Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models by Jichao Wu, Die Huang, Jiefang Li, Jingxing Yi, Yu Lei, Jun Yin

“…Background: Cardiovascular disease (CVD) is a leading cause of death globally, with its incidence and mortality rates continuing to rise. …”
Get full text

An MPPT method using phasor particle swarm optimization for PV‐based generation system under varying irradiance conditions by Injila Sajid, Adil Sarwar, Mohd Tariq, Shafiq Ahmad, Farhad Ilahi Bakhsh, Adamali Shah Noor Mohamed, Md. Rasidul Islam

“…The inclusion of bypass diodes in parallel to each PV module mitigates this problem to an extent but leads to the formation of several peaks in the P‐V characteristics. …”
Get full text

Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care... by Richard D Neal, Kevin Franks, David Torgerson, Rachael L Murray, David R Baldwin, Michael Darby, Henrik Moller, Richard Booton, Una MacLeod, Sam M Janes, Samantha L Quaife, Sebastian Hinde, Matthew EJ Callister, Suzanne Rogerson, Rhian Gabe, Mark Sculpher, Philip AJ Crosbie, Irene Simmonds, Martyn Kennedy, Nazia Ahmed, Ann Cochrane, Mike Messenger, Puvanendran Tharmanathan

“…Introduction Lung cancer is the world’s leading cause of cancer death. Low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% in the US National Lung Screening Trial. …”
Get full text

Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial by Mark Conaway, David R Boulware, Scott K Heysell, Stellah G Mpagama, Christopher C Moore, Alphonce Liyoyo, Conrad Muzoora, Catherine Gitige, Bibie Said, Edwin Nuwagira, Rinah Arinaitwe, Rhina Mushagara, Peter Buzaare, Anna Chongolo, Samuel Jjunju, Precious Twesigye, Megan Null, Tania A Thomas

“…In high HIV and tuberculosis (TB) prevalent settings such as sub-Saharan Africa, TB is the leading cause of sepsis. However, anti-TB therapy is often delayed and may not achieve adequate blood concentrations in patients with sepsis. …”
Get full text

Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…Aging significantly affects intercellular communication between vascular endothelial cells (ECs) and hematopoietic cells, leading to vascular inflammation and age-associated diseases. …”
Get full text

Can Electric Vehicle Charging Stations Be Carbon Neutral With Solar Renewables? by Alpaslan Demirci, Zafer Ozturk, Musa Terkes, Said Mirza Tercan, Recep Yumurtaci, Umit Cali

“…Self-consumption decreases by 30% during high charging demand in the morning and evening hours, leading to increased dependency on the grid and emphasizing the critical requirement for improved strategies to reduce carbon emissions. …”
Get full text

Cost-Effectiveness of Bariatric Surgery versus Medication Therapy for Obese Patients with Type 2 Diabetes in China: A Markov Analysis by Bin Wan, Nan Fang, Wei Guan, Haixia Ding, Ying Wang, Xin Ge, Hui Liang, Xin Li, Yiyang Zhan

“…Bariatric surgery is a dominant intervention over a 40-year time horizon, which leads to significant cost savings to the health insurance payer and increases in health benefits for the management of recently diagnosed T2DM in obese patients in China.…”
Get full text

Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS by Bradford C. Berk, Bradford C. Berk, Amanda Pereira, Velia Sofia Vizcarra, Christoph Pröschel, Chia George Hsu, Chia George Hsu, Chia George Hsu

“…Previous research has established a connection between disrupted sympathetic regulation and splenocyte apoptosis in high thoracic SCI, leading to pulmonary dysfunction. The aim of this study was to investigate whether mice with low-level SCI exhibit increased susceptibility to acute lung injury by eliciting systemic inflammatory responses that operate independently of the sympathetic nervous system. …”
Get full text

Screening for diabetic retinopathy at a health centre in South Africa: A cross-sectional study by Ntokozo Zulu, Patrick Ngassa Piotie, Elizabeth M. Webb, Wezi G. Maphenduka, Steve Cook, Paul Rheeder

“…Background: In South Africa, screening for diabetic retinopathy (DR) is non-existent at the primary healthcare (PHC) level because of the absence of a screening programme. This leads to preventable vision loss. Aim: To describe the clinical characteristics and outcomes of eye screenings and subsequent referrals. …”
Get full text

Influential Mechanisms of Roughness on the Cyclic Shearing Behavior of the Interfaces Between Crushed Mudstone and Steel-Cased Rock-Socketed Piles by Yue Liang, Jianlu Zhang, Bin Xu, Zeyu Liu, Lei Dai, Kui Wang

“…Consequently, the sample undergoes more significant shear contraction, leading to reduced interfacial shear strength and anisotropy in the later stages. (2) The damping ratio of the rough interface exhibits an initial increase followed by a decrease, while the smooth interface demonstrates the exact opposite trend. …”
Get full text

Fracture behavior of a thermoplastic polyolefin (TPO) under airbag deployment conditions evaluated through Reversed Charpy tests by E.A. Paredes-Mogica, U. Figueroa-López, S.B. Mohd Yasin, A.C. Taylor, A. Guevara-Morales

“…This works shows how the Reversed Charpy test can characterize the fracture of instrument panel materials, leading to cheaper evaluation of new materials and safer airbag deployment in an accident.…”
Get full text

Ultrasonic-assisted MoS2/GO/TiO2 ceramic coatings: Enhancing anti-friction performance through dual-interface optimization by Ziwei Guo, Yongnan Chen, Nan Wang, Yiku Xu, Qinyang Zhao, Zhimin Hou, Guangrui Gao, Yan Kang, Haifei Zhan

“…The change in interlayer spacing induced dislocation evolution at incoherent interface, leading to dual interface formation. At MoS2 (0.534 nm)/TiO2 interface: dislocation dipoles evolve to create considerable distortion, facilitating releasing shear stresses and inhibiting crack propagations. …”
Get full text

Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope <i>Helicobacter pylori</i> Vaccines in a BALB/c Mouse Model by Rita Amaral, Tomás Concha, Jorge Vítor, António J. Almeida, Cecília Calado, Lídia M. Gonçalves

“…<b>Background/Objectives</b>: <i>Helicobacter pylori</i> is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. …”
Get full text

Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…The loss of MAF1 protein levels and the molecular mechanisms leading to cell damage were investigated. Results It was shown in the SAE models that MAF1 was expressed at low levels. …”
Get full text

A self-configuration framework for balancing services in the fog of things by Edson Mota, Jurandir Barbosa, Gustavo B. Figueiredo, Maycon Peixoto, Cássio Prazeres

“…However, managing numerous gateways in an IoT network poses service distribution and network management challenges, leading to imbalances and inefficiencies. Within this context, this paper presents a novel self-organizing environment based on the Fog of Things approach, designed to address these challenges. …”
Get full text

The Association Between Periodontitis, Gingivitis, Tooth Loss and Stroke: An Umbrella Study with Meta-Analysis by Jad El Masri, Ahmad Al Malak, Diala El Masri, Maya Ghazi, Silva Al Boussi, Yasmina El Masri, Mohammad Hassoun, Maryam Tlayss, Pascale Salameh, Hassan Hosseini

“…The relation reached favors the suggested role of some inflammatory changes in the pathogenic pathway leading to atherosclerotic changes.…”
Get full text

Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages by Yuan Li, Yanping Chen, Yuan Meng, Meng Shen, Fan Yang, Xiubao Ren

“…Objective: The combination of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) leads to an increased incidence of severe immune-related adverse events (irAEs). …”
Get full text

Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico by Victor Gonzalez-Uribe, MD, MSc, Luis A. Hernandez-Zarate, MD, Cesar F. Pozo Beltran, MD, Christian R. Alcocer-Arreguin, MD, Paola de Baro Alvarez, MD, MEd, Natalia Coello-Niembro, MD, Pablo Jimenez-Feria, MD, Zaira S. Mojica Gonzalez, MD, Carlos Andres Gomez-Nuñez, MD, Ricardo Martinez-Tenopala, MD, Martín R. Basile-Alvarez, MD, Berenice Velasco-Benhumea, MD, Roberto Fernandez-Soto, MD, Daniela E. García-Fajardo, MD, Herberth Perez-Avilés, MD, Cesar Pinto-Solis, MD, Luis A. Rios-Villalobos, MD, Roberto Ureña-Ortiz, MD, Leticia Lezama-Vazquez, MD, Patricio Acosta-Rodriguez-Bueno, MD, MSc, Blanca Estela Del Rio-Navarro, MD

“…Background: Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition characterized by eosinophil infiltration in the esophagus, leading to symptoms such as food impaction and growth delays. …”
Get full text

Effect of molybdenum supply on crop performance through rhizosphere soil microbial diversity and metabolite variation by Muhammad Shoaib Rana, Muhammad Shoaib Rana, Dikhnah Alshehri, Dikhnah Alshehri, Rui-Long Wang, Muhammad Imran, Yousif Abdelrahman Yousif Abdellah, Faiz Ur Rahman, Marfat Alatawy, Hanaa Ghabban, Hanaa Ghabban, Amany H. A. Abeed, Cheng-xiao Hu

“…Our results indicated that the nutrient availability (N, P, K) was higher under Mo supply leading to improved biological yield and nutrient uptake efficiency in both crops. …”
Get full text

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…These abnormalities, which resemble phenotypes associated with Wnt signalling pathways, result in severe and persistent skeletal defects including a severe deficit in hip joint and patella, and markedly deformed and low-density long bones leading to dwarfism and impaired mobility. Mechanistically, we show that LRP1 regulates core non-canonical Wnt/planar cell polarity (PCP) components that may explain the malformation of long bones. …”
Get full text