Appropriateness in Dentistry: A Survey Discovers Improper Procedures in Oral Medicine and Surgery by Giacomo Oteri, Vera Panzarella, Antonia Marcianò, Olga Di Fede, Laura Maniscalco, Matteo Peditto, Giuseppina Campisi

“…Our results confirm the necessity to reduce inappropriate practices in dentistry, implementing formation and information, leading to correct prescriptions, and optimizing patients’ oral health. …”
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Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice by Yu Fu, Jing Luo, Zhenquan Jia, Wei Zhen, Kequan Zhou, Elizabeth Gilbert, Dongmin Liu

“…In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced glucose-stimulated insulin secretion (GSIS) in high-fat diet (HFD-) induced middle-aged obese mice. …”
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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…Ischemic stroke, resulting from the obstruction of blood flow to the brain, remains a leading cause of morbidity and mortality worldwide. …”
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Fate and Occurrence of Pharmaceutically Active Organic Compounds during Typical Pharmaceutical Wastewater Treatment by Qiao Luo, Jing Wang, JianHui Wang, Yu Shen, Peng Yan, YouPeng Chen, ChengCheng Zhang

“…Other organic compound classes including organosilicon compounds, acids, esters, heterocycles, and alcohols are mostly biodegraded, which leads to high concentrations of hydrocarbons in the wastewater effluent. …”
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Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice by Ji-Hun Lee, Eun-Seon Yoo, Na-Won Kim, Won-Yong Shim, Han-Bi Jeong, Dong-Hyun Kim, Young-Jun Park, Sun-Min Seo, Jun-Won Yun, Jun Won Park, Kang-Seuk Choi, Ho-Young Lee, Jun-Young Seo, Ki Taek Nam, Je Kyung Seong, Yang-Kyu Choi

“…Mice lacking OSNs exhibited reduced levels of viral transmission to the brain, leading to significantly improved outcomes following SARS-CoV-2 infection. …”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Yury Rubtsov, Кirill Goryunov, Аndrey Romanov, Yulia Suzdaltseva, George Sharonov, Vsevolod Tkachuk

“…ICAM-1 is involved in the control of T cell activation leading to immunosuppression or modest stimulation depending on the T cell status. …”
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Adrenomedullin 2 attenuates anxiety-like behaviors by increasing IGF-II in amygdala and re-establishing blood–brain barrier by Denian Wang, Zhi Yang, Pengfei Wu, Qingyan Li, Chunyan Yu, Ying Yang, Yuefan Du, Mengwei Jiang, Junpeng Ma

“…Abstract Anxiety disorder, a prevalent mental health issue, is one of the leading causes of disability worldwide. Damage to the blood–brain barrier (BBB) is implicated in anxiety, but its regulatory mechanisms remain unclear. …”
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Cellular therapies in rheumatic and musculoskeletal diseases by Pedro Franco-Fuquen, Juana Figueroa-Aguirre, David A. Martínez, Eider F. Moreno-Cortes, Juan E. Garcia-Robledo, Fabio Vargas-Cely, Daniela A. Castro-Martínez, Mustafa Almaini, Januario E. Castro

“…Preliminary data from patients with RMDs, particularly those with lupus erythematosus and dermatomyositis, suggest that CAR T-cells targeting CD19 can induce rapid and sustained depletion of circulating B cells, leading to complete clinical and serological responses in cases that were previously unresponsive to conventional therapies.This review will provide an overview of the current state of preclinical and clinical studies on the use of CAR T-cells and other cellular therapies for RMDs. …”
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Static voltage stability margin evaluation for a DC distribution network with DC electric springs by Xiaolong Xu, Qianggang Wang, Jianquan Liao, Yuan Chi, Tao Huang, Niancheng Zhou, Yiyao Zhou, Xuefei Zhang

“…Initially, the relationship between the outputs of a DC electric spring and load power is analyzed in a simplified circuit, leading to the derivation of bus type conversion logic for buses with DC electric springs, considering their output limits. …”
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Validation of an AMSR2 Thin-Ice Thickness Algorithm for Global Sea-Ice-Covered Oceans Using Satellite and In Situ Observations by Kazuki Nakata, Misako Kachi, Rigen Shimada, Eri Yoshizawa, Masato Ito, Kay I. Ohshima

“…The detection of thin-ice thickness using satellite microwave radiometers is a strong tool for estimating sea-ice production in coastal polynyas, which leads to dense water formation driving ocean thermohaline circulation. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Rheumatoid arthritis is a chronic autoimmune disease affecting typically synovial joints and leading to progressive articular damage, disability, and reduced quality of life. …”
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Study on Long-Term Dynamic Mechanical Properties and Degradation Law of Sandstone under Freeze-Thaw Cycle by Qingsong Pu, Junhong Huang, Fuling Zeng, Yi Luo, Xinping Li, Jixue Zhou, Shilong Zheng

“…The results showed that the dynamic compressive strength of sandstone subjected to multiple freeze-thaw cycles under 0.04 MPa air pressure has a greater damage ratio than that under 0.055 MPa and 0.07 MPa air pressure, which was more likely to cause damage to slope sandstone than in actual engineering; the dynamic compressive strength and elastic modulus of sandstone decrease greatly within a certain range of freeze-thaw cycles and loading strain rate, leading to significant deterioration. When the freeze-thaw cycle exceeded 200 times and the strain rate was greater than 200 s−1, the physical and mechanical properties of sandstone gradually tended to be stable.…”
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Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway by Sisi Wei, Xinyi Fan, Xiaoya Li, Wei Zhou, Zhihua Zhang, Suli Dai, Huilai Lv, Yueping Liu, Baoen Shan, Lianmei Zhao, Qimin Zhan, Yongmei Song

“…Mechanistically, lnc191 interacts with GRP78 (78‐kDa glucose‐regulated protein), one of the endoplasmic reticulum chaperone proteins, leading to its translocation to the membrane, where GRP78 binds with EGFR and enhances its phosphorylation (Y845), further activates ERK/MAPK signaling pathway, and thereby in favor of the progression of ESCC. …”
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Graph pangenome reveals the regulation of malate content in blood-fleshed peach by NAC transcription factors by Wenbo Chen, Qi Xie, Jia Fu, Shaojia Li, Yanna Shi, Jiao Lu, Yuanyuan Zhang, Yingjie Zhao, Ruijuan Ma, Baijun Li, Bo Zhang, Donald Grierson, Mingliang Yu, Zhangjun Fei, Kunsong Chen

“…Furthermore, we demonstrate that PpBL works synergistically with another NAC TF, PpNAC1, to activate the transcription of the aluminum-activated malate transporter PpALMT4, leading to increased malate content. Conclusions These findings, along with previous research showing that PpBL and PpNAC1 also regulate anthocyanin accumulation, explain the red coloration and sour taste in blood-fleshed peach fruits.…”
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A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice by De-Kui Zhang, Jian-Jie Yu, Yu-Min Li, Li-Na Wei, Yi Yu, Yan-Hu Feng, Xiang Wang

“…The administration of picroliv leads to an amelioration of DSS-induced colitis, suggesting administration of picroliv may provide a therapeutic approach for UC.…”
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A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects by Ermei Lu, Kecheng Zhou, Jiansen Miao, Yanlin Zhu, Jiyao Tang, Siting Du, Yanzhen Feng, Linyuan Jiang, Tianyao Jiang, Ting Huang, Ping Li, Xinjun Miao, Qi Han, Jian Xiao

“…This approach combines the regenerative effects of low-dose PTX with the immunoregulatory properties of LNT M2, leading to remarkable neurological recovery in SCI rats. …”
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Medication-focused telehealth interventions to reduce the hospital readmission rate: a systematic review by Fatemeh Emadi, Racha Dabliz, Rebekah Moles, Stephen Carter, Jenny Chen, Charu Grover, Manya Angley, Rohan A. Elliott, Deirdre Criddle, Deborah Rigby, Sepehr Shakib, Frank Sanfilippo, Charley Budgeon, Kim-Huong Nguyen, Paul Yates, Katie Phillips, Anna Packer, Linda Krogh, Simon Poon, Jonathan Penm

“…Background Transition of care from hospital to community is a period that carries significant risk for medication errors, potentially leading to hospital readmission, and causing financial and emotional strain on patients and caregivers. …”
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Contrast-Enhanced Magnetic Resonance Cholangiography: Practical Tips and Clinical Indications for Biliary Disease Management by Stefano Palmucci, Federica Roccasalva, Marina Piccoli, Giovanni Fuccio Sanzà, Pietro Valerio Foti, Alfonso Ragozzino, Pietro Milone, Giovanni Carlo Ettorre

“…In recent years, three-dimensional T2-weighted fast-recovery fast spin-echo images have been added to the conventional protocol, increasing the possibility of biliary anatomy demonstration and leading to a significant benefit over conventional 2D imaging. …”
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. …”
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies by Yujiao He, Yanchen Liu, Mingyue Zheng, Yuxiu Zou, Mujie Huang, Linsheng Wang, Ge Gao, Zhongjun Zhou, Guoxiang Jin

“…A blocking peptide, TAT‐PEP, specifically abrogating ATAD3A phosphorylation, results in elevated cell death by preventing doxorubicin‐induced senescence, thus leading to enhanced tumor sensitivity to chemotherapy. …”
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