Mitigating antimicrobial resistance through effective hospital wastewater management in low- and middle-income countries by Yaovi Mahuton Gildas Hounmanou, Yaovi Mahuton Gildas Hounmanou, Adonias Houefonde, I-CRECT Consortium, Tram Thuy Nguyen, Anders Dalsgaard, Linh Viet Nguyen, Tung Xuan Nguyen, Troung Nhat My, Lan Thi Le, Huyen Thi Vu, Ngoc Thi Bich Hoang, Dien M. Tran, Thi Anh Mai Pham, Phuc D. Pham, Dennis Nurjadi, Flavie Goutard, Thirumalaisamy P. Velavan, Van Anh Thi Dinh, Bent Jörgensen, Le Huu Song, Nhung T.T. Nguyen, Etienne Loire, Åse Östholm, Lennart E. Nilsson, Tuyet Hanh T. Tran, Phuc H. Phan, Mattias Larsson, Linus Olson, Håkan Hanberger

“…This threat is of particular concern in low- and middle-income countries (LMICs), where untreated effluents are often used for irrigating vegetables crops, leading to direct and indirect human exposure. Despite being a potential hotspot for the spread of antimicrobial resistance (AMR), existing HWW treatment systems in LMICs primarily target conventional pollutants and lack effective standards for monitoring the removal of ARB and ARGs. …”
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C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability by Santhosh Kumar Nagarajan, Joy Weber, Daniel Roderer, Jörg Piontek

“…The pore-forming Clostridium perfringens enterotoxin (CPE), a common cause of foodborne diseases, facilitates Ca2+ influx in enterocytes, leading to cell damage. Upon binding to certain claudins (e.g., claudin-4), CPE forms oligomeric pores in the cell membrane. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…In approximately a quarter of PIPs, there was disagreement on the outcome of the WoE analysis leading to the addition (3%), modification (10%), or removal (11%) of JAS. …”
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Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway by Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

“…Abstract Atherosclerosis, a chronic inflammatory condition characterized by plaque formation, often leads to instability, particularly under Type 2 diabetes mellitus (T2DM) conditions, which exacerbate cardiovascular risks. …”
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Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia by Franziska Eisenhuth, Joy E. Agbonze, Adam M. R. Groh, Jesse M. Klostranec, David A. Rudko, Jo Anne Stratton, Adam J. Shapiro

“…Rodent models of PCD exhibit marked hydrocephalus leading to early animal mortality, however, most humans with PCD do not develop hydrocephalus for unknown reasons. …”
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Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3 by Yiting Zhang, Chao Li, Siyi Li, Yiping Lu, Sitong Du, Xinning Zeng, Xi Chen, Jie Chen

“…Occupational exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response that eventually leads to abnormal tissue repair, disability, and death. …”
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Genetic analysis of Pinna rudis L 1758 (Mollusca, Bivalvia, Pinnidae) in the Northwest Cabo Verde Islands (Central-East Atlantic) by Evandro P. Lopes, Sarah Santos, Raquel Xavier, Joana L. Santos, M. Pilar Cabezas, Fernando Sequeira, António M. Santos

“…Habitat degradation is considered the primary cause of population decline, leading to the designation ‘Vulnerable’ in certain regions. …”
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Integrating multi-source monitoring data and deep convolutional autoencoder technology for slope failure pattern recognition by Nana Han, Nana Han, Wending Miao, Mingzhi Li, Mohd Ashraf Mohamad Ismail, Qiang Hu, Liyuan Duan, Liyuan Duan, Jintao Tang

“…The trained model is then utilized for structural anomaly detection by leveraging the characteristic that reconstruction errors for failure mode samples are significantly higher than for normal samples.ResultsA case study was conducted on a specific slope where, on 24 May 2024, the displacement development rate in some areas increased significantly, ultimately leading to collapse. The proposed model accurately identified the time and evolution of the landslide, demonstrating its capability to detect failure events effectively.DiscussionValidation results confirm that the model can effectively distinguish previously unseen abnormal modes, offering significant practical value for identifying similar structural anomalies. …”
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The Physics Case for an Electron-Muon Collider by Meng Lu, Andrew Michael Levin, Congqiao Li, Antonios Agapitos, Qiang Li, Fanqiang Meng, Sitian Qian, Jie Xiao, Tianyi Yang

“…The collision of an electron and muon beam leads to less physics background compared with either an electron-electron or a muon-muon collider, since electron-muon interactions proceed mostly through higher-order vector boson fusion and vector boson scattering processes. …”
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Towards Privacy-Aware and Trustworthy Data Sharing Using Blockchain for Edge Intelligence by Youyang Qu, Lichuan Ma, Wenjie Ye, Xuemeng Zhai, Shui Yu, Yunfeng Li, David Smith

“…Furthermore, adversaries launch poisoning attacks to falsify the health data, which leads to misdiagnosing or even physical damage. To protect private health data, we propose a personalized differential privacy model based on the trust levels among users. …”
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METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis by Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan

“…METTL16 depletion results in a significantly upregulated transcriptome on sex chromosomes in pachytene spermatocytes and leads to reduced DSB formation and recombination, and increased SYCP1 depositioin during the first wave of spermatogenesis. …”
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Einasto Profile as the Halo Model Solution Coupled to the Depletion Radius by Yifeng Zhou, Jiaxin Han

“…In the halo model framework, the matter distribution in the Universe can be decomposed into the spatial distribution of halos convolved with their internal structures. This leads to a set of linear equations in Fourier space that uniquely determines the matching halo profiles for any given halo catalog. …”
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Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…Aim: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, and there is a pressing need to explore novel therapeutic strategies that enhance the efficacy of existing treatments. …”
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Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway by Jun Zhang, Xing Zhu, Yong Li, Yinyu Wu, Yunxia Du, Hai Yang, Zhengchao Liu, Haoyu Pei, Rui Li, Huan Luo, Deyu Zuo, Han She, Qingxiang Mao

“…Abstract Background Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial in the development of sepsis-induced coagulopathy (SIC). …”
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ZooCNN: A Zero-Order Optimized Convolutional Neural Network for Pneumonia Classification Using Chest Radiographs by Saravana Kumar Ganesan, Parthasarathy Velusamy, Santhosh Rajendran, Ranjithkumar Sakthivel, Manikandan Bose, Baskaran Stephen Inbaraj

“…Pneumonia, a leading cause of mortality in children under five, is usually diagnosed through chest X-ray (CXR) images due to its efficiency and cost-effectiveness. …”
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Semiclassical Estimates of Pressure-induced Line Widths for Infrared Absorption in Hot (Exo)planetary Atmospheres by Jeanna Buldyreva, Kathleen Stehlin, Sergei N. Yurchenko, Elizabeth R. Guest, Jonathan Tennyson

“…Only the index related to the leading long-range interaction term, molecular masses and kinetic diameters, as well as temperature are used as input parameters. …”
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Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment by Franca Marino, Luigina Guasti, Matteo Tozzi, Laura Schembri, Luana Castiglioni, Elisabetta Molteni, Gabriele Piffaretti, Patrizio Castelli, Marco Cosentino

“…Atherosclerosis is an inflammatory disease characterized by immunological activity, in which endothelial dysfunction represents an early event leading to subsequent inflammatory vascular damage. …”
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Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation... by Jian Liu, Peiyong Wang, Lan He, Yuquan Li, Jinwen Luo, Lihong Cheng, Qianhong Qin, Lawrence A. Brako, Woo-kuen Lo, William Lewis, Qinglin Yang

“…However, previous studies demonstrated that cardiomyocyte-restricted PPARβ/δ deficiency in mice leads to severe cardiac pathological development, whereas global PPARα knockout shows a benign cardiac phenotype. …”
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Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease by Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han, Zhentao Zhang, Zhaohui Zhang, Yingjie Zhu, Zuxin Chen, Xifei Yang, Keqiang Ye

“…Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY‐box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6+/ALDH1A1+) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT‐rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT‐rich DNA sequences, and toxic dopamine metabolite accumulation. …”
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Optimization of Well Patterns in Offshore Low-Permeability Thin Interbedded Reservoirs: A Numerical Simulation Study in the Bozhong Oilfield, China by Guangai Wu, Yingwen Ma, Yanfeng Cao, Anshun Zhang, Wei Liu, Jinghe Wang, Xinyi Yang

“…Furthermore, offshore low-permeability reservoirs often have sparse well placement and wide well spacing, in contrast to onshore low-permeability fields, which leads to low recovery. Additionally, there is a lack of comprehensive theory on optimizing the well patterns and fracture networks to maximize net income, highlighting the need for further research. …”
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