Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population by Nuwayyir Abdullah Alqasimi, Lujain Hatim Aljohani, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Bader Saad AlQahtani, Bader Saad AlQahtani, Nasser Saleh Al Haydar, Bdour Raja Alanazi, Danah Tariq Alfurayhan, Lina Sami Hussain Saber, Fatemah Saleh Alsalem, Nawaf Abdullah Alqahtani, Jose Manuel Vargas

“…Eye rubbing has been recognized as one of the leading risk factors for KC.ObjectivesThis study aimed to assess the knowledge and awareness about KC and its relation to eye rubbing among the population of the Kingdom of Saudi Arabia.MethodsA cross-sectional study was conducted in 2024 among people residing in different regions of Saudi Arabia. …”
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A Multi-Target Threat Assessment Method Based on Objective Three-Way Decision by Humberto Baldessarini Pires, Lamartine Nogueira Frutuoso Guimaraes, Sergio Reboucas

“…An objective analysis of attribute uncertainties revealed that the compared methods applied overly high-risk avoidance coefficients, leading to inaccurate decisions, a finding also supported by the second case. …”
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Collaborative arts therapies as a supportive intervention for autism spectrum disorders: Bibliometric analysis, insights, and directions by Aijia Zhang, Xuexing Luo, Fangtian Ying, Jue Wang, Guanghui Huang

“…In terms of quantity, the USA is the leading country which has the greatest influence in advancing the field. …”
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Evaluation of Medical School Students in Terms of Attention Deficit Hyperactivity Disorder and Emotional Regulation Difficulties by Ayşe Akan, Engin Burak Selçuk, Burcu Kayhan Tetik, Mustafa Akan, Ahmet Kadir Arslan

“…Studies have indicated that adults with ADHD often experience emotion dysregulation as much as they exhibit the core symptoms of the disorder, leading to significant problems in social life. This study aimed to evaluate ADHD symptoms and emotional regulation difficulties in medical students studying at a university hospital. …”
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Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050 by Mengxia Fu, Zhiming Peng, Min Wu, Dapeng Lv, Yanping Li, Shuzhen Lyu

“…China and India are the leading contributors to both new cases and deaths, with projections indicating that by 2050, around 1.4 million new breast cancer cases and 0.5 million deaths are expected to occur in Asia. …”
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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

“…Downregulation of SQSTM1 in diabetic keratinocytes leads to autophagy inhibition and modulates the protein level of ACSL4. …”
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ZEB1 as a marker of metastasis in thyroid carcinomas: review of literature and own data by P.P. Zinych, V.M. Pushkarev, N.I. Levchuk, M. Tronko

“…Metastases are the leading cause of death from malignant tumors. The metastatic process involves the exit of cancer cells from the primary tumor into the blood or other transport system, colonization and proliferation in a distant organ. …”
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Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing by Qianwen Ge, Qianwen Ge, Liangxing Fang, Liangxing Fang, Liangxing Fang, Yang Yu, Yang Yu, Yang Yu, Ruanyang Sun, Ruanyang Sun, Xiaoping Liao, Xiaoping Liao, Xiaoping Liao, Peng Zhang, Peng Zhang, Peng Zhang

“…IntroductionGlaesserella parasuis causes Glässer’s disease in pigs, a leading cause of death in swine herds and a major contributor to economic losses in the global swine industry. …”
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The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications by Monika Kamińska, Maria Jasiewicz, Magdalena Miernik-Skrzypczak, Aleksandra Spyra, Marta Malicka, Natalia Dąbrowska, Aleksandra Kozioł, Katarzyna Moczyróg

“…Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). …”
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Morphological, Physiological, and Molecular Responses to Heat Stress in Brassicaceae by Iram Batool, Ahsan Ayyaz, Tongjun Qin, Xiaofen Wu, Weiqi Chen, Fakhir Hannan, Zafar Ullah Zafar, Muhammad Shahbaz Naeem, Muhammad Ahsan Farooq, Weijun Zhou

“…Several studies show that extreme temperature fluctuations during crucial growth stages negatively affect plants, leading to impaired growth and reduced seed production. …”
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Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product by Michael Pino, Karen Mujica, Paola Mora-Uribe, Héctor Garcias-Papayani, Braulio Paillavil, Camilo Avendaño, Diego Flores-Crisosto, Rodrigo Norambuena, Victoria Rojas-Martínez, Matías Aguilera, Nicolás Cifuentes Muñoz, Pablo Cifuentes, Hans Pieringer, Soledad Ulloa

“…Salmonella is a zoonotic pathogen transmitted through food and one of the four leading global causes of diarrheal disease in humans. …”
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Influence of tension cracks on moisture infiltration in loess slopes under high-intensity rainfall conditions by Xuancheng Ren, Weifeng Sun, Hengxing Lan, Han Bao, Langping Li, Shijie Liu, Changgen Yan, Xiaochan Wang, Zhouchen Li, Chaoyang Tian

“…These cracks significantly affect the spatiotemporal distribution of moisture infiltration during rainfall, potentially leading to slope instability. This study investigates the impact of crest-tension cracks on moisture infiltration in loess slopes under extreme rainfall conditions, focusing on crack position, depth, and width. …”
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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…Utilizing the mouse model of RIBI and irradiated BV2 cells, we further demonstrated that irradiation caused mitochondrial damage to microglia, leading to violent release of reactive oxygen species (ROS), which enhanced the transcription of SUR1, TRPM4, and NLRP3 inflammasome-related molecules. …”
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Understanding the dynamics driving obesity in socioeconomically deprived urban neighbourhoods: an expert-based systems map by Fleur ter Ellen, Joost Oude Groeniger, Karien Stronks, Luc L. Hagenaars, Carlijn B.M. Kamphuis, Joreintje D. Mackenbach, Mariëlle A. Beenackers, Karen Freijer, Pieter Coenen, Maartje Poelman, Karen M. Oude Hengel, Frank J. van Lenthe

“…Conclusions Our study sheds light on the system dynamics leading to neighbourhoods with an unhealthy food environment, challenging socioeconomic conditions, a widening distance between social groups and an infrastructure that discouraged physical activity while promoting sedentary behaviour. …”
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Functional Tests and Surveys Used to Assess Nervous System Dysfunction in Patients with Fabry Disease – A Review by Stanislaw Jesionek, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Partycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Justyna Jankowska

“… Introduction and Purpose: Fabry disease (FD) is a rare, X-linked lysosomal storage disorder caused by a deficiency of the enzyme alpha-galactosidase A, leading to progressive multi-organ damage. Among the various complications, autonomic nervous system dysfunction has been suggested as a significant aspect of the disease’s pathophysiology. …”
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Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…Our findings revealed that VAGINNE^® treatment enhanced the growth of beneficial <i>Lactobacillus</i> species while suppressing <i>C. albicans</i> proliferation, leading to a more balanced vaginal microbiome. Additionally, VAGINNE^® significantly reduced pro-inflammatory cytokines (IL-17A, IL-22, IL-23) in vaginal tissues and systemic inflammatory markers (IL-6, IL-1β) in plasma. …”
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Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives by Won-Sik Choi, Seok-Woo Nam, Il-Doo Kim, Seung-Han Kim, Kun-Ho Park, In-Kyung Bae, Eun-Sil Park, Hwang-Ju Jeon, Sung-Eun Lee

“…Comp I was used as the leading compound in this study. The compounds were synthesized by reacting them with two functional groups, 3-thiophenyl and 2-thiophenyl groups, instead of 4-chloro-2-fluorophenyl group in Comp I. …”
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Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors by Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone

“…The ASGPR recognizes and binds to glycoproteins exposed to terminal galactose or N‐acetylgalactosamine residues, leading to receptor‐mediated endocytosis. Recent studies have demonstrated that sialylation of O‐linked glycan plays a role in protecting against macrophage galactose lectin (MGL)‐mediated clearance. …”
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Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats by Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng

“…Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves. Recently, endothelial‒mesenchymal transition (EndMT), in which activin plays an important role, has been shown to be an important factor in RHD valvular injury. …”
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Increasing exposure of cotton growing areas to compound drought and heat events in a warming climate by Shengli Liu, Wei Zhang, Tongtong Shi, Tong Li, Hui Li, Guanyin Zhou, Zhanbiao Wang, Xiongfeng Ma

“…Furthermore, major cotton-producing countries exhibited similar CDHE trends, leading to a heightened probability of synchronous CDHE occurrences, except in countries connected to India and Pakistan. …”
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