Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…Such functional diversity is correlated with their structural characteristics: the N-terminal region contributes to autoantigenicity, while the C-type lectin fragment near the C-terminal determines the trophic action. …”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…This may implicate altered lectin-ligand interactions on the cell surface potentially affecting the CD21low B-cell function. …”
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Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma by Jianlin Chen, Yue Zheng, Zhen Wang, Qi Gao, Kun Hao, Xiongfeng Chen, Nantian Ke, Xiang Lv, Jiamiao Weng, Yuhong Zhong, Zhixin Huang, Miao Fu, Lilan Zhao, Fan Lin, Hui Mi, Haijun Tang, Chundong Yu, Yi Huang

“…Fucosylated (Fuc-) and sialylated (Sia-) EVs were isolated utilizing Lentil lectin (LCA) and wheat germ lectin (WGA)-coated magnetic beads, respectively. …”
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Previable Preeclampsia Diagnosed by Renal Biopsy in Setting of Novel Diagnosis of C4 Glomerulopathy by Jessica Parrott, Timothy A. Fields, Marc Parrish

“…She developed posterior reversible encephalopathic syndrome and pregnancy termination was recommended. Conclusion. The lectin complement pathway may play a role in the pathophysiology of severe, early onset preeclampsia. …”
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Restenosis and Therapy by Laszlo Denes, Laszlo Entz, Veronika Jancsik

“…The review summarizes the alteration process and demonstrates some of the clinical genetic background showing the role of complement and the genotypes of mannose-binding lectin (MBL2). Those could be useful markers of carotid restenosis after stent implantation. …”
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Dynamic Production of Soluble Extracellular Polysaccharides by Streptococcus mutans by Eva-Maria Decker, Ilka Dietrich, Christian Klein, Christiane von Ohle

“…The aim of this study was the evaluation of a novel glucan-specific Lectin assay for monitoring water-soluble EPS produced by S. mutans during several growth periods in different media. …”
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Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica by Anjana Singh, Eric Houpt, William A. Petri

“…Circulating Gal/GalNac lectin antigens can be detected in the serum of patients with untreated amoebic liver abscess. …”
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Immune Evasion Strategies of Trypanosoma cruzi by Ana Flávia Nardy, Célio Geraldo Freire-de-Lima, Alexandre Morrot

“…It interferes with the antigen presenting function of dendritic cells via an action on host sialic acid-binding Ig-like lectin receptors. These receptors also induce suppression of CD4+ T cells responses, and we presented evidence that the sialylation of parasite-derived mucins is required for the inhibitory effects on CD4 T cells. …”
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MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia by Chiara Agostinis, Fleur Bossi, Elisa Masat, Oriano Radillo, Maddalena Tonon, Francesco De Seta, Francesco Tedesco, Roberta Bulla

“…We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs. …”
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Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms by Stefan Bidula, Darren W. Sexton, Silke Schelenz

“…Pathogens are primarily removed by direct opsonisation following the recognition of cell surface carbohydrates and other immunostimulatory molecules or via the activation of the lectin complement pathway, which results in the deposition of C3b and the recruitment of phagocytes. …”
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PD-L1 knockout or ZG16 overexpression inhibits PDAC progression and modulates TAM polarization by Hui Meng, Manman Nan, Yizhen Li, Yi Ding, Xiaokun Fang, Weiqian Ma, Mingzhi Zhang

“…CRISPR/Cas9-mediated genome editing has the potential to delete PD-L1 both on the cell surface and inside the cell, thereby inhibiting tumor growth and migration and overcoming immunosuppression. ZG16, with its lectin structure, can reduce PD-L1 expression on the cell surface. …”
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The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host by Alexandre Morrot

“…In what follows we propose that signaling via sialic acid-binding Ig-like lectin receptors for these highly sialylated structures on host cells contributes to the arrest of cell cycle progression in the G1 phase and may allow the parasite to modulate the immune system of the host.…”
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Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells by Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu

“…Within these toxic vesicles, a protein cargo is identified called lectin galactoside‐binding soluble 3 binding protein (Lgals3bp) that acted as a potent inducer of osteochondrogenic transformation in VSMCs. …”
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Atypical hemolytic uremic syndrome with a C3 variant following COVID-19: a case report by Masato Ando, Kazuo Kubota, Kazuo Kubota, Saori Kadowaki, Minako Kawamoto, Norio Kawamoto, Haruka Okamoto, Soichiro Nagaya, Yuki Miwa, Hidenori Ohnishi, Hidenori Ohnishi

“…It has been shown that the complement lectin pathway can be activated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike and N proteins, and the alternative pathway can be activated by the SARS-CoV-2 spike protein. …”
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Antibodies Recognizing Yersinia enterocolitica Lipopolysaccharides of Various Chemotypes in Synovial Fluids From Patients With Juvenile Idiopathic Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Mateusz Michalski, Łukasz Eppa, Mikael Skurnik, Zbigniew Żuber, Maciej Cedzyński

“…Furthermore, we confirmed in vitro that Yersinia LPS processing leads to the exposure of its core region and enhanced potency of complement lectin pathway activation.…”
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LOX-1, OxLDL, and Atherosclerosis by Angela Pirillo, Giuseppe Danilo Norata, Alberico Luigi Catapano

“…Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of OxLDL. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the main OxLDL receptor of endothelial cells, and it is expressed also in macrophages and smooth muscle cells. …”
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Immunological Responses and Epitope Mapping by Tuberculosis-Associated Antigens within the RD1 Region in Japanese Patients by Hideaki Nagai, Maho Suzukawa, Yumi Sakakibara, Ken Ohta, Pedro A. Reche, Koichi Suzuki, Yoshihiko Hoshino

“…In addition, programmed death-1 (PD-1)/killer cell lectin-like receptor G1 (KLRG-1) double positive cells were found only in treated patients and not in those with active TB. …”
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Label-Free Glucose Detection Using Cantilever Sensor Technology Based on Gravimetric Detection Principles by Shuchen Hsieh, Shu-Ling Hsieh, Chiung-wen Hsieh, Po-Chiao Lin, Chun-Hsin Wu

“…We first modified the AFM tip with aminopropylsilatrane (APS) and then adsorbed glucose-specific lectin concanavalin A (Con A) onto the surface. The Con A/APS-modified probes were then used to detect glucose by monitoring shifts in the cantilever resonance frequency. …”
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An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp by Ji-Hyun Jang, Hee Woong Shin, Jung Min Lee, Hyeon-Woo Lee, Eun-Cheol Kim, Sang Hyuk Park

“…Currently identified PRR families are the Toll-like receptors (TLRs), the C-type lectin receptors (CLRs), the nucleotide-binding oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR). …”
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Innate Immune Recognition of Mycobacterium tuberculosis by Johanneke Kleinnijenhuis, Marije Oosting, Leo A. B. Joosten, Mihai G. Netea, Reinout Van Crevel

“…Several classes of pattern recognition receptors (PPRs) are involved in the recognition of M. tuberculosis, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs). …”
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