Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain by Noriko Horii-Hayashi, Takayo Sasagawa, Wataru Matsunaga, Mayumi Nishi

“…Here, we examined the starting period of PNN formation in male mice ranging in age from postnatal day 3 to week 11, mainly focusing on several cortical areas, limbic structures, hypothalamus, and brain stem, using lectin histochemistry with Wisteria floribunda agglutinin (WFA). …”
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Trichosanthes dioica Roxb.: A vegetable with diverse pharmacological properties by Mahia Khandaker, Saleha Akter, Mohammad Zafar Imam

“…Different types of bioactive compounds have been identified and isolated from T. dioica including peptides namely trichosanthin and lectin; a number of triterpenes like cucurbitacin B, euphol, α-amyrin, β-amyrin, lupeol, taraxerol, betulin, and karounidiol; sterols, steroidal saponin, tannin, flavonoids etc. …”
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Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Moreover, FOXO1 expression was positively associated with multiple immune checkpoints, such as sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15), indoleamine 2,3-dioxygenase 1 (IDO1), programmed cell death 1 ligand 1 (PD-L1/CD274), hepatitis A virus cellular receptor 2 (HAVCR2), programmed cell death 1 (PDCD1), cytotoxic T lymphocyte antigen 4 (CTLA4), and programmed cell death 1 ligand 2 (PDCD1LG2). …”
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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy by Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang

“…Presently, we interrogated glycopatterns in urine specimens using a lectin microarray. The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration. …”
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Seasonality Influence on Biochemical and Hematological Indicators of Stress and Growth of Pirarucu (Arapaima gigas), an Amazonian Air-Breathing Fish by Rosiely Felix Bezerra, Maria do Carmo Figueiredo Soares, Athiê Jorge Guerra Santos, Elba Verônica Matoso Maciel Carvalho, Luana Cassandra Breitenbach Barroso Coelho

“…Seasonality effect analysis was performed on biochemical (lectin activity, lactate dehydrogenase, and alkaline phosphatase activities) and hematological (total count of red blood cells, hematocrit, hemoglobin, and hematimetric Wintrobe indexes) stress indicators, as well as on growth and wellbeing degree expressed by pirarucu condition factor developed in captivity. …”
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Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells by Jie-Jen Lee, Yi-Chiung Hsu, Ying-Syuan Li, Shih-Ping Cheng

“…However, the pharmacological lectin-based approach has not been well studied. In the present study, we aimed to investigate the therapeutic potential of novel galectin-3 inhibitors by treating thyroid cancer cells with different concentrations of GB1107 or TD139. …”
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Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…Tumor-Associated Macrophages (TAMs) are abundantly present in the stroma of solid tumors and modulate several important biological processes, such as neoangiogenesis, cancer cell proliferation and invasion, and suppression of adaptive immune responses. Myeloid C-type lectin receptors (CLRs) constitute a large family of transmembrane carbohydrate-binding receptors that recognize pathogens as well as endogenous glycoproteins. …”
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Navigating transfusion challenges: Bombay blood group in focus by Romesh Jain, Vilasini Patil, Pratul Sinha, Snehashish Mishra, Rut Naik

“…This suggests that patient was having a strong antibody other than anti-A and anti-B, which was reacting strongly with O cell at all temperatures. Anti-H lectin reaction was negative. The patient was diagnosed with probable Bombay phenotype (hh), and we tried to manage anemia with patient blood management. …”
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Identification and Characterization of TEX101 in Bovine Epididymal Spermatozoa by Subir K. Nagdas, Eric L. McLean, Leeá P. Richardson, Samir Raychoudhury

“…The objective of the study was to identify and to characterize RCA binding glycoprotein of the bovine sperm plasma membranes (PM). Lectin blots of caput and cauda sperm PM revealed a 38 kDa polypeptide exhibiting the highest affinity to RCA among the several major RCA binding polypeptides. …”
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Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease by Kazuhiro Nomoto, Takeshi Nishida, Yuko Nakanishi, Makoto Fujimoto, Ichiro Takasaki, Yoshiaki Tabuchi, Koichi Tsuneyama

“…Galectin-3, a β-galactoside-binding animal lectin, is a multifunctional protein. This protein is involved in inflammatory responses and carcinogenesis. …”
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Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes by Charlotte Berg Holt, Jakob Appel Østergaard, Esben Axelgaard, Gitte Krogh Nielsen, Yuichi Endo, Steffen Thiel, Troels Krarup Hansen

“…Recently mannan-binding lectin (MBL) was shown to worsen diabetic kidney changes. …”
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A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients by Kacper DZIEDZIC, Kavita BATRA, Michal PRUC, Monika TOMASZEWSKA, Krzysztof KUREK, Murat YILDIRIM, Mahmood BAHRAMIZADEH, Francesco CHIRICO, Nicola Luigi BRAGAZZI, Hicham KHABBACHE, Aldo SITIBONDO, Lukasz SZARPAK, Gabriella NUCERA

“…Introduction: Galectin-3 is a β-galactoside-binding lectin with several roles in the immune- inflammatory response. …”
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Investigation of the Proliferation, Apoptosis/Necrosis, and Cell Cycle Phases in Several Human Multiple Myeloma Cell Lines. Comparison of Viscum album QuFrF Extract with Vincristin... by Eva Kovacs

“…Viscum album QuFrF (VAQuFrF) extract is an experimental drug that is not used in the treatment in tumour patients. It contains 2000 ng lectin and 10 µg viscotoxin in 10 mg extract. In this study, the effects of VAQuFrF extract were compared with those of vincristine in six human multiple myeloma cell lines (Molp-8, LP-1, RPMI-8226, OPM-2, Colo-677, and KMS-12-BM) using an in vitro model. …”
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CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells by Ping Meng, Chunli Liu, Jingchun Li, Ping Fang, Bo Yang, Wei Sun, Yunfang Zhang

“…Furthermore, CXCR7 was specifically expressed primarily in the Lotus Tetragonolobus Lectin-expressing segment of tubules, was slightly expressed in the peanut agglutinin-expressing segment, and was barely expressed in the Dolichos biflorus agglutinin-expressing segment. …”
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The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Marta Przybyła, Janusz Szemraj, Jarosław Barski, Mikael Skurnik, Andrzej Kałużyński, Maciej Cedzyński

“…It was demonstrated that murine mannose-binding lectin C (MBL-C) recognizes the inner core heptoses of the Rd1 chemotype LPS of Yersinia. …”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Additionally, Mincle, a C-type lectin receptor, interacts with Fu-Hp to amplify the inflammatory responses and signaling. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…TCZ had no effect on the lectin cascade throughout the follow-up.ConclusionTCZ reduces the activity of the classical and alternative pathways of the complement system in RA patients regardless of the improvement in disease activity. …”
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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

“…., glycans) shape immune responses through lectin binding, and manipulate the metabolism of immune cells, including DCs to alter their function and escape immune surveillance. …”
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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons by Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

“…To this end, 3’ mRNA-Seq transcriptome analysis was employed, unexpectedly revealing downregulation of key genes associated with the NOD-like receptor signaling pathway (Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, Cxcl1, and Traf5), the C-type lectin receptor signaling pathway (Nfkb2, Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, and Ptgs2), the NF kappa B signaling pathway (Nfkbia, Ikbkg, Nfkb2, Rela, Traf5, Cxcl1, and Ptgs2), and the IL 17 signaling pathway (Nfkbia, Ikbkg, Mapk3, Rela, Traf5, Cxcl1, and Ptgs2). …”
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Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats by Mahtab Fouladi, Maryam Mahmoudabady, Zahra Gholamnezhad, Sadegh Shabab, Saeed Niazmand, Hossein Salmani

“…After 6 weeks, biochemical parameters in serum and oxidative stress markers and mRNA expression of endothelial nitric oxide synthase (eNOS), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and intercellular adhesion molecule-1 (ICAM-1) in aorta tissue were assessed. …”
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