Comparing efficacy and safety of low-dose versus standard-dose antiplatelet therapy in stroke patients: a meta-analysis by Zhao Ren, Chunxing Li, Xin Zhang, Lichaoyue Sun, Hui Zhu, Dongxiao Wang, Yumin Wang, Shuo Liang, Guanchun Wang

“…BackgroundStroke is the leading cause of disability globally, with antiplatelet therapy being crucial for secondary prevention but also increasing bleeding risks. …”
Get full text

Shifting shadows: Assessing the habitat and climate change response of binturong (Arctictis binturong) in the conservation landscape of the Asian continent by Imon Abedin, Tanoy Mukherjee, Ah Ran Kim, Hyun-Woo Kim, Soo Rin Lee, Shantanu Kundu

“…Owing to accelerated climate change, recent decades have witnessed a concerning trend of deforestation and habitat conversion, particularly in Asia, leading to significant habitat loss for a large number of wildlife, including several keystones and/or indicator species. …”
Get full text

Investigating processes influencing simulation of local Arctic wintertime anthropogenic pollution in Fairbanks, Alaska, during ALPACA-2022 by N. Brett, N. Brett, K. S. Law, S. R. Arnold, J. G. Fochesatto, J.-C. Raut, T. Onishi, R. Gilliam, K. Fahey, D. Huff, G. Pouliot, B. Barret, E. Dieudonné, R. Pohorsky, J. Schmale, A. Baccarini, A. Baccarini, S. Bekki, G. Pappaccogli, F. Scoto, S. Decesari, A. Donateo, M. Cesler-Maloney, W. Simpson, P. Medina, B. D'Anna, B. Temime-Roussel, J. Savarino, S. Albertin, S. Albertin, J. Mao, B. Alexander, A. Moon, P. F. DeCarlo, V. Selimovic, R. Yokelson, E. S. Robinson

“…Inclusion of a novel power plant plume rise treatment that considers the presence of surface and elevated temperature inversion layers leads to improved agreement with observed CO and <span class="inline-formula">NO_<i>x</i></span> plumes, with discrepancies attributed to, for example, displacement of plumes by modelled winds. …”
Get full text

Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats by Justin Stadler, Justin Stadler, Justin Stadler, Lucas G. Garmo, Lucas G. Garmo, Lucas G. Garmo, David Doyle, David Doyle, David Doyle, Chin-I. Cheng, Garrett Richardson, Garrett Richardson, Zain Waheed, Zain Waheed, Tim Tofan, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Ajit Sharma, Robert B. Petersen, Gary L. Dunbar, Gary L. Dunbar, Gary L. Dunbar, Julien Rossignol, Julien Rossignol, Julien Rossignol

“…IntroductionIschemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently limited. …”
Get full text

Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany by Janis Evers, Natalie Altschuck, Claudia Mehl, Lilly Rüthrich, Lorenz Harst, Felix Walther, Oliver Steidle, Arnt Suckow, Ruth Hecker, Jochen Schmitt, Max Geraedts

“…While intensive care capacities were overloaded by COVID cases, not only elective cases but also non-COVID cases requiring urgent treatment unexpectedly decreased, potentially leading to a deterioration in health outcomes. However, these developments were only uncovered retrospectively. …”
Get full text

Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…VSMCs had no time window to repair the damaged DNA, leading to generation of micronuclei in cytoplasm. …”
Get full text

Linkage Analysis between Solid-Fluid Coupling and the Strength Reduction Method for Karst Cave Water Inrush in Mines by Yanlin Zhao, Jian Liao, Qiang Liu, Yang Li, Jianchao Cheng

“…It is proposed that thickness of the water-proof rock pillar whose safety factor equals 1.5 is regarded as the calculating safety thickness of the water-proof rock pillar, and the safety thickness of the water-proof rock pillar setting in mining engineering should be equal to the sum of the blasthole depth, blasting disturbance depth, and the calculating safety thickness. The reason leading to Karst water inrush of Qiyi Mine is that without advanced boreholes, the water-proof rock pillar is set so small that it could not possess safety margin, so the confined Karst cave water breaks the water-proof rock pillar and bursts out. …”
Get full text

Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…Background: Botulinum neurotoxins (BoNTs), produced by <i>Clostridium botulinum</i>, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system. …”
Get full text

Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis by Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki

“…Immunofluorescence findings for the tubular injury markers (NGAL and KIM-1) were consistent with biomarker expression in tissue lysates.ConclusionNeonatal E. coli sepsis leads to increased expression of renal tissue inflammation and injury biomarkers consistent with AKI, which may be attenuated with PTX combined with antibiotic treatment.…”
Get full text

Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against <i>Klebsiella pneumoniae</i> Infection by Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Alena S. Kartseva, Tatiana A. Ivashchenko, Vladimir N. Gerasimov, Mikhail E. Platonov, Victoria V. Firstova, Andrey P. Anisimov

“…The introduction of alternative lysing factors into <i>K. pneumoniae cells</i> instead of the E protein leads to the loss of the murein skeleton. The resulting frameless cell envelops are more reminiscent of bacterial sacs or bacterial skins than BGs. …”
Get full text

Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…Cardiovascular diseases (CVDs) include atherosclerosis, which is an inflammatory disease of large and medium vessels that leads to atherosclerotic plaque formation. The key factors contributing to the onset and progression of atherosclerosis include the pro-inflammatory cytokines interferon (IFN)α and IFNγ and the pattern recognition receptor (PRR) Toll-like receptor 4 (TLR4). …”
Get full text

Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity by Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Reza Khorasani, Hamed Haghi-Aminjan, Mahdi Gholami, Mahban Rahimifard, Mona Navaei-Nigjeh, Mohammad Abdollahi

“…Introduction: Sodium arsenite (SA), NaAsO2, is among the most hazardous toxicants, and wide use and presence of this toxicant leads to a severe environmental threat. Exposure to SA is associated with many health concerns, such as the prevalence of cancer and diabetes mellitus type 2 (DMT2). …”
Get full text

Anticancer Peptides Classification Using Long-Short-Term Memory With Novel Feature Representation by Nazer Al Tahifah, Muhammad Sohail Ibrahim, Erum Rehman, Naveed Ahmed, Abdul Wahab, Shujaat Khan

“…Existing techniques either suffer from low accuracy or employ high-dimensional feature sets, frequently producing sparse features and leading to ineffective model designs. This work presents a novel set of features and a long-short-term-memory (LSTM)-based classification strategy to create an efficient model. …”
Get full text

Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…Reduced AOPPs accumulation by antioxidant NAC leaded to improvement of the bone-fat imbalance in aged mice. …”
Get full text

CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…Cardiovascular disease is the leading cause of disease burden and death worldwide and is fueled by vascular inflammation. …”
Get full text

Renewal of wheat cultivars enhances ozone resistance in yield but detrimentally impacts quality: a survey of Chinese wheat by Yinsen Qian, Zheng Zhao, Yifan Cao, Quan Ma, Nanyan Zhu, Lingqi Song, Min Zhu, Min Zhu, Chunyan Li, Chunyan Li, Jinfeng Ding, Jinfeng Ding, Wenshan Guo, Wenshan Guo, Xinkai Zhu, Xinkai Zhu, Xinkai Zhu

“…With China being the leading wheat producer of the world, contributing 17.8% to global output, the vulnerability of wheat to O3 is of particular concern. …”
Get full text

Detection of genetic determinants of potentially oncogenic representatives of the intestinal microbiota as biomarkers of colorectal cancer by Viktoriya N. Shumilova, Artemij E. Goncharov, Daniil V. Azarov, Stanislav I. Sitkin, Elgudzha L. Latariya, Batyrbek I. Aslanov, Mikhail A. Bobrakov, Rustem E. Topuzov

“…Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. Non-invasive diagnostic methods based on the determination of hidden blood in the stool (fecal immunochemical test, guaiac test), which have been proven to be effective in clinical studies, are used for CRC screening. …”
Get full text

Investigating processes influencing simulation of local Arctic wintertime anthropogenic pollution in Fairbanks, Alaska, during ALPACA-2022 by N. Brett, N. Brett, K. S. Law, S. R. Arnold, J. G. Fochesatto, J.-C. Raut, T. Onishi, R. Gilliam, K. Fahey, D. Huff, G. Pouliot, B. Barret, E. Dieudonné, R. Pohorsky, J. Schmale, A. Baccarini, A. Baccarini, S. Bekki, G. Pappaccogli, F. Scoto, S. Decesari, A. Donateo, M. Cesler-Maloney, W. Simpson, P. Medina, B. D'Anna, B. Temime-Roussel, J. Savarino, S. Albertin, S. Albertin, J. Mao, B. Alexander, A. Moon, P. F. DeCarlo, V. Selimovic, R. Yokelson, E. S. Robinson

“…Inclusion of a novel power plant plume rise treatment that considers the presence of surface and elevated temperature inversion layers leads to improved agreement with observed CO and <span class="inline-formula">NO_<i>x</i></span> plumes, with discrepancies attributed to, for example, displacement of plumes by modelled winds. …”
Get full text

Grain yield and water productivity of maize under deficit irrigation and salt stress: Evidences from field experiment and literatures by Jia Gao, Lin Li, Risheng Ding, Shaozhong Kang, Taisheng Du, Ling Tong, Jian Kang, Wanli Xu, Guangmu Tang

“…However, it is not desirable to improve WP by reducing irrigation if it leads to a decrease in yield. This study aimed to investigate the effects of deficit irrigation and salt stress on maize yield and WP, as well as the underlying mechanism, and to explore agronomic practices to jointly improve maize yield and WP based on literature analysis. …”
Get full text

Deflection of screen surface and spatial deformation law of screen apertures during 1 mm elastic screening by Haishen JIANG, Ran YANG, Runyu LIU, Shijie YU, Peng GUO, Miao PAN, Long HUANG, Chenlong DUAN

“…Under the action of water and clay minerals, the process of wet material screening has some problems such as strong adhesion between fine particles, significant agglomeration effect, difficulty in particle separation and layering, and severe clogging on the screen surface, leading to difficulties in material sieving and poor screening performance, which can severely restrict the large-scale upgrading and processing of coal. …”
Get full text