Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…These VLPs serve as antigens to immunize mice, leading to the isolation of the monoclonal antibody 45G3. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Nevertheless, PPIs are often overused leading to potential adverse effects and unnecessary healthcare costs. …”
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Truncated NS1 Influenza A Virus Induces a Robust Antigen-Specific Tissue-Resident T-Cell Response and Promotes Inducible Bronchus-Associated Lymphoid Tissue Formation in Mice by Anna-Polina Shurygina, Marina Shuklina, Olga Ozhereleva, Ekaterina Romanovskaya-Romanko, Sofia Kovaleva, Andrej Egorov, Dmitry Lioznov, Marina Stukova

“…Notably, PR8/NS124 immunisation also leads to the development of inducible bronchus-associated lymphoid tissue (iBALT) in the lungs by day 28, characterised by the presence of antigen-specific Tfh cells and GL7+Fas+ germinal centre B cells. …”
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Minimally invasive needle tenotomy vs. platelet rich plasma injection in the treatment of chronic elbow epicondylitis by Chantal T. Nguyen, MD, Michelle H. Lee, MD, Matthew W. Kaufman, MD, Yue Meng, MD, Jyotsna A. Koduri, MD, Geoffrey Abrams, MD, Emilie V. Cheung, MD, Michael T. Freehill, MD, Eugene Y. Roh, MD

“…Though symptoms are generally self-limiting, 10% of cases are refractory to conservative management, persisting for greater than 18 months, and leading to surgery, which can have increased risk of complications. …”
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Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases by Luca Perico, Federica Casiraghi, Fabiane Sônego, Marta Todeschini, Daniela Corna, Domenico Cerullo, Anna Pezzotta, Patricia Isnard-Petit, Silvia Faravelli, Federico Forneris, Kader Thiam, Ariela Benigni, Giuseppe Remuzzi

“…Systemic administration of BiAATE to mice transgenic for human CD3 reduced anti-PLA2R antibody levels following active immunization with PLA2R.DiscussionShould this approach be confirmed for other autoimmune diseases, BiAATEs could represent a promising off-the-shelf therapy for precision medicine in virtually all antibody-mediated autoimmune diseases for which the pathogenic autoantigen is known, leading to a paradigm shift in the treatment of these diseases.…”
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Prediction of compressive strength and characteristics analysis of semi-flexible pavement desert sand grouting material based upon hybrid-BP neural network by Wenbang Zhu, Yuhang Li, Xiumei Zheng, Enze Hao, Dali Zhang, Zhen Wang

“…DS effectively dispersed the DSGM cementitious material slurry, leading to a more uniform distribution of hydration products and a stronger bond in the transition zone of the aggregate interface. …”
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Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials by Konrad E Bloch, Mona Lichtblau, Silvia Ulrich, Felix C Tanner, Talant Sooronbaev, Maamed Mademilov, Michael Furian, Helga Preiss, Laura Mayer, Simon Rafael Schneider, Julian Müller, Stephanie Saxer, Anna Titz, Anwer Shehab, Lena Reimann

“…Background Hypoxic pulmonary vasoconstriction leads to an increase in pulmonary artery pressure (PAP) and potentially right heart failure in healthy individuals and patients with respiratory diseases. …”
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Pathogenetic Treatment of Gastritis as a Basis for the Prevention of Gastric Cancer in the Countries of the Commonwealth of Independent States: Literature Review and the Resolution... by V. T. Ivashkin, I. V. Maev, J. V. Gorgun, K. S. Kaliaskarova, M. M. Karimov, A. V. Kononov, T. L. Lapina, N. A. Markaryan, M. S. Moldobaeva, S. I. Pimanov, A. A. Sheptulin

“…In 2012, gastric cancer was recognized as the 3rd leading malignant disease in the Kyrgyz Republic and the Republic of Uzbekistan, 5th — in Belarus and Kazakhstan, 6th — in Armenia and the Russian Federation. …”
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Incidence of HTLV-1-associated myelopathy in the UK from 1991 to 2024: a longitudinal observational cohort study by Carolina Rosadas, Jerico Baylon, Claire Greiller, Adine Adonis, Divya Dhasmana, Nicholas W. S. Davies, Graham P. Taylor, Graham P. Taylor

“…IntroductionHuman T-cell lymphotropic virus type 1 (HTLV-1) may cause spinal cord inflammation, leading to HTLV-1-associated myelopathy (HAM). HAM is a chronic and progressive neurological disorder that is associated with increased mortality and impaired quality of life. …”
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The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…Background: Cigarette smoking is a leading cause of preventable death worldwide, with its associated diseases and conditions. …”
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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational... by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye

“…Introduction Lung cancer is the leading cause of cancer death in the USA and worldwide, and lung cancer screening (LCS) with low-dose CT (LDCT) has the potential to improve lung cancer outcomes. …”
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Evaluation of outcome relevance of quality indicators in the emergency department (ENQuIRE): study protocol for a prospective multicentre cohort study by Anna Slagman, Felix Greiner, Martin Möckel, Rainer Röhrig, Susanne Drynda, Wencke Schindler, Johannes Pollmanns, Dirk Horenkamp-Sonntag, Wiebke Schirrmeister, Ronny Otto, Jonas Bienzeisler, Saskia Drösler, Rolf Lefering, Jennifer Hitzek, Enno Swart, Felix Walcher

“…The data collected for this purpose comprise medical records from the ED treatment, discharge (claims) data from hospitalised patients, a patient questionnaire to be answered 6–8 weeks after emergency admission, and outcome measures in a 12-month follow-up obtained as claims data from the SHI.Descriptive and analytical statistics will be applied to provide summaries about the characteristics of QIs and associations between quality measures and patient outcomes.Ethics and dissemination Approval of the leading ethics committee at the Medical Faculty of the University of Magdeburg (reference number 163/18 from 19 November 2018) has been obtained and adapted by responsible local ethics committees.The findings of this work will be disseminated by publication of peer-reviewed manuscripts and presentations as conference contributions (abstracts, poster or oral presentations).Moreover, results will be discussed with clinical experts and medical associations before being proposed for implementation into the quality management of EDs.Trial registration number German Clinical Trials Registry (DRKS00015203); Pre-results.…”
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Protective Effects of Phycobiliproteins from <i>Arthrospira maxima</i> (Spirulina) Against Cyclophosphamide-Induced Embryotoxicity and Genotoxicity in Pregnant CD1 Mice by Yuliana García-Martínez, Amparo Celene Razo-Estrada, Ricardo Pérez-Pastén-Borja, Candelaria Galván-Colorado, Germán Chamorro-Cevallos, José Jorge Chanona-Pérez, Oscar Alberto López-Canales, Hariz Islas-Flores, Salud Pérez-Gutiérrez, Joaquín Cordero-Martínez, José Melesio Cristóbal-Luna

“…Despite its great efficacy, has been associated with the production of oxidative stress and DNA damage, leading to embryotoxicity, genotoxicity, and teratogenicity in the developing <i>conceptus</i>. …”
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A Reliable Medium for Monitoring Atmospheric Deposition near Emission Sources by Using Snow from Agricultural Areas by Jiayang Liu, Zaijin Sun, Wenkai Lei, Jingwen Xu, Qian Sun, Zhicheng Shen, Yixuan Lyu, Huading Shi, Ying Zhou, Lan Zhang, Zefeng Wu, Yuepeng Pan

“…This method has limitations in agricultural areas because polluted soil particles may become resuspended and eventually deposited into these cylinders, leading to overestimates in the amount of atmospheric deposition in soil. …”
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Multisensory Stimulation in Rehabilitation of Dementia: A Systematic Review by Andrea Calderone, Angela Marra, Rosaria De Luca, Desirèe Latella, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

“…<b>Background/Objectives</b>: Dementia leads to cognitive decline, affecting memory, reasoning, and daily activities, often requiring full-time care. …”
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Validation of the Zarit Burden Interview in Informal Caregivers of Patients with Severe Visual Impairment and Blindness by Raul E. Ruiz-Lozano, Monica I. Herrera-Rodriguez, Jazmin A. Mendoza-Pallares, Natalia Reyes-Godinez, Veronica E. Tamez-Tamez, Eugenia M. Ramos-Dávila, Luis G. Villagomez-Valdez, Lucas A. Garza-Garza, Manuel E. Quiroga-Garza, Ali Khodor, Jose J. Gongora-Cortes, Alejandro Rodriguez-Garcia

“…Abstract Introduction The needs of family caregivers providing care to relatives with visual impairment are often dismissed, leading to caregiver burden. The Zarit Burden Interview (ZBI) can measure the caregiver burden of caring for a family member with vision impairment. …”
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Resident action in smart waste management during landfill disclosure transition: Insights from Yogyakarta's smart city initiatives by Sapta Suhardono, Chun-Hung Lee, Thi Thanh Thuy Phan, I Wayan Koko Suryawan

“…Findings demonstrate that combining cutting-edge technology with community-centric initiatives leads to significant improvements in waste management outcomes. …”
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Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial by Phillip Knebel, Thilo Hackert, Markus W Büchler, Ilse Rooman, Markus K Diener, Felix J Hüttner, André L Mihaljevic, Oliver Strobel, Gauthier Bouche, Johannes Hüsing

“…Introduction Pancreatic cancer is the fourth-leading cause of cancer-related death in developed countries. …”
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A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults by Xiaomeng Mao, Xiaohan Hua, Chengyi Wu, Xiaoyun Ge, Jie Zhang, Xiaojie Wu, Robert J. Kubiak, Ulrika Wählby Hamrén, Tonya Villafana, Georgios Christou, Jannine Green, Therese Takas, Yuwen Jin

“…Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. …”
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Bridging the gap: challenges and adoption of climate-resilient agriculture technologies in agricultural landscapes across agro-climatic zones of Bihar, India by Raj Kumar Jat, Vijay Singh Meena, Vijay Singh Meena, Shubham Durgude, Ravindra Kumar Sohane, Ratnesh Kumar Jha, Abhay Kumar, Ujjwal Kumar, Anjani Kumar, Raj Narain Singh, Suneel Kumar, Illathur R. Reddy, S. Pazhanisamy, Rakesh Kumar, Sunita Kumari Meena, Ved Prakash, Sanjay Kumar, Anirban Mukherjee, Brijendu Kumar, Umesh Narayan Umesh, Ranjan Kumar Singh, Ranjan Kumar Singh, Ravikant Chaubey, Vikash Kumar, Mukesh Kumar, Vinod Kumar, Kumari Sharda, Susheel Singh, Rama Kant Singh, Rama Kant Singh, Seema Kumari, Kamleshwari Prasad Singh, Govind Kumar, Ravindra Kumar Tiwari, Vineeta Kashyap, Suneeta Kushwaha, Sripriya Das, Prem Prakash Gautam, Nurnabi Meherul Alam, Shailesh Kumar, Sanjay Kumar, Sanjay Kumar, Bharati Upadhaya, Sumit Kumar Singh, Sanchita Ghosh, Shubham Bhagat, Shubham Bhagat, Amit Kumar Lenka

“…Targeted efforts in these areas can significantly increase the adoption of the CRATs, leading to more resilient and sustainable farming systems. …”
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