A novel technique of cryodenervation for murine vagus nerve: implications for acute lung inflammation by Di Wu, Ximing Liao, Jing Gao, Kun Wang, Wujian Xu, Feilong Wang, Zhixian Jin, Dandan Wu, Qiang Li, Wei Gao

“…However, a lack of cryodenervation model in laboratory rodents leads to the obscure mechanisms for techniques used in clinic. …”
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High-time-cadence Spectroscopy and Photometry of Stellar Flares on M dwarf YZ Canis Minoris with the Seimei Telescope and TESS. I. Discovery of Rapid and Short-duration Prominence... by Yuto Kajikiya, Kosuke Namekata, Yuta Notsu, Hiroyuki Maehara, Bunei Sato, Daisaku Nogami

“…Our discovery of short-duration events suggests that previous studies with low time cadence may have missed these events, potentially leading to an underestimation of the occurrence frequency of prominence eruptions/CMEs.…”
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Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract by Eli Compaoré, Moussa Compaoré, Vincent Ouédraogo, Ablassé Rouamba, Alimata Bancé, Mignini R. Dofini, Martin Kiendrebeogo

“…Background: Infectious diseases are one of the leading causes of death worldwide because of antibiotic resistance. …”
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Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

“…Put together, our findings show that dampening Blimp-1 expression altered the phenotype and function of anti-BCMA CAR T cells, leading to augmented therapeutic efficacy in MM.…”
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Dufulin Impacts Plant Defense Against Tomato Yellow Leaf Curl Virus Infecting Tomato by Liping Huang, Yingying Tang, Shuaixin Wang, Jianbin Chen, Jiao Du, Shuo Yan, Deyong Zhang, Xiaobin Shi, Yong Liu, Fan Li

“…<i>Tomato yellow leaf curl virus</i> (TYLCV) poses a significant threat to tomato production, leading to severe yield losses. The current control strategies primarily rely on the use of pesticides, which are often nonselective and costly. …”
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SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden by Bethany K. Hughes, Andrew Davis, Deborah Milligan, Ryan Wallis, Federica Mossa, Michael P. Philpott, Linda J. Wainwright, David A. Gunn, Cleo L. Bishop

“…Importantly, utilising scRNA-seq from 3D deeply senescent fibroblasts refines our ML model leading to improved detection of senescent cells in vivo. …”
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Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“… Objective: The third gender community, commonly referred to as the ‘hijra’ community and including transgender, intersex, and eunuch individuals, faces widespread societal discrimination, leading to marginalization and reduced opportunities for social and economic participation. …”
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Case report: Deciphering the clinical significance of a novel partial BRCA1 exon 10 duplication in a patient with triple-negative breast cancer by Alice Faversani, Debora Manuelli, Davide Barteselli, Giulia Melloni, Carlo Santaniello, Luigi Corsaro, Luigi Corsaro, Davide Sacco, Davide Sacco, Davide Clerici, Laura Gargiulo, Fulvio Ferrara, Lucy Costantino

“…Using specific primers, we were able to identify the breakpoint at the DNA level and characterize the alteration as a tandem duplication leading to the formation of a premature stop codon after 10 residues. …”
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Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells by Tianhua Ren, Yumei Qiu, Weiyun Wu, Xiao Feng, Shicai Ye, Zhuang Wang, Ting Tian, Yanting He, Caiyuan Yu, Yu Zhou

“…These results confirm that A3AR is expressed in human colonic epithelial cells and demonstrate that its activation has an anti-inflammatory effect, through the inhibition of NF-κB signaling pathway, which leads to inhibition of downstream IL-8 and IL-1β expression. …”
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A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…BackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. …”
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An Arctic Marine Source of Fluorescent Primary Biological Aerosol Particles During the Transition from Summer to Autumn at the North Pole by Julia Kojoj, Gabriel Pereira Freitas, Morven Muilwijk, Mats A. Granskog, Tuomas Naakka, Annica M. L. Ekman, Benjamin Heutte, Julia Schmale, Anderson Da Silva, Rémy Lapere, Louis Marelle, Jennie L. Thomas, Christian Melsheimer, Benjamin J. Murray, Paul Zieger

“…Our analysis shows that the observed fPBAPs were independent of local wind speed and the co-occurrence of other coarse mode particles, suggesting sources other than local sea spray from leads, melt ponds, re-suspension of particles from the surface, or other wind-driven processes within the pack ice. …”
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How to enhance company engagement in public-private emergency collaborations in the supply of essential goods by Markus Lüttenberg, Alexander Zienau, Marcus Wiens, Ole Hansen, Florian Diehlmann, Frank Schultmann

“…This paper aims to empirically investigate expectations and motivation to better understand the motives leading companies to participate in public–private emergency collaborations. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…The DNA damage response (DDR) pathway is frequently altered during PDAC development, leading to an increased occurrence of DNA damage. …”
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Biocontrol yeast Kurtzmaniella quercitrusa BS-AY-S1 controls postharvest green mold of citrus fruit by producing metabolites with antifungal activity by Bi Liao, Ou Chen, Hongyan Zhang, Wenjun Wang, Lanhua Yi, Honghai Li, Kaifang Zeng

“…Green mold caused by Penicillium digitatum is the leading postharvest disease in citrus fruit. While chemical fungicides are commonly used for management, yeast-based biological control strategy offers a promising and eco-friendly alternative. …”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. …”
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A physically-based formulation for texture evolution during dynamic recrystallization. A case study of ice by Chauve, Thomas, Montagnat, Maurine, Dansereau, Véronique, Saramito, Pierre, Fourteau, Kévin, Tommasi, Andréa

“…Owing to this anisotropy, recrystallization is essential for ensuring strain compatibility, and the development of textures leads to anisotropic softening. Accurate prediction of the effect of recrystallization on the texture evolution of ice is therefore crucial to adequately account for texture-induced mechanical anisotropy in large-scale models of glacial ice flow. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…We found that mechanosensitive (MS) channels are activated, leading to ROS accumulation, Src protein modulation, and histone H3 acetylation. …”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
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Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations by Jian Yuan, Ruowen Qiu, Yuhan Wang, Zhen Ji Chen, Haojun Sun, Wei Dai, Yinghao Yao, Ran Zhuo, Kai Li, Shilai Xing, Myopia Associated Genetics and Intervention Consortium, Xiaoguang Yu, Liya Qiao, Jia Qu, Jianzhong Su

“…Abstract Background High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. …”
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The scoping, design, and plasma physics optimization of the Eos neutron source stellarator by C.P.S. Swanson, D.A. Gates, S.T.A. Kumar, M.F. Martin, T.G. Kruger, D.W. Dudt, P.J. Bonofiglo, the Thea Energy team

“…At this foundational stage of the design, analytic and approximate models are sufficient to capture the leading-order effects, and fast enough to run in the inner loop of an optimizer. …”
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