Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris by Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang

“…DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORγt and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…Like other therapeutics, PROTACs function by recruiting a protein target and a ubiquitin ligase that leads to the degradation of the target protein; however, unlike most other drugs, PROTACs do not simply disable the target’s function through steric hindrance. …”
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Costs of colorectal cancer screening in Sweden: an observational, longitudinal cost description by Johannes Blom, Naimi Johansson, Camilla Nystrand

“…The screening strategy was faecal occult blood testing (FOBT) sent to individuals’ home addresses, with a positive test result leading to an invitation to diagnostic colonoscopy. …”
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Is There a Role for Daratumumab Retreatment in Patients with Relapsed/Refractory Multiple Myeloma? by Davor Galusic, Ivan Krecak, Viktor Blaslov, Andela Krstulovic Opara, Toni Valkovic, Sandra Basic Kinda

“…Multiple myeloma (MM) is a hematologic disease characterized by the clonal expansion of malignant plasma cells that accumulate in the bone marrow, leading to osteolytic bone disease, hypercalcemia, anemia, and renal dysfunction. …”
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Deep Learning-Based Damage Assessment in Cherry Leaves by Burakhan Cubukcu, Hazel BOZCU

“…In future studies, the reliability of this study can be increased by using more diverse datasets, and disease detection performance can be enhanced by using different deep learning methods, leading to reduced disease detection times.…”
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Label credibility correction based on cell morphological differences for cervical cells classification by Wenbo Pang, Yue Qiu, Shu Jin, Huiyan Jiang, Yi Ma

“…In addition, pathologists can deduce different criteria for judgment based on The Bethesda System, leading to potential confusion during data labeling. …”
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The effect of labour migration and structural changes on economic development by O. Nosova

“…Diversifying the economy, increasing product/service sophistication, using comparative advantages and transfer of resources (both labour and capital) leads to more productive activities and a rise in well-being.…”
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Pediatric Sickle Cell Disease in Sudan: Complications and Management by Meysaa Talha, Bashier Osman, Safa Abdalla, Hind Mirghani, Iman Abdoon

“…Sickle cell disease (SCD) is a life-threatening genetic disorder due to the formation of sickle hemoglobin molecule (HbS) that polymerizes in hypoxic conditions leading to SCD-related complications. Different approaches have been used in the management of SCD including symptomatic management, supportive management, and preventive management. …”
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Assessment and Optimization of Ecological Networks in Trans-Provincial Metropolitan Areas—A Case Study of the Xuzhou Metropolitan Area by Yijia Zhao, Peiyuan Zhang, Hao Xu, Wei Liu

“…Economic development in metropolitan areas inevitably leads to ecological degradation and fragmentation, threatening biodiversity. …”
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Potential mutagenicity of aflatoxin B1 in Egyptian spices by Basma El Geoshi, Gehan El-Akabawy, Mohammed El Metwally, Magda I. Soliman

“…The data obtained indicated that AFB1 not only has the ability to induce various alterations in the process of mitosis, ranging from increasing to decreasing mitotic and phase indices but also leads to many mitotic aberrations. The abnormalities observed varied on the basis of the ratio of AFB1 to treatment time. …”
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Interproximal tunneling combined with customized connective tissue graft to improve severe papillary defects in the aesthetic zone: a case report and literature review by MAO Yudian, BAO Han, AI Luying, CHEN Weirong, CHEN Ling, WU Yun

“…Methods A patient with severe periodontitis leading to severe papillary defects in the upper anterior teeth from 12 to 23 was treated using interdental tunnel technique combined with personalized connective tissue grafting for periodontal plastic surgery, and stable soft tissue augmentation was achieved. …”
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Role of Janus Kinase inhibitors in the management of pulmonary involvement due to Long COVID-19 disease: A case control study by Pawan Kumar Singh, Vinod Kumar Sharma, Lokesh Kumar Lalwani, Dhruva Chaudhry, Manjunath B. Govindagoudar, Chaudhari Pramod Sriram, Aman Ahuja

“…OBJECTIVES: Ongoing symptomatic coronavirus disease 2019 (OSC) is defined as persistent symptoms beyond 4 weeks of acute illness. OSC leads to prolonged hospitalization and oxygen dependence. …”
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Povidone-iodine in ophthalmological practice by I.A. Koroleva, Kozhukhov A.A

“…Reuse of local antibiotics in such a situation leads to colonization of the eye surface by bacteria with resistance to them. …”
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Theoretical and Methodological Framework of Typologization of Digital Identity by O.A. Persidskaya

“…It is shown that research optics in identifying the content parameters of this identity is often narrowed, which leads to the reduction of a complex, multi–component education – the identity of a person in the digital world – to a separate part, which is not enough to build a complex image of a modern man. …”
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A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke by Zhijian Zheng, Xiaohui Lin, Zijun Zhao, Qiang Lin, Ji Liu, Manli Chen, Wenwen Wu, Zhiyun Wu, Nan Liu, Hongbin Chen

“…Further in vivo experiments revealed that this vascular endothelial growth factor–loaded hydrogel scaffold facilitated the transplantation of adipose-derived stem cells, leading to a reduction in infarct volume and neuronal apoptosis in a rat model of stroke induced by transient middle cerebral artery occlusion. …”
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Determining an optimal case definition using mid-upper arm circumference with or without weight for age to identify childhood wasting in the Philippines. by Lyle Daryll Dimaano Casas, Jhanna Uy, Eldridge Ferrer, Charmaine Duante, Paluku Bahwere, Rene Gerard Galera, Alice Nkoroi, Behzad Noubary, Mueni Mutunga, Sanele Nkomani, Roland Kupka, Valerie Gilbert Ulep

“…MUAC alone, however, may miss identification of many wasted children, leading to untimely intervention and potentially death. …”
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Foliar applied calcium chloride alleviated drought stress in pearl millet (Pennisetum glaucum L.) by improving growth and yield contributing traits and antioxidant activity. by Tauqeer Ahmad Yasir, Wasif Azhar, Qaisar Ali, Muhammad Usman Masood Bhutta, Muhammad Ateeq, Allah Wasaya, Mubshar Hussain, Rehana Riaz

“…Drought-induced stress presents a substantial threat as it disrupts the normal growth of cereal crops and leads to decreased yields. The persistent occurrence of drought conditions significantly impacts the growth and development of pearl millet. …”
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3-DOF Inertial Piezoelectric Actuator for Angular Positioning of the Optical Mirror by Andrius Ceponis, Dalius Mazeika, Regimantas Bareikis

“…Numerical analysis identified the vibration modes, resonant frequencies, and mechanical and electromechanical characteristics of the actuator, leading to design optimization of clamping beams and contact locations on the bimorph plates. …”
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Comparison evaluation of bacterial DNA extraction methods for improved molecular diagnostic accuracy of sepsis-causing pathogens in clinical whole blood samples by Byungjoon Na, Junghun Park, Sojin Park, Eunseon Park, Jimin Jang, Yu-Hee Kim, Jinyeop Lee, Hae-Sun Chung

“…Abstract Sepsis, a leading cause of mortality, requires rapid and accurate pathogen identification to ensure effective treatment. …”
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Transformasi Kota Cerdas dalam Mitigasi Banjir: Pemodelan Curah Hujan DKI Jakarta dengan Pendekatan Spatial Vector Autoregressive (SpVAR) dan Pemetaan Bobot Queen Contiguity by Rinda Lolita Melanwati, Eni Sumarminingsih, Henny Pramoedyo

“…Abstract Climate change and extreme weather pose global challenges, including in Indonesia, leading to increased floods in DKI Jakarta. Addressing this requires accurate rainfall forecasts. …”
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