Polymer Design of Microwell Hydrogels Influences Epithelial–Mesenchymal Interactions During Human Bronchosphere Formation by Madeline K. Eiken, Justin E. Levine, Shinyeong Lee, Samantha Lukpat, Eleanor M. Plaster, Vikram Bala, Jason R. Spence, Claudia Loebel

“…., bronchial, tracheal) cells, require three‐dimensional (3D) Matrigel, a complex mouse tumor‐derived matrix that typically leads to heterogeneous size and structures. Synthetic and naturally derived polymeric hydrogels show increased opportunities as an alternative to Matrigel culture. …”
Get full text

Ultrasound pretreatment and solvent extraction parameters effects on the nutritional characteristics of Indonesian shortfin eel (Anguilla bicolor bicolor) protein concentrate by Andri Cahyo Kumoro, Dyah Hesti Wardhani, Tutuk Djoko Kusworo, Mohamad Djaeni, Yusuf Ma'rifat Fajar Azis, Misbahudin Alhanif, Tan Chin Ping

“…The protein content of EPC increased gradually with the increase of SSFR until it reached a ratio of 6:1, further increase in SSFR promoted the development of a pseudo-homogeneous system, leading to a reduction in the solvent-eel flesh contact and the relative velocity between the extracting solvent and eel flesh, and consequently decreased the extraction yield. …”
Get full text

Enhancing drug discovery and patient care through advanced analytics with the power of NLP and machine learning in pharmaceutical data interpretation by Nagalakshmi R, Surbhi Bhatia Khan, Ananthoju Vijay kumar, Mahesh T R, Mohammad Alojail, Saurabh Raj Sangwan, Mo Saraee

“…Comprehensive analysis demonstrates the scalability and adaptability of these technologies in real-world healthcare settings, potentially leading to substantial improvements in patient outcomes and operational efficiencies within the healthcare system.…”
Get full text

Influence of surface roughness of thermal barrier coating on the cooling performance of a film-cooled turbine vane by Xiaoyu Song, Feng Liu, Yan Yan, Wen Wang, Yaning Wang, Wei Sun, Jiahuan Cui

“…Results indicate a notable enhancement in vane film cooling efficiency, particularly in proximity to the leading edge (LE), owing to the presence of TBC. As TBC surface roughness increases, heat transfer coefficients on the suction side (SS) and pressure side (PS) near the trailing edge (TE) generally rise, diminishing both cooling and TBC effectiveness. …”
Get full text

Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Treatment of cancer cell lines with the Disarib derivatives, DSR 43 and 4-OCH3 led to the activation of the apoptotic pathway without generating any ROS or disrupting the mitochondrial membrane potential within the cells, leading to cell death. Western blot analysis in tandem with Annexin V/PI staining confirmed the activation of apoptosis. …”
Get full text

Enhancing helmet pressure sensing with advanced 3D printed gyroid architectures by Chao Bao, Danielle Jaye Agron, Taeil Kim, Chris Vattathichirayi, Edwin L. Thomas, Woo Soo Kim

“…Existing simulation models often overlook the complexities of the 3D printing process, leading to discrepancies between isotropic models and empirical data. …”
Get full text

A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging by Zheyi Dong, Xiaofei Wang, Sai Pan, Taohan Weng, Xiaoniao Chen, Shuangshuang Jiang, Ying Li, Zonghua Wang, Xueying Cao, Qian Wang, Pu Chen, Lai Jiang, Guangyan Cai, Li Zhang, Yong Wang, Jinkui Yang, Yani He, Hongli Lin, Jie Wu, Li Tang, Jianhui Zhou, Shengxi Li, Zhaohui Li, Yibing Fu, Xinyue Yu, Yanqiu Geng, Yingjie Zhang, Liqiang Wang, Mai Xu, Xiangmei Chen

“…Abstract Differentiating between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) without a kidney biopsy remains a major challenge, often leading to missed opportunities for targeted treatments that could greatly improve NDRD outcomes. …”
Get full text

IMPROVEMENT OF OIL PRODUCTION BY MATRIX ACIDIZING OF A WELL IN SANDSTONE RESERVOIR by Darel Sontia Fouazong, Isidore Komofor Ngongiah, André Chéagé Chamgoué, Alain Francis Talla, Jean Jacques Dikongue Jemea

“…The acid treatment successfully dissolved the fine particles, leading to an increased oil flow rate of 1006 barrels per day. …”
Get full text

Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family by Virginia J. Savin, Mukut Sharma, Jianping Zhou, David Gennochi, Timothy Fields, Ram Sharma, Ellen T. McCarthy, Tarak Srivastava, Jos Domen, Aurélie Tormo, Jean-François Gauchat

“…CLCF-1 increased phosphorylation of STAT3 in multiple cell types, activated podocytes leading to formation of lamellipodia and decrease in basal stress fibers, increased glomerular albumin permeability, and increased STAT3 phosphorylation of peripheral blood cells and renal cortex. …”
Get full text

Developmet the Complex Technology for Highly Concentrated Acid Solutions of Electroplating Industry by IVANENKO Olena, DOVHOLAP Sergii, NOSACHOVA Yuliia, PLASHYKHIN Sergii, PAVLIUK Nonna, SKLADANNYY Denys

“…At the same time, an increase in the iron (II) ions concentration leads to a significant increase in TEDC – even with a sulfuric acid concentration of 8–13 g/dm3, TEDC reached the level of 1.35 g-eq/dm3, which corresponds to the sorption level of neutral dilute solutions. …”
Get full text

The Guyana Diabetes and Foot Care Project: Improved Diabetic Foot Evaluation Reduces Amputation Rates by Two-Thirds in a Lower Middle Income Country by Julia Lowe, R. Gary Sibbald, Nashwah Y. Taha, Gerald Lebovic, Madan Rambaran, Carlos Martin, Indira Bhoj, Brian Ostrow

“…Type 2 diabetes is the fourth leading cause of death in Guyana, South America. A complex, interprofessional, quality improvement intervention to improve foot and diabetes care was rolled out in two phases. …”
Get full text

Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Here, we report that disease-causing PDE12 variants in three unrelated families are associated with mitochondrial respiratory chain deficiencies and wide-ranging clinical presentations in utero and within the neonatal period, with muscle and brain involvement leading to marked cytochrome c oxidase (COX) deficiency in muscle and severe lactic acidosis. …”
Get full text

Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis by Jiaxuan He, Peiye Xu, Ting Xu, Haiyang Yu, Lei Wang, Rongbing Chen, Kun Zhang, Yueliang Yao, Yanyan Xie, Qinsi Yang, Wei Wu, Da Sun, Dejun Wu

“…Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. …”
Get full text

Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

“…Abstract Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. …”
Get full text

Effects of alkali treatment on the bending and fracture behavior of biomaterial bamboo by Xiaohan Chen, Xianke Wang, Shaohua Gu, Aiyue Huang, Haitao Cheng

“…Microstructurally, after alkali treatment, the loosening between cells increases the compressible space, leading to a significant prolongation of the plastic stage, especially when loaded from the radial bamboo yellow side (Mode II). …”
Get full text

Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS by Meilin Yang, Die Liu, Yan Tan, Jieting Chen, Fan Yang, Chaoming Mei, Qi Zeng, Yong Lin, Dan Li

“…Abstract Background Incomplete radiofrequency ablation (iRFA) stimulates residual hepatocellular carcinoma (HCC) metastasis, leading to a poor prognosis for patients. Therefore, it is imperative to develop an effective therapeutic strategy to prevent iRFA-induced HCC metastasis. …”
Get full text

Effect of Sodium Sulfate Solution Coupled with Wetting–Drying Cycles on the Properties of Nano-Alumina-Modified Concrete by Kai Gao, Dun Chen, Chunqing Li, Guoyu Li, Yuncheng Mao, Xuyang Wu, Anshuang Su, Hang Zhang, Xu Wang

“…Their microscopic morphology revealed loose particles and poor compactness. The leading causes of damage to concrete due to erosion by the sodium sulfate were its crystallization pressure and the swelling-induced stress caused by the deposition of crystals in its pores. …”
Get full text

Explainable machine learning framework for cataracts recognition using visual features by Xiao Wu, Lingxi Hu, Zunjie Xiao, Xiaoqing Zhang, Risa Higashita, Jiang Liu

“…Abstract Cataract is the leading ocular disease of blindness and visual impairment globally. …”
Get full text

In situ polymerized polyetherimide/Al2O3 nanocomposites with significantly improved capacitive energy storage performance at high temperatures by Li Tan, Jiufeng Dong, Li Li, Chengyuan Wang, Yuqi Liu, Yujuan Niu, Zizhao Pan, Liang Sun, Hong Wang

“…In contrast to the nanocomposites obtained by blending PEI polymers with AO, the in situ nanocomposites exhibit substantially improved filler dispersion, together with largely suppressed conduction loss at high fields and high temperatures, leading to comprehensive enhancements of breakdown strength (Eb), charge-discharge efficiency (η) and Ue, simultaneously. …”
Get full text

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). …”
Get full text