Effects of proton pump inhibitor (PPI) use on migraine – a critical review by Viktoria Tischler-Strasser, Irma Burdiladze, Goncalo Cabral, Esme Ekizoglu, Olga Grodzka, Keshet Pardo, Patryk Sochan, Laura Zaunandra, Antoinette MaassenVanDenBrink, Christian Lampl, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

“…In this narrative review, we aim to critically evaluate existing data and offer a potential approach to accurately identify any connections and interactions, leading to a better understanding of how these conditions may influence each other.…”
Get full text

Decadal transformations of antarctic sea ice modes by Benli Guo, Benli Guo, Benli Guo, Peng Yang, Peng Yang, Peng Yang, Jie Yuan, Jie Yuan, Jie Yuan, Honglian Xing, Honglian Xing, Honglian Xing, Wenjie Yuan, Wenjie Yuan, Wenjie Yuan, Yuanku Meng, Yuanku Meng, Yuanku Meng

“…The Weddell Sea and West Pacific exhibit the fastest declines at -6.1% and -5.8% per year, leading to an overall average melting trend of -4.6% per year. …”
Get full text

The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling by Yangyang Fu, Shishun Huang, Rulu Pan, Xingan Chen, Ting Liu, Rongzhe Zhang, Fangsheng Zhu, Qiwei Fang, Liyue Wu, Juji Dai, Ouchen Wang, Liting Lu, Xiduan Wei, Liangxing Wang, Xincheng Lu

“…Depletion of PDE4DIP mislocalizes PKA RIIα from the Golgi and leads to its degradation, thereby compromising its negative regulatory effect on PKA signalling. …”
Get full text

Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis by Ilonka Rohm, Yevgeniya Atiskova, Stefanie Drobnik, Michael Fritzenwanger, Daniel Kretzschmar, Rudin Pistulli, Jürgen Zanow, Thomas Krönert, Gita Mall, Hans Reiner Figulla, Atilla Yilmaz

“…Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells. Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. …”
Get full text

Study on the mechanical properties of Ti-6Al-4V alloy with minimal surface structures: effects of different heat treatment temperatures by Kai Qian, Shuangyu Liu, Fulong Zhang, Guihua Hang, Bo Cui, Ziwei Guo, Qiushi Zhang, Wang Binhua

“…In contrast, Primitive porous scaffolds demonstrated stress concentration regions that reach yield limits under compression, leading to fracture. Heat treatment did not alleviate these stress concentrations but instead reduced the material’s yield limit, accelerating scaffold failure.…”
Get full text

Effect of ethanol concentration on the catalytic performance of WO3/MCF-Si and WO3/SBA-15 catalysts toward ethanol dehydration to ethylene by Pantita Trongjitraksa, Mohammad Yazdanpanah, Mohammad Fereidooni, Piyasan Praserthdam, Bunjerd Jongsomjit

“…Additionally, the use of lower ethanol concentrations (with higher water content) as a feed enhanced the selectivity of ethylene and inhibited the formation of Bronsted acid sites leading to a decrease of coke formation. On the contrary, it also had an adverse effect by attenuating the ethanol conversion. …”
Get full text

Orthostatic Dysregulation during Postural Change on the Dental Chair and Intraoperative Monitoring by Heart Rate Variability Analysis by Yukihiro Momota, Shigemasa Tomioka, Mayuko Furukita, Kenji Fujisawa, Hideyuki Takano, Masayuki Azuma

“…OD-associated autonomic dysfunction is induced by postural changes and easily leads to disturbance in circulatory dynamics; however, most dental practices have not yet realized the importance of managing OD. …”
Get full text

Examination of empirical and Machine Learning methods for regression of missing or invalid solar radiation data using routine meteorological data as predictors by Konstantinos X Soulis, Evangelos E Nikitakis, Aikaterini N Katsogiannou, Dionissios P Kalivas

“…Sensors are prone to malfunction, leading to blank or erroneous measurements that cannot be ignored in most practical applications. …”
Get full text

Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple‐Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1‐Regulated Cholesterol Metabolism by Yilan Yang, Jiatao Liao, Zhe Pan, Jin Meng, Li Zhang, Wei Shi, Xiaofang Wang, Xiaomeng Zhang, Zhirui Zhou, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Yi‐Zhou Jiang, Zhi‐Min Shao, Fei Xavier Chen, Xiaoli Yu, Xiaomao Guo

“…Combining CDK4/6 and CDK7 inhibitors significantly enhances therapeutic effectiveness, leading to a marked decrease in cholesterol biosynthesis within cells. …”
Get full text

Nursing of a pediatric patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (1例罕见IPEX综合征患儿的护理) by ZHU Huiyun (朱慧云), WANG Suling (王苏玲)

“…Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, fatal autoimmune disorder caused by mutations in the FOXP3 gene leading to the disruption of signaling pathways involved in regulatory T-lymphocyte function. …”
Get full text

PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway by Zhendong Deng, Shanliang Sun, Nian Zhou, Yumeng Peng, Long Cheng, Xichao Yu, Yuxia Yuan, Mengjie Guo, Min Xu, Yuexin Cheng, Fan Zhou, Nianguang Li, Ye Yang, Chunyan Gu

“…Mechanistically, PNPO oxidizes disheveled 3M282 (DVL3), leading to abnormal activation of the Wnt/β‐catenin pathway. …”
Get full text

Development of Diagnostic Biomarkers for Detecting Diabetic Retinopathy at Early Stages Using Quantitative Proteomics by Jonghwa Jin, Hophil Min, Sang Jin Kim, Sohee Oh, Kyunggon Kim, Hyeong Gon Yu, Taesung Park, Youngsoo Kim

“…Diabetic retinopathy (DR) is a common microvascular complication caused by diabetes mellitus (DM) and is a leading cause of vision impairment and loss among adults. …”
Get full text

Effects of annealing and quenching temperature on microstructure evolution and mechanical properties in Fe-0.17C-2.10Mn-0.51Si steel by Panpan Yuan, Depeng Shen, Wei Sun, Bingtao Tang

“…XRD analysis shows carbide precipitation at 730 °C shifts peaks to lower angles, while dissolution at 850 °C and 910 °C leads to lattice expansion. Minimal peak shifts at 790 °C correlate with optimal properties. …”
Get full text

Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C by Wan-Jung Lu, Shih-Chang Lin, Chang-Chou Lan, Tzu-Yin Lee, Chih-Hsuan Hsia, Yung-Kai Huang, Hsiu-Chuan Lee, Joen-Rong Sheu

“…Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis. …”
Get full text

Genomic relationships among diploid and polyploid species of the genus Ludwigia L. section Jussiaea using a combination of molecular cytogenetic, morphological, and crossing invest... by Barloy, Dominique, Portillo-Lemus, Luis, Krueger-Hadfield, Stacy, Huteau, Virginie, Coriton, Olivier

“…Our results suggest the existence of several processes of hybridization, leading to polyploidy, and possibly allopolyploidy, in the section Jussiaea due to the diversity of ploidy levels. …”
Get full text

Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury by Zhida Ma, Congpeng Meng, Xiang Wang, Yuanzhe Zhao, Jingwen Wang, Yihao Chen, Yiteng Li, Yan Jiang, Fangru Ouyang, Jianjian Li, Meige Zheng, Li Cheng, Juehua Jing

“…Abstract Background Myelin-laden foamy macrophages accumulate extensively in the lesion epicenter, exhibiting characteristics of autophagolysosomal dysfunction, which leads to prolonged inflammatory responses after spinal cord injury (SCI). …”
Get full text

Multivariate stochastic modeling for transcriptional dynamics with cell-specific latent time using SDEvelo by Xu Liao, Lican Kang, Yihao Peng, Xiaoran Chai, Peng Xie, Chengqi Lin, Hongkai Ji, Yuling Jiao, Jin Liu

“…However, this modeling strategy inadequately captures the intrinsically stochastic nature of transcriptional dynamics governed by a cell-specific latent time across multiple genes, potentially leading to erroneous results. Here, we present SDEvelo, a generative approach to inferring RNA velocity by modeling the dynamics of unspliced and spliced RNAs via multivariate stochastic differential equations (SDE). …”
Get full text

A Case of Aspiration Pneumonia Caused by Cerebrospinal Fluid Leaks Associated with Delayed Identification of Iatrogenic Skull Base Injury during Endoscopic Sinus Surgery by Takashi Anzai, Akira Baba, Shin Ito, Yo Suzuki, Shori Tajima, Satoshi Hara, Yusuke Takata, Fumihiko Matsumoto, Katsuhisa Ikeda

“…Although meningitis is a well-known complication of CSF leaks, the case we present is a rare and cautionary case of CSF leakage associated with ESS leading to aspiration pneumonia. A 43-year-old man with CSF leaks after ESS was referred to our hospital. …”
Get full text

The impact of the forced displacement of universities due to the occupation of certain territories of Ukraine on the effectiveness of their activities: “Top 200 Ukraine” universiti... by Tetiana Sych, Liubov Panchenko, Olga Saienko, Olga Ptakhina, Yevhen Ivanov

“…A review of scholarly research on the strategic management of higher education institutions and their leading role in regional development underscores the necessity of preserving these institutions to facilitate the socio-economic reconstruction of war-affected territories.…”
Get full text

Musician’s dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments by Joy Grifoni, Joy Grifoni, Valeria Crispiatico, Anna Castagna, Rosa Maria Converti, Marina Ramella, Angelo Quartarone, Teresa L’Abbate, Teresa L’Abbate, Karolina Armonaite, Karolina Armonaite, Luca Paulon, Luca Paulon, Francescaroberta Panuccio, Franca Tecchio

“…This model integrates with established literature to form a comprehensive framework for understanding MD as an impaired FeeSyCy-mediated relationship between the individual and their environment, ultimately leading to trauma. The proposed approach provides significant advantages by enabling the development of innovative therapeutic and preventive strategies. …”
Get full text