Drivers in the conservation of urban green space depletion: A case study of Wa Municipality, Ghana by Sabastian Batasuma, Wei Cao, Nathan Awelama Atigah, Emefa Acorlor Garnet, Joshua Kojo Bonzo, Justice Gyimah

“…In rapidly developing regions, especially in emerging economies like Ghana, the decline of greenery is an urgent concern. This ongoing trend leads to the significant loss of land and green areas, which worsens environmental challenges and imposes substantial costs on Local as well as state governments. …”
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Design and Verification of Simulation Data Generator for Rail Transit Switch Machine Oriented to Intelligent Operation and Maintenance by ZOU Jinbai, WEI Shiyan, LIU Jiang, SHA Quan, WU Jie, JI Guoyi

“…［Objective］ Difficulty in easily obtaining fault data of various rail transit equipment leads to insufficient data to support the research on machine intelligence algorithms such as fault diagnosis and prediction. …”
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Influence of Stress Sensitivity on Water-Gas Flow in Carbonate Rocks by Shuaishi Fu, Lianjin Zhang, Yingwen Li, Xuemei Lan, Roohollah Askari, Junjie Wang, Wen Wen, Xinze Li, Shaobin Cai, Ke Wang, Jie Liu, Yushu Wang, Yongfei Yang

“…Therefore, the irreversible closure of pores leads to the decrease of permeability and the increase of gas-phase seepage resistance, especially in carbonate rocks with fractures, vugs, and large pores. …”
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How spinal GABAergic circuits modulate cerebral processing of postsurgical pain by Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn

“…Surgical procedures cause tissue damage and inflammation, leading to peripheral and central sensitization, resulting in pain at rest or mechanical and heat hyperalgesia. …”
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Safety and Biodistribution of an Autologous Bone Marrow-Derived Mononuclear Cell Infusion into Renal Arteries in Patients with Focal Segmental Glomerulosclerosis: A Phase 1 Study by Bruno Freire Botelho, André Luis Barreira, Marcio Gomes Filippo, Karina Dutra Asensi, Lanuza A P Faccioli, Anna Beatriz dos Santos Salgado, Elizabeth Figueiredo de Salles, Carlos Eduardo Cruz Marques, Pedro Leme Silva, Regina Coeli dos Santos Goldenberg, Angelo Maiolino, Bianca Gutfilen, Sergio Augusto Lopes de Souza, Maurilo Leite Junior, Marcelo Marcos Morales

“…Patients with focal segmental glomerulosclerosis (FSGS) who are refractory to drug treatment may present progressive loss of kidney function, leading to chronic kidney disease stage 5 under dialysis treatment. …”
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A Turbo‐Charging System‐Like Contrast Agent for MRI‐Guided STING Pathway‐Activated Cancer Immunotherapy by Bin Ren, Sihua Yan, Zongheng Li, Ya Huang, Haobin Cai, Jing Yang, Qingdeng Fan, Chunmei Chen, Fanchao Que, Guochao Wu, Lin Huang, Ruilong Zhou, Jiaoyang Zhu, Chenggong Yan, Gang Liu, Zheyu Shen, Shipeng Ning

“…After accumulation in tumors and internalization in tumor cells, the disulfide linkage in Turbo S undergoes a cleavage process catalyzed by glutathione (GSH), leading to the release of Gd/PAA and SR717. The released Gd/PAA gain a high r1 value (17.11 mM−1 s−1 at 7.0 T; 57.81 mM−1 s−1 at 3.0 T), indicating its strong T1 imaging capability. …”
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Fatigue State Evaluation of Urban Railway Transit Drivers Using Psychological, Biological, and Physical Response Signals by Hao Wu, Yubo Jiao, Chaozhe Jiang, Tong Wang, Jiangbo Yu

“…The results indicate that as the length of the time window increases, the data captures more comprehensive information, leading to improved fatigue detection accuracy. Furthermore, multi-feature fusion significantly enhanced model performance. …”
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Comparative Genomics Analysis of Plasmid pPV989-94 from a Clinical Isolate of Pantoea vagans PV989 by Lei Xu, Min Yin, Tingyuan Zhu, Yabo Liu, Yuanyuan Ying, Junwan Lu, Chaoqing Lin, Jianchao Ying, Teng Xu, Liyan Ni, Qiyu Bao, Shunfei Lu

“…It can be divided into four regions, including three conservative regions related to replication (R1), transfer conjugation (R2), and transfer leading (R3), and one variable region (R4). Further analysis showed that pPV989-94 is most similar to plasmids LA637P2 and pEA68 of Erwinia amylovora strains isolated from fruit trees. …”
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PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. …”
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MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo by Karolin Walter, Kanishka Tiwary, Marija Trajkovic-Arsic, Ana Hidalgo-Sastre, Laura Dierichs, Sven T. Liffers, Jiangning Gu, Johann Gout, Lucas-Alexander Schulte, Jan Münch, Thomas Seufferlein, Bruno Sainz, Jens T. Siveke, Eva Rodriguez-Aznar, Patrick C. Hermann

“…At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. Despite extensive work on new therapeutic approaches, the median overall survival is only 6-12 months after diagnosis and the 5-year survival is less than 7%. …”
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Experimental Study on Flow Characteristics of Aeolian Sand in Fractures by Jiarui Chen, Wenhu Gu, Jihua Zhang, Jitao Tang, Zhengzheng Cao, Jingke Wu, Jianxiong Liu, Weizhong He, Fang Shi

“…It is one of the important safety problems in the process of mining shallow coal seams in western China that the rock mass affected by mining stress breaks and forms a penetrating fracture, leading to a sand burst in the working face. The self-developed test system is used to carry out the experimental study on the flow characteristics of Aeolian sand in fractures. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…As we age, the efficiency of the NRF2 pathway declines due to several factors including increased activity of its repressors, impaired NRF2-mediated antioxidant and cytoprotective gene expression, and potential epigenetic changes, though the precise mechanisms remain unclear. This leads to diminished antioxidant defenses, increased oxidative damage, and exacerbated metabolic dysregulation and inflammation—key contributors to age-related diseases. …”
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HDAC3 inhibitors induce drug resistance by promoting IL-17 A production by T cells by Hao Chen, Anqi Qin, Fan Xu, Shuai Guo, Ge Zhang, Aihong Zhang, WenTing Li, Feng Tian, Quanhui Zheng

“…These findings demonstrate that the use of RGFP966 or T cell-specific loss of hdac3 promotes the expression of IL-17 A in splenic T cells, leading to tumor resistance and providing insights for clinical treatment.…”
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Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA: Possible Role in Proliferative Diabetic Retinopathy by Sally L. Elshaer, Mohammed A. Abdelsaid, Ahmad Al-Azayzih, Parag Kumar, Suraporn Matragoon, Julian J. Nussbaum, Azza B. El-Remessy

“…Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. …”
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The association between the health promotion levy and employment in South Africa: an interrupted time series analysis by Chengetai Dare, Micheal Kofi Boachie, Susan Goldstein, Evelyn Thsehla

“…However, the levy has been opposed by the sugar industry, claiming that it leads to jobs losses. Against this backdrop, this study seeks to investigate the association between the HPL and employment in the sugar industry. …”
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The COVID-19 pandemic and its impact on mental health. Causes and consequences - an overview by Michał Jakub Cioch, Urszula Kaczmarska, Aleksandra Woźniak, Julia Nowak, Kamil Hermanowicz, Katarzyna Doman, Agnieszka Najdek, Daria Oleksy, Marcin Mycyk, Dawid Komada

“…It will discuss risk factors leading to mental health disorders during the pandemic. …”
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An Aptamer Sensor Based on Alendronic Acid-Modified Upconversion Nanoparticles Combined with Magnetic Separation for Rapid and Sensitive Detection of Thiamethoxam by Qian Huang, Lu Han, Hui Ma, Weijie Lan, Kang Tu, Jing Peng, Jing Su, Leiqing Pan

“…Thiamethoxam specifically attached to apt-MNPs, leading to their separation from cDNA-UCNPs, which in turn led to a reduction in fluorescence intensity at 544 nm following separation by an external magnetic field. …”
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Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection by Wei-Chih Liao, Chia-Huei Chou, Mao-Wang Ho, Jo-Tsen Chen, Shu-Ling Chou, Yu-Tsen Huang, Ngoc-Niem Bui, Hui-Yu Wu, Chi-Fan Lee, Wei-Chien Huang, Chih-Ho Lai

“…Background: Cigarette smoking remains a leading cause of mortality worldwide. Streptococcus pneumoniae, also known as pneumococcus, is one of the most common pathogens that colonizes the human respiratory tract, causing life-threatening infections. …”
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Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention by Sonia Youhanna, Aurino M. Kemas, Shane C. Wright, Yi Zhong, Britta Klumpp, Kathrin Klein, Aikaterini Motso, Maurice Michel, Nicole Ziegler, Mingmei Shang, Pierre Sabatier, Aimo Kannt, Hongda Sheng, Nuria Oliva‐Vilarnau, Florian A. Büttner, Brinton Seashore‐Ludlow, Jonas Schreiner, Maike Windbergs, Martin Cornillet, Niklas K. Björkström, Andreas J. Hülsmeier, Thorsten Hornemann, Jesper V. Olsen, Yi Wang, Roberto Gramignoli, Michael Sundström, Volker M. Lauschke

“…Abstract Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of chronic liver disease with few therapeutic options. …”
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Generation of Rational Drug-like Molecular Structures Through a Multiple-Objective Reinforcement Learning Framework by Xiangying Zhang, Haotian Gao, Yifei Qi, Yan Li, Renxiao Wang

“…As an appealing approach for discovering novel leads, the key advantage of de novo drug design lies in its ability to explore a much broader dimension of chemical space, without being confined to the knowledge of existing compounds. …”
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