Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration by Guido Carpino, Anastasia Renzi, Antonio Franchitto, Vincenzo Cardinale, Paolo Onori, Lola Reid, Domenico Alvaro, Eugenio Gaudio

“…Stem/progenitor niches have important implications in regenerative medicine for the liver and biliary tree and in pathogenic processes leading to diseases of these tissues.…”
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Optimal WSN Deployment to Measure Air Quality in Dynamic Multi-Source Dispersion Scenarios: A Case Study in Arequipa by Alexander Hilario-Tacuri, Alberth Tamo, Marco Pinares-Mamani, Walter Butron, Romel Jimenez

“…According to the World Health Organization, air pollution causes approximately 7 million premature deaths each year, with 99% of the global population exposed to air that fails to meet recommended quality standards. Poor air quality leads to severe health issues, including respiratory and cardiovascular diseases. …”
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Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells by Shinan Li, Shinan Li, Dhiraj Kumar Sah, Archana Arjunan, Mohamed Yazeer Ameer, Bora Lee, Young-Do Jung

“…In this study, we showed that Triptolid inhibits ROS/ERK-mediated AP-1 and ROS-mediated NF-κB axes potentially leading to an improved treatment outcome for gastric cancer and its associated tumor microenvironment.…”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…Further in vivo and in vitro pharmacokinetic analyses reveal that obese db/db mice exhibited a diminished capacity to metabolize BBR in their livers. This reduction leads to prolonged retention of BBR, subsequently resulting in chronic and sustained hepatic PPARγ agonism. …”
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Development and validation of a new reverse-phase high-performance liquid chromatography (RP-HPLC) method for the quantifications of tolperisone loaded in liposomes by Rawan N. AlKaraki, Rula R. Haddadin, Shahed K. Tarawneh, Marwa A.M. Alimari, Rehan M. Alkasasbeh, Tebat Al-ferdous E. Shamaileh, Mustafa S. Almohtaseb, Malek G. Hajaya

“…Tolperisone (TOL) is a muscle relaxant that tends to undergo uncontrollable degradation in the intestinal medium, leading to low oral bioavailability and the generation of genotoxic degradants. …”
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Implementing E-MOTIVE for detection and treatment of postpartum haemorrhage in South Africa by M Singata-Madliki, S Fawcus, N Moran, E Arends, E Muller, S Mandondo, G J Hofmeyr

“… Postpartum haemorrhage is the leading cause of preventable maternal mortality in South Africa. …”
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Reduction behavior of Tin-containing phase in Tin-bearing iron concentrates under CO-CO2 mixed gases by Yu Y., Li H.-J., Li L.

“…The kinetic study shows that activation energy of the reaction SnO2(s)+CO(g)=Sn(l)+ CO2(g) is 144.75 kJ/mol at 1073-1223 K, being far lower than the one in the reduction of SnO2(s) into SnO(g) at 1273-1323 K, which leads to a conclusion that the tin in tin-bearing iron concentrates could be removed effectively after the Sn(l) sulfurated into SnS at relatively lower temperatures (1073-1223 K) using the sulfidation roasting method.…”
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Ruthenium(II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy by Yue Zheng, Wen‐Jin Wang, Jing‐Xin Chen, Kun Peng, Xiao‐Xiao Chen, Qing‐Hua Shen, Bing‐Bing Liang, Zong‐Wan Mao, Cai‐Ping Tan

“…Meanwhile, the peroxidation of polyunsaturated lipids occurs due to the deactivation of glutathione peroxidase 4 (GPX4) and the overexpression of acyl‐CoA synthetase long‐chain family member 4 (ACSL4), leading to the immunogenic ferroptosis. Ultimately, both innate and adaptive immunity are invigorated, indicating the tremendous antitumor capability of Ru‐LipM in vivo. …”
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Controlling the formation of microstructure at the melt-pool boundaries during directed energy deposition of aluminum alloy with a modified continuous growth restriction factor by Shanshan Xu, Bo Yin, Jiale Wang, Liquan Jin, Yu Yin, Zhenhua Li, David H. StJohn, Petro Pavlenko, Yueling Guo

“…However, existing analytical models fail to consider internal and external factors, particularly the solute concentration and scan speed, leading to low prediction accuracy of the solidified microstructure. …”
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Exploring the potentialities and challenges of deep learning for simulation and prediction of urban sprawl features by Ange Gabriel Belinga, Stéphane Cedric Tékouabou Koumetio, Mohamed El Haziti

“…Rapid urbanization poses several challenges, especially when faced with an uncontrolled urban development plan. Therefore, it often leads to anarchic occupation and expansion of cities, resulting in the phenomenon of urban sprawl (US). …”
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Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice by Mina Zhang, Bo Lian, Rui Zhang, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Xuerui Wang, Qingquan Liu, Xiaolong Xu

“…Sepsis-induced inflammatory response leads to intestinal damage and secondary bacterial translocation, causing systemic infections and eventually death. …”
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…The subsequent release of 2-DG inhibits glycolysis and adenosine triphosphate (ATP) production, ultimately leading to secondary GSH consumption. This nanodrug combines dual GSH depletion, starvation therapy, and RT to promote immunogenic cell death and stimulate the systemic immune response. …”
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Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression by Sofiia Melnyk, Marc Stierhof, Dmytro Bratiichuk, Franziska Fries, Rolf Müller, Yuriy Rebets, Andriy Luzhetskyy, Bohdan Ostash

“…The organization of lim BGC, data on the structures of revealed metabolites as well as manipulations of lim genes allowed us to put forward an initial hypothesis about a biosynthetic pathway leading to LIM. We provide initial data on two LIM derivatives as well as updated NMR spectra for the main product. …”
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Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila by Miaomiao Pan, Chenglang Qian, Shaoye Huo, Yuchen Wu, Xinyi Zhao, Yueming Ying, Boyu Wang, Hao Yang, Anaguli Yeerken, Tongyao Wang, Mengwei Fu, Lihong Wang, Yuhuan Wei, Yunhua Zhao, Chunhai Shao, Huijing Wang, Chao Zhao

“…Taken together, these findings suggest that enteric lactate and A. muciniphila collaboratively restore the imbalance in tryptophan metabolism, leading to increased 5-HT activity and alleviating anxiety phenotypes. …”
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The follow-up of patients with celiac disease by Marco Di Tola, Hetty J. Bontkes, Juan Irure-Ventura, Marcos López-Hoyos, Nicola Bizzaro

“…Celiac disease (CD) is a very common immune-mediated enteropathy resulting from the interaction between dietary gluten and the immune system in genetically predisposed individuals. The immune response leads to intestinal damage, malabsorption and, ultimately, to a broad spectrum of both intestinal and extra-intestinal symptoms. …”
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Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps by Venera Cristina Dinescu, Liviu Martin, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Marius Bunescu, Mihai Andrei Ruscu, Madalina Aldea, Alexandra Daniela Rotaru-Zavaleanu

“…Carpal Tunnel Syndrome (CTS) is a prevalent neuropathic disorder caused by chronic compression of the median nerve, leading to sensory and motor impairments. Conventional treatments, such as corticosteroid injections, wrist splinting, and surgical decompression, often fail to provide adequate outcomes for chronic or recurrent cases, emphasizing the need for innovative therapies. …”
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Constructing the biomolecular networks associated with diabetic nephropathy and dissecting the effects of biomolecule variation underlying pathogenesis by Zi-Han Wang, Qi Dong, Qian Yan, Wan-Rong Yu, Dan-Dan Zhang, Ran Yi

“…Complication of DN (CDN) ranks as the second leading cause of end-stage renal disease globally. …”
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Melting ternary hybrid nanofluid stagnation point flow with velocity slip past a stretching/shrinking sheet: Numerical simulation and validation via P2SATRA by Nur Syahirah Wahid, Nur Ezlin Zamri, Siti Zulaikha Mohd Jamaludin, Nur Hazirah Adilla Norzawary, Mohd Shareduwan Mohd Kasihmuddin, Mohd. Asyraf Mansor, Norihan Md Arifin, Ioan Pop

“…Reducing the melting parameter and second-order velocity slip may expand the solution range, leading to a delay in boundary layer separation. The stable numerical solution for the heat transfer rate is then validated with the use of a logic mining model namely Permutation 2 Satisfiability Reverse Analysis (P2SATRA). …”
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Explainable AI-Based Approach for Age-Related Macular Degeneration (AMD) Detection via Fundus Imaging by Ainhoa Osa-Sanchez, Hossam Magdy Balaha, Ali Mahmoud, Ashraf Sewelam, Mohammed Ghazal, Begonya Garcia-Zapirain, Ayman El-Baz

“…Age-related macular degeneration (AMD) is a leading cause of vision loss in older people and is characterized by subtle retinal changes that make early identification difficult. …”
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Transmission of HIV and HCV within Former Soviet Union Countries by Lazzat Aibekova, Aizada Bexeitova, Arailym Aldabergenova, Gonzalo Hortelano, Zhangwen Ge, Feng Yi, Yiming Shao, Jack DeHovitz, Sten H. Vermund, Syed Ali

“…In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. …”
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