Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases by Leay-Kiaw Er, Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Yu-Ching Sun, Yu-Lin Ko

“…Stepwise logistic regression analysis showed that C-reactive protein level, leptin level, triglyceride level, eGFR, rs3735167 genotypes, sex, and soluble P-selectin level were independently associated with chemerin levels. …”
Get full text

Adipokines in Breast Cancer: Decoding Genetic and Proteomic Mechanisms Underlying Migration, Invasion, and Proliferation by Ließem A, Leimer U, Germann GK, Köllensperger E

“…While numerous studies suggest their role in promoting tumor growth, the exact mechanisms of their involvement are not yet completely understood.Methods: In this project, varying concentrations of recombinant human adipokines (Leptin, Lipocalin-2, PAI-1, and Resistin) were used to study their effects on four selected breast cancer cell lines (EVSA-T, MCF-7, MDA-MB-231, and SK-Br-3). …”
Get full text

Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet by Ravinder Nagpal, Tiffany M. Newman, Shaohua Wang, Shalini Jain, James F. Lovato, Hariom Yadav

“…This study aimed to determine the association between non-high-fat diet-induced obesity- (non-DIO-) associated gut microbiome dysbiosis with gut abnormalities like cellular turnover of intestinal cells, tight junctions, and mucin formation that can impact gut permeability. We used leptin-deficient (Lepob/ob) mice in comparison to C57BL/6J control mice, which are fed on identical diets, and performed comparative and correlative analyses of gut microbiome composition, gut permeability, intestinal structural changes, tight junction-mucin formation, cellular turnover, and stemness genes. …”
Get full text

Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats by Miwa Nahata, Yayoi Saegusa, Yumi Harada, Naoko Tsuchiya, Tomohisa Hattori, Hiroshi Takeda

“…Although plasma levels of the appetite-suppressing hormone leptin were significantly decreased in GERD rats, no changes were observed in cholecystokinin levels. …”
Get full text

Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of α-Glucosidase Activity by Wujie Cai, Lijing Yu, Yu Zhang, Li Feng, Siyuan Kong, Hongsheng Tan, Hongxi Xu, Cheng Huang

“…We found that the extracts blocked the increase of fasting blood glucose, serum triglyceride (TG), insulin, leptin, and liver lipid levels and prevented the development of glucose tolerance impairment and insulin resistance in the C57BL/6 mice induced by a high-fat diet. …”
Get full text

Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women by Bin Wu, Jingshan Huang, Keisuke Fukuo, Kazuhisa Suzuki, Gen Yoshino, Tsutomu Kazumi

“…Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and systemic oxidative stress marker. …”
Get full text

Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring by Lourdes Rodríguez, Paola Otero, María I. Panadero, Silvia Rodrigo, Juan J. Álvarez-Millán, Carlos Bocos

“…Recently, we found that an intake of fructose (10% wt/vol) throughout gestation produces an impaired fetal leptin signalling. Therefore, we have investigated whether maternal fructose intake produces subsequent changes in their progeny. …”
Get full text

The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats. by Ana Aguilar-Lozano, Berenice Palacios-González, Martha Guevara-Cruz, Armando R Tovar, Alam Palma-Guzman, Lilia G Noriega

“…The prepubertal CD prevented fat mass accumulation, lean mass loss and metabolic inflexibility, showed lower insulin, leptin and cholesterol concentrations in adulthood despite the chronic HFD. …”
Get full text

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Releva... by Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova

“…These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies. …”
Get full text

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants by Alexander V. Shestopalov, Vadim V. Davydov, Genrik T. Tumanyan, Elena D. Teplyakova, Tatiana P. Shkurat, Elena V. Mashkina, Mikhail A. Shkurat, Andrey M. Gaponov, Anastasia A. Sadova, Olga V. Borisenko, Sergey A. Roumiantsev

“…Obese boys homozygous for Ser447Ser have more elevated leptin levels than girls. They also demonstrate lower adiponectin, apelin, prolactin, and osteocrine levels than those in obese girls with the same genotype. …”
Get full text

Acinetobacter baumannii Lipopolysaccharide Influences Adipokine Expression in 3T3-L1 Adipocytes by Yuka Unno, Yoshinori Sato, Satoshi Nishida, Akiyo Nakano, Ryuichi Nakano, Tsuneyuki Ubagai, Yasuo Ono

“…., MIP-2, MCP-1, TNF-α, IL-6, lipocalin-2, and FABP4) in 3T3-L1 adipocytes and significantly reduced the expression of leptin and adiponectin. The effects of A. baumannii-derived LPS on MIP-2 expression were similar in comparison with that of LPS prepared from Pseudomonas aeruginosa and Escherichia coli in our cell culture-based system. …”
Get full text

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy by Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng

“…In in vitro cell experiments, after cultured podocytes were stimulated with leptin, similar to ORG mice, we found aggravated podocyte injury, formatted lipid droplet, increased expression of ADRP and CD36, activated NLRP3 inflammasome, and released IL-1β. …”
Get full text

Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis by Zhang Q, Zhao YX, Li LF, Fan QQ, Huang BB, Du HZ, Li C, Li W

“…As key mediators of MetS, metabolic adipokines such as leptin, lipocalin, and resistin regulate inflammation and bone metabolism through distinct or synergistic signaling pathways. …”
Get full text

Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats by Vandana Zaman, Denise Matzelle, Naren L. Banik, Azizul Haque

“…Interestingly, levels of several hormonal peptides related to hyperinsulinemia, such as insulin, leptin, pancreatic peptide (PP), peptide YY (PYY), and gastric inhibitory polypeptide (GIP), were significantly upregulated. …”
Get full text

Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies by Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli

“…We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications. …”
Get full text

Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects by Dalia Dauksiene, Janina Petkeviciene, Jurate Klumbiene, Rasa Verkauskiene, Jelena Vainikonyte-Kristapone, Audrone Seibokaite, Jonas Ceponis, Vygantas Sidlauskas, Laura Daugintyte-Petrusiene, Antanas Norkus, Birute Zilaitiene

“…In the nonnodular thyroid group, thyroid volume was also positively related to serum insulin and HOMA-IR, whereas a negative correlation between thyroid volume and leptin was identified in the nodular thyroid group. …”
Get full text

Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat by Ghupurjan Gheni, Norihide Yokoi, Masayuki Beppu, Takuro Yamaguchi, Shihomi Hidaka, Ayako Kawabata, Yoshikazu Hoshino, Masayuki Hoshino, Susumu Seino

“…We recently established a novel animal model of obese type 2 diabetes (T2D), the Zucker fatty diabetes mellitus (ZFDM) rat strain harboring the fatty mutation (fa) in the leptin receptor gene. Here we performed a phenotypic characterization of the strain, focusing mainly on the prediabetic state. …”
Get full text

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…PP5 (proteomics, p=0.01) included interleukin-1 receptor antagonist (IL-1ra) and leptin with positive relations to MUO and galanin that correlated positively to MHO. …”
Get full text

Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat by B. S. Muhlhausler, R. Cook-Johnson, M. James, D. Miljkovic, E. Duthoit, R. Gibson

“…Samples from distinct adipose depots (omental and retroperitoneal) were collected and mRNA expression of the pro-lipogenic transcription factors Sterol-Retinoid-Element-Binding-Protein1c (SREBP1c) and Peroxisome Proliferator Activated Receptor-γ (PPARγ), lipogenic enzymes Sterol-coenzyme Desaturase1 (SCD-1), Fatty Acid Synthase (FAS), lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (G3PDH) and adipokines leptin and adiponectin determined by qRT-PCR. Increasing dietary ALA content resulted in altered expression of SREBP1c, FAS and G3PDH mRNA in both adipose depots. …”
Get full text

Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction by Hernán Gonzalo Villagarcía, Vanesa Sabugo, María Cecilia Castro, Guillermo Schinella, Daniel Castrogiovanni, Eduardo Spinedi, María Laura Massa, Flavio Francini

“…MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). …”
Get full text