Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol by Arghavan Memarzia, Fatemeh Amin, Amin Mokhtari-Zaer, Zohre Arab, Saeideh Saadat, Mahrokh Heydari, Zahra Ghasemi, Farzaneh Naghdi, Mahmoud Hosseini, Mohammad Hossein Boskabady

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Genome-wide quantification of polycistronic transcription in Leishmania major by Janne Grünebast, Stephan Lorenzen, Joachim Clos

“…ABSTRACT Leishmania major is a human-pathogenic, obligate parasite and the etiological agent of the most prevalent, cutaneous form of leishmaniasis, which is an important neglected, tropical disease with ~1.2 million new infections per year. …”
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Neglected tropical diseases in Yemen: a systematic review of epidemiology and public health challenges by Ibrahim Ahmed Ahmed Alhothily, Rahmat Dapari, Nazri Che Dom

“…Schistosomiasis and ascariasis were the most reported helminth infections, whereas leishmaniasis and malaria were the leading protozoal NTDs. …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. …”
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. by Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina

“…There is thus an urgent need for innovative initiatives to identify new chemotypes displaying selective activity against intracellular Leishmania amastigotes that develop and proliferate inside macrophages, thereby causing the pathology of leishmaniasis.<h4>Methodology/principal findings</h4>We have developed a biologically sound High Content Analysis assay, based on the use of homogeneous populations of primary mouse macrophages hosting Leishmania amazonensis amastigotes. …”
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Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…Infliximab may also have beneficial effects on the prognosis of cutaneous leishmaniasis by reducing the parasite burden.…”
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Protozoan Parasites of Rodents and Their Zoonotic Significance in Boyer-Ahmad District, Southwestern Iran by Zeinab Seifollahi, Bahador Sarkari, Mohammad Hossein Motazedian, Qasem Asgari, Mohammad Javad Ranjbar, Samaneh Abdolahi Khabisi

“…Wild rodents are reservoirs of various zoonotic diseases, such as toxoplasmosis, babesiosis, and leishmaniasis. The current study aimed to assess the protozoan infection of rodents in Boyer-Ahmad district, southwestern Iran. …”
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Data Platform for Animal Mortality Information System (DATASIMA): Monitoring Companion Animal’s Euthanasia Causes in City of João Pessoa, Brazil by Eduardo S. S. Sousa, Maria E. S. Sousa, Moisés D. C. A. Pereira, Ricardo A. M. Negreiros, Lilian R. C. Eloy, Arthur W. L. Brasil, Inácio J. Clementino, Sérgio S. Azevedo, Ricardo B. Lucena

“…The most common diseases leading to euthanasia were as follows: (i) Sporotrichosis (171 cats); (ii) Leishmaniasis (75 dogs); (iii) Distemper (35 dogs); (iv) Trauma from vehicle collisions (ten dogs and nine cats). …”
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Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol by Marcele Neves Rocha, Paula Monalisa Nogueira, Cynthia Demicheli, Ludmila Gonçalvez de Oliveira, Meiriane Mariano da Silva, Frédéric Frézard, Maria Norma Melo, Rodrigo Pedro Soares

“…Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. …”
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Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens by Ikbel Naouar, Thouraya Boussoffara, Melika Ben Ahmed, Nabil Belhaj Hmida, Adel Gharbi, Sami Gritli, Afif Ben Salah, Hechmi Louzir

“…The nature of effector cells and the potential immunogenicity of Leishmania major excreted/secreted proteins (LmES) were evaluated using peripheral blood mononuclear cells (PBMCs) from healed zoonotic cutaneous leishmaniasis individuals (HZCL) and healthy controls (HC). …”
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An integrative taxonomic approach reveals two putatively novel species of phlebotomine sand fly (Diptera: Psychodidae) in Thailand by Samiullah Soomro, Siwaporn Tuangpermsub, Thongchai Ngamprasertwong, Morakot Kaewthamasorn

“…Abstract Background The subfamily Phlebotominae comprises 1028 species of sand fly, of which only 90 are recognized as vectors of pathogenic agents such as Trypanosoma, Leishmania, and Bartonella. In Thailand, leishmaniasis—a sand fly-borne disease—is currently endemic, with 36 documented sand fly species. …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…., human African trypanosomiasis, leishmaniasis, and Chagas disease) and malaria. Moreover, we will comment on potential perspectives that this innovative approach can provide in aiding the discovery and development of new antiprotozoal drugs.…”
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Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va by Elisama Azevedo, Leandro Teixeira Oliveira, Ana Karina Castro Lima, Rodrigo Terra, Patrícia Maria Lourenço Dutra, Verônica P. Salerno

“…Leishmaniasis is a neglected tropical disease with no effective vaccines. …”
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A short ncRNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis by José C. Quilles, Caroline R. Espada, Lissur A. Orsine, Tânia A. Defina, Letícia Almeida, Fabíola Holetz, Angela K. Cruz

“…The protozoan parasite Leishmania spp. is a causative agent of leishmaniasis, a disease that affects millions of people in more than 80 countries worldwide. …”
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Effect of Environmental Disturbance on the Population of Sandflies and Leishmania Transmission in an Endemic Area of Venezuela by Elsa Nieves, Luzmary Oraá, Yorfer Rondón, Mireya Sánchez, Yetsenia Sánchez, Masyelly Rojas, Maritza Rondón, Maria Rujano, Nestor González, Dalmiro Cazorla

“…These changes on the composition of sandflies population and structure emerging species could cause increasing of leishmaniasis transmission.…”
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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid by João S. B. da Luz, Erwelly B. de Oliveira, Monica C. B. Martins, Nicácio H. da Silva, Luiz C. Alves, Fábio A. B. dos Santos, Luiz L. S. da Silva, Eliete C. Silva, Paloma L. de Medeiros

“…Leishmaniasis is considered by the World Health Organization as one of the infectious parasitic diseases endemic of great relevance and a global public health problem. …”
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Brazilian Gold Miners Working Irregularly in French Guiana: Health Status and Risk Determinants by Amanda Figueira da Silva, Vivian da Cruz Franco, Maylis Douine, Hermano Gomes Albuquerque, Louise Hureau, Alice Sanna, Pamela Mosquera Atehortua, Rafael dos Santos Pereira, Simone da Silva Santos, Paola Barbosa Marchesini, Gustavo Bretas, Margarete do Socorro Mendonça Gomes, Yann Lambert, Martha Cecília Suárez-Mutis

“…The study population mentioned numerous health problems: malaria, followed by leishmaniasis, flu, body aches, headaches, and digestive problems. …”
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Analysis of the IGS rRNA Region and Applicability for Leishmania (V.) braziliensis Characterization by Tayná C. de Goes, Rayana C. S. de Morais, Maria G. N. de Melo, Rômulo P. e Silva, Antônio M. Rezende, Milena de Paiva-Cavalcanti

“…The causative species is an important factor influencing the evolution of American cutaneous leishmaniasis (ACL). Due to its wide distribution in endemic areas, Leishmania (V.) braziliensis is considered one of the most important species in circulation in Brazil. …”
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Seroprevalence of Asymptomatic Leishmania donovani among Laborers and Associated Risk Factors in Agricultural Camps of West Armachiho District, Northwest Ethiopia: A Cross-Sectiona... by Animen Ayehu, Yibeltal Aschale, Wossenseged Lemma, Animut Alebel, Ligabaw Worku, Ayalew Jejaw, Abebe Genetu Bayih

“…Background. Visceral leishmaniasis (VL, also called kala-azar) is a public health problem in Ethiopia, especially in sesame and sorghum growing areas. …”
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Differential Recruitment of Dendritic Cells Subsets to Lymph Nodes Correlates with a Protective or Permissive T-Cell Response during Leishmania (Viannia) Braziliensis or Leishmania... by A. K. Carvalho, K. Carvalho, L. F. D. Passero, M. G. T. Sousa, V. L. R. da Matta, C. M. C. Gomes, C. E. P. Corbett, G. E. Kallas, F. T. Silveira, M. D. Laurenti

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