Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…However, CD11b can bind to multiple different ligands, leading to various myeloid cell functions such as adhesion, migration, phagocytosis, and proliferation. …”
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Place of retinoprotective therapy in modern ophthalmologic practice by E.A. Egorov, D.A. Dorofeev

“…<br> <b>Conclusion</b>: the probability of appointing retinoprotective therapy increases with an increase of working experience, and if the working experience is more than 5 years the probability of prescribing retinoprotective therapy for glaucoma is 81%, which is probably due to the fact that the acquisition of clinical experience leads to realizing that without retinoprotective therapy the patient either cannot be observed or further observation will be inappropriate.…”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“….-32-13T>G variant, found in 40–70% of LO-PD alleles, is a leaky splicing mutation interfering with the correct GAA exon 2 recognition by the spliceosome leading to the production of non-functional GAA transcripts. …”
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Evaluating cutinase from Fusarium oxysporum as a biocatalyst for the degradation of nine synthetic polymer by Maycon Vinicius Damasceno de Oliveira, Gabriel Calandrini, Clauber Henrique Souza da Costa, Carlos Gabriel da Silva de Souza, Cláudio Nahum Alves, José Rogério A. Silva, Anderson H. Lima, Jerônimo Lameira

“…Abstract Plastic poses a significant environmental impact due to its chemical resilience, leading to prolonged and degradation times and resulting in widespread adverse effects on global flora and fauna. …”
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Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway by Lianbo Shao, Yihuan Chen, Jingjing Li, Jingfan Chao, Ziying Yang, Yinglong Ding, Han Shen, Yueqiu Chen, Zhenya Shen

“…Myocardial infarction is a leading cause of mortality worldwide. Angiogenesis in the infarct border zone is vital for heart function restoration after myocardial infarction. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Conclusions This study revealed a novel role for NUAK1, which promotes the transcriptional expression of PD-L1 by activating GSK3β/β-catenin signaling pathway, leading to immune escape of hepatocellular carcinoma. …”
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Psychological peculiarities of professional development in late adulthood by E. F. Zeer, E. E. Symanyuk, A. A. Ryabukhina, G. I. Borisov

“…Modern technologies are generating new types of production and transformation of old ones, which results in the loss of jobs, income and status among the representatives of elder generation and leads to a professional loss crisis. All these factors make it necessary to study the peculiarities of professional development in late adulthood.The aim of the current publication is to investigate psychological peculiarities of professional development in late adulthood.Methodology and research methods. …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…As industrial and economic growth intensifies, greenhouse gases are released into the atmosphere, leading to a shift in global warming and climate change patterns. …”
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Susceptibility profile and associated factors of urinary tract infections among women with established preterm labor delivering at a tertiary teaching hospital in Eastern Uganda: a... by Abdirizak Ahmed Ifrah, Marie Pascaline Sabine Ishimwe, Carlos Antonio Batista Cedeño, Eilu Emmanuel, Theoneste Hakizimana

“…Abstract Background Urinary tract infections have been recognized as a significant health issue since ancient times, but they are particularly concerning during pregnancy due to their potential to cause severe complications like preterm labor and low birth weight leading to significant neonatal morbidity and mortality. …”
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IOP-lowering effect and tolerability of prostaglandin analogues in primary open-angle glaucoma and ocular hypertension as risk factors for glaucoma progression by A.V. Belogurova, E.N. Eskina, Zh.G. Oganezova

“…Oganezova²<br> ¹LLC “Сlinic “Sphere”, Moscow, Russian Federation<br> ²Pirogov Russian National Research Medical University, Moscow, Russian Federation<br> <br> Glaucoma is still one of the leading causes of irreversible low vision and blindness worldwide. …”
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Particulate matter emission in agricultural biomass residue combustion by M.G. Nugraha, A. Sharfan, V.S.Y. Prakoso, M. Hidayat, H. Saptoadi

“…Open burning practices in Yogyakarta exhibit a correlation with heightened rainfall, which in turn leads to higher emissions from April to August due to reduced rain frequency. …”
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Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…Introduction: Periodontitis is defined as a chronic inflammatory disease caused by specific microbes, which triggers the production of inflammatory mediators. This process leads to the loss of tissue structure and function. …”
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Upadacitinib was generally well tolerated, with exposure-adjusted event rates (EAERs) for TEAEs, serious adverse events (AEs), and AEs leading to study drug discontinuation of 207.5, 8.7, and 5.3 events/100 PY, respectively. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…An imbalance in the precursor proportions for HA synthesis leads to a significant decrease in HA MW, indicating that controlling the precursor ratio may serve as a potential method for regulating HA MW. …”
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Common mental disorders and associated factors among adult patients admitted in non-psychiatric wards of public hospitals in Harari regional State, Eastern Ethiopia by Hirko Assefa, Tilahun Ali, Ibsa Mussa, Tadesse Misgana, Dawit Abdi, Abinet Zewudie, Abdi Temesgen

“…Abstract Introduction Common mental disorders represent psychiatric co-morbidity in medical illness, which leads to poor adherence to treatment, increased exposure to diagnostic procedures and the cost of treatment, longer hospital stay, and increasing the risk of complications that result in morbidity and mortality among patients admitted to non-psychiatric wards. …”
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The fundus changes in pathological myopia by Markosyan G.A., Tarutta E.P, Tarasova N.A., Maksimova M.V.

“…Markosian — MD, PhD, Leading Researcher of Department of Refractive Pathology, ORCID iD 0000-0002-2841-6396;<br> Elena P. …”
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Estimating Trends in Cardiovascular Disease Risk for the EXPOSE (Explaining Population Trends in Cardiovascular Risk: A Comparative Analysis of Health Transitions in South Africa a... by Shaun Scholes, Jennifer S Mindell, Mari Toomse-Smith, Annibale Cois, Kafui Adjaye-Gbewonyo

“… BackgroundCardiovascular diseases (CVDs) are the leading cause of death globally. Demographic, behavioral, socioeconomic, health care, and psychosocial variables considered risk factors for CVD are routinely measured in population health surveys, providing opportunities to examine health transitions. …”
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Non-small cell lung cancer in ever-smokers vs never-smokers by Jeremy R. Burt, Naim Qaqish, Greg Stoddard, Amani Jridi, Parker Sage Anderson, Lacey Woods, Anna Newman, Malorie R. Carter, Reham Ellessy, Jordan Chamberlin, Ismail Kabakus

“…Abstract Background Lung cancer is a leading cause of cancer-related mortality. Non-small cell lung cancer (NSCLC) comprises 85% of cases with rising incidence among never-smokers (NS). …”
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Insights into ozone pollution control in urban areas by decoupling meteorological factors based on machine learning by Y. Qiu, X. Li, X. Li, W. Chai, Y. Liu, M. Song, X. Tian, Q. Zou, W. Lou, W. Zhang, J. Li, Y. Zhang

“…When meteorological conditions deteriorate, the atmosphere's capacity to cleanse pollutants decreases, leading to the accumulation of air pollutants. Although a series of emission reduction measures have been implemented in urban areas, the effectiveness of O<span class="inline-formula">₃</span> pollution control proves inadequate. …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…These findings suggest that energy deprivation inhibits the function of the HPO axis, leading to impaired follicle development and reduced egg production, and that refeeding can partially restore these indicators.…”
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