Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…The resulting constitutive activation of the FGFR2 signaling causes the premature osteogenic differentiation of calvarial mesenchymal stromal cells in skull sutures, leading to early suture ossification. Craniectomy is the gold standard treatment, being invasive and burdened by complications. …”
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Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion by Lili Yang, Weili Lin, Colleen A. Nugent, Shijun Hao, Haiyan Song, Tao Liu, Peiyong Zheng

“…Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver transplantation. Lingguizhugan decoction (LGZG), a classical Chinese herbal formula, has beneficial effects on NAFLD animal models. …”
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Abnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility by Shengqin Zang, Shuqi Zou, Xiangyi Chen, Bo Pan, Ao Ning, Jianpeng Qin, Yaozong Wei, Kunlin Du, Jiangfeng Ye, Qiuxia Liang, Yi Fang, Qiongla, Cirenlamu, Tianzeng Song, Tianzeng Song, Guangbin Zhou

“…The results revealed that goat sperm exhibited mitochondrial vacuolization, reduced matrix density, and significantly decreased levels of high-membrane potential mitochondria and adenosine triphosphate content, accompanied by a substantial increase in reactive oxygen species levels, ultimately leading to a significant decline in sperm viability. …”
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Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100 by Maghraby Gamal Mohamed El, Elzayat Ehab Mostafa, Alanazi Fars Kaed

“…However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in situ gelling alginate formulations capable of sustaining dextromethorphan release throughout the gastrointestinal tract. …”
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The Health Impacts of Air Pollution in the Context of Changing Climate in Africa: A Narrative Review with Recommendations for Action by Lynn M Atuyambe, Raphael E Arku, Natasha Naidoo, Thandi Kapwata, Kwaku Poku Asante, Guéladio Cissé, Belay Simane, Caradee Y Wright, Kiros Berhane

“…Introduction: Despite the broad improvement in air quality, air pollution remains a major leading global risk factor for ill health and deaths each year. …”
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The moderating effect of psychological capital on the relationship between nurses’ perceived workplace bullying and emotional exhaustion: a cross-sectional study by Xiao Peng, Jing Ma, Ying Chen, Ying Han, Hong Zhou, Aiping Gong, Fang Peng, Xinzhang Sun, Xingfen Wang, Xunya Xiong, Li Li, Mengting Huang, Qingsong Zeng

“…Abstract Background Workplace bullying (WPB) is common in nursing profession, leading to adverse effects on nurses’ health and teamwork. …”
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Implementing a closed loop clinical decision support system for sustainable preoperative care by José Luis Gracia Martínez, Bernadette Pfang, Miguel Ángel Morales Coca, Cristina Caramés Sánchez, Marta del Olmo Rodríguez, Marco Antonio Villegas García, Jorge Short Apellaniz, Javier Arcos Campillo, Juan Antonio Álvaro de la Parra, Florencia Manzano Lorefice, Luis Enrique Muñoz Alameda

“…We observed a significant reduction (p < 0.001) of 83% (−83.4% to −83.1%) for chest X-ray orders, 54% (−54.7% to −54.2%) for ECG orders, 50% for blood type testing (−50.5% to −50.1%), and 29% (−29.5% to −29.0%) for preoperative blood test order sets, leading to overall cost-savings of €1,013,666. No increase in postoperative adverse events or same-day cancellations was observed. …”
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Irritable Bowel Syndrome: Gut Microbiota Dysbiosis and Psychological Co-morbidities by Bijita Bhowmick, Sharmistha Banerjee, Sanchaita Gayen, Supriya Samanta, Nilotpal Banerjee

“…The broader consequences of IBS extend beyond individual health, leading to considerable impairment in daily functioning, reduced workplace efficiency and diminished Quality of Life (QoL). …”
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The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation by Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

“…ARHGEF7, also known as ß-PIX, is a guanine nucleotide exchange factor for Rac1 and Cdc42, thereby activating Rac1/Cdc42 and the downstream pathway, leading to the upregulation of spine formation/maintenance. …”
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Numerical Evaluation of Thermal Comfort and Indoor Air Quality in an Office Space Equipped with a Radiant Ceiling Cooling System and Hybrid Radiative-Convective Cooling System by Mohammad Amini, Asgar Minaei, Negin Moallemi Khiavi

“…Also, a hybrid radiative-convective cooling system leads to higher indoor air quality than a radiant ceiling cooling system.…”
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Targeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines by Sanchari Paul, Mustafa Kaya, Olivia Johnsson, Hanna Grauers Wiktorin, Andreas Törnell, Mohammad Arabpour, Kristoffer Hellstrand, Anna Martner

“…Both mucosal (intranasal) and systemic (intraperitoneal) vaccine administration provided effective protection against intravenously injected tumor cells, with intranasal administration leading to superior induction of CD4+ T cells at metastatic sites. …”
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Role of transforming growth factor-β1 in regulating adipocyte progenitors by Nguyen Quynh Phuong, Muhammad Bilal, Allah Nawaz, Le Duc Anh, Memoona, Muhammad Rahil Aslam, Sana Khalid, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Keisuke Okabe, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Shiho Fujisaka, Ryuji Hayashi, Kazuyuki Tobe

“…The Tgf-β1 gene, specifically from CD206+ M2-like macrophages, deletion stimulated APs’ proliferation and differentiation, leading to the generation of smaller mature adipocytes, therefore enhancing insulin sensitivity and improving glucose metabolism under normal chow conditions. …”
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Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma by Rina Nulianti, Hartanto Bayuaji, Mulyanusa Amarullah Ritonga, Tono Djuwantono, Dian Tjahyadi, Anita Rachmawati, Sri Ratna Dwiningsih, Aisyah Shofiatun Nisa, Putri Nadhira Adinda Adriansyah

“…This disruption can trigger oxidative injury and an inflammatory response, leading to ferroptosis, particularly in the endometrioma phenotype. …”
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Linear-Rotary Position Control System With Enhanced Disturbance Rejection for a Novel Total Artificial Heart by Rosario V. Giuffrida, Andreas Horat, Dominik Bortis, Tim Bierewirtz, Krishnaraj Narayanaswamy, Marcus Granegger, Johann W. Kolar

“…The machine design of the Permanent Magnet Synchronous Machine (PMSM)-based linear-rotary actuator was conducted in previous work of the authors, leading to the construction of a hardware prototype satisfying the application requirements in terms of electromechanical force, torque, power losses, and volume. …”
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D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier by Xuejiao Zhang, Ang Li, Yuanyifei Wang, Jin Wang, Bowei Zhang, Yan Zhang, Jingmin Liu, Shuo Wang

“…Collectively, the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs, which leads to the damage of the mucosal barrier and the intensification of inflammatory invasion.…”
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Modelling mixed crop-livestock systems and climate impact assessment in sub-Saharan Africa by Amit Kumar Srivastava, Jaber Rahimi, Karam Alsafadi, Murilo Vianna, Andreas Enders, Wenzhi Zheng, Alparslan Demircan, Mame Diarra Bousso Dieng, Seyni Salack, Babacar Faye, Manmeet Singh, Krishnagopal Halder, Frank Ewert, Thomas Gaiser

“…The results demonstrate that in the future, the northern part of the study area will likely experience a significant decline in crop biomass (up to -56%) and grass biomass (up to -57%) production leading to a decrease in livestock numbers (up to -43%). …”
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Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…CD95 is one of the best studied members of the death receptor family. Activation of CD95 leads to the induction of the cell death programme, apoptosis, via formation of the death-inducing signaling complex (DISC). …”
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Evaluation of parabolic shaped solar dryer (PSSD) for drying of tomatoes under semi-arid climate zone by Jude Joel, Abba Kaka Alkali, Bala Ibrahim, Abubakar Ahmad Adamu, Fatima Jamu Babba, Oshadumo Dayo

“…The result showed that Parabolic Shaped Solar Dryer recorded a maximum temperature of 68.2 °C, and a drying rate of 5.2 kg/day leading to a moisture content of 14.5% within the 6 days drying period. …”
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Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling by Lu Wang, Fangzheng Hu, Qianqian Cui, Huarui Qiao, Lingyun Li, Tengjie Geng, Yuying Li, Zengchao Sun, Siyu Zhou, Zhongyun Lan, Shaojue Guo, Ying Hu, Jiqiu Wang, Qilun Yang, Zenan Wang, Yuanyuan Dai, Yong Geng

“…Our findings unveil how LGR4 content mediates diverse assemblies, leading to conformational rearrangements in ZNRF3 to regulate WNT/β-catenin signaling, and provide a structural foundation for drug development targeting Wnt-driven cancers.…”
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In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition by Priscila Goes Camargo, Helena Tiemi Suzukawa, Patrícia Morais Lopes Pereira, Mariana Luiza Silva, Fernando Macedo Jr, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Sueli Fumie Yamada-Ogatta, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo

“…THD3 and THD5 were found to have strong interactions within the hydrophobic channel of CYP51 due to their aliphatic side chains, leading to favorable binding free energies. Despite the possibility of cross-reactivity between THD5 and human CYP2C9, the results indicate low identity and similarity between the homolog enzymes and possible selectivity of THD5 for the protozoan one, suggesting that these compounds could inhibit sterol biosynthesis, crucial for the parasite’s survival​. …”
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