Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…An appropriate dosage of GO-2-ME/rGO-2-ME, in which GO/rGO is a carrier of 2-methoxyestradiol (2-ME), can ensure effective penetration of the active substance through biological boundaries/membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of malignant cells.Keywords: new graphene-based anticancer drugs, graphene-based oncological therapy, new anticancer treatment, biomedical innovations, drugs delivery systems…”
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Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action by Lindsley AW, Lugogo N, Reeh KAG, Spahn J, Parnes JR

“…Approved biologics for severe asthma target several distinct mechanisms of action, leading to differential effects on the spectrum of T2 inflammation, inflammatory biomarkers, and treatment efficacy (reducing asthma exacerbations, improving lung function, and diminishing symptoms). …”
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Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2. by Bradly Burke, Savannah M Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A Charley, Juergen A Richt, Susan R Weiss, Ronald B Tjalkens, David Veesler, Tawfik Aboellail, Tony Schountz

“…Collectively, these data show that Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but that expression of human ACE2 in their lungs leads to robust infection and an adaptive immune response with low-titer antibodies and a regulatory T cell-like response that may explain the lack of prominent inflammation in the lungs. …”
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Epidemiological pattern of trauma among children 0-9 years in Cameroon. by Odette Dzemo Kibu, Sithombo Maqungo, Georges Nguefack-Tsague, Dickson Shey Nsagha, Nicholas Tendongfor, Fanny Nadia Dissak Delon, Darwin Touko, Elvis Asangbeng Tanue, Rasheedat Oke, Sandra Irene McCoy, Sabrinah Ariane Christie, Catherine Juillard, Alain Chichom-Mefire

“…<h4>Background</h4>In low- and middle-income countries, trauma is the leading cause of death among youth and it is also a major cause of disability. …”
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Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line by Ivan M. Petyaev, Naylia A. Zigangirova, Elena Y. Morgunova, Nigel H. Kyle, Elena D. Fedina, Yuriy K. Bashmakov

“…Furthermore, propagation of C. trachomatis in CWR-R1 cells leads to enhanced transcription of interleukin-6 and fibroblast growth factor-2, genes encoding two important proinflammatory cytokines implicated in the molecular mechanisms of chemoresistance of prostate cancer and its ability to metastasize. …”
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Disability of military personnel in Ukraine for 2014-2022 by I.Y. Khanyukova, N.O. Hondulenko, N.A. Sanina

“…Most identified as disabled (62.5%) received disabilities because of diseases, not traumas. The leading causes of non-traumatic disability among military personnel are cardiovascular diseases (32.4%), musculoskeletal diseases (8.7%), and mental and behavioral disorders (8.3%).…”
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Predicting rapid decline in kidney function among type 2 diabetes patients: A machine learning approach by Eri Nakahara, Kayo Waki, Hisashi Kurasawa, Imari Mimura, Tomohisa Seki, Akinori Fujino, Nagisa Shiomi, Masaomi Nangaku, Kazuhiko Ohe

“…Background: Diabetic kidney disease (DKD) is one of the typical complications of type 2 diabetes (T2D), with approximately 10 % of DKD patients experiencing a Rapid decline (RD) in kidney function. RD leads to an increased risk of poor outcomes such as the need for dialysis. …”
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PENGGUNAAN MEDIA SOSIAL SEBAGAI MEDIA KOMUNIKASI PEMERINTAH DAERAH ISTIMEWA YOGYAKARTA UNTUK PROMOSI WISATA by Akmalia Hermastuti, Dian Eka Rahmawati

“…The research aims to analyze the use of Instagram and Tiktok as communication media for the DIY Provincial government to promote tourism as one of the leading sectors of DIY Province to increase regional income. …”
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Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…However, a long-term exposure to hypertonic PD solutions leads to peritoneal membrane (PM) injury, resulting in ultrafiltration (UF) failure. …”
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Barriers and Facilitators to User Engagement and Moderation for Web-Based Peer Support Among Young People: Qualitative Study Using the Behavior Change Wheel Framework by Ananya Ananya, Janina Tuuli, Rachel Perowne, Leslie Morrison Gutman

“…MethodsDrawing upon the Theoretical Domains Framework (TDF) and the Behavior Change Wheel (BCW), this study conducted qualitative interviews and gathered open-ended questionnaires from service users and moderators of The Mix, the United Kingdom’s leading web-based mental health platform providing peer support groups for young people. …”
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Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…The 5-alpha-reductase type 2 deficiency (5ARD2) is an autosomal recessive condition associated with impairment in the conversion of testosterone to dihydrotestosterone. This condition leads to undervirilisation in 46,XY individuals. …”
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A systematic review and meta-analysis of exercise-based intervention to prevent gestational diabetes in women with overweight or obesity by Teresa E. Santa Cruz, Cristina Sarasqueta, Juan Carlos Muruzábal, Eukene Ansuategui, Olga Sanz

“…Conclusions The present study does not allow us to conclude that structured exercise programs for pregnant women with overweight or obesity leads to a reduction in the risk of gestational diabetes. …”
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The impact of the U.S federal minimum legal drinking age law on alcohol involved firearm suicide: a regression discontinuity approachResearch in context by Vageesh Jain, Matthew Miller, David Hemenway

“…Summary: Background: Suicide is a leading cause of death for young people. Half of young adult suicides are by firearm, and many involve alcohol consumption. …”
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Evidence Communication Rules for Policy (ECR-P) critical appraisal tool by Evangelos Danopoulos, John A. D. Aston, Aarushi Shah, Claudia R. Schneider

“…ECR-P comprises a set of preliminary considerations which capture key aspects for the assessment, leading on to the main tool whose structure is domain-based, each domain mapping to one of the five rules of evidence communication. …”
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Water quality assessment using IRWQIsc and NSFWQI water quality indicators; A case study: Talar River (Iran) by Mohammad Roshani-Sefidkouhi, Fatemeh Mortezazadeh, Masoumeh Eslamifar, Esmaeil Babanezhad, Masoomeh Sheikhi, Fathollah Gholami-Borujeni

“…One of the driest countries in the world, Iran has been facing several challenges related to water shortage, leading to serious social, economic, and environmental impacts. …”
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Barriers and enablers to young people accessing sexual and reproductive health services in Pacific Island Countries and Territories: A scoping review. by Maggie Ikinue Baigry, Robin Ray, Daniel Lindsay, Angela Kelly-Hanku, Michelle Redman-MacLaren

“…Factors such as lack of accurate sexual and reproductive health knowledge and social stigma were the leading causes of young people's limited access to sexual and reproductive health services. …”
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Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

“…Our data indicate that KLF4 up-regulates miR-101 expression, leading to the downregulation of COL10A1 expression, inhibition of EMT and renal fibrosis during the pathogenic process of I/R-related renal fibrosis.…”
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The Study’s Chemical Interaction of the Sodium Silicate Solution with Extender Pigments to Investigate High Heat Resistance Silicate Coating by Cuong Manh Le, Thu-Huong Le

“…Thus, we proposed that the geopolymerization process between sodium silicate solution and extender pigments (ZnO, TiO2, Fe2O3, CaCO3, and Na2SiF6) increases when the curing time from 1 to 20 days leads to forming geopolymer silicate with high thermal stability. …”
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Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt by Asmaa A. El Leithy, Amira Salah El-Din Youssef, Auhood Nassar, Ramy K. Aziz, Nadin M. Khaled, Mina T. Mahrous, Ghobrial N. Farahat, Aya H. Mohamed, Yasser Mabrouk Bakr

“…Abstract Background Colorectal cancer (CRC) is among the five leading causes of cancer incidence and mortality. …”
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Accelerating phase field simulations through a hybrid adaptive Fourier neural operator with U-net backbone by Christophe Bonneville, Nathan Bieberdorf, Arun Hegde, Mark Asta, Habib N. Najm, Laurent Capolungo, Cosmin Safta

“…For one such process as liquid-metal dealloying (LMD), phase field models have been developed to understand the mechanisms leading to complex morphologies. However, the LMD governing equations in these models often involve coupled non-linear partial differential equations (PDE), which are challenging to solve numerically. …”
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