Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis by Benny Drieghe, Gunther vanLoon, Sabrina Stuyvaert, Marc L. De Buyzere, Thierry Bové, Tine De Backer

“…Hemodynamic measurements and blood sampling for renin, angiotensin, and aldosterone were performed in baseline conditions and during progressive balloon inflation in the renal artery leading to stepwise 5% Pd decrements. Resistive index (RI) was computed as (1‐(End Diastolic V/Maximum Peak Systolic V))*100. …”
Get full text

Study of dissipation dynamics and persistent toxicity of selected insecticides in chilli using LCMSMS by Sivasankari Sivakumar, Suganthi Angappan, Elaiyabharathi Thiyagarajan, Shanmugam Pagalahalli Sankaran, Renukadevi Perumal, Veeranan Arun Giridhari Veeranan, Bimal Kumar Sahoo, Kiruthika Kanagaraj, Mohammad Ikram

“…The reliance on pesticides could result in residue contamination, adversely affecting quality, leading to export rejections and health risks to consumers. …”
Get full text

Tungsten impurity reduction by ICRH in a high power injection and high performance H-mode discharge on EAST by Zhen Zhou, Shengyu Shi, Ling Zhang, Tao Zhang, Xiaohe Wu, Yunxin Cheng, Wenmin Zhang, Chaowei Mai, Shengyu Fu, Yifei Jin, Xiang Jian, Kaixuan Ye, Lin Yu, Ziqiang Zhou, Jiuyang Ma, Shuqi Yang, Kangning Geng, Gongshun Li, Jia Huang, Fei Wen, Yunfeng Liang, Xiang Gao

“…Theoretical modeling results indicate that the reduction in toroidal rotation leads to less W poloidal asymmetry and neoclassical pinch, which is more efficient in alleviating the core W accumulation than the improvement of isotropic hydrogen (H) minority temperature. …”
Get full text

Case report: Selpercatinib in the treatment of RET fusion-positive advanced lung adenocarcinoma: a challenging clinical case by Raffaella Pagliaro, Raffaella Pagliaro, Paola Maria Medusa, Paola Maria Medusa, Fabiana Vitiello, Luigi Aronne, Luigi Aronne, Susan F. M. Campbell, Susan F. M. Campbell, Fabio Perrotta, Fabio Perrotta, Andrea Bianco, Andrea Bianco

“…Selpercatinib was initiated as a targeted therapy, leading to a notable radiographic response and clinical improvement. …”
Get full text

Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…Type 1 diabetes (T1D) is related to the autoimmune destruction of β-cells, leading to their almost complete absence in patients with longstanding T1D. …”
Get full text

Efficient photocatalytic degradation of bisphenol A on 2D-3D spherically hierarchical structure Zn5In2S8 by Zongwen Zhang, Yi Zhang, Huili Han, Riyadh Ramadhan Ikreedeegh, Riyadh Ramadhan Ikreedeegh, Syed Shoaib Ahmad Shah, Muhammad Tayyab

“…Compared to the conventional g-C3N4 photocatalyst, ZIS exhibits enhanced optical and electrical properties, leading to remarkable photocatalytic performance, with an apparent reaction rate constant of 2.36 h⁻1, 6.56 times greater than that of g-C3N4. …”
Get full text

Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism by Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Valeria Salerno Gonzales, Tadataka Tsuji, Siying Wei, Matthias Blüher, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni

“…Here we show that m6A methyltransferase-like 14 (METTL14) differentially regulates transcriptome in brown versus white adipose tissue (BAT and WAT), leading to divergent metabolic outcomes. In humans and mice with insulin resistance, METTL14 expression differs significantly from BAT and WAT in the context of its correlation with insulin sensitivity. …”
Get full text

Retracing the Cold Plasma Dispersion Law in Pulsar B0329+54: New Insights into Frequency-dependent Dispersion Measures by Shyam S. Sharma, Tetsuya Hashimoto, Tomotsugu Goto, Shotaro Yamasaki, Simon C.-C. Ho

“…In contrast, using times of arrival from widely adopted pulsar timing techniques (e.g., FFTFIT) leads to frequency-dependent DMs. We investigated the potential causes of these frequency-dependent DMs in this pulsar and their relationship with the underlying magnetic field geometry corresponding to the radio emission. …”
Get full text

Membrane-embedded CdaA is required for efficient synthesis of second messenger cyclic di-AMP by Alexander J. Foster, Haoyang Li, Panagiotis Drougkas, Gea. K. Schuurman-Wolters, Joeri ten Kate, Cristina Paulino, Bert Poolman

“…Cryo-EM and in-silico structure prediction of CdaA show that the two DAC dimers engage in a head-to-head interaction, leading to cyclic-di-AMP formation. The inhibitor phosphoglucomutase prevents this active conformation. …”
Get full text

Invasive plant and honeybee alter native plant-pollinator network structure in dry forest by RODRIGO F. R. CARMO, CÁSSIO H. CARVALHO, REGINALDO A.F. GUSMÃO, LUCAS F.C.S. ALENCAR, JEFERSON VIZENTIN-BUGONI, GABRIEL X. BOLDORINI, GABRIELA A. GALVÃO, JOYCE C.B. BRITO, THIAGO GONÇALVES-SOUZA

“…The dominance of invasive grass leads to an increased niche overlap among native pollinators. …”
Get full text

Interleukin 15‐Presenting Nanovesicles with Doxorubicin‐Loaded Ferritin Cores for Cancer Immunochemotherapy by Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai, Pengcheng Zhang, Yaping Li

“…Concurrently, membrane‐bound IL15c recognizes and activates IL15 receptor β/γc heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16‐fold and 28‐fold) and NK cells (37‐fold and 50‐fold). …”
Get full text

Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently encounter problems with poor absorption, toxicity, and a lack of specificity. …”
Get full text

Handle Region Peptide Ameliorating Insulin Resistance but Not β Cell Functions in Male Rats Neonatally Treated with Sodium L-Glutamate by Guo-shu Yin, Shao-da Lin, Dong-chuan Xu, Ru-qiong Sun, Kun Lin, Chu-jia Lin

“…HRP ameliorating insulin resistance but not β-cell functions leads to hyperglycemia in the end in male MSG rats, and the dual characters of HRP may partly account for the phenomenon.…”
Get full text

Metagenomic insights into pathogenic bacteria and antimicrobial resistance in offshore coastal sediments – An example from Gulf waters by Nazima Habibi, Saif Uddin, Hanan Al Sarawi, Ahmad Aldhameer, Montaha Behbehani, Saja Fakhraldeen, Waleed Al-Zekri, Nasreem Abdulrazzack, Farhana Zakir, Anisha Shajan

“…The presence of ARGs in non-polluted sites likely suggests that they are not restricted to waste outlets; it is quite probable that other emerging contaminants are also leading to AMR occurrence in the region. Hence, comprehensive screening and constant surveillance are warranted.…”
Get full text

Seeing beyond words: nanotechnology in hepatocellular carcinoma - a bibliometric study by Talaiti Tuergan, Talaiti Tuergan, Aimitaji Abulaiti, Alimu Tulahong, Alimu Tulahong, Ruiqing Zhang, Ruiqing Zhang, Zhongdian Yuan, Zhongdian Yuan, Yanze Lin, Yanze Lin, Yingmei Shao, Yingmei Shao, Yingmei Shao, Tuerganaili Aji, Tuerganaili Aji

“…The “International Journal of Nanomedicine” was identified as the leading publisher, while “Biomaterials” ranked highest in citations. …”
Get full text

Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles by Seyyed Sam Mehdi Hosseininasab, Rasoul Ebrahimi, Shirin Yaghoobpoor, Kiarash Kazemi, Yaser Khakpour, Ramtin Hajibeygi, Ashraf Mohamadkhani, Mobina Fathi, Kimia Vakili, Arian Tavasol, Zohreh Tutunchian, Tara Fazel, Mohammad Fathi, Mohammadreza Hajiesmaeili

“…., Toxoplasma gondii), have been linked to AD due to their ability to activate the immune system, induce inflammation and increase oxidative stress, thereby leading to cognitive decline and AD. In addition, microRNAs (miRNAs) might play a crucial role in the pathogenesis mechanisms of these pathogens since they are utilized to target various protein-coding genes, allowing for immune evasion, maintaining latency, and suppressing cellular signaling molecules. …”
Get full text

Synthesis, Magnetization, and Electrical Transport Properties of Mn3Zn0.9Cu0.1N by Y. Yin, J. C. Han, T. P. Ying, J. K. Jian, Z. H. Zhang, L. S. Ling, L. Pi, B. Song

“…It is found that Mn3Zn0.9Cu0.1N exhibits a first-order antiferromagnetism (AFM) to paramagnetic (PM) transition with the Néel temperature TN ~163 K, and substitution of Cu for Zn would favor ferromagnetism (FM) state and weaken AFM ground state, leading to a convex curvature character of M(T) curve. …”
Get full text

Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America by Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti

“…The data suggest that T regulatory FoxP3+ cells and the regulatory cytokines, especially TGF-β, play an important role in the immunopathogenesis of NUCL, modulating a cellular immune response in the skin, avoiding tissue damage, and leading to low tissue parasitic persistence.…”
Get full text

Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men by Pedro Fernandez, Charnita M. Zeigler-Johnson, Elaine Spangler, André van der Merwe, Mohamed Jalloh, Serigne M. Gueye, Timothy R. Rebbeck

“…Prostate cancer is the most common cancer in men in developed countries and the leading cause of mortality in males in less developed countries. …”
Get full text

Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model by Livia Aparecida Procópio Gomes, Lívia Mara Alves Figueiredo, Ana Luiza do Rosário Palma, Barbara Maria Corrêa Geraldo, Kelly Cristine Isler Castro, Luciana Ruano de Oliveira Fugisaki, Antônio Olavo Cardoso Jorge, Luciane Dias de Oliveira, Juliana Campos Junqueira

“…Injection of high concentration (200, 100, and 25 mg/mL) of PGE showed a toxic effect, leading them to death. A suspension of P. gingivalis (106 cells/mL) was inoculated in the left last proleg and PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) were injected into the right proleg. …”
Get full text