Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection by Daniela Proverbio, Eva Spada, Giada Bagnagatti De Giorgi, Roberta Perego

“…Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2 mg/kg q 24 hr) and allopurinol (10 mg/kg q 12 hr) for 28 days. …”
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Construction of Two mCherry Plasmids (pXG-mCherry) for Transgenic Leishmania: Valuable Tools for Future Molecular Analysis by Andrés Vacas, Conor Sugden, Óscar Velasco-Rodriguez, Miriam Algarabel-Olona, José Peña-Guerrero, Esther Larrea, Celia Fernández-Rubio, Paul A. Nguewa

“…Leishmania is the causative agent of leishmaniasis, a neglected tropical disease that affects more than 12 million people around the world. …”
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Chemical Constituents from Uapaca guineensis (Phyllanthaceae), and the Computational Validation of Their Antileishmanial and Anti-inflammatory Potencies by Gervais Mouthé Happi, Mireille Towa Yimtchui, Sikiru Akinyeye Ahmed, Shina Salau, Liliane Clotilde Dzouemo, Klev Gaïtan Sikam, Jean Duplex Wansi

“…Since the plant is widely used for the treatment of skin diseases, leishmaniasis and inflammatory diseases, the antileishmanial and anti-inflammatory potencies of all the isolated compounds have been computationally validated through their ability to inhibit the receptors 1QCC and 2XOX (for the antileishmanial studies) and 6Y3C and 1CX2 (for the anti-inflammatory studies). …”
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The current status of neglected tropical diseases in Japan: A scoping review. by Yuriko Harada, Hanako Iwashita, Taeko Moriyasu, Sachiyo Nagi, Nobuo Saito, Mariko Sugawara-Mikami, Kota Yoshioka, Rie Yotsu, Japan NTD Study Group

“…Other NTDs, such as chikungunya, cystic echinococcosis, cysticercosis, leishmaniasis, leprosy, lymphatic filariasis, rabies, and schistosomiasis, have been imported into the country. …”
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Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains by C. Mary, F. Faraut, M. Deniau, J. Dereure, K. Aoun, S. Ranque, R. Piarroux

“…The aim of this study was to detect and quantify the amplification of these genes in clinical strains of visceral leishmaniasis agents: Leishmania infantum, L. donovani, and L. archibaldi. …”
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Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol by Arghavan Memarzia, Fatemeh Amin, Amin Mokhtari-Zaer, Zohre Arab, Saeideh Saadat, Mahrokh Heydari, Zahra Ghasemi, Farzaneh Naghdi, Mahmoud Hosseini, Mohammad Hossein Boskabady

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Neglected tropical diseases in Yemen: a systematic review of epidemiology and public health challenges by Ibrahim Ahmed Ahmed Alhothily, Rahmat Dapari, Nazri Che Dom

“…Schistosomiasis and ascariasis were the most reported helminth infections, whereas leishmaniasis and malaria were the leading protozoal NTDs. …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. …”
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Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…Infliximab may also have beneficial effects on the prognosis of cutaneous leishmaniasis by reducing the parasite burden.…”
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Protozoan Parasites of Rodents and Their Zoonotic Significance in Boyer-Ahmad District, Southwestern Iran by Zeinab Seifollahi, Bahador Sarkari, Mohammad Hossein Motazedian, Qasem Asgari, Mohammad Javad Ranjbar, Samaneh Abdolahi Khabisi

“…Wild rodents are reservoirs of various zoonotic diseases, such as toxoplasmosis, babesiosis, and leishmaniasis. The current study aimed to assess the protozoan infection of rodents in Boyer-Ahmad district, southwestern Iran. …”
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Data Platform for Animal Mortality Information System (DATASIMA): Monitoring Companion Animal’s Euthanasia Causes in City of João Pessoa, Brazil by Eduardo S. S. Sousa, Maria E. S. Sousa, Moisés D. C. A. Pereira, Ricardo A. M. Negreiros, Lilian R. C. Eloy, Arthur W. L. Brasil, Inácio J. Clementino, Sérgio S. Azevedo, Ricardo B. Lucena

“…The most common diseases leading to euthanasia were as follows: (i) Sporotrichosis (171 cats); (ii) Leishmaniasis (75 dogs); (iii) Distemper (35 dogs); (iv) Trauma from vehicle collisions (ten dogs and nine cats). …”
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Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens by Ikbel Naouar, Thouraya Boussoffara, Melika Ben Ahmed, Nabil Belhaj Hmida, Adel Gharbi, Sami Gritli, Afif Ben Salah, Hechmi Louzir

“…The nature of effector cells and the potential immunogenicity of Leishmania major excreted/secreted proteins (LmES) were evaluated using peripheral blood mononuclear cells (PBMCs) from healed zoonotic cutaneous leishmaniasis individuals (HZCL) and healthy controls (HC). …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…., human African trypanosomiasis, leishmaniasis, and Chagas disease) and malaria. Moreover, we will comment on potential perspectives that this innovative approach can provide in aiding the discovery and development of new antiprotozoal drugs.…”
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Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va by Elisama Azevedo, Leandro Teixeira Oliveira, Ana Karina Castro Lima, Rodrigo Terra, Patrícia Maria Lourenço Dutra, Verônica P. Salerno

“…Leishmaniasis is a neglected tropical disease with no effective vaccines. …”
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A short ncRNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis by José C. Quilles, Caroline R. Espada, Lissur A. Orsine, Tânia A. Defina, Letícia Almeida, Fabíola Holetz, Angela K. Cruz

“…The protozoan parasite Leishmania spp. is a causative agent of leishmaniasis, a disease that affects millions of people in more than 80 countries worldwide. …”
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Effect of Environmental Disturbance on the Population of Sandflies and Leishmania Transmission in an Endemic Area of Venezuela by Elsa Nieves, Luzmary Oraá, Yorfer Rondón, Mireya Sánchez, Yetsenia Sánchez, Masyelly Rojas, Maritza Rondón, Maria Rujano, Nestor González, Dalmiro Cazorla

“…These changes on the composition of sandflies population and structure emerging species could cause increasing of leishmaniasis transmission.…”
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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid by João S. B. da Luz, Erwelly B. de Oliveira, Monica C. B. Martins, Nicácio H. da Silva, Luiz C. Alves, Fábio A. B. dos Santos, Luiz L. S. da Silva, Eliete C. Silva, Paloma L. de Medeiros

“…Leishmaniasis is considered by the World Health Organization as one of the infectious parasitic diseases endemic of great relevance and a global public health problem. …”
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Brazilian Gold Miners Working Irregularly in French Guiana: Health Status and Risk Determinants by Amanda Figueira da Silva, Vivian da Cruz Franco, Maylis Douine, Hermano Gomes Albuquerque, Louise Hureau, Alice Sanna, Pamela Mosquera Atehortua, Rafael dos Santos Pereira, Simone da Silva Santos, Paola Barbosa Marchesini, Gustavo Bretas, Margarete do Socorro Mendonça Gomes, Yann Lambert, Martha Cecília Suárez-Mutis

“…The study population mentioned numerous health problems: malaria, followed by leishmaniasis, flu, body aches, headaches, and digestive problems. …”
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Analysis of the IGS rRNA Region and Applicability for Leishmania (V.) braziliensis Characterization by Tayná C. de Goes, Rayana C. S. de Morais, Maria G. N. de Melo, Rômulo P. e Silva, Antônio M. Rezende, Milena de Paiva-Cavalcanti

“…The causative species is an important factor influencing the evolution of American cutaneous leishmaniasis (ACL). Due to its wide distribution in endemic areas, Leishmania (V.) braziliensis is considered one of the most important species in circulation in Brazil. …”
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Seroprevalence of Asymptomatic Leishmania donovani among Laborers and Associated Risk Factors in Agricultural Camps of West Armachiho District, Northwest Ethiopia: A Cross-Sectiona... by Animen Ayehu, Yibeltal Aschale, Wossenseged Lemma, Animut Alebel, Ligabaw Worku, Ayalew Jejaw, Abebe Genetu Bayih

“…Background. Visceral leishmaniasis (VL, also called kala-azar) is a public health problem in Ethiopia, especially in sesame and sorghum growing areas. …”
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