Physico-chemical characterization of natural nano calcium extracted from different fish bones in catfish (Clarias gariepinus) and snakehead fish (Channa striata) by Sri Fatmawati, Siti Mualimatul Istiqomah, Nur Hasanah, Maria Elfiana Ina Kewa Helan, Mardi Santoso, Zjahra Vianita Nugraheni, Nurul Jadid, Annis Catur Adi, Heni Rachmawati

“…However, calcium absorption from fish bone flour is limited, leading to potential deficiencies. Nanotechnology addresses this by reducing calcium particles to nanoscale, significantly improving bioavailability. …”
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From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair by Rajiv Borah, Daniel Diez Clarke, Jnanendra Upadhyay, Michael G. Monaghan

“…Peripheral nerve repair (PNR) is a major healthcare challenge due to the limited regenerative capacity of the nervous system, often leading to severe functional impairments. While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). …”
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Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing by Weilin Ye, Linfeng He, Weihao Liu, Zhile Yuan, Kaiyuan Zheng, Guolin Li

“…Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. …”
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Characterization of a chemically induced osteoarthritis model in zebrafish by Gongyi Xiao, Jin Qin, Huiping Yang, Qizhi Song, Ruobin Zhang, Junlan Huang, Yuexi Mou, Wen Liu, Xianding Sun, Mao Nie

“…Abstract Osteoarthritis (OA) is characterized by the progressive degeneration of the synovial joint, leading to irreversible damage to articular cartilage and subchondral bone. …”
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Involvement of the posterior limb of the internal capsule independently predicts the prognosis of patients with basal ganglia and thalamic hemorrhage by Sohan Gupta, Mengxuan Xiao, Na Liu, Na Liu, Yunxiao Zhao, Xiaolin Zhao, Yunqiang Huang, Yongming Wu, Zhenzhou Lin, Zhong Ji, Haihao Xu, Minzhen Zhu, Suyue Pan, Kaibin Huang

“…Basal ganglia hemorrhage and thalamic hemorrhage are the most common types of ICH, accounting for 50–70% of all ICH cases, leading to disability and death, and it involves the posterior limb of the internal capsule to varying degrees. …”
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UTE MRI technical developments and applications in osteoporosis: a review by Soo Hyun Shin, Hee Dong Chae, Hee Dong Chae, Arya Suprana, Arya Suprana, Saeed Jerban, Eric Y. Chang, Eric Y. Chang, Lingyan Shi, Robert L. Sah, Jeremy H. Pettus, Gina N. Woods, Jiang Du, Jiang Du, Jiang Du

“…Osteoporosis (OP) is a metabolic bone disease that affects more than 10 million people in the USA and leads to over two million fractures every year. The disease results in serious long-term disability and death in a large number of patients. …”
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Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness by Stepanka Pruhova, Petra Dusatkova, Pavel J. Kraml, Michal Kulich, Zdena Prochazkova, Jan Broz, Jaroslav Zikmund, Ondrej Cinek, Michal Andel, Oluf Pedersen, Torben Hansen, Jan Lebl

“…GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. …”
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Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) trial: study protocol for a multicentre, double-blinded, placebo-controlled, phase IIa trial by Julian R Marchesi, Emma Nicholson, Benjamin H Mullish, Renuka Palanicawandar, Graham Wheeler, Francesca Kinsella, Andrew J Innes, Lauren A Roberts, Shian Anim-Burton, Lee Webber, Nicholas A Johnson, Rohma Ghani, Pakhshan Farshi, Anjum B Khan, Panagiotis Kottaridis, Pramila Krishnamurthy, Frances Davies, Jiří Pavlů

“…We hypothesised that IMT performed prior to initiation of HCT conditioning restores microbiome diversity during the early stages of HCT, leading to decreased frequency of complications and improved outcomes of HCT.Methods and analysis 50 adult patients receiving allogeneic HCT will be recruited into this phase IIa trial and randomised 1:1 to receive capsulised IMT or matched placebo shortly prior to initiation of HCT conditioning and followed for up to 12 months. …”
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Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs by Elizabeth Manson, Jessica L. Ward, Maria Merodio, Emilie Guillot, Thomas Blondel, Karin Allenspach, Oliver Domenig, Jonathan P. Mochel

“…Conclusions and Clinical Importance The combined CARDALIS® product leads to dose‐dependent alterations of RAAS metabolites. …”
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High-resolution Observations of an X-1.0 White-light Flare with Moving Flare Ribbons by Xu Yang, Meiqi Wang, Andrew Cao, Kaifan Ji, Vasyl Yurchyshyn, Jiong Qiu, Sijie Yu, Jinhua Shen, Wenda Cao

“…The separation motion of two white-light kernels is recorded by the high-cadence GST/TiO images and is well accompanied by the motion of the VIS H α flare ribbon leading edge. One kernel, located in a 150 Gauss field within a granulation area, exhibited an average apparent motion speed of 55 km s ^−1 , which is the highest average speed ever reported. …”
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Identification of new candidate genes for the hereditary predisposition to uveal melanoma: IGCMU trial by Mélanie Godiveau, Mélanie Godiveau, Mélanie Godiveau, Angeline Ginzac, Angeline Ginzac, Angeline Ginzac, Yannick Bidet, Yannick Bidet, Flora Ponelle-Chachuat, Flora Ponelle-Chachuat, Maud Privat, Maud Privat, Xavier Durando, Xavier Durando, Xavier Durando, Xavier Durando, Mathias Cavaillé, Mathias Cavaillé, Mathis Lepage, Mathis Lepage

“…This study could also contribute to a better understanding of the genetic landscape of UM, potentially leading to more personalized and effective options for its detection.Trial registrationClinicalTrials.gov, identifier NCT06550674, registered in August 2024. …”
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Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling by Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Rui Manuel Reis, Renato Jose da Silva-Oliveira, Renato Jose da Silva-Oliveira

“…Were identified 30 overexpressed genes in the resistance model, implicating in signaling pathways that leads to AKT activation and heightened protein expression levels of phosphorylated AKT and p38. …”
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Five-year carry-over effects in dune slack vegetation response to hydrology by Lisanne van Willegen, Hilary Wallace, Angela Curreli, Ciara Dwyer, John Ratcliffe, Davey L. Jones, Graham Williams, Martin Hollingham, Laurence Jones

“…Maximum water level (MAX) also performed well, but MSL was preferred as MAX can be enhanced or truncated by topography leading to anomalies for individual slacks. MSL is also flexible to implement within manual monitoring programmes, which could be targeted to 3-months per year over the spring as a minimum requirement. …”
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Groundwater vulnerability and, risk assessment of seawater intrusion for the development of a strategy plan towards sustainability: Case of the Souss-Massa coastal area, Morocco by Yassine Ez-zaouy, Lhoussaine Bouchaou, Mohammed Hssaisoune, Abdelhaq Aangri, Gianluigi Busico, Saadou Oumarou Danni, Oumaima Attar, Mohamed Nehmadou, Aicha Saad, Yassine Ait Brahim

“…This situation exacerbates aquifer depletion, reduce groundwater quality, and leads to seawater intrusion. Hence, the investigation of vulnerability and risk of seawater intrusion became a priority in the SMCA. …”
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Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…TXNIP inhibits the disulfide reductase enzymatic activity of thioredoxin (Trx), impairing its antioxidant function and, ultimately, leading to the disruption of cellular redox homeostasis. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. …”
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Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study by Danial Fotros, Azita Hekmatdoost, Fereshteh Pashayee-khamene, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…Abstract Background Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. …”
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SMARCA4 deficiency in small cell lung cancer: A case report and narrative review of the literature by Andreas M. Matthaiou, Ioannis Tomos, Nikoleta Bizymi, Ioannis Vamvakaris, Nektarios Anagnostopoulos, Aikaterini Papadopoulou, Kalliopi Angelou, Grigoris Stratakos, Adamantia Liapikou

“…So far, their absence in non-small cell lung cancer has been observed in a series of studies involving primary tumors and cell lines, where it is associated with loss of differentiation and heightened tumorigenic potential leading to an unfavorable prognosis. SMARCA2 and SMARCA4 deficiency is frequent in solid predominant adenocarcinomas and tumors with low levels of bronchial epithelial markers, including thyroid transcription factor 1. …”
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Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury by Xiaozhen Chen, Yinglin Wang, Xiang Xie, Hongfei Chen, Qiqi Zhu, Zhidong Ge, Hua Wei, Jingshong Deng, Zhengyuan Xia, Qingquan Lian

“…Background. Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress. …”
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The Impact of Amniotic Fluid Interleukin-6, Interleukin-8, and Metalloproteinase-9 on Preterm Labor: A Narrative Review by Theodoros Karampitsakos, Despoina Mavrogianni, Nikolaos Machairiotis, Anastasios Potiris, Periklis Panagopoulos, Sofoklis Stavros, Panos Antsaklis, Peter Drakakis

“…Background/objectives: Preterm labor is a leading cause of neonatal morbidity and mortality worldwide. …”
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