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25901
Prevalence and Factors Associated with Intestinal Parasitic Infections among Pregnant Women in West Gojjam Zone, Northwest Ethiopia
Published 2020-01-01“…The prevalence of hookworm 138 (18.6%) was the leading cause of intestinal parasitosis followed by E. histolytica/dispar 113 (15.2%). …”
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25902
Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications
Published 2025-02-01“…Abstract Introduction Chronic back pain (CBP) is a leading cause of disability worldwide and is commonly managed with pharmacological, non-pharmacological, and procedural interventions. …”
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25903
HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease
Published 2025-02-01“…Graph neural networks (GCNs) have emerged as a leading approach for predicting drug-disease associations by integrating drug and disease-related networks with advanced deep learning algorithms. …”
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25904
Development of SacB-based counterselection for efficient allelic exchange in Fusobacterium nucleatum
Published 2025-01-01“…Post-counterselection with 5% sucrose, chromosomal plasmid loss occurred in all colonies, leading to gene alternations in half of the screened isolates. …”
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25905
High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele
Published 2020-01-01“…The aim of this study was to determine whether homozygous or heterozygous PiZ allele carriage leads to elevated level of IL-17 and other proinflammatory cytokines in COPD patients. …”
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25906
Boron adsorption in semiarid Mediterranean soils under the influence of background electrolytes
Published 2022-10-01“…This causes a low rate of boron assimilated by plants, which leads to the decrease of the crop yield and the agricultural production, and subsequently hurt the Tunisian national economy.…”
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25907
Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia
Published 2025-01-01“…Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by multiple known recurrent genetic aberrations that inform prognosis, the most common being hyperdiploidy and t(12;21) <i>ETV6::RUNX1</i>. …”
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25908
Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells
Published 2020-03-01“…When evaluating the proliferative activity of cells under the influence of the Miramistin antibiotic in different concentrations, it was found that increasing the dose to 50, 75, 100, 125, 150 μg/cm3 leads to decrease in the rate of cell growth compared to the control. …”
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25909
Socioeconomic inequality in hypertension and its determinants in people over 60 years in Fasa, southern Iran: a Blinder-Oaxaca decomposition
Published 2025-01-01“…The decomposition model revealed a significant gap in HTN rate between rich and poor individuals, with those in the lower income bracket having a 7.59% higher rate of HTN (p = 0.001). Additionally, the leading factors contributing to the greatest disparities in HTN among older adults from different socioeconomic backgrounds include education level (33.07%), employment status (12.78%), BMI (12.25%), physical activity (-15.02%), and WHR (-9.22%). …”
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25910
Spatiotemporal Variations of Particulate Matter and their Association with Criteria Pollutants and Meteorology in Malaysia
Published 2022-07-01“…The PCA analysis indicates that the major sources leading to the formation of particulate matter are from the contribution of secondary aerosols and combustion-related sources. …”
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25911
Improvement of a MALDI-TOF database for the reliable identification of Candidozyma auris (formally Candida auris) and related species
Published 2025-01-01“…To make matters worse, its biochemical assimilation profile was found to be similar to that of closely related and even no-related species, leading to frequent misidentification. To improve diagnostics of this and closely related species, we created a database of reference mass spectra resulting in the efficient and correct identification of all Candidozyma species by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). …”
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25912
PPAR-γ agonist mitigates intestinal barrier dysfunction and inflammation induced by Clostridioides difficile SlpA in vitro
Published 2024-12-01“…Abstract Clostridioides difficile is the leading cause of healthcare- and antibiotic-associated diarrhea. …”
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25913
Comparison of Accounting Profit Between Offshore and Deep-sea Commercial Fishing Industry in Pahang State, East Coast of Peninsular Malaysia
Published 2023-05-01“…Moreover, there are more trawlers vessels operating in the Pahang state fishing ground and the open access nature of the fishery like larger profit invites more effort to use in the fishery which is leading to the over exploitation of fishery resources and threatening the sustainable condition of the fishery. …”
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25914
Global, regional, and national burden of young COPD, 1990–2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021
Published 2025-01-01“…Joinpoint regression analysis indicated a slight increase in both the ASPR (APC: 0.13; 95% CI: 0.06 to 0.19) and the ASIR (APC: 0.17; 95% CI: 0.10 to 0.24) during the period from 1990 to 1994. The leading DALYs attributable to risk factors for young COPD are household air pollution from solid fuels (20.4%), ambient particulate matter pollution (17.9%), and smoking (13.5%). …”
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25915
Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain
Published 2025-02-01“…Moreover, silencing C/EBP-β reversed the enhanced expression of TGF-β 1 induced by Vincristine, attenuated astrocyte A1 polarization and proinflammatory factor release.Conclusion: Vincristine induced spinal cord inflammation by promoting A1 polarization of astrocytes via upregulating the C/EBP-β/TGF-β 1 signal pathway, thus leading to neuropathic pain. It was different from the traditional signal pathway, this study shown a new signal pathway for astrocyte A1 polarization, which may provide a possibility for clinical treatment of neuropathic pain.Keywords: neuropathic pain, astrocytes, C/EBP-β, TGF-β 1, neuroinflammation…”
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25916
Klasifikasi Sinyal Phonocardiogram Menggunakan Short Time Fourier Transform dan Convolutional Neural Network
Published 2023-04-01“…Abstract According to a report by the American Heart Association, cardiovascular disease is the leading global cause of death. Phonocardiogram (PCG) and electrocardiogram (ECG) are commonly used to detect heart disease. …”
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25917
STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment
Published 2021-02-01“…For T cell repertoireβ-CDR3 analyses, T cell CDR3 was sequenced from gDNA isolated from splenocytes and enzymatically digested tumors.Results We report that activation of STING within the TME leads to slowed melanoma growth in association with increased production of antiangiogenic factors including Tnfsf15 (Vegi) and Cxcl10, and TLS-inducing factors including Ccl19, Ccl21, Lta, Ltb and Light. …”
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25918
An Updated Demographic Profile of Orthopaedic Surgery Using a New ABOS Data Set
Published 2025-03-01“…The American Board of Orthopaedic Surgery (ABOS) is the leading board certification organization for orthopaedic surgeons in the United States. …”
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25919
Characteristics of metabolic syndrome in the servicemen with erosive esophagitis in wartime conditions
Published 2024-12-01“…Among the well-known factors contributing to the prevalence of erosive esophagitis, the leading one is an increase in the number of individuals with obesity and insulin resistance. …”
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25920
Single-staged Surgical Correction of Kyphotic Deformity due to Dorsal Spinal Tuberculosis in Pediatric Patients: Outcome Analysis
Published 2024-05-01“…It can result in the collapse of the affected vertebrae, leading to deformities such as kyphosis and sagittal imbalance; the deformity and progression can be worse in the pediatric age-group due to their growth spurt. …”
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