Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity by Renata de Azevedo Melo Luvizotto, André Ferreira do Nascimento, Maria Teresa de Síbio, Regiane Marques Castro Olímpio, Sandro José Conde, Ana Paula Lima-Leopoldo, André Soares Leopoldo, Antonio Carlos Cicogna, Célia Regina Nogueira

“…To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. …”
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Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ by Edward H. Leiter, Marjorie Strobel, Adam O'Neill, David Schultz, Andrew Schile, Peter C. Reifsnyder

“…The more progressive development of obesity produces a maturity-onset development of hyperglycemia in contrast to the juvenile-onset diabetes observed in the morbidly obese db/db model. Unlike the leptin receptor-deficient db/db models with central leptin resistance, the new models develop a progressive peripheral leptin resistance and are able to maintain reproductive function. …”
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A Data Mining Approach Identified Salivary Biomarkers That Discriminate between Two Obesity Measures by Ping Shi, J. Max Goodson

“…We identified C-reactive protein (CRP), insulin, leptin, adiponectin, as salivary biomarkers associated with OBW, plus a clinical feature fitness level. …”
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Adipocytokine Associations with Insulin Resistance in British South Asians by D. R. Webb, K. Khunti, S. Chatterjee, J. Jarvis, M. J. Davies

“…We investigated adiponectin, leptin, and TNF-α and assessed the contribution of these molecules to insulin resistance in south Asians. …”
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Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

“…The independent effects of asthma, obesity, and their interaction effect on these inflammatory markers were assessed using multiple regression analysis.ResultsAsthma was associated with the increased expression of pro-inflammatory cytokines, including IL-2, IL-5, IL-13, IL-17A, IL-22, IL-33, and TNF-α, and reduced levels of anti-inflammatory cytokine, IL-10 and adipokine, leptin in the circulation. Overweight/obesity was also linked to increased plasma levels of IL-5, IL-17A, IL-22, IL-33, TNF-α, and leptin and decreased levels of IL-10. …”
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Fetal Growth Trajectories and Their Association with Maternal, Cord Blood, and 5-year Child Adipokines by H. C. Bartels, A. A. Geraghty, E. C. O’Brien, A. Kranidi, J. Mehegan, C. Yelverton, C. M. McDonnell, F. M. McAuliffe

“…Studies have highlighted the important role of biochemical growth markers such as leptin and adiponectin on fetal growth. Objective. …”
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Characteristics of NAFLD Based on Hypopituitarism by Kazuhisa Kodama, Atsuhiro Ichihara, Yasufumi Seki, Yuichi Ikarashi, Takaomi Sagawa, Tomomi Kogiso, Maiko Taniai, Katsutoshi Tokushige

“…The levels of adipocytokines, serum adiponectin, and serum soluble TNFR-2 showed no correlation with hepatic fibrosis, whereas the serum leptin levels were significantly correlated with liver fibrosis (R = 0.696). …”
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Effect of Rosiglitazone and Insulin Combination Therapy on Inflammation Parameters and Adipocytokine Levels in Patients with Type 1 DM by Metin Guclu, Ozen Oz Gul, Soner Cander, Oguzkaan Unal, Guven Ozkaya, Emre Sarandol, Canan Ersoy

“…Combination therapy did not significantly improve metabolic and inflammatory parameters, insulin sensitivity, and adiponectin levels. While leptin and resistin levels decreased in both groups (group 1: resistin 6.96 ± 3.06 to 4.99 ± 2.64, P=0.006; leptin 25.8 ± 17.6 to 20.1 ± 12.55, P=0.006; group 2: resistin 7.16 ± 2.30 to 5.57±2.48, P=0.031; leptin 16.72 ± 16.1 to 14.0 ± 13.4, P=0.007) Hgb and fibrinogen levels decreased only in group 1 (Hgb 13.72 ± 1.98 to 13.16 ± 1.98, P=0.015, and fibrinogen 4.00 ± 1.08 to 3.46 ± 0.90, P=0.002). …”
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Negative Effects of High Glucose Exposure in Human Gonadotropin-Releasing Hormone Neurons by Annamaria Morelli, Paolo Comeglio, Erica Sarchielli, Ilaria Cellai, Linda Vignozzi, Gabriella B. Vannelli, Mario Maggi

“…High glucose exposure (22 mM; 40 mM) significantly reduced gene and protein expression of GnRH, KISS1R, KISS1, and leptin receptor, as compared to normal glucose (5 mM). …”
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Effects of Aerobic Exercise on Rats with Hyperandrogenic Polycystic Ovarian Syndrome by Na Li, Chenghao Yang, Huiyu Xie, Yinghong Liu, Yuanpeng Liao

“…Results indicated that the concentrations of leptin (LP) in the EC group were significantly lower than those in the NC group (p<0.05). …”
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Variations in the Obesity Gene “LEPR” Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis by Ming Ming Yang, Jun Wang, Jiao Jie Fan, Tsz Kin Ng, Dian Jun Sun, Xin Guo, Yan Teng, Yan-Bo Li

“…Leptin is a hormone protein regulating food intake and energy expenditure. …”
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Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function by Irina Zyubanova, Nadezhda Ryumshina, Victor Mordovin, Musheg Manukyan, Valeriya Lichikaki, Ekaterina Solonskaya, Anna Gusakova, Tatjana Suslova, Stanislav Pekarskiy, Simzhit Khunkhinova, Anastasia Popova, Veronika Rudenko, Alla Falkovskaya

“…Lowering BP in women was associated with increased leptin levels after RDN (r = −0.47 for SBP, r = −0.48 for DBP). …”
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Impaired Muscle Regeneration in Ob/ob and Db/db Mice by Mai-Huong Nguyen, Ming Cheng, Timothy J. Koh

“…Impaired regeneration in ob/ob and db/db mice could be due partly to the lack of leptin signaling, since leptin is expressed both in damaged muscle and in cultured muscle cells. …”
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Is Chronic Inflammation a Possible Cause of Obesity-Related Depression? by Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocełak, Joanna Janowska, Elżbieta Semik-Grabarczyk, Tomasz Wikarek, Wojciech Gruszka, Piotr Dąbrowski

“…We did not observe differences of serum concentrations of TNF-α, sTNFRs, leptin, and IL-6 between subgroup A and subgroups B and C. …”
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Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract by Soundararajan Kamalakkannan, Ramaswamy Rajendran, Ramasamy V. Venkatesh, Paul Clayton, Mohammad A. Akbarsha

“…Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. …”
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Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases by Éric Toussirot, Béatrice Gaugler, Malika Bouhaddi, Nhu Uyen Nguyen, Philippe Saas, Gilles Dumoulin

“…In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary Sjögren's syndrome, sarcoidosis, mixed connective tissue disease, vasculitis, CREST syndrome, and polymyositis) and in 15 healthy female controls. …”
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Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity by Mario Solis-Paredes, Salvador Espino y Sosa, Guadalupe Estrada-Gutierrez, Sonia Nava-Salazar, Veronica Ortega-Castillo, Mario Rodriguez-Bosch, Eyerahi Bravo-Flores, Aurora Espejel-Nuñez, Maricruz Tolentino-Dolores, Rubí Gaona-Estudillo, Nancy Martinez-Bautista, Otilia Perichart-Perera

“…Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. …”
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A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats by Kristin J. Speaker, Madeline M. Paton, Stewart S. Cox, Monika Fleshner

“…Glucose, nonesterified free fatty acids (NEFAs), insulin, leptin, and corticosterone were measured in plasma and tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-10 in plasma, and subcutaneous, intraperitoneal, and visceral compartments of white adipose tissue (WAT). …”
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Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes by Ulrika Andersson-Hall, Carolina Gustavsson, Anders Pedersen, Daniel Malmodin, Louise Joelsson, Agneta Holmäng

“…., insulin, glucose, HbA1c, adiponectin, leptin, and lipid levels) and NMR metabolomics. Based on the OGTT, women were divided into three groups: normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. …”
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Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress by S. Kaur, K. Zilmer, V. Leping, M. Zilmer

“…Adiponectin level in patients was increased (P < 0.0001), but neither adiponectin nor leptin correlated significantly with the biomarkers of inflammation or OxS. …”
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