Identification and validation of a prognostic risk model based on radiosensitivity-related genes in nasopharyngeal carcinoma by Yi Li, Xinyi Hong, Wenqian Xu, Jinhong Guo, Yongyuan Su, Haolan Li, Yingjie Xie, Xing Chen, Xiong Zheng, Sufang Qiu

“…Background: Despite advancements with intensity-modulated radiation therapy (IMRT), about 10 % of nasopharyngeal carcinoma (NPC) patients remain resistant to radiotherapy, leading to recurrence and poor prognosis. This study aims to identify radiosensitivity-related genes in NPC and develop a prognostic model to predict patient outcomes. …”
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Nanotechnology-assisted cryopreservation of ovine semen: evaluation of Thymus vulgaris essential oil as a natural antioxidant by Samia Khnissi, Rania Maaloul, Hela Chalouati, Laura Mara, Dorra Aouadi, Basma Adouani, Maria Dattena, Ikram Khémiri, Sami Fattouch

“…On the other hand, the study identified a negative impact of thyme EO nanoemulsions on catalase concentrations, potentially leading to mobility inhibition (p<0.05). In addition, the nanoemulsion significantly (p<0,05) decreased the malondialdehyde concentration, increased the total protein and the glucose contents, the lactate dehydrogenase activity. …”
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Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer by Xinwen Wang, Min Wang, Qijun Lin, Lixin He, Baolin Zhang, Xin Chen, Guanhong Chen, Hong Du, Chuandong Lang, Xinsheng Peng, Yuhu Dai

“…Mechanistically, ECM1 interacts with the enolase 1 (ENO1) receptor on the prostate cancer cell membrane, leading to its phosphorylation at the Y189 site. This event further recruits adapter proteins including growth factor receptor‐bound protein 2 (GRB2) and son of sevenless homolog 1 (SOS1), which activates the downstream mitogen‐activated protein kinase (MAPK) signaling pathway to induce anti‐androgen resistance. …”
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…Mechanistically, the MAPK pathway transduces mechanical cues from disturbed flow in ECs, leading to increased secretion of EVs. Pharmacological inhibition of the MAPK pathway reduced the secretion of EVs even under disturbed flow conditions. …”
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Three months of weekly rifapentine plus isoniazid for TB prevention among people with HIV by R. Borse, B. Randive, S. Mattoo, P. Malik, H. Solanki, A. Gupta, R.E. Chaisson, V. Mave, N. Suryavanshi

“…CONCLUSION: 3HP TPT completion rate of 92%, with few adverse events leading to 3HP discontinuation, providing evidence of the scalability and safety of 3HP TPT among PLHIV in Indian health program settings.…”
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Guidelines for the Management of Complications of Diabetes in Saudi Arabia Using Delphi Technique for Consensus Among National Experts by Raed Aldahash, Mohammed A. Batais, Ashraf El-Metwally, Saja Alhosan, Mohammed Alharbi, Mohammed Almutairi, Abdulghani Alsaeed, Mohammed Alsofiani, Mohammed AlMehthel, Mohammed Aldubayee, Khaled Aldossari, Sulieman Alshehri

“…(1) Background: Saudi Arabia has one of the leading cases of diabetes globally, with approximately 27.8% of adults suffering from the disease. …”
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Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s by Peiye Chang, Yongwang Fu, Ping Zhao, Chunmei Wang, Mingfang Jiang, Rui Li, Yulin He

“…Recently, there have been reports of SLC6A3 genetic variants leading to PD. However, the role of 3′ end of SLC6A3 in PD is less studied in different ethnic groups. …”
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High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes by Mary E. Jung, Jessica E. Bourne, Mark R. Beauchamp, Emily Robinson, Jonathan P. Little

“…High-intensity interval training (HIIT) leads to improvements in various markers of cardiometabolic health but adherence to HIIT following a supervised laboratory intervention has yet to be tested. …”
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Genetic ancestry and the colonial legacies of race in genomics: a cross-disciplinary dialogue by Ernesto Schwartz-Marin, Tayyaba Jiwani, Sarah Abel, Yulia Egorova, Amade M’charek, Diogo Meyer, Andrés Moreno Estrada, Katharina Schramm, Peter Wade, Michel Naslavsky, Michel Naslavsky

“…This roundtable brings leading population geneticists grappling with the question of genetic identity and ancestry, especially in the global South, together with some of the most prominent scholars of race in genomics. …”
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Development of a microbiome for phenolic metabolism based on a domestication approach from lab to industrial application by Wei Zhao, Liuyang Shi, Yifan Han, Xingbiao Wang, Jingjing Wang, Song Xu, Xiaoxia Zhang, Zhiyong Huang

“…Within the domestication and application processes for treating phenolic resin wastewater, a powerful functional microbiome was built by self-assembly. This leads to an augmented biodiversity and the development of more intricate phenol and formaldehyde metabolic pathways. …”
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Integrating Social Relationships and Personality into MAS-Based Group Recommendations by Ariel Monteserin, Daiana Elin Madsen, Daniela Godoy, Silvia Schiaffino

“…The proposed approach introduces a multi-agent recommender system for a group of users by considering their personality traits, relationships and social interactions during the negotiation process that leads to the generation of recommendations. While traditional recommendation techniques do not take into account the effects of personality traits and relationships between individuals, our approach demonstrates that personality traits, especially personality types in the context of conflict management, and social relationships can significantly impact on the group recommendation. …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…C. burnetii was identified in blood samples from five patients, leading to a clinical diagnosis of Q fever. These diagnoses were subsequently confirmed by qPCR at the Beijing CDC. …”
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Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

“…In the MC38 tumor-bearing model, Epinastine significantly enhanced the infiltration of T cells and NK cells into the tumor site and augmented their secretion of IFN-γ, leading to effective suppression of tumor growth. …”
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The Contribution of Secondary Particles Following Carbon Ion Radiotherapy to Soft Errors in CIEDs by Yudai Kawakami, Makoto Sakai, Hiroaki Masuda, Masami Miyajima, Takao Kanzaki, Kazutoshi Kobayashi, Tatsuya Ohno, Hiroshi Sakurai

“…<italic>Introduction:</italic> While carbon ion radiotherapy is highly effective in cancer treatment, it has a high risk of causing soft error, which leads to malfunctions in cardiac implantable electrical devices (CIEDs). …”
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Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats by Charissa E. van den Brom, Chantal A. Boly, Carolien S. E. Bulte, Rob F. P. van den Akker, Rick F. J. Kwekkeboom, Stephan A. Loer, Christa Boer, R. Arthur Bouwman

“…Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state.…”
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Diversity of microbial communities in cigar filler leaves with different initial water contents analyzed based on high-throughput sequencing technology by Yumeng Gao, Yumeng Gao, Yihui Wang, Bingqing Hou, Guo Zhang, Chun Jiang, Song Fang, Qian Wang, Yang Ning

“…Among the 18 cigar filler leaf samples, the predominant phyla identified were Proteobacteria, Firmicutes, Actinobacteria, Ascomycota, and Basidiomycota, with the leading genera being Staphylococcus, Sphingomonas, Methylobacterium-Methylorubrum, Pseudomonas, and Humicola. …”
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Experimental and Numerical Study of Mechanical Properties of Concrete Containing Biochar by S.O Odeyemi, M.O Adisa, M.A Olawale, A.O Abdulsalam, J.A Oloba, H.A Ibrahim, B.O Sanusi, J.O Eda, F.O Obisiji

“… The production of cement is responsible for 7% of worldwide CO2 emissions, leading to environmental threats and harm to ecosystems. …”
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women by Tao Zhang, Yanting Liu, Fang Liu, Kaiyu Guo, Runhua Tang, Jingwei Ye, Li Xue, Zhipeng Su, Zhe Bao Wu

“…In contrast, knockdown of USP11 leads to a substantial reduction in both POMC transcription and ACTH secretion, as demonstrated in both in vitro and in vivo models. …”
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Enhancing in Vitro anti-metastatic efficacy and deep penetration into tumor spheroid of docetaxel-loaded liposomes via size optimization for prostate cancer treatment by Saksorn Klibaim, Nutthanit Thumrongsiri, Natsorn Watcharadulyarat, Walailuk Chonniyom, Prattana Tanyapanyachon, Paweena Dana, Nattika Saengkrit

“…The results showed significant cellular internalization improvement with smaller LDTX, leading to better cytotoxicity in a monolayer cell culture than with larger LDTX. …”
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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…The description and characterization of the toxicological MoA leading to non-alcoholic fatty liver disease (NAFLD) are of specific interest, due to its increasing incidence in the modern society. …”
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