng Lin, Huayang Li, Fazhuang Lin, Zhenhong Lu, Weiting Chen

“…Gerbera (<i>Gerbera hybrida</i>) is a popular cut flower on the market, so extending its vase life (VL) is an important goal in the horticultural industry. …”
Get full text

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy by Wenjie Xi, Weijie Wu, Lili Zhou, Qi Zhang, Shushu Yang, Lihong Huang, Yijun Lu, Jing Wang, Xinjin Chi, Yang Kang

“…Sepsis is a serious and life-threatening condition, which can lead to organ failure and death clinically. …”
Get full text

Reducing personal protective equipment waste in the emergency department of a large regional hospital: codesign informed by system science by Mike Forrester, Rebecca Patrick, Steven Allender, Jaithri Ananthapavan, Urvi Thanekar, Hasini Gunasiri, Minoo Naebe, Maryam Naebe

“…There were 25 participants including ED doctors, nurses and allied health staff (n=10), sustainability manager (n=1), waste management coordinator (n=1), infection prevention, (n=2) procurement leads, (n=1) external stakeholders (eg, Department of Health, and sustainability authority) (n=3), consumer representatives (n=2), and experts in materials and implementation science (n=2) life-cycle analysis (n=2) and health economics (n=1).Results A causal loop diagram was developed representing the drivers of PPE waste, and codeveloped solutions prioritised by feasibility and impact. …”
Get full text

Research progress on application of digital health interventions in patients with cutaneous ureterostomy (数字健康干预在输尿管皮肤造口患者中的应用进展) by JI Xuebi (吉学碧), WANG Jun (王俊), WANG Ping (王萍), YE Yingao (叶迎奥), WANG Haifeng (王海峰)

“…Concurrently, the accelerated advancement of mobile technology and information systems has led to the integration of digital health interventions, which significantly enhance the convenience for these patients, thereby elevating their quality of life and providing assistance. This paper reviews studies on concepts and related policies of digital health, and current status of clinical application of digital health interventions in patients with cutaneous ureterostomy. …”
Get full text

Implementation of a Cost and Variation Reduction Program for Hemostasis Products at a Large Academic Medical Center: A Multi-Stakeholder Perspective by Shah T, Brethauer S, Danker III WA, Doshi I, O'Hara M, Silber A, Vasileff WK

“…., Raritan, NJ, USA; 3Trinity Life Sciences, Waltham, MA, USA; 4Department of Orthopaedics, Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USACorrespondence: Stacy Brethauer, Email Stacy.Brethauer@osumc.eduGoal: Cost-saving initiatives targeting surgical supplies management have become increasingly common to address rising healthcare costs. …”
Get full text

Mesalazine for People with Diverticular Disease: A Systematic Review of Randomized Controlled Trials by Andrea Iannone, Marinella Ruospo, Germaine Wong, Michele Barone, Mariabeatrice Principi, Alfredo Di Leo, Giovanni F. M. Strippoli

“…We estimated risk ratios (RR) for dichotomous outcomes (disease remission/recurrence, acute diverticulitis in symptomatic uncomplicated diverticular disease, need for surgery/hospitalization, all-cause/disease-related mortality, adverse events), mean differences (MD) or standardized MD (SMD) for continuous outcomes (quality of life, symptoms score, time to recurrence/remission), and their 95% confidence intervals (CI) using random-effects models. …”
Get full text

Classification of Epileptic Seizures by Simple Machine Learning Techniques: Application to Animals&#x2019; Electroencephalography Signals by Illia Pidvalnyi, Anna Kostenko, Oleksandr Sudakov, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal, Olena Iegorova, Ievgen Kabin, Zoya Dyka, Steffen Ortmann, Peter Langendorfer

“…Small electronic devices capable of doing that will improve the quality of life for epilepsy patients while also open new opportunities for pharmacological intervention. …”
Get full text

A Novel Convolutional Neural Network-Based Approach for Fault Classification in Photovoltaic Arrays by Farkhanda Aziz, Azhar Ul Haq, Shahzor Ahmad, Yousef Mahmoud, Marium Jalal, Usman Ali

“…Fault diagnosis in photovoltaic (PV) arrays is essential in enhancing power output as well as the useful life span of a PV system. Severe faults such as Partial Shading (PS) and high impedance faults, low location mismatch, and the presence of Maximum Power Point Tracking (MPPT) make fault detection challenging in harsh environmental conditions. …”
Get full text

Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord by Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda, Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto

“…This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient receptor potential ankyrin 1 (TRPA1) pathways are believed to be essential in recruiting an allodynia response. …”
Get full text

The role of partial splenic artery embolization in the management of refractory esophageal variceal bleeding due to portal vein thrombosis by Büşra Tetik Dinçer, Nafiye Urgancı, Aylin Hasanefendioğlu Bayrak, Özlem Durmaz, İlgin Özden

“…Abstract Background Gastro-esophageal variceal hemorrhage (GEVH) is one of the major causes of life-threatening gastrointestinal bleeding in children. …”
Get full text

Therapeutic Efficacy of Ultrasound-Guided High-Voltage Long-Duration Pulsed Radiofrequency for Pudendal Neuralgia by Feng Ji, Shuzhuan Zhou, Caixia Li, Yongyan Zhang, Hua Xu

“…In conclusion, the ultrasound-guided high-voltage long-duration PRF approach not only reduced the pelvic pain caused by PN but also improved the quality of life by extending sitting time without nerve injury.…”
Get full text