Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons by Breuer Helen, Bell-Simons Michael, Zempel Hans

“…In tauopathies, such as Alzheimer’s disease (AD), TAU sorting, and neuronal polarity are disrupted, leading to MT loss. However, modeling and studying MTs in human neuronal cells relevant to the study of AD and TAU-related neurodegenerative diseases (NDD) is challenging. …”
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Representing unsegmented vessels using available vascular data for bioheat transfer simulation by Rohan Amare, Amir A. Bahadori, Amir A. Bahadori, Steven Eckels, Steven Eckels

“…Due to the dimensional scale of blood vessels, not all vessels are captured in a given voxel resolution, leading to discontinuous blood vessels in the segmentation. …”
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Biomechanical and Biological Multidisciplinary Strategies in the Orthodontic Treatment of Patients with Periodontal Diseases: A Review of the Literature by Gaia Viglianisi, Alessandro Polizzi, Teresa Lombardi, Mariacristina Amato, Cristina Grippaudo, Gaetano Isola

“…By integrating periodontal considerations into orthodontic treatment planning and execution, clinicians can ensure straight teeth and a healthy and stable periodontium, ultimately leading to successful treatment outcomes and long-term oral health.…”
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Defect engineering and alloying strategies for tailoring thermoelectric behavior in GeTe and its alloys by Qiyong Chen, Cheng Yang, Tong Xing, Jinyang Xi, Wenqing Zhang, Jiong Yang, Lili Xi

“…However, GeTe is prone to producing Ge vacancies, leading to high p-type carrier concentration, which results in elevated electronic thermal conductivity and a low Seebeck coefficient. …”
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The Study of Cost-Effectiveness of Rivaroxaban versus Warfarin in Patients with Atrial Fibrillation Who Developed Ischemic Stroke by Neda Jaberi, Zahra Kavosi, Etrat Hooshmandi, Nasrin Moradi, Khosro Keshavarz, Afshin Borhani-Haghighi

“…This economic evaluation study was conducted among 144 selected nonrandomly patients who were treated with rivaroxaban or warfarin and suffered from AF leading to stroke, in the stroke ward of Shiraz Nemazee Hospital in 2019. …”
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Innovative trend analysis of precipitation changes over Nigeria: A case study of locations across the Niger and Benue Rivers by Emmanuel P. Agbo, Golden C. Offorson, Abubakar S. Yusuf, John O. Bassey, Moses A. Okono, Ugochukwu Nkajoe, Patrick O. Ushie

“…Studies have presented correlative relationships between climate change and the existing alterations in the global water cycle, leading to more extreme precipitation events, including both droughts and floods. …”
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Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 by M. Bastard, D. Falzon, S. Bertagnolio, R. Silva, S.S. Thwin, C. Siquiera Boccolini, J. Rylance, J. Diaz, M. Zignol

“…BACKGROUND: TB is a leading infectious cause of death worldwide. The COVID-19 pandemic raised concerns that the burden of TB disease and death would increase due to the synergy between the two conditions. …”
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Cobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells by Peng-Hsiang Fang, Tzu-Yu Lin, Chiu-Chen Huang, Yung-Chang Lin, Cheng-Hung Lai, Bill Cheng

“…Diabetic retinopathy is characterized by hyperglycemic retinal pigment epithelial cells that secrete excessive pro-inflammatory cytokines and VEGF, leading to retinal damage and vision loss. Cobalt protoporphyrin (CoPP) is a compound that can reduce inflammatory responses by inducing high levels of HO-1. …”
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Effect of Glucosamine and Ascorbic Acid Addition on Beef Burger Textural and Sensory Attributes by Philip Soladoye, Yuliya Hrynets, Mirko Betti, Zeb Pietrasik

“…However, level of GlcN above 1.5% resulted in significant flavour and textural deterioration (p<0.05), leading to decline in consumer acceptability of beef burger. …”
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Investigating skyrmion stability and core polarity reversal in NdMn2Ge2 by Samuel K. Treves, Victor Ukleev, Andreas Apseros, Jamie Robert Massey, Kai Wagner, Paul Lehmann, Aki Kitaori, Naoya Kanazawa, Jeffrey A. Brock, Simone Finizio, Joakim Reuteler, Yoshinori Tokura, Patrick Maletinsky, Valerio Scagnoli

“…Its inclusion in the simulation leads to a reversal of the skyrmionic object core polarity, which is not experimentally observed. …”
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Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, A. A. Sheptulin, I. V. Mayev, Ye. K. Baranskaya, A. S. Trukhmanov, T. L. Lapina, S. G. Burkov, A. V. Kalinin, A. V. Tkachev

“…Helicobacter pylori infection has a leading role as PUD ethological factor. None H. pylori-associated gastroduodenal ulcers may be caused by NSAID intake or may develop within the other nosological entities (symptomatic stomach and duodenal ulcers). …”
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DSIA U-Net: deep shallow interaction with attention mechanism UNet for remote sensing satellite images by Naga Surekha Jonnala, Renuka Chowdary Bheemana, Krishna Prakash, Shonak Bansal, Arpit Jain, Vaibhav Pandey, Mohammad Rashed Iqbal Faruque, K. S. Al-mugren

“…However, due to limitations in computational resources and the complexity of network architectures, many sophisticated semantic segmentation models struggle with efficiency in real-world applications, leading to an interest in developing lightweight model like borders. …”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“… Introduction Ovarian cancer is a leading cause of cancer mortality globally due to late-stage diagnosis and limited treatment options. …”
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Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles by Chutima Chaiwut, Sarin Tadtong, Puriputt Akachaipaibul, Jutamas Jiaranaikulwanitch, Sudarshan Singh, Siriporn Okonogi, Dwi Marlina Syukri, Chuda Chittasupho

“…Fungal keratitis is a severe ocular infection caused by pathogenic fungi, leading to potential vision loss if untreated. Current antifungal treatments face limitations such as low solubility, poor corneal penetration, and limited therapeutic options. …”
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Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction by Tianhui Chen, Zhongxing Chen, Juan Du, Min Zhang, Zexu Chen, Qingyi Gao, Aodong Chen, Qinghao Meng, Yang Sun, Yan liu, Linghao Song, Xinyue Wang, Pranav Prakash Edavi, Chen Xu, Hongmei Zhang, Jinhai Huang, Yongxiang Jiang

“…Cataract surgery is the only treatment method for EL, but it leads to the loss of accommodative power of the lens post-operatively. …”
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Dias-Logan syndrome with a p.Leu360Profs*212 heterozygous pathogenic variant of in a Chinese patient: A case report by Yizhuo Shu, Xiaoling Chen, Zhuoqun Wei, Chunyue Chen

“…We report an 8-year-old Han Chinese male patient with Dias-Logan syndrome who carries a de novo heterozygous pathogenic variant, c.1078dupC (p.Leu360Profs*212), in the BCL11A gene, leading to ID and γ-globin suppression, identified through trio-based whole exome sequencing (trio-WES). …”
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Left Gastric Vein Direct Anastomosis as Alternative to Portal Flow Reconstruction in Liver Transplantation by Raquel Lima Sampaio, MD, Gustavo Rego Coelho, MD, PhD, Denissa Ferreira Gomes Mesquita, MD, Carlos Eduardo Lopes Soares, BM, José Huygens Parente Garcia, MD, PhD

“…The most relevant limiting factor for performing end-to-end anastomosis is portal vein thrombosis (PVT), which leads to challenging vascular reconstructions. This study aimed to analyze a single center’s experience using the left gastric vein (LGV) for portal flow reconstruction in liver transplantation (LT). …”
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Phenomenon and Critical Conditions of Chamber Soil Sliming during EPB Shield Tunneling in Water-Rich Weathered Diorite: Case Study of Jinan Metro, China by Lu Wang, Wei Zhu, Yongjin Qian, Chao Xu, Jiannan Hu, Huitang Xing

“…A large amount of water seepage from the stratum around the tunnel excavation surface and shield to the chamber is a significant factor leading to chamber soil sliming during the construction process. …”
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Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs by Bryan Tegner Jacobson, Jessica DeWit-Dibbert, LaShae Zanca, Sobha Sonar, Carol Hardy, Michael Throolin, Patricia C. Brewster, Kaitlyn Andujo, Kerri Jones, Jonathon Sago, Stephen Smith, Lizabeth Bowen, Diane Bimczok

“…In summary, our study suggests that bypassing protective mechanisms of the URT by delivering respiratory pathogens to the LRT leads to more severe respiratory disease and lung damage than delivery to the URT.…”
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Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng

“…These new secondary metabolites with novel structures and potent bioactivities will continue to guide the separation or synthesis of structurally novel and biologically active compounds and will offer leading compounds for the development and innovation of pharmaceuticals and pesticides.…”
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