The burden of Alagille syndrome: uncovering the potential of emerging therapeutics – a comprehensive systematic literature review by Philip Bufler, Robin Howard, Lucia Quadrado, Guy Lacey, Jolan Terner-Rosenthal, Andrea Goldstein, Pamela Vig, Deirdre Kelly

“…Aim: Alagille syndrome (ALGS) is a rare, cholestatic multiorgan disease associated with bile duct paucity, leading to cholestasis. Clinical symptoms of cholestasis include debilitating pruritus, xanthomas, fatsoluble vitamin deficiencies, growth failure, renal disease and impaired health-related quality of life (HRQoL). …”

The cultivation status of Traditional Chinese Medicine nurses in China (中医护理人才培养现状) by LI Jiaji (李佳霁), XU Jingjin (徐京巾), LI Ye (李野), TANG Ling (唐玲)

“…In recent years, the talent team of TCM nursing science has been growing, the quality of employees has been gradually improved, the training of grass-roots talents has been continuously strengthened, and the scientific and technological achievements of high-end talents have becoming more prominent, which plays an increasingly important role in the field of health services and leading the international development of TCM. At the same time, there are some prominent problems, such as the cultivation of high-level academic talents can not meet the needs of nursing discipline development, and the scale of clinical talents is difficult to meet the needs of health services. …”
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Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis by Mehdi Mirzaeipour, Fattaneh Mikaeili, Qasem Asgari, Mohammad Nohtani, Sajad Rashidi, Mohammad Saleh Bahreini

“…Toxoplasma parasite alters the transduction of neurotransmitter signals and leads to changes in the level of brain neurotransmitters including tyrosine and dopamine, so behavior changes can occur in infected hosts. …”
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Identification and optimization of urban wetland ecological networks in highly urbanized areas: A case study of Haidian District, Beijing by Wang Zecheng, Zhao Xinsheng, Cui Lijuan, Lei Yinru, Guo Ziliang, Wang Jinzhi, Li Jing, Zhai Xiajie, Wang Rumiao, Li Wei

“…With the rapid development of urbanization, urban wetlands have been severely damaged by human activities and natural factors, leading to problems such as reduced area and decreased connectivity between wetlands. …”
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Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats by Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

“…STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI.…”
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3D Localization of FRB 20190425A for Its Potential Host Galaxy and Implications by Da-Chun Qiang, Zhi-Qiang You, Sheng Yang, Zong-Hong Zhu, Ting-Wan Chen

“…Recently, due to spatial and temporal proximity, the potential association of GW190425 with FRB 20190425A has drawn attention, leading to the identification of a likely host galaxy, UGC 10667, albeit without confirmed kilonova emissions. …”
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Quantitative characterization of the multiscale mechanical properties of low-permeability sandstone roofs of coal seams based on nanoindentation and triaxial tests and its implicat... by Feng Cao, Jianhua He, Hongxiu Cao, Hucheng Deng, Andrew D. La Croix, Rui Jiang, Ruixue Li, Jiarun Li

“…The macro-mechanical properties of tight sandstone samples are weakened by increased microstructural inhomogeneity and larger grain size. This leads to a higher likelihood of splitting damage, characterized by a high degree of discrete and weak stress sensitivity. …”
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3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma by Mengjie Liu, Xuqiang Liu, Kaiyue He, Yongping Jian, Yujia Li, Jinrong Guo, Jingyu Yang, Zhixiang Xu, Wenyi Kang

“…Application of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP, activation of AMP-activated protein kinase (AMPK), and inhibition of mTOR. …”
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More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration by Sihui Ouyang, Xiong Wu, Li Meng, Xuerui Jing, Liying Qiao, Jia She, Kai Zheng, Xianhua Chen, Fusheng Pan

“…Furthermore, the alloying of Ag accelerated the cathodic reaction of pure Mg, leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion. …”
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Association between JAK2 rs4495487 Polymorphism and Risk of Budd-Chiari Syndrome in China by Peijin Zhang, Yanyan Zhang, Jing Zhang, Hui Wang, He Ma, Wei Wang, Xiuyin Gao, Hao Xu, Zhaojun Lu

“…Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. …”
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Consistency between headache diagnoses and ICHD-3 criteria across different levels of care by Lucas Hendrik Overeem, Marlene Ulrich, Mira Pauline Fitzek, Kristin Sophie Lange, Ja Bin Hong, Uwe Reuter, Bianca Raffaelli

“…Abstract Background Diagnosing headache disorders poses significant challenges, particularly in primary and secondary levels of care (PSLC), potentially leading to misdiagnosis and underdiagnosis. This study evaluates diagnostic agreement for migraine, tension-type headache (TTH), and cluster headache (CH) between PSLC and tertiary care (TLC) and assesses adherence to the International Classification of Headache Disorders 3rd edition (ICHD-3) guidelines. …”
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Valorization of Olive Pruning Residues through Bioconversion into Edible Mushroom Pleurotus ostreatus (Jacq. Ex Fr.) P. Kumm. (1871) of Improved Nutritional Value by Sami Abou Fayssal, Mohammed A. Alsanad, Zeina El Sebaaly, Ahmed I. H. Ismail, Youssef N. Sassine

“…In several Mediterranean countries, olive pruning residues (OLPRs) are abandoned or burned leading to several environmental problems. Valorization of these agrowastes could be a challenge for the primary decomposer Pleurotus ostreatus, turning them into edible biomass. …”
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High-Precision Sub-Wavelength Motion Compensation Technique for 3D Down-Looking Imaging Sonar Based on an Acoustic Calibration System by Jun Wang, Peihui Liang, Junqiang Song, Pan Xu, Yongming Hu, Peng Zhang, Kang Lou, Rongyao Ren, Wusheng Tang

“…Simulation and real data experiments show that the motion compensation method can effectively eliminate the influence of motion error and make the imaging energy more focused, leading to higher-quality acoustic images. Under equal average energy, the maximum superimposed sound intensity values in the imaging results increased by 20.75 dB and 6.57 dB, respectively, for simulation and real data. …”
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Evaluating machine learning models for supernova gravitational wave signal classification by Y Sultan Abylkairov, Matthew C Edwards, Daniil Orel, Ayan Mitra, Bekdaulet Shukirgaliyev, Ernazar Abdikamalov

“…However, normalizing time by the peak signal frequency, which partially compensates for the absence of the time dilation effect in GREP, leads to a notable improvement in accuracy. Despite this, the accuracy does not exceed 70 per cent, suggesting that GREP lacks the precision necessary for EOS classification. …”
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A Video-Based Cognitive Emotion Recognition Method Using an Active Learning Algorithm Based on Complexity and Uncertainty by Hongduo Wu, Dong Zhou, Ziyue Guo, Zicheng Song, Yu Li, Xingzheng Wei, Qidi Zhou

“…However, due to the high cost of marking and training video samples, feature extraction is inefficient and ineffective, which leads to a low accuracy and poor real-time performance. …”
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Global visualization of adolescent idiopathic scoliosis treatment: a bibliometric analysis by Xiaodong Zheng, Xiaodong Zheng, Wenjin Han, Shan Gao, MengLong Jia, LiJun Liu, LiJun Liu, Longtan Yu

“…The United States emerged as the leading contributor among countries, institutions, and authors. …”
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Midlatitude mesosphere and lower thermosphere variations during the extreme gannon geomagnetic storm in May 2024 by Tao Yuan, Tao Yuan, P. D. Pautet, P. D. Pautet, M. J. Taylor, M. J. Taylor

“…The lack of such MLT observations during the presence of aurora leads to a critical gap in the understanding of upper atmospheric dynamics. …”
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An Analysis of Factors Contributing to Cost Overruns in the Global Construction Industry by Ahmed Mohammed Abdelalim, Maram Salem, Mohamed Salem, Manal Al-Adwani, Mohamed Tantawy

“…With the use of this dual analysis, a novel mapping of the main causes of cost overruns was produced, leading to the discovery of seven core factors that significantly affected project outcomes, including planning and scheduling issues, project estimation problems, and design inefficiencies. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…They were efficiently taken up by tumor cells and induced increased production of reactive oxygen species (ROS), leading to tumor cell proliferation inhibition and apoptosis, particularly in the TNBC cell line 4T1. …”
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Urinary glucose detection with spiral shape hollow core photonic crystal fiber: Towards improved diabetes management by Md. Safiul Islam, A.H.M. Iftekharul Ferdous, Md. Jakir Hossen, Abdullah Al Mamun, Khalid Sifulla Noor, Diponkar Kundu, Md. Galib Hasan

“…Currently, diabetes is a prevalent ailment worldwide. Insufficient insulin leads to an inability to transform glucose into energy, resulting in increased amounts of glucose in human body. …”
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