Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Allogenic bone-marrow transplantation (BMT) was performed from B10.D2. to BALB/c mice, leading to sclerodermatous GVHD. GVHD mice were treated with delgocitinib eye drops or ointment with samples analyzed at 4 weeks post-BMT. …”
Get full text

Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction by Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, Kazuhiro Satomi, Takeharu Hayashi

“…The loss or reduced activity of GLA leads to damage to multiple organs, resulting in the intracellular accumulation of globotriaosylceramide in various organs, including the heart, kidneys, and nervous system. …”
Get full text

Optimizing Polar Air Traffic: Strategies for Mitigating the Effects of Space Weather‐Induced Communication Failures Poleward of 82°N by Dabin Xue, Zhizhao Liu, Donghe Zhang, Cheng‐Lung Wu, Jian Yang

“…However, space weather events can disrupt the ionosphere conditions and damage satellites, leading to High‐Frequency (HF) communication blackouts and satellite communication failures. …”
Get full text

The global, regional burden of pancreatic cancer and its attributable risk factors from 1990 to 2021 by Weidong Yu, Danyi Zhou, Fanhao Meng, Jinjing Wang, Bo Wang, Jianling Qiang, Lijun Shen, Maofeng Wang, Hezhi Fang

“…Abstract Background Pancreatic cancer is the 12th most common type of cancer, and the sixth leading cause of cancer-related mortality, worldwide. …”
Get full text

J Point and ST Elevation Resembling Brugada: A Marker of Mortality in Methanol Toxicity by Mohammad Hossein Nikoo, Alireza Estedal, Kiana Khatami, Maryam Pakfetrat, Alireza Arjangzadeh, Shahrokh Sadeghi Boogar, Sina Danesh, Seyed Taghi Heydari

“…J point and coved ST elevation in right precordial leads (not produced by coronary artery disease) are still a matter of challenge, especially when resembling Brugada patients. …”
Get full text

Snow as an indicator of atmospheric transport of anthropogenic particles (microplastics and microfibers) from urban to Arctic regions by Jasmine T. Yu, Miriam L. Diamond, Eric Ward, Jennifer K. Adams, Amaya Cherian-Hall, Mary Gamberg, Tyler Obediah, Michael Palmer, Andrew Platt, Cassandra Worthy, Sarah A. Finkelstein, Liisa M. Jantunen

“…Back trajectory analyses performed for days leading up to sample collection showed high-frequency transport (>10%) from population centres exceeding 200 km distance. …”
Get full text

Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Rheumatoid arthritis (RA) is an autoimmune disorder that leads to severe cartilage deterioration and synovial impairment in the joints. …”
Get full text

Environmental and human health impact of recycle concrete powder: an emergy-based LCA approach by Aneel Manan, Zhang Pu, Mohanad Muayad Sabri, Wael Alattyih, Jawad Ahmad, Abdullah Alzlfawi

“…Notably, the analysis indicates that higher RCP content leads to reduce environmental impacts. Specifically, the mix containing 15% RCP showed substantial improvements, lowering ozone depletion impacts from 100% to 90% and photochemical oxidant formation from 100% to 92%. …”
Get full text

Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy by Zekai Cui, Xiaoxue Li, Yiwen Ou, Xihao Sun, Jianing Gu, Chengcheng Ding, Zhexiong Yu, Yonglong Guo, Yuqin Liang, Shengru Mao, Jacey Hongjie Ma, Hon Fai Chan, Shibo Tang, Jiansu Chen

“…Diabetic keratopathy (DK), a significant complication of diabetes, often leads to corneal damage and vision impairment. Effective models are essential for studying DK pathogenesis and evaluating potential therapeutic interventions. …”
Get full text

The abundance of microplastics in coral reef ecosystems in the waters of Krueng Raya, Aceh Besar by Ulfah Maria, Juliani Rika, Agustina Sri, Purnawan Syahrul, Malayana Intan, Muliari, Miswari Nur, Yusrizal, Irfannur

“…This pollution is caused by human activities such as tourism, fishing, and domestic waste, leading to the generation of plastic waste and microplastics. …”
Get full text

Evaluating the impact of drought and water restrictions on agricultural production in irrigated areas through crop water productivity functions and a remote sensing-based evapotran... by Joaquim Bellvert, Magí Pamies-Sans, Jaume Casadesús, Joan Girona

“…In Mediterranean regions, climate change is leading to reduced precipitation, along with more frequent and severe droughts, and prolonged periods of water scarcity. …”
Get full text

Dicobalt orthosilicate-graphitic carbon nitride nanocomposites as promising visible-light nanocatalysts for removal of water-soluble organic dyes by Masoud Hosseini, Mojgan Ghanbari, Makarim A. Mahdi, Mohammed H. Almaamori, Zainab Abbas Abd Alhassan, Masoud Salavati-Niasari

“…The kinetic investigation showed that a bigger rate constant (k = 0.0166 min‒1) leads to higher efficiency (90.0%). The combination of CSO and CN as composites shows great potential for efficient photocatalytic dye degradation applications. …”
Get full text

Case report: Successful treatment of a thallium sulfate intoxication in a dog with use of Prussian blue by Fergal M. McDermott, Anne A. Kan, Claudine C. Hunault, Joris H. Robben, Dylan W. de Lange, Marieke A. Dijkman

“…A 5-year-old miniature Schnauzer, ingested a thallium sulfate based rodenticide leading to lethargy, anorexia, regurgitation, abdominal pain, borborygmi, constipation, ataxia, dermatitis and progressive alopecia. …”
Get full text

Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1α signal pathway and modulation of gut microbiota by Lijuan Li, Yating zhao, Yuxin Ding, Lanze Guo, Ruiyao Dai, Aixiang Chen, Guofeng Duan

“…Oxidative stress can trigger excessive apoptosis in intestinal epithelial cells, leading to dysfunction of the small intestinal mucosa and impaired intestinal absorption. …”
Get full text

Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis by Sheryl L. Coutermarsh-Ott, John T. Doran, Caroline Campbell, Tere M. Williams, David S. Lindsay, Irving C. Allen

“…Infection with T. gondii results in activation of nucleotide binding domain and leucine rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. …”
Get full text

PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy by Yujia Liang, Shufang Ning, Mekhrdod S. Kurboniyon, Khaiyom Rahmonov, Zhengmin Cai, Shirong Li, Jinling Mai, Xiaojing He, Lijuan Liu, Liping Tang, Litu Zhang, Chen Wang

“…Through facilitating electron transfer and enhancing active sites, the enhanced peroxidase-like (POD-like) enzymatic activity and glutathione (GSH) depletion abilities of nanozymes are boosted through a simple co-reduction process, leading to promising anti-tumor activity. The electron transfer between Pd and Ru of PdRu@PEI nanoalloys contributes to POD-like activity. …”
Get full text

Enhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistant Aeromonas veronii by Xin Cao, Yanqiong Tang, ZhenZhang Lu, Xiang Ma, Hong Li, Xue Chi, Juanjuan Li, Zhu Liu

“…This combined treatment exhibited a more distinct effect in removing mature biofilms and inhibiting biofilm formation, leading to a considerable decrease in bacterial density within the biofilm. …”
Get full text

Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer by Sangsang Tang, Yangyang Li, Yifeng Fang, Mengyan Tu, Shenglong Wu, Yixuan Cen, Junfen Xu

“…Meanwhile, Ga2S3-BSA NMs significantly inhibited NF-κB signaling and Bcl2 protein expression, leading to cell apoptosis. Furthermore, Ga2S3-BSA NMs increased cellular lipid peroxidation and triggered ferroptosis. …”
Get full text

3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects by Kai Chen, Fang Wang, Xiumei Sun, Wenwei Ge, Mingjun Zhang, Lin Wang, Haoyu Zheng, Shikang Zheng, Haoyu Tang, Zhengjie Zhou, Guomin Wu

“…Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. …”
Get full text

Effects of shrinkage, temperature and the degree of connection (N/N f) on the behavior of steel-concrete composite beams by Halima Aouad, Nacer Rahal, Houda Beghdad, Mohamed Sadoun, Abdelaziz Souici, Sara Zatir, Khaled Benmahdi

“…In this present study, the main contribution is the introduction of the effect of the connection degree (N/Nf) at the steel-concrete interface, thus leading to an analytical model capable of predicting additional stresses brought by shrinkage and temperature in composite steel-concrete beams in partial shear connection. …”
Get full text