Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…GAD is often underdiagnosed, leading to negative consequences for individuals, healthcare systems, and society. …”
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Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context by Anis Rassi, Jr, Alyssa Grimshaw, Ashwin Sarwal, Ranjit Sah, Sangam Shah, Nelson I. Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Samantha Kaplan, Luis A. Marcos, Edgar A. Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F. Henao-Martínez

“…Summary: Background: Endemic in more than 20 countries, Chagas disease affects 6.3 million people worldwide, leading to 28,000 new infections and 7700 deaths each year. …”
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Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Background: Shigella infections remain endemic in places with poor sanitation and are a leading cause of diarrheal mortality globally, as well as a major contributor to gut enteropathy and stunting. …”
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Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…Among the models, LSTM demonstrated superior predictive accuracy but showed overestimation trends in ancient landslide areas.DiscussionReservoir water level adjustments emerged as a critical driver of subsidence, with rapid water level declines leading to increased pore pressure and soil compression. …”
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Determinants of Uterine Rupture and Its Management Outcomes among Mothers Who Gave Birth at Public Hospitals of Tigrai, North Ethiopia: An Unmatched Case Control Study by Meresa Berwo Mengesha, Desta Abraha Weldegeorges, Yared Hailesilassie, Weldu Mammo Werid, Mulu Gebretsadik Weldemariam, Fissaha Tekulu Welay, Senait Gebreslasie Gebremeskel, Berhanu Gebresilassie Gebrehiwot, Hagos Degefa Hidru, Hirut Teame, Haftay Gebremedhin, Natnael Etsay Assefa

“…Uterine rupture is a leading cause of maternal death in Ethiopia. Despite strengthening the health care system and providing basic and comprehensive emergency obstetric care closer to the communities, uterine rupture continues to produce devastating maternal and fetal outcomes. …”
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The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…Our study indicates that assimilating OCO-3 XCO<span class="inline-formula">₂</span> retrievals alone leads to an underestimation of land sinks at high latitudes and that a joint assimilation of OCO-2 XCO<span class="inline-formula">₂</span> and the OCO-3 XCO<span class="inline-formula">₂</span> retrievals observed in the afternoon is required for a better estimation of global terrestrial NEE.…”
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The Influence of Edaphic and Climatic Factors on the Morphophysiological Behavior of Young Argan Plants Cultivated in Orchards: A Comparative Analysis of Three Regions in Southwest... by Fatima Ezzahra Tiouidji, Assma Oumasst, Salma Tabi, Naima Chabbi, Abdelaziz Mimouni, Meriyem Koufan, Naima Ait Aabd, Abdelghani Tahiri, Youssef Karra, Jamal Hallam, Redouan Qessaoui, Rachid Bouharroud, Fouad Elame, Nadya Wahid, Ahmed Wifaya

“…In Morocco, recent years have seen an exacerbation of the harmful effects of climate change, leading to an alarming decline in the natural regeneration of this species in its original habitats. …”
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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…A gene expression signature that is characteristic of CD4+ cytotoxic T lymphocytes (CD4-CTLs) was found to be elevated at baseline in non-responders to apheresis, although this could not be validated with statistical significance (n=19 MS patients).ConclusionOur data reveal that therapeutic apheresis in MS rapidly leads to a significant decrease in IgG reactivities against EBNA1 (391-410) and cross-reactive targets such as GlialCAM (370-389) and also has an impact on the gene expression of B cells and T cells. …”
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Comprehensive analysis of Pan-Immune Inflammation and all-cause mortality in rheumatoid arthritis: a database-driven approach, 1999-2018 by Muradil· Mardan, Huoliang Zheng, Qingyin Xu, Shaokuan Song, Zeyu Lu, Hui Deng, Hao Cai, Qizhu Chen, Bingyi Yang, Kudelaiti· Abuduwufuer, Pengbo Chen, Bo Li, Shengdan Jiang, Leisheng Jiang, Xin-feng Zheng

“…BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation and immune dysregulation, leading to a higher risk of all-cause mortality. The Pan-Immune Inflammation Value (PIV), a novel biomarker capturing immune-inflammatory activity, has shown prognostic value in various diseases. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…Abstract Background Diabetic foot ulcers (DFUs) represent a major complication of diabetes, often leading to poor healing outcomes with conventional treatments. …”
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Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…Background Aortic coarctation (CoA) is a congenital anomaly leading to upper-body hypertension and lower-body hypotension. …”
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Non-Immersive Virtual Reality Exercise Can Increase Exercise in Older Adults Living in the Community and in Long-Term Care: A Randomized Controlled Trial by Sheehy L, Bharadwaj L, Nissen KA, Estey JL

“…Most were interested to continue beyond the study.Conclusion: Non-immersive virtual reality for home-based and facility-based older adults is safe, enjoyable and feasible and may increase users’ weekly levels of physical activity leading to clinical benefits for functional walking in facility-based users.Trial Registration: ClinicalTrials.gov (NCT04083885; registered 2019– 09-06).Plain language summary: Regular exercise is so important for older adults. …”
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Interior Peak Solutions for a Semilinear Dirichlet Problem by Hissah Alharbi, Hibah Alkhuzayyim, Mohamed Ben Ayed, Khalil El Mehdi

“…We construct interior peak solutions with isolated bubbles. This leads to a multiplicity result for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>(</mo><msub><mi mathvariant="script">P</mi><mi>ε</mi></msub><mo>)</mo></mrow></semantics></math></inline-formula>. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Abstract Background Hepatocellular carcinoma (HCC) is a prevalent primary liver malignancy and a leading cause of cancer-related mortality worldwide. …”
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Application of “Tree Hole Listening” psychological support service in emotional management of neurology nurses (“树洞倾听”心理支持服务在神经内科护士情绪管理中的应用)... by FEI Cailian (费才莲), WANG Yu (王瑜), ZHANG Jingyi (张静怡), XIE Juan (谢娟)

“…There was a significant improvement in nurses' ability to express emotions and a reduction in expressive suppression after intervention of the “Tree Hole Listening” psychological support service(P＜0. 05), leading to increased nursing satisfaction. Conclusion Application of' “Tree Hole Listening” psychological support service as an emotional management method could effectively regulated the psychological state of neurology nurses, resulting in decreased psychological pressure, improved emotional stability and positivity, enhanced emotional management abilities among nurses, and an increase in nurse satisfaction. …”
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L’aqueduc de Fontanières : un cinquième aqueduc romain à Lyon ? by Jean-Yves Barbier

“…Germain de Montauzan and, more recently, the leading experts on the “Four Lyon aqueducts,” a working group led by the Archéologie et Archéométrie (ArAr) laboratory. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Finally, smell is fundamental for social life and interaction with other people. Anosmia leads to some disturbances in food enjoyment, detecting harmful food and smoke, and to some extent in social situations and working life. …”

Evaluation of a peer support group programme for vulnerable host population and refugees living with diabetes and/or hypertension in Lebanon: a before-after study by Leah Anku Sanga, Carla Njeim, Éimhín Ansbro, Rima Kighsro Naimi, Ali Ibrahim, Benjamin Schmid, Jasmin Lilian Diab, Jytte Roswall, Tim Clayton, Lars Bruun Larsen, Pablo Perel

“…Abstract Background Non-communicable diseases (NCDs) are the leading cause of death globally, and many humanitarian crises occur in countries with high NCD burdens. …”
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Research Progress in and Planning Strategies for Multi-scale Measurement of the Efficiency of Urban Blue-Green Infrastructure in Carbon Sink Enhancement and Emission Reduction by Song LIU, Zhaocheng BAI, Dizi LIU, Peiyu SHEN

“…Contradictory results may occur at different scales, and large-scale research often lacks characterization of internal features, leading to unclear mechanisms of influencing factors and obstructing practical planning. …”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Many of us may experience another pandemic, arising under the current scenarios of climate alterations leading to disease vectors spreading in new areas, the return of old ones, and aggravated human transmission pathways. …”
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