LncRNA TUG1 mitigates chronic kidney disease through miR-542-3p/HIF-1α/VEGF axis by Luoxiang Qian, Wanru Hu, Yanping Wang, Yousuf Abdulkarim Waheed, Shuqun Hu, Dong Sun, Shulin Li

“…Renal interstitial fibrosis (RIF) is a common pathway in chronic kidney disease (CKD) that ultimately leads to end-stage renal failure, worsening both glomerulosclerosis and interstitial fibrosis. …”
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Comparison of Tick Control and Antibiotic Use Practices at Farm Level in Regions of High and Low Acaricide Resistance in Uganda by Joseph Byaruhanga, Fred Odua, Yvette Ssebunya, Olivia Aketch, Dickson Stuart Tayebwa, Innocent B. Rwego, Patrick Vudriko

“…Overall, the study provides vital information linking acaricide resistance to antibiotic use practices, consequently leading to antibiotic residues in milk.…”
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Outcomes of COVID-19 in the Omicron-predominant wave: large-scale real-world data analysis with a comparison to influenza by Koichi Miyashita, Hironao Hozumi, Kazuki Furuhashi, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Toshiyuki Ojima, Takafumi Suda

“…Conclusions In the Omicron-predominant wave, the mortality rate of COVID-19 decreased, but the number of patients increased, leading to a substantial increase in the number of deaths, especially among the elderly. …”
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Thermal performance enhancement in evacuated tube solar collector with working fluid MWCNT/Al2O3/MgO tri-hybrid nanofluid by Sathish Thanikodi, Jayant Giri, Rathinasamy Saravanan, Shafiq Ahmad, Ahmad O. Hourani

“…The result of tri-hybrid nanofluid leads to a higher thermal performance than others. …”
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The synchronous improvement of thermal stability, mechanical properties, thermal conductivity of oxide dispersion strengthened Cu–Cr alloy by microalloying Si by Yaju Zhou, Shengming Yin, Qian Lei, Jianglei Fan, Shizhong Wei, Youwei Yan

“…However, the addition of Al or Si leads to grain refinement and further refinement of the oxide nanoparticles. …”
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Conceptional design of photoneutralization test system for negative ion-based neutral beam injection by Hui-hui Hong, Li-zhen Liang, Yuan-lai Xie, Qian-xu Wang, Zhuo Pan, Yao Jiang

“…Additionally, the cost associated with laser target surpasses the benefit gained from increased neutralization efficiency, leading to its lack of practical application thus far. …”
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High levels of type II Fusarium head blight resistance conferred in wheat by combining wheat gene Fhb1 with Lophopyrum elongatum gene Fhb7The2 by Jan Dvorak, Karin R. Deal, Patrick E. McGuire, Emily J. Conley, James A. Anderson, George Fedak, Julia A. Malvick, Han Chen, Hans-Georg Müller

“…Wheat Fusarium head blight (FHB) leads to losses of grain yield and quality. Ingestion of diseased grain is detrimental to human health due to the mycotoxins present in the grain. …”
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Enhancing resilience: the impact of a near-peer mentoring program on medical students by Lea Pölczman, Lea Pölczman, Dorottya Árva, Dorottya Árva, Zsuzsa Győrffy, Márk Jámbor, András Végh, András Végh, Gergő Kristóf, György Purebl, Edmond Girasek

“…IntroductionEmerging adulthood is a vulnerable period and can be a crisis for many youth, leading to serious mental health problems. Medical students are especially vulnerable due to their high exposure to stressors, requiring enhanced resilience to cope with academic challenges. …”
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Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study by Simona Truglia, Simona Truglia, Francesco Ciccia, Silvia Mancuso, Antonella Capozzi, Aroldo Rizzo, Francesca Romana Spinelli, Fulvia Ceccarelli, Tania Colasanti, Cristina Garufi, Francesca Miranda, Maurizio Sorice, Cristiano Alessandri, Fabrizio Conti

“…IntroductionLupus nephritis (LN), caused by immune complexes produced in situ or deposited from the bloodstream, is one of the most severe features of Systemic Lupus Erythematosus (SLE) leading to an increased morbidity and mortality. Toll like receptors (TLRs), such as TLR3, TLR7 and TLR9, may play a key role in its pathogenesis. …”
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Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis by O.V. Shvaratska, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Y.V. Vilenskyi, T.M. Plekhanova, T.K. Mavropulo

“…Systemic autoinflammatory diseases (SAIDs) are a group of inherited monogenic diseases characterized by dysregulated innate immunity leading to excessive activation of inflammatory pathways. …”
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mHealth-based intervention by community workers to support family caregivers of persons with dementia living at home: study protocol for a cluster randomised controlled trial by Pankaj Bhardwaj, Hanne Konradsen, Manoj Kumar Gupta, Abhik Sinha, Nitin Kumar Joshi, Suresh K Sharma, Naresh Nebhinani, Marie Tyrrell, Åsa G Craftman, Zarina Nahar Kabir

“…Background India is undergoing a significant demographic shift with a growing older population, leading to an anticipated increase in people with dementia. …”
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. …”
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Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9 by Xuemei Zhang, Meiyu Qiu, Bing Han, Li Liao, Xinrong Peng, Jiapeng Lin, Ning Zhang, Lati Hai, Long Liang, Yila Ma, Wenrong Li, Mingjun Liu

“…The FecB allele in sheep is a mutation in the BMPRIB gene, recognized as the first major gene responsible for the high fecundity trait in sheep, leading to an increased ovulation rate in ewe. In this study, we employed CRISPR/Cas9-mediated homologous-directed repair (HDR) to introduce a defined point mutation (c.746 A > G) using single-stranded oligonucleotides (ssODN) and the ligase IV inhibitor (SCR7) into the BMPRIB gene of fine wool sheep. …”
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Prevalence of Diarrhea Disease and Associated Factors Among Children Under 5 Years in Geshiyaro Project Implementation Sites in Ethiopia: A Cross‐Sectional Study by Zinabu Assefa Alemu, Aderajew Mekonnen Girmay, Kirubel Tesfaye Teklu, Ermias Alemayehu Adugna, Melaku Gizaw Serte, Tsigereda Assefa Alemayehu, Badasa Wagari Likasa, Benjamin Collyer, Zelalem Mehari, Mihretab Salasibew, Getachew Tollera, Masresha Tessema

“…ABSTRACT Background Globally, infectious diseases such as pneumonia, diarrhea, and malaria are the leading causes of death for children under 5. Diarrheal disease is a significant public health concern and causes the death of approximately 525,000 children under the age of 5 every year. …”
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A new and automated risk prediction of coronary artery disease using clinical endpoints and medical imaging-derived patient-specific insights: protocol for the retrospective GeoCAD... by Louisa Jorm, Daniel Moses, Dona Adikari, Ramtin Gharleghi, Shisheng Zhang, Arcot Sowmya, Sze-Yuan Ooi, Susann Beier

“…Introduction Coronary artery disease (CAD) is the leading cause of death worldwide. More than a quarter of cardiovascular events are unexplained by current absolute cardiovascular disease risk calculators, and individuals without clinical risk factors have been shown to have worse outcomes. …”
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ZINQ-L: a zero-inflated quantile approach for differential abundance analysis of longitudinal microbiome data by Shuai Li, Runzhe Li, John R. Lee, John R. Lee, Ni Zhao, Wodan Ling

“…However, the complex microbiome data frequently violate these distributional assumptions, leading to inflated false discovery rates. In addition, the existing methods are mostly mean-based, unable to identify heterogeneous associations such as tail events or subgroup effects, which could be important biomedical signals.MethodsWe propose a zero-inflated quantile approach for longitudinal (ZINQ-L) microbiome differential abundance test. …”
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BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…The findings reveal that exposure to BPZ leads to a reduction in early embryo quality and hinders developmental progression. …”
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Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress by Aya Barzelay, Shira Weisthal Algor, Anat Niztan, Sebastian Katz, Moshe Benhamou, Itay Nakdimon, Noam Azmon, Sandy Gozlan, Daphna Mezad-Koursh, Meira Neudorfer, Michaella Goldstein, Benjamin Meilik, Anat Loewenstein, Adiel Barak

“…Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. …”
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Emergency Laparotomy in the Critically Ill: Futility at the Bedside by Niels D. Martin, Sagar P. Patel, Kristen Chreiman, Jose L. Pascual, Benjamin Braslow, Patrick M. Reilly, Lewis J. Kaplan

“…Emergency OR laparotomy leads to mortality in nearly half of such patients and is anticipatable based on concurrent abnormal physiology.…”
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Towards an ontology of mental health: Protocol for developing an ontology to structure and integrate evidence regarding anxiety, depression and psychosis [version 2; peer review: 1... by Jennifer Potts, Micaela Santilli, Claire Friedrich, Jaycee Kennett, Janna Hastings, Susan Michie, Paulina M. Schenk

“…Background Research about anxiety, depression and psychosis and their treatments is often reported using inconsistent language, and different aspects of the overall research may be conducted in separate silos. This leads to challenges in evidence synthesis and slows down the development of more effective interventions to prevent and treat these conditions. …”
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