Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice by Xiaohang Wang, Xiaohang Wang, Xiaohang Wang, Qianqian Wang, Zhensheng Cai, Chengming Ni, Huan Wang, Hui Liu, Yusong Zhao, Jinbang Wang, Subo Liu, Xueying Wang

“…AimsIndividuals with type 2 diabetes mellitus (T2DM) are at-risk for developing vascular dementia (VaD). Hyperglycemia leads to the activation of astrocytes. These activated cells produce proinflammatory mediators like cytokines or chemokines, that cause cerebrovascular damage. …”
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A20 as a Potential Therapeutic Target for COVID‐19 by Yongyao Wu, Lilan He, Rong Li, Jiuxuan Li, Qing Zhao, Bin Shao

“…This inopportune immune rhythm not only makes patients more susceptible to the virus but also leads to numerous complications resulting from the excessive production of inflammatory factors. …”
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The size-fractionated composition of particulate biogenic silica and its ecological significance in the Changjiang Estuary area by Xizhen Liu, Xizhen Liu, Bin Wang, Bin Wang, Siyang Chen, Haiyan Jin, Haiyan Jin, Yanpei Zhuang, Zhibing Jiang, Hongliang Li, Hongliang Li, Jianfang Chen, Jianfang Chen

“…Consequently, the proliferation of diatoms (siliceous phytoplankton) in the midupper water significantly contributed to the hypoxic conditions at the bottom, as diatoms underwent dissolution during sedimentation, leading to oxygen depletion.…”
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Ophthalmologists’ and patients’ perspectives on treatments for diabetic retinopathy and maculopathy in Vietnam: a descriptive qualitative study by Tunde Peto, Nathan Congdon, Lynne Lohfeld, Hoang Tran, Katie Curran, Van Thu Nguyen, Tung Thanh Hoang, Hue Thi Nguyen, Quan Nhu Nguyen, Catherine Dardis, Hoang Huy Tran, Anh Tuan Vu, Mai Quoc Tung

“…Introduction Globally, diabetic retinopathy (DR) is the leading cause of blindness in working-aged adults. …”
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A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data by Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N. Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

“…Background: Dementia is the leading cause of disability and imposes a significant burden on society. …”
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Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis by Jing Li, Xueting Ren, Lin Cao, Kaixiang Min, Meng Wang, Shuai Lin, Lei Lei, Zengqi Tan, Xiaoliang Cheng, Xiang Li, Feng Guan

“…Notably, GAS6 was decorated with bisecting GlcNAc, which promoted its degradation in donor cells, leading to reduced GAS6 levels in sEVs and attenuating GAS6-mediated CAFs activation. …”
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SHP2 is essential for the progesterone-promoted proliferation and migration in breast cancer cell lines by Hui-Chen Wang, Hui-Chen Wang, Wen-Sen Lee, Wen-Sen Lee, Wen-Sen Lee, Wen-Sen Lee

“…However, knockdown of SHP2 expression increased the complex formations of PR-cSrc-caveolin-1-Csk-p140Cap and the levels of p-caveolin-1, p-Csk and p-cSrcY527 (inactivated form of cSrc).DiscussionOur data suggest that SHP2 can bind to cSrc-negative regulatory proteins (p140Cap and Csk), hence preventing the interaction between cSrc and cSrc-negative regulatory proteins, leading to decreased phosphorylation of cSrc Y527 and prolonged cSrc activation. …”
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Dataset of microscale atmospheric flow and pollutant concentration large-eddy simulations for varying mesoscale meteorological forcing in an idealized urban environmentZenodo by Eliott Lumet, Thomas Jaravel, Mélanie C. Rochoux

“…Assessing these risks requires the development of microscale meteorological models that quickly and accurately predict wind velocity and pollutant concentration with high resolution, as the heterogeneity of urban environments leads to complex wind patterns and strong pollutant concentration gradients. …”
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Severe primary graft failure: Are there lasting impacts? Analysis from the PHTS Database by Jennifer Conway, MD, Tara Pidborochynski, MSc, James K. Kirklin, MD, Ryan Cantor, PhD, Hong Zhao, PhD, Aryaz Sheybani, MD, Jacqueline Lamour, MD, Lakshmi Gokanapudy Hahn, MD, Leslie Collins, MD, Jessica Laks, MD, Darren H. Freed, MD, PhD

“…Background: Primary graft failure (PGF) is a leading cause of early morbidity and mortality after heart transplantation (HTx). …”
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Efficacy of rituximab as second-line therapy for autoimmune encephalitis: A systematic review and meta-analysis by Lin-ming Zhang, Xuan-lin Xing, Bing-ran Zhang, Qiu-juan Zhang, Yan-lin Zhu, Shu-ji Gao, Ming-wei Liu

“…Background: Approximately 20%–50 % of individuals with autoimmune encephalitis (AE) demonstrate suboptimal responses to first-line therapies, leading to persistent neurological deficits and the need for second-line interventions. …”
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Stock price prediction with attentive temporal convolution-based generative adversarial network by Ying Liu, Xiaohua Huang, Liwei Xiong, Ruyu Chang, Wenjing Wang, Long Chen

“…However, recurrent networks such as LSTM and GRU may exhibit susceptibility to overfitting the training data, leading to suboptimal performance in real-world predictions due to the inherent noise and volatility of stock market data. …”
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Citizen engagement in public food procurement, a novel choose-your-own-adventure canteen campaign case study by Luke John Schafer, Anna Gundorph, Carla Mingolla, Christian Bugge Henriksen, Marin Lysak, Reni Todorova Boncheva, Maarten Crivits

“…Citizen engagement is an often-overlooked tool that can facilitate food system change with its participatory approaches leading to distributed learning and decentralised knowledge generation. …”
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Effect of Nebulisation with Dexmedetomidine versus Magnesium Sulphate on Haemodynamic Response to Laryngoscopy and Intubation and Incidence of Postoperative Sore Throat: A Randomis... by Fateh Pal Singh Gill, Chhaya Suryawanshi

“…Introduction: Laryngoscopy and endotracheal intubation are essential procedures in general anaesthesia but can induce sympathetic hyperactivity, leading to transient increase in blood pressure and Heart Rate (HR). …”
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Piloting of a Screen-Triage-Treat Surgical Approach Model for Management of Anal Cancer in Liberia by Christopher W. Reynolds, Whitney Lieb, Andrea Schecter, Michael M Gaisa, Stephen K. McGill, Evans L. Adofo, Ann Marie Beddoe

“…Background: While cancer is a leading cause of death worldwide, significant disparities exist in care access in low- and middle-income countries (LMICs). …”
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Comparative effects of methamphetamine, cannabis, and polysubstance use on oral health by Osman Hasan Tahsin Kılıç, Duygu Kürklü Arpaçay, Onur Çağdaş Gezen, Zehra Nur Bayram, Aysel Başer

“…The study also found a moderate positive correlation between MA use and DMFT scores, indicating that longer and higher usage leads to poorer oral health, while no significant association was observed between THC use and DMFT scores. …”
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Postpartum Remote Health Coaching Intervention for Individuals With a Hypertensive Disorder of Pregnancy: Proof-of-Concept Study by Jaclyn D Borrowman, Lucas J Carr, Gary L Pierce, William T Story, Bethany Barone Gibbs, Kara M Whitaker

“… Abstract BackgroundCardiovascular disease (CVD) is the leading cause of death among women in America. Hypertensive disorders of pregnancy (HDP) negatively impact acute and long-term cardiovascular health, with approximately 16% of all pregnancies affected. …”
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Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery by Chaoxiang You, Guiqiong Xie, Shun Lin, Shuang Li, Mengying Jia, Xiufei Wu, Xiaoxuan Zhang, Yi Zhou, Hongyan Kou

“…The decrease in quality of life leads to an increase in the severity of symptom clusters. …”
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A multidisciplinary collaborative care model involving family members in the treatment of type 2 diabetes mellitus and associated diabetes distress in young and middle-aged patient... by Wang Yan-Ping, Peng Lu-Yao, Yuan Xian-Ming, Chen Ting-Ting, Li Lin, Deng Kai-Qin

“…Diabetes mellitus (DM) represents a significant and enduring health concern and, due to various complications arising from inadequate management, leads to disability and mortality. The aim of this study was to examine the impact of the family-engaged multidisciplinary collaborative care (FEC) model on the management of type 2 DM (T2DM) in young and middle-aged patients, considering the presence of DM distress. …”
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Nutritional Profiles and Factors Associated with the Intake of Certain Food Types in Patients Undergoing Maxillofacial Prosthetic Rehabilitation: A Cross-Sectional Study by Nehasha Pradhan, Mai Murase, Masako Akiyama, Hiroko Tani, Yuka I. Sumita, Noriyuki Wakabayashi

“…<b>Background:</b> Malnutrition is a significant concern for head and neck cancer (HNC) patients, as treatment often impairs mastication, causes dysphagia, and alters taste and smell, leading to reduced food intake and a diminished quality of life. …”
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Prevalence and Determinants of Hypertension Awareness, Treatment, and Control in Botswana: A Nationally Representative Population-Based Survey by Neo M. Tapela, Lei Clifton, Gontse Tshisimogo, Moagi Gaborone, Tebogo Madidimalo, Virginia Letsatsi, Tiny Masupe, Mosepele Mosepele, Joseph Makhema, Shahin Lockman, David J. Hunter

“…Introduction. Hypertension is a leading risk factor for cardiovascular mortality and an emerging public health concern in sub-Saharan Africa. …”
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