Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass by Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto

“…Severe hypertriglyceridemia is a pathological condition caused by genetic factors alone or in combination with environmental factors, sometimes leading to acute pancreatitis (AP). In this study, exome sequencing and biochemical analyses were performed in 4 patients with hypertriglyceridemia complicated by obesity or diabetes with a history of AP or decreased post-heparin LPL mass. …”
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Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats by D. Saul, J. H. Kling, R. L. Kosinsky, D. B. Hoffmann, M. Komrakova, M. Wicke, B. Menger, S. Sehmisch

“…Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle. …”
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Space Weather Environment During the SpaceX Starlink Satellite Loss in February 2022 by Tzu‐Wei Fang, Adam Kubaryk, David Goldstein, Zhuxiao Li, Tim Fuller‐Rowell, George Millward, Howard J. Singer, Robert Steenburgh, Solomon Westerman, Erik Babcock

“…Working closely with the Starlink team, the thermospheric densities along the satellite orbits were estimated and the neutral density increase leading to the satellite loss was investigated. Simulation results suggest that during the geomagnetic storm, pre‐launch Monte Carlo analyses performed by the Starlink team using empirical neutral density inputs from NRLMSISE‐00 tended to underestimate the impact relative to predictions from the operational coupled Whole Atmosphere Model and Ionosphere Plasmasphere Electrodynamics physics‐based model. …”
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Damage evolution mechanism and low-damage grinding technology of silicon carbide ceramics by Chen Li, Kechong Wang, Oleg Zakharov, Hailong Cui, Mingtao Wu, Tianchen Zhao, Yongda Yan, Yanquan Geng

“…However, the inherent high hardness and brittleness of SiC ceramics present significant challenges during grinding, leading to severe brittle fracture and tool wear that compromise both surface integrity and production efficiency. …”
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Hierarchical forecasting of causes of death with trend breaks in mortality modeling: Kenyan case by Nicholas Bett, Juma Kasozi, Daniel Ruturwa

“…Results based on the mean absolute percentage error criteria across the causes of death showed that all the models apart from the base model showed significant improvement after accounting for the trend breaks with the best being the auto machine learning approach leading with seven causes of death. Updating forecasts based on the computed trend breakpoints that varied between 2007 to 2011 generally improved forecast accuracy. …”
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Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population by Le-le Li, Wei-jun Gu, Jing-tao Dou, Guo-qing Yang, Zhao-hui Lv, Yi-ming Mu, Ju-ming Lu

“…Routine medical checkup was found to have the greatest chance (43.59%) of revealing clinical onsets leading to discovery. Biochemical and functional evaluation revealed 54 (69.23%) cases of nonfunctional lesions, 12 (15.38%) of subclinical Cushing syndrome, 6 (7.69%) of primary hyperaldosteronism, 1 (1.28%) of metastasis, and 5 (6.41%) of unknown functional status. …”
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Galactic Cosmic Radiation in the Interplanetary Space Through a Modern Secular Minimum by F. Rahmanifard, W. C. deWet, N. A. Schwadron, M. J. Owens, A. P. Jordan, J. K. Wilson, C. J. Joyce, H. E. Spence, C. W. Smith, L. W. Townsend

“…For the case of conditions similar to the Dalton (or Gleissberg) minimum, the heliospheric magnetic field could drop to 3.61 (or 4.06) nT, leading to a dose rate increase of ∼75% (or 34%). …”
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Understanding the Impacts of Recurrent Peat Fires in Padang Island – Riau Province, Indonesia by Ari Susanti, Oka Karyanto, Agus Affianto, Ismail Ismail, Satyawan Pudyatmoko, Trias Aditya, Haerudin Haerudin, Hendra Arditya Nainggolan

“…Padang Island in Riau Province of Indonesia has been severely impacted by recurrent fires in 2014 and 2015, leading to severe peat ecosystem degradation and people´s livelihood. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…Background Diarrhoea remains a leading cause of death in children. An intestinal adsorbent may reduce diarrhoea duration and severity.Methods Randomised controlled feasibility trial with two phases: phase 1 (0–4 hours and double-blind) and phase 2 (up to 5 days and open-label). 50 children aged 6–59 months with acute diarrhoea presenting with no or some dehydration to the emergency paediatric unit and outpatient clinic at Edward Francis Small Teaching Hospital, Banjul, The Gambia were randomised to either standard treatment (oral rehydration fluid and zinc) or standard treatment with polymethylsiloxane polyhydrate for up to 5 days.Results Recruitment was completed in 7 months. …”
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Impact of comb type on production performance, egg production quality, reproductive performance, and blood biochemical indexes in Tianfu chickens by Yuxin Zhou, Hengyong Xu, Wei Du, Yuxiang Lu, Zhi Hu, Qingqing Deng, Xi Wang, Yiping Liu, Yao Zhang, Yan Wang

“…In roosters, single-comb had higher germ cell counts, thicker seminiferous epithelium, and better semen quality, leading to improved fertilization rates and hatchability. …”
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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…The search for innovative therapeutic strategies remains critical in addressing cancer, one of the leading global health challenges. Ribosomal S6 Kinase 2 (RSK2), a serine/threonine kinase, has emerged as a promising target for cancer therapy because it is implicated in oncogenic signaling. …”
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Clinical management of female patients with Fabry disease based on expert consensus by Eva Brand, Aleš Linhart, Patrick Deegan, Ruxandra Jurcut, Antonio Pisani, Roser Torra, Ulla Feldt-Rasmussen

“…Abstract Fabry disease is an X-linked lysosomal storage disorder that causes accumulation of glycosphingolipids in body tissues and fluids, leading to progressive organ damage and life-threatening complications. …”
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Improving Rotational Doppler Velocimetry Accuracy and Spectral Characteristics of Vortex Beam in Maritime Atmospheric Turbulence by Hongyang Wang, Zijing Zhang, Chengshuai Cui, Xinran Lv, Hao Yun, Hao Liu, Yuan Zhao

“…Simulation results indicate that the compensation for mode dispersion induced by the receiving aperture limitation in the remote transmission of long-wavelength beams leads to average purity improvements of up to 50.55%. …”
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FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma by Xuejuan Gao, Donglan Huang, Ying Liu, Gui Zhang, Xiaofen Zheng, Baiye Guan, Aiwen Chen, Jiayao Wu, Shi-Ming Luo, Zonghua Liu, Luxuan Chen, Xiaohui Liu, Jingjie Jin, Xingfeng Yin, Zhenghua Sun, Yunfang Zhang, Meizhi Lu, Gong Zhang, Wanting Liu, Langxia Liu

“…Specifically, FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression, leading to the inhibition of proliferation and migration of LUAD cells. …”
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An Investigation of Hand Gestures for Controlling Video Games in a Rehabilitation Exergame System by Radhiatul Husna, Komang Candra Brata, Irin Tri Anggraini, Nobuo Funabiki, Alfiandi Aulia Rahmadani, Chih-Peng Fan

“…However, traditional rehabilitation methods can be expensive and may lack engagement, leading to poor adherence to therapy exercise routines. …”
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Economics of Acute Kidney Injury in the Critical Care Setting: Kidneys Need More Time and Money! by Reema Nair, Somu G, Srinivas Vinayak Shenoy, Laxmitha Shetty, Aparna Satish

“…Demographic and clinical data, including AKI etiology, healthcare costs, and insurance coverage, were collected and analyzed.Results: Of the 132 patients, 57.6% developed AKI, with sepsis identified as the leading cause (78%). Patients with AKI incurred significantly higher total healthcare costs (US$ 2452.4 vs. …”
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Further Analysis of the Passive Dynamics of the Compass Biped Walker and Control of Chaos via Two Trajectory Tracking Approaches by Essia Added, Hassène Gritli, Safya Belghith

“…We show first by means of bifurcation diagrams and by varying the slope angle of the walking surface and also the length of the lower leg segment that the passive dynamic walking exhibits successive period-doubling bifurcations leading to chaos. Furthermore, in order to control chaos and hence obtain one-periodic walking behavior, we propose two control approaches based on tracking a desired trajectory. …”
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Hydrometallurgical Recovery of Copper from Computer-Printed Circuit Boards by Abdol Jani Wan Nur Fazlina, Abdul Rani Noor Hidayu, Mohamad Nor Fadilah, Sayed Jamaludin Sharifah Iziuna

“…Modern electronic devices contain up to 60 different metals, leading to a growing interest in exploring secondary sources, particularly electronic waste (e-waste), to address potential shortages. …”
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Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway by Jincan Chen, Jie Wang, Yuanyuan Deng, Tao Wang, Tifang Miao, Chengpeng Li, Xianhong Cai, Ying Liu, Justin Henri, Lanmei Chen

“…Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/Bad ratio, enhancing cellular reactive oxygen species (ROS) accumulation, triggering DNA damage, decreasing mitochondrial membrane potential (MMP), and leading cytochrome c release from mitochondria. Notably, complex Ru-1 showed low toxicity to developing zebrafish embryos. …”
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Predicting branch retinal vein occlusion development using multimodal deep learning and pre-onset fundus hemisection images by Eun Young Choi, Dongyoung Kim, Jinyeong Kim, Eunjin Kim, Hyunseo Lee, Jinyoung Yeo, Tae Keun Yoo, Min Kim

“…Abstract Branch retinal vein occlusion (BRVO) is a leading cause of visual impairment in working-age individuals, though predicting its occurrence from retinal vascular features alone remains challenging. …”
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