DFT and molecular docking analyses of the effects of solvent polarity and temperature on the structural, electronic, and thermodynamic properties of p-coumaric acid: Insights for a... by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tadesse Lemma Wakjira, Dereje Gelanu, Tesfaye Feyise, Jebel Haji Mahamud, Abdulkerim Abdela, Kebede Shankute Gizew

“…Time-dependent DFT (TDDFT) analysis revealed that solvent polarity influenced UV–Vis absorption and excited-state dipole moments, leading to significant changes in electronic transitions. …”
Get full text

Impact of surgical site infection (SSI) following gynaecological cancer surgery in the UK: a trainee-led multicentre audit and service evaluation by Rachel L O’Donnell, Georgios Angelopoulos, James P Beirne, Ioannis Biliatis, Helen Bolton, Melissa Bradbury, Elaine Craig, Ketan Gajjar, Michelle L Mackintosh, Wendy MacNab, Thumuluru Kavitha Madhuri, Mark McComiskey, Eva Myriokefalitaki, Claire L Newton, Nithya Ratnavelu, Sian E Taylor, Amudha Thangavelu, Sarah A Rhodes, Emma J Crosbie, Richard J Edmondson, Yee-Loi Louise Wan

“…Wound drains (OR 2.92[95% CI 1.41 to 6.04], p=0.004) and staple closure (OR 3.13[95% CI 1.50 to 6.56], p=0.002) were also associated with increased risk of SSI.Conclusions SSI is common in women undergoing surgery for gynaecological cancer leading to delays in discharge and adjuvant treatment. …”
Get full text

Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle by Sarah Damery, Kerry Allen, Lisa Dikomitis, Harry Hill, David Coyle, Maatla Tshimologo, Mark Lambie, Simon J Davies, Iestyn Williams, James Fotheringham, Louise Phillips-Darby, Ivonne Solis-Trapala

“…Survey results, linked to patient-level data from the UK Renal Registry, will populate a causal graph describing patient and centre-level factors, leading to uptake of home dialysis and multistate models incorporating patient-level treatment modality history and mortality. …”
Get full text

Transforming the Health Research Workforce in Mozambique: Achievements of the Mozambique Institute for Health Education and Research (MIHER) over a 13-Year Journey by Emília Virgínia Noormahomed, Sérgio Noormahomed, Matchecane Cossa, Nicole Joyce, Regina Daniel Miambo, Irina Mendes Sousa, Noémia Nhacupe, Tufária Mussá, Jahit Sacarlal, Lídia Gouveia, Luís Jorge Ferrão, Carla Carrilho, Mamudo Ismail, Davey Smith, Natasha K. Martin, Ravi Goyal, Kim E. Barrett, Sónia Santana Afonso, Amélia Mandane, Alarquia Saíde, Pompílio Vintuar, Brígida Singo, Boaventura Aleixo, Luck Injage, Elizabeth A. Winzeler, Paulo Correia-de-Sá, Maria do Rosário Oliveira Martins, Paulo Ferrinho, Sam Patel, Ana Olga Mocumbi, Stephen W. Bickler, Constance A. Benson, Roberto Badaró, Robert T. Schooley

“…Conclusions: MIHER has emerged as a leading RSC of Excellence, fostering synergies and promoting a quality research culture in Mozambique, fueled in part, by its ability to identify and incorporate key collaborations. …”
Get full text

Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ... by Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, Jonas Mattsson, MD, PhD

“…Despite decades of post–allogeneic hematopoietic cell transplantation (HCT) growth factor utilization, its role remains undefined, leading to ongoing debates and research. The theoretical impacts of growth factors have been challenged in numerous studies. …”
Get full text

A Study of Volatile Organic Compounds in Patients with Obstructive Sleep Apnea by Chuan Hao Gui, Zhunan Jia, Zihao Xing, Fuchang Zhang, Fang Du, Alex Chengyao Tham, Ming Yann Lim, Yaw Khian Chong, Agnes Si Qi Chew, Khai Beng Chong

“…<b>Background</b>: Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder characterized by intermittent upper airway obstruction, leading to significant health consequences. Traditional diagnostic methods, such as polysomnography, are time-consuming and resource-intensive. …”
Get full text

Evaluation of the Effects of Degradable Mulching Film on the Growth, Yield and Economic Benefit of Garlic by Jiangping Song, Huixia Jia, Yang Wang, Xiaohui Zhang, Wenlong Yang, Tingting Zhang, Naijian Wang, Jianqiang Yang, Haiping Wang

“…However, the prolonged use of this material leads to serious environmental issues that adversely affect soil health and plant growth. …”
Get full text

Rectal temperature and heat transfer dynamics in the eye, face, and breast of broiler chickens exposed to moderate heat stress by Moustafa Yehia, Amani Askri, Ahlem Achour, Jean-Michel Allard Prus, Véronique Ouellet, Nabeel Alnahhas

“…However, heat transfer rates are significantly reduced leading to increased heat load of the birds. These findings provide further insights into thermoregulation in broiler chickens.…”
Get full text

Development of monoclonal antibodies against P. gingivalis Mfa1 and their protective capacity in an experimental periodontitis model by Mingya Cao, Siyu Wang, Shengke Zhou, Min Yan, Yu Zou, Yuan Cui, Xinyu Lou, Yichang Gao, Ying Chen, Zijing Han, Yi Qian, Jingying Chen, Xia Li

“…ABSTRACT Porphyromonas gingivalis (P. gingivalis), a gram-negative, black-pigmented anaerobe, is a major etiological agent and a leading cause of periodontitis. Fimbriae protein Mfa1 is a key virulence factor of P. gingivalis and plays a crucial role in bacterial adhesion, colonization, biofilm formation, and persistent inflammation, making it a promising therapeutic target. …”
Get full text

Pneumonia among Under-Five Children in Northwest Ethiopia: Prevalence and Predictors—A Community-Based Cross-Sectional Study by Zewudu Andualem, Tsegaye Adane, Abiye Tigabu, Walelign Worku Yallew, Sintayehu Daba Wami, Henok Dagne, Jember Azanaw, Gebisa Guyasa, Zelalem Nigussie Azene, Mastewal Endalew

“…Acute respiratory infections in particular pneumonia constitutes the leading cause of morbidity and mortality among children under five years of age throughout the world. …”
Get full text

HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…We also showed that activity of the BAF chromatin remodeling complex is repressed by HINT1, whose expression in heart increases with age, leading to decreased transcription of Tfam, which promotes mitochondrial biogenesis. …”
Get full text

Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Background and Aims: Hepatitis E virus (HEV) infection is a leading cause of acute hepatitis worldwide. Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. …”
Get full text

Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients by Liu Yang, Zhuo Xu, Zhenyan Wang, Fangping Ding, Zhipeng Wu, Xiaoqian Shi, Jing Wang, Yingmin Ma, Jiawei Jin

“…Conclusions The increase of HDL-pro-SFTPB promotes HDL pro-inflammatory transition during septic ARDS, leading to exacerbated progression of ARDS through enhancing M1 macrophage polarization. …”
Get full text

Disease-Related Knowledge, Stress, and Quality of Life of Parental Caregivers of Children with Cleft Lip and Palate in a Selected Hospital in Ho Chi Minh City, Vietnam by Phung Le Thi Kim, Leonora Collantes, Phuong Lam Hoai, An Phan Huynh, Nghia Le Trung, Tu Nguyen Thanh, Anh Nguyen Viet, Kieu Nguyen Thi Thanh, Truc Pham Thanh Luu, Phi Duong Nguyen

“…Parental caregivers, particularly mothers, face considerable challenges in managing complex treatment pathways and addressing their children's multifaceted needs. This often leads to increased stress and decline in the quality of life (QoL). …”
Get full text

Ocular infections in international travelers by Francesca F. Norman, Julio J. González-López, Diego Gayoso-Cantero, Marta Vicente-Antolin, Maria-Dolores Corbacho-Loarte, Rogelio López-Vélez, Marta González-Sanz

“…Increasing exposure to animals, undercooked food consumption or poor hygiene during international travels might be leading to the emergence of certain parasitic eye diseases. …”
Get full text

Identification of Co-Expression Modules of Cotton Plant Height-Related Genes Based on Weighted Gene Co-Expression Network Analysis by Qian Huang, Li Liu, Hang Li, Xuwen Wang, Aijun Si, Liangrong He, Yu Yu

“…Transcriptome data from 18 treated cotton stem tissue samples were analyzed using Weighted Gene Co-expression Network Analysis (WGCNA), leading to the identification of 21 gene co-expression modules. …”
Get full text

Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease by Shiqun Chen, Yang Zhou, Guoxiao Liang, Wanying Wu, Zhigang Huang, Lile Shi, Yuwei Gao, Xia Gu, Dongmei Wang

“…Background Renal dysfunction leads to poor prognosis of patients with coronary artery disease (CAD). …”
Get full text

CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation by Hussain Z, Abdulrahim Abdul Moti L, Jagal J, Thu HE, Khan S, Kazi M

“…Zahid Hussain,1,2 Lama Abdulrahim Abdul Moti,1 Jayalakshmi Jagal,2 Hnin Ei Thu,3 Shahzeb Khan,4 Mohsin Kazi5 1Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; 2Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; 3Department of Pharmacology, Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia; 4Center for Pharmaceutical Engineering Science, Faculty of Life Sciences, School of Pharmacy and Medical Sciences, University of Bradford, West Yorkshire Bradford, BD7 1DP, UK; 5Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451 Saudi ArabiaCorrespondence: Zahid Hussain, Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates, Email zhussain@sharjah.ac.aeIntroduction: Owing to its high prevalence, colossal potential of chemoresistance, metastasis, and relapse, breast cancer (BC) is the second leading cause of cancer-related fatalities in women. …”
Get full text

Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…The release of PGI from the metacestode vesicles, leading to the structural destruction of the inner surfaces. …”
Get full text

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and h... by Yidan Wang, Pengxiao Liu, Zihao Li, Shiya Wu, Meijuan Long, Yang Li, Juan Jiao, Zheng Xie

“…Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. …”
Get full text