MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke by Xiaoqing Ma, Ho Jun Yun, Kenneth Elkin, Yunliang Guo, Yuchuan Ding, Guangwen Li

“…In MCAO rats, miR-29b overexpression reduced brain infarct volume and brain edema, decreasing IL-1β levels in leukocytes and in the brain 24 hours poststroke. miR-29b attenuated IL-1β expression via C1QTNF6 inhibition, leading to decreased blood-brain barrier (BBB) disruption and leukocyte infiltration. …”
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Study on Permeability of Soil-Rock Mixture in Water-Blocking Layer of Open-Pit Coal Mine Dump Site by Boyu Luan, Wei Zhou, Xin Meng, Xiang Lu, Zhichao Liu

“…With the increase of hydraulic pressure, the migration of the internal fine particles in the sample with a rock block proportion of 40% or less leads to the partial cracks closure, which gradually reduces the permeability. …”
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Optimized YOLOV8: An efficient underwater litter detection using deep learning by Faiza Rehman, Mariam Rehman, Maria Anjum, Afzaal Hussain

“…Human waste is deposited into lakes, rivers, and seas which leads to polluted water. The underwater litter harms aquatic life and pollutes water bodies and ecosystems. …”
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From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy by E. Pinto, L. Lione, M. Compagnone, M. Paccagnella, E. Salvatori, M. Greco, V. Frezza, E. Marra, L. Aurisicchio, G. Roscilli, A. Conforti

“…Abstract In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. …”
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KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14) by Aino Komatsu, Mizuki Fujibayashi, Kazato Kumagai, Hidemasa Suzuki, Yuki Hata, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Junko Kyozuka

“…Activation of MpLOG by KAI2-dependent signaling occurs in a highly cell-type-specific manner, leading to cell-specific induction of GEMMA CUP-ASSOCIATED MYB1 (GCAM1), the master regulator of vegetative reproduction of M. polymorpha. …”
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English Medium Instruction in the Russian University by T. B. Alenkina

“…Realization of the interdisciplinary approach to education has been the Russian case study of the course “English Medium Instruction” in the leading research university MIPT. The article considers the case of cooperation of the teacher with the course participants - MIPT faculty - in the process of the writing up of the syllabus. …”
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Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Abstract Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause of death. In recent years, immunotherapy has firmly established itself as a new paradigm in cancer care that activates the body’s immune defense to cope with cancer. …”
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Reflectance and Thermal Micrometeorological Characteristics of an Urban Green Space in the Mediterranean During July’s 2023 Heatwave by Nikolaos D. Proutsos, Alexandra D. Solomou, Stefanos P. Stefanidis, Ioannis X. Tsiros

“…Artificial materials absorb more heat compared to natural vegetation, leading to high surface temperature values, reaching at noon, for example, 58.9 °C for asphalt. …”
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Media image of the Russian Orthodox Church and the challenge of the pandemic by N. S. Zimova, E. V. Fomin

“…Rhetorical, technical and analytical (social technologies) methods of framing the image of the Russian Orthodox Church are revealed.It can be argued that the Internet is dominated by a stereotypical negative and distorted image of the Russian Orthodox Church. This leads to a violation of the understanding of the social functions of the Church and a decrease in its role in public life.…”
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Balancing Explainability and Privacy in Bank Failure Prediction: A Differentially Private Glass-Box Approach by Junyoung Byun, Jaewook Lee, Hyeongyeong Lee, Bumho Son

“…Traditional machine learning models often lack transparency, which poses challenges for stakeholders who need to understand the factors leading to predictions. In this study, we employ differentially private glass-box models, namely Explainable Boosting Machine (EBM) and Neural Additive Models (NAM), to address these issues. …”
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Efficient Feature Selection and Hyperparameter Tuning for Improved Speech Signal-Based Parkinson’s Disease Diagnosis via Machine Learning Techniques by Deepak Painuli, Suyash Bhardwaj, Utku Kose

“…Conventional diagnostic methods often rely on subjective interpretations of movement, which can be subtle and challenging to assess accurately, potentially leading to misdiagnoses. However, recent studies indicate that over 90% of individuals with PD exhibit vocal abnormalities at the onset of the disease. …”
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Nonlinear response and driving mechanisms of ecological restoration project effectiveness to drought by Xin Liu, Qi Wang, Xiaoyu Zhu, Yujun Zhang

“…The number and intensity of impact pathways are much more pronounced in moderately arid regions than in arid regions, leading to greater direct impacts (−0.891, −0.203) and indirect impact benefits (−0.079, −0.01). (3) Further identification of priority areas for restoration and management based on hot and cold spots, and provided governance insights in three aspects: zoning, governance pathways, and priority management areas. …”
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Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Article presents pathogenic mechanisms of the most important lesions of the liver – alcoholic and non-alcoholic steatohepatitis in pathogenesis of which the leading part belongs to accumulation of fat in cells of the organ and enhancement of lipid peroxidation processes with development of necrosis of hepatic cells. …”
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Current prevalence and determinants of generalized anxiety disorder from a nationally representative, population-based survey of India by Pavithra Jayasankar, Satish Suhas, Lakshmi P. Nirisha, Sharad Philip, Narayana Manjunatha, Girish N. Rao, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, NMHS National Collaborators Group

“…Introduction: Generalized anxiety disorder (GAD) is one of the common anxiety disorders leading to impairment and burden. However, GAD remains the least studied anxiety disorder. …”
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Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report by Christov S, Ohm F, Augustin M, Wagner JN

“…Ixekizumab, a IL-17A antagonist, was administered leading to a rapid and significant reduction in disease severity within the first 16 weeks. …”
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Geomagnetically Induced Currents and Harmonic Distortion: High Time Resolution Case Studies by Mark A. Clilverd, Craig J. Rodger, James B. Brundell, Michael Dalzell, Ian Martin, Daniel H. Mac Manus, Neil R. Thomson

“…Boxcar averaging of the magnetic field fluctuations using running windows of ±2 min leads to spectral power profiles similar to those of GIC profiles, with reduced power at frequencies >0.003 Hz (periods <5 min). …”
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Exploring the protective role of caffeine against Taraxacum-Induced ribotoxic stress mediated through autophagy and mitochondrial depolarization by Chien-Jung Lin, Shu-Ting Liu, Zih-Syuan Wu, Shih-Ming Huang, Teng-Wei Chen

“…Abstract The ribotoxic stress response is a pathway that gets activated when ribosomes get impaired, leading to disruptions in protein synthesis, increased inflammatory signaling, and cell death if left unresolved. …”
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Semantic-Aware Top-k Multirequest Optimal Route by Shuang Wang, Yingchun Xu, Yinzhe Wang, Hezhi Liu, Qiaoqiao Zhang, Tiemin Ma, Shengnan Liu, Siyuan Zhang, Anliang Li

“…In KOR-SP, we define a dominance relationship between two partially explored routes which leads to a smaller searching space and consider the semantic similarity of keywords and the number of single POI’s services. …”
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Experimental studies of the influence of deformations in nodal joints on the stress-strain state in a full-scale support made of MIC-C by V. N. Dolzhikov, E. N. Dolzhikova

“…The pliability of bolted joints leads to increase in the total deformations of structural structures by 40 % and change in the forces in the elements by up to 30 %. …”
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IMPACT OF FLOODING ON HUMAN SECURITY IN NORTHERN NIGERIA by DUBE PHILEMON ABRAK, ADELAKUN RASHEED ADEYINKA, ISHAKU AISHA YUSUF, UBON UDOH HUMAPWA, MUKHTAR BELLO MUHAMMAD, CHUKWUEDO N. HENRY, OGBUKE KINGSLEY NNAMDI

“… The study provides insights into how flooding exacerbates health issues and the direct and indirect effects on physical and food security in northern Nigeria through the increased prevalence of waterborne diseases such as cholera and malaria, displacement of people, leading to overcrowded and unsanitary living conditions in temporary shelters and the disruption of agricultural activities, resulting in food shortages and increased prices, undermining food security in the region. …”
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