An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…In this system, the CRISPR/Cas13a complex acts as a catalyst: in the presence of a specific RNA target sequence, the enzymatic function is activated and the polyU RNA reporter strands are cleaved from the Au nanoparticles, inducing a loss of negative charges on the rGO layer. This phenomenon leads to measurable changes in the transfer curve of the transistors. …”
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A 10-Year Risk Assessment and Primary Prevention Study of Atherosclerotic Cardiovascular Disease Among Adult Patients in Saudi Arabia: A Cross-Sectional Study by Abdulhameed Alkhalaf, Qasem Aljabr, Khalid Al Mulla, Duaa Almubarak, Abdul Sattar Khan, Zainab Y. Al Jaziri, Ibrahim Albahrani

“…<i>Background and Objectives</i>: Cardiovascular diseases (CVDs), primarily driven by atherosclerosis, are the leading cause of mortality worldwide. In Saudi Arabia, the prevalence of atherosclerotic cardiovascular disease (ASCVD) poses a significant public health challenge. …”
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PET-Assessed Metabolic Tumor Volume Across the Spectrum of Solid-Organ Malignancies: A Review of the Literature by Anusha Agarwal, Chase J. Wehrle, Sangeeta Satish, Paresh Mahajan, Suneel Kamath, Shlomo Koyfman, Wen Wee Ma, Maureen Linganna, Jamak Modaresi Esfeh, Charles Miller, David C. H. Kwon, Andrea Schlegel, Federico Aucejo

“…Solid-organ malignancies represent a significant disease burden and remain one of the leading causes of death globally. In the past few decades, the rapid evolution of imaging modalities has shifted the paradigm towards image-based precision medicine, especially in the care of patients with solid-organ malignancies. …”
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End-to-End Mandarin Speech Reconstruction Based on Ultrasound Tongue Images Using Deep Learning by Fengji Li, Fei Shen, Ding Ma, Jie Zhou, Shaochuan Zhang, Li Wang, Fan Fan, Tao Liu, Xiaohong Chen, Tomoki Toda, Haijun Niu

“…The loss of speech function following a laryngectomy usually leads to severe physiological and psychological distress for laryngectomees. …”
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Chemical structure–property relationships of photocurable monomers/macromers: Potential binder candidates for ceramic/metal vat photopolymerization by Setareh Zakeri, Antonia Ressler, Piie Konnunaho, Teemu Sandblom, Joshua Cunningham, Milla Rinne, Matti Järveläinen, Anastasia Elias, Erkka J. Frankberg, Erkki Levänen

“…The compression tests showed that an excess of ethylene oxide groups in the chemical structure of used monomers introduces a higher degree of flexibility and softness to the cured structure, leading to a reduction in mechanical properties. Furthermore, it was observed that methacrylate-containing resins shrank more compared to their acrylate-containing counterparts. …”
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The impact of family members on aging persons’ technology use intentions by Freek Van Baelen, Melissa De Regge, Bart Larivière, Katrien Verleye, Kristof Eeckloo

“…The greatest intentions to use technology are observed when there is a fit in beliefs. In contrast, misfit leads to lower usage intentions. The direction of misfit further reveals that aging person's beliefs about their capabilities are more decisive than their family caregiver's beliefs in promoting their technology usage intentions. …”
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Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB by Yongzhan Sun, Quan Zou, Huizheng Yu, Xiaoping Yi, Xudan Dou, Yu Yang, Zhiheng Liu, Hong Yang, Junya Jia, Yupeng Chen, Shao-Kai Sun, Lirong Zhang

“…Mechanistically, we observed that MMPP directly binds to the bZIP DNA-binding domain of CREB, leading to competitive inhibition of CREB’s DNA binding ability and subsequent reduction in CREB target gene expression. …”
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Assessment of the effect of agro-industrial by-products rich in polyphenols on in vitro fermentation and methane reduction in sheep by Alessandro Vastolo, Blandine Mora, Dieu donné Kiatti, Martina Nocerino, Serkos Haroutounian, Rania D. Baka, Panagiota Ligda, Monica Isabella Cutrignelli, Vincent Niderkorn, Vincent Niderkorn, Serena Calabrò

“…The concentration of polyphenols in the selected agro-industrial by-products could modify fermentation parameters and metabolic pathways, leading to reduced methane production.…”
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Effects of soil management strategies based on different principles on soil microbial communities and the outcomes for plant health by Xing Zhou, Qian Zhang, Yuanyuan Yan, Jisong Qu, Jun Zhou, Jun Zhao, Jinbo Zhang, Zucong Cai, Chuanchao Dai, Xinqi Huang

“…Biological management optimized the bacterial and core microbiomes, leading to increased bacterial diversity and stimulated the growth of potential disease-suppressive agents, which contributed to resistance to F. oxysporum invasion and consistently prompted plant health. …”
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Multifeature Alignment and Matching Network for SAR and Optical Image Registration by Xin Hu, Yan Wu, Zhikang Li, Zhifei Yang, Ming Li

“…Second, speckle noise in SAR images inevitably leads to some noise labels, which decreases the accuracy and robustness of our supervised algorithm. …”
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Intramural pregnancy after intrauterine insemination in a nulligravid patient without previous uterine trauma, complicated by idiopathic thrombocytopenic purpura: A case report by Koyo Yamamoto, Tsuyoshi Takiuchi, Kengo Kiso, Saki Ishii, Satoshi Nakagawa, Yasuto Kinose, Michiko Kodama, Yutaka Ueda, Kenjiro Sawada, Takahiro Tsuboyama, Tadashi Kimura

“…The patient later resumed ART and successfully achieved term pregnancy, leading to a normal vaginal delivery 3 years after the initial surgery. …”
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A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () by Akashlal M. MD (Ay), Pratibha P Nair MD (Ay), Devi R Nair MD (Ay), Azeem Ahmad MD (Ay), B Chandrasekhararao MD (Ay), D Sudhakar MD (Ay), Srikanth Narayanam PhD (Ay), Rabinarayan Acharya PhD (Ay)

“…Quantitative analysis was unfeasible due to inadequate studies, leading to a qualitative analysis. All studies, except one, exhibited substantial bias upon risk of bias assessment. …”
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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…Allogenic stem cell transplantation was proposed leading to HIV testing, which revealed seropositivity, with an HIV viral load of 5.5 Log10/mL and severe CD4 T cell depletion (24 cells/mm3). …”
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Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats by Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes

“…Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB and Nrf2 serve as crucial mediators in the gut-liver axis, with NF-κB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. …”
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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…A dysregulated immune response leads to progressive organ dysfunction. Although numerous inflammatory pathways were described, most are still vague and need to be studied in terms of the mechanisms to improve the therapeutic intervention. …”
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A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications by Arthi Srinivasan, Arun Gupta, Vigneswaran Narayanamurthy

“…Despite its importance, large volumes of collagen-rich organic waste generated by meat, leather, and seafood industries remain underutilized, leading to significant environmental challenges. Piscine waste contributes up to 70 % of total fish body weight, while poultry farms produce approximately 89,000 tons of solid waste annually. …”
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Efficient Dual Cas9 Nickase Correction of a Prevalent Pathogenic LAMB3 Variant for Junctional Epidermolysis Bullosa by Alex du Rand, John Hunt, Daniel Verdon, Ben Buttle, P. Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard

“…Dual-Cas9n–corrected JEB keratinocytes demonstrated restored laminin-332 expression and secretion in vitro, leading to improved cellular adhesion and accurate laminin-332 localization in engineered skin equivalents. …”
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Interactive effects of multiple stressors in coastal ecosystems by Shubham Krishna, Shubham Krishna, Carsten Lemmen, Serra Örey, Serra Örey, Serra Örey, Jennifer Rehren, Julien Di Pane, Moritz Mathis, Miriam Püts, Sascha Hokamp, Himansu Kesari Pradhan, Himansu Kesari Pradhan, Matthias Hasenbein, Jürgen Scheffran, Kai W. Wirtz

“…The combined effect of heat stress and ocean acidification leads to decreased growth rate, shell size, and acid-base regulation capacity in bivalves. …”
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Solid‐Solution Limits and Thorough Characterization of Bulk β‐(AlxGa1‐x)2O Single Crystals Grown by the Czochralski Method by Zbigniew Galazka, Andreas Fiedler, Andreas Popp, Palvan Seyidov, Saud Bin Anooz, Roberts Blukis, Jana Rehm, Kornelius Tetzner, Mike Pietsch, Andrea Dittmar, Steffen Ganschow, Arub Akhtar, Thilo Remmele, Martin Albrecht, Tobias Schulz, Ta‐Shun Chou, Albert Kwasniewski, Manuela Suendermann, Thomas Schroeder, Matthias Bickermann

“…This work has shown, that incorporation of only [Ga] ≥ 5 mol% into α‐Al2O3 crystals leads to a phase separation of (α + θ)‐Al2O3. With electrical measurements this work proves an increase of the electrical resistivity of β‐(AlxGa1‐x)2O3:Mg as compared to β‐Ga2O3:Mg. …”
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