Top 100 most-cited articles on apoptosis of non-small cell lung cancer over the past two decades: a bibliometrics analysis by Leshi Ma, Jing Zhang, Zi Dai, Pei Liao, Jieshan Guan, Jieshan Guan, Jieshan Guan, Jieshan Guan, Jieshan Guan, Zhijie Luo, Zhijie Luo, Zhijie Luo, Zhijie Luo

“…The most influential articles appeared in 2005 and 2007 (n=13). The leading countries (regions), institutions, journals and authors were identified as the United States (n=60), Harvard University (n=64), CANCER RESEARCH (n=15), SUN M and YANG JS (n=6). …”
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The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis by Denise Vianna Machado Ayres, Sabrina Saemy Tome Uchiyama, Andréa Oliveira Prates, Rosana Aparecida Freitas Lopes, Antenor Bispo Santos Silva, Denise Rodrigues Tsukimoto, Rosimeire Alves Amorim, Taynah Souza Ribeiro, Artur Cesar Aquino Santos, André Tadeu Sugawara, André Tadeu Sugawara, Marcos Montagnini, Linamara Rizzo Battistella, Linamara Rizzo Battistella, Marta Imamura, Marta Imamura

“…BackgroundKnee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.ObjectiveDescribe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.DesignObservational prospective study.SettingAcademically affiliated rehabilitation outpatient center in Brazil.MethodsThe program consisted of three in-person educational sessions (4.5 hr each) for 55 community dwelling adults, aged ≥50 years, with primary KOA-related pain. …”
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Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

“…Abstract Background Chronic nonspecific neck pain (CNSNP) is a common musculoskeletal disorder, particularly in the elderly, leading to reduced cervical muscle strength, impaired functional balance, and decreased postural stability. …”
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Prevalence of Diabetic Retinopathy in Patients with Cerebrovascular Accident: A Cross-sectional Study by (Col.) OK Radhakrishnan, Rutu K Rao, Varsha Manade, Swaranjali Gore, Shreya Gandhi, Khushboo Goyal, Tushar Agrawal

“…Introduction: Diabetes Mellitus (DM) causes high blood sugar, leading to complications such as cerebrovascular events, chronic kidney disease, cardiovascular issues and retinopathy. …”
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Development and Validation of a Risk Prediction Model for Ventricular Arrhythmia in Elderly Patients with Coronary Heart Disease by Ying Dong, Yajun Shi, Jinli Wang, Qing Dan, Ling Gao, Chenghui Zhao, Yang Mu, Miao Liu, Chengliang Yin, Rilige Wu, Yuqi Liu, Yang Li, Xueping Wang

“…Sudden cardiac death is a leading cause of death from coronary heart disease (CHD). …”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…Abstract Background Unhealthy alcohol use, a spectrum of use inclusive of risky consumption and alcohol use disorder (AUD), is a leading cause of preventable death in the United States. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…Abstract Sialic acids at the cell surface of dendritic cells (DCs) play an important immunomodulatory role, and their manipulation enhances DC maturation, leading to heightened T cell activation. Particularly, at the molecular level, the increased stability of surface MHC-I molecules in monocyte-derived DCs (MoDCs) underpins an improved DC: T cell interaction. …”
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First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems by Charlotte J. Neumann, Rokhsareh Mohammadzadeh, Pei Yee Woh, Tanja Kobal, Manuela-Raluca Pausan, Tejus Shinde, Victoria Haid, Polona Mertelj, Eva-Christine Weiss, Vassiliki Kolovetsiou-Kreiner, Alexander Mahnert, Christina Kumpitsch, Evelyn Jantscher-Krenn, Christine Moissl-Eichinger

“…In contrast, the microbiomes of non-breastfed infants are more mature from the first month, leading to a steadier development without distinct transitional phases in the first year. …”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…BackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. …”
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Study on the correlation between microstructural evolution and hydrogen storage properties in hyper-eutectic Mg-xNi (x = 15, 20, 25) alloys by So Jin Jung, Seok Su Sohn, Da Hye Lee, Won-Seok Ko, Tae Jun Ha, Ryun-Ho Kwak, Byeong-Chan Suh, Young Min Kim, Hyung-Ki Park

“…As the Ni content increased, the phase percentage of the Mg2Ni phase increased, leading to a reduction in the maximum hydrogen storage capacities of the Mg–20Ni and Mg–25Ni alloys to 5.01 and 4.67 wt%, respectively. …”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…<b>Background:</b> Diabetic foot ulcers (DFUs) represent severe complications in diabetic patients, often leading to chronic infections and potentially resulting in nontraumatic lower-limb amputations. …”
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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…A module of proteins was found to statistically correlate with the potency of IL-6 modulation, leading to the selection of one of the hUCMSCs as the most promising line. …”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…Conclusions There are significant sex differences in the anatomico‐functional assessment of coronary artery disease leading to differences in clinical management, costs, and adverse events.…”
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Development of a one-step multiplex RT-qPCR method for rapid detection of bovine diarrhea viruses by Dequan Yang, Li Ma, Zhongping Yang, Xianchao Yang, Jian Wang, Houbin Ju, Chunguang Lu, Yonggang Weng, Heping Zhao, Haixiao Shen, Xin Li, Feifei Ge, Xiaoxu Wang, Xiujuan Wu, Meng Xiang, Guidan Feng, Congsheng Tang, Shixin Huang, Hongjin Zhao

“…IntroductionViral calf diarrhea poses a significant challenge to the cattle industry worldwide due to its high morbidity and mortality rates, leading to substantial economic losses. The clinical symptoms associated with various diarrhea pathogens often overlap, complicating accurate diagnosis; thus, there is an urgent need for rapid and precise diagnostic methods to improve prevention and treatment efforts. …”
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Metabolomic profiling and antibacterial efficacy of probiotic-derived cell-free supernatant encapsulated in nanostructured lipid carriers against canine multidrug-resistant bacteri... by Nay Zin Myo, Nay Zin Myo, Ratchnida Kamwa, Ratchnida Kamwa, Thitirat Jamnong, Busaba Swasdipisal, Papavarin Somrak, Phanchompoo Rattanamalakorn, Vipada Neatsawang, Prasert Apiwatsiri, Teerapong Yata, David J. Hampson, Nuvee Prapasarakul, Nuvee Prapasarakul

“…The acidic nature of the CFS, combined with bioactive antibacterial metabolites like Kanzonol V and 1-Hexanol, likely contributed to its inhibitory effects against pathogenic bacteria; notably, Kanzonol V was abundant in the CFS of L22F, BF12 and BYF26 (L22F_CFS, BF12_CFS and BYF26_CFS), while 1-Hexanol was particularly enriched in CFS of P72N (P72N_CFS), with both compounds effectively targeting bacterial cell membranes to disrupt cell integrity, leading to bacterial cell death. Other beneficial compounds such as Pyroglutamylleucine, Trigoneoside VIII and 18-Nor-4(19),8,11,13-abietatetraene which are likely to have anti-inflammatory, antimicrobial and antioxidant activities, were also detected in the CFS. …”
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The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises by Sumaya N. Almohareb, Sumaya N. Almohareb, Sumaya N. Almohareb, Norah Aljammaz, Nada Yousif, Mayar Sunbul, Raghad Alsemary, Lama Alkhathran, Mohammed Aldhaeefi, Omar A. Almohammed, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya

“…BackgroundThe global prevalence of diabetes has been rising rapidly in recent years, leading to an increase in patients experiencing hyperglycemic crises like diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). …”
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Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes by Hailing Zhao, Haojun Zhang, Yan Wang, Tingting Zhao, Meihua Yan, Xi Dong, Qian Wang, Jialin Li, Liang Ma, Ping Li

“…Diabetic kidney disease (DKD) is one of the most common complications of diabetes and the leading cause of end-stage renal disease. Here, we investigated the association of PNPLA2 gene variations with DKD susceptibility in a Chinese Han population. …”
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Barriers to 12-month treatment of common anxiety, mood, and substance use disorders in the World Mental Health (WMH) surveys by Maria Carmen Viana, Alan E. Kazdin, Meredith G. Harris, Dan J. Stein, Daniel V. Vigo, Irving Hwang, Sophie M. Manoukian, Nancy A. Sampson, Jordi Alonso, Laura Helena Andrade, Guilherme Borges, Brendan Bunting, José Miguel Caldas-de-Almeida, Giovanni de Girolamo, Peter de Jonge, Oye Gureje, Josep Maria Haro, Elie G. Karam, Viviane Kovess-Masfety, Jacek Moskalewicz, Fernando Navarro-Mateu, Daisuke Nishi, Marina Piazza, José Posada-Villa, Kate M. Scott, Cristian Vladescu, Bogdan Wojtyniak, Zahari Zarkov, Ronald C. Kessler, Timothy Kessler, World Mental Health Survey collaborators

“…The n = 2,444 such respondents who did not receive treatment were asked about barriers to receiving treatment, whereas the n = 926 respondents who received treatment with a delay were asked about barriers leading to delays. Consistent with previous research, we distinguished five broad classes of barriers: low perceived disorder severity, two types of barriers in the domain of predisposing factors (beliefs/attitudes about treatment ineffectiveness and stigma) and two types in the domain of enabling factors (financial and nonfinancial). …”
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Carbon cycle and climate feedbacks under CO₂ and non-CO₂ overshoot pathways by I. Melnikova, I. Melnikova, P. Ciais, K. Tanaka, K. Tanaka, H. Shiogama, K. Tachiiri, K. Tachiiri, T. Yokohata, O. Boucher

“…<span class="inline-formula">CO₂</span> forcing leads to both carbon–climate and carbon–concentration feedbacks, whereas non-<span class="inline-formula">CO₂</span> gases give rise to the carbon–climate feedback only. …”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…IntroductionTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. A crucial factor in Mtb's virulence is the ESX-5 secretion system, which transports PE/PPE proteins such as PE18 and PPE26. …”
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