Crystal structure and Hirshfeld surface analysis of supramolecular aggregate of 2,2,6,6-tetramethylpiperidin-1-ium bromide with 1,2,3,4-tetrafluoro-5,6-diiodobenzene by Atash V. Gurbanov, Tuncer Hökelek, Gunay Z. Mammadova, Khudayar I. Hasanov, Tahir A. Javadzade, Alebel N. Belay

“…In the crystal, the bromide anions link the 2,2,6,6-tetramethylpiperidine molecules by intermolecular C—H...Br and N—H...Br hydrogen bonds, leading to dimers, with the coplanar 1,2,3,4-tetrafluoro-5,6-diiodobenzene molecules filling the space between them. …”
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Structural insights into how Cas9 targets nucleosomes by Reina Nagamura, Tomoya Kujirai, Junko Kato, Yutaro Shuto, Tsukasa Kusakizako, Hisato Hirano, Masaki Endo, Seiichi Toki, Hiroaki Saika, Hitoshi Kurumizaka, Osamu Nureki

“…Despite previous structural analyses focusing on Cas9 cleaving free DNA, structural insights into Cas9 targeting of DNA within nucleosomes are limited, leading to uncertainties in understanding how Cas9 operates in the eukaryotic genome. …”
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Numerical Simulation of Tornado-like Vortices Induced by Small-Scale Cyclostrophic Wind Perturbations by Yuhan Liu, Yongqiang Jiang, Chaohui Chen, Yun Zhang, Hongrang He, Xiong Chen, Ruilin Zhong

“…The centrifugal force in the central area exceeded the pressure gradient force, causing air particles to flow outward, leading to a pressure drop and strong pressure gradient. …”
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Rural-Urban Disparity in Premature Cancer Mortality in Young People Aged 15–44 Years in China, 2004–2021 by Chunrong Chen, Xing Xing, Shaojie Li, Bo Qu, Chunyu Liu, He Zhu, He Zhu

“…However, the decrease was relatively slower in rural areas, where ASMRs for pancreatic and ovarian cancers showed increasing trends. The five leading types of cancer deaths consistently remained liver, lung, leukemia, stomach, and other cancers in both rural and urban areas after 2013.ConclusionOur findings indicate that there were rural-urban disparities in cancer mortality in young people, which showed a different pattern compared to other age groups. …”
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The components of evaluating the effectiveness of factors affecting the academic silence of secondary school students: Thematic analysis approach by Mohammad Ali Pirkamali, Hasan Rahimi, Ahmad Aryainasab, Nematollah Pirkamali, Mahdiye yahyavezhad

“…One of the important foundations in the teaching and learning process is the educational interactions that provide the basis for improving education, academic silence is a psychological phenomenon that prevents the interaction and active participation of students in the classroom. Therefore, it leads to a decrease in the effectiveness of teaching in educational environments. …”
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Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome by Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li

“…Therapeutic administration of rapamycin suppresses mTORC1 activity, leading to the attenuation of aberrant SMC behavior, reduced inflammatory infiltration, and restoration of extracellular matrix integrity—collectively decelerating TAA advancement in our mouse model. …”
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miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma by Enrico Pozzo, Laura Yedigaryan, Nefele Giarratana, Chao-chi Wang, Gabriel Miró Garrido, Ewoud Degreef, Vittoria Marini, Gianmarco Rinaldi, Bernard K. van der Veer, Gabriele Sassi, Guy Eelen, Mélanie Planque, Alessandro Fanzani, Kian Peng Koh, Peter Carmeliet, Jason T. Yustein, Sarah-Maria Fendt, Anne Uyttebroeck, Maurilio Sampaolesi

“…Pharmacological MPC inhibition induces a similar metabolic shift, reducing metastatic potential and leading to cell cycle exit. Overall, miR-449 and miR-340 orchestrate FN-RMS cell identity, positioning MPC inhibition as a strategy to shift FN-RMS cells toward a non-tumorigenic, quiescent state.…”
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Ingestion of melamine cleaning sponges-derived microplastic fibers affects the survival and reproduction of Daphnia magna by Huimin Li, Wenwen Song, Songfeng Wang, Yanhua Wang, Yunfeng Ma, Yu Su, Rong Ji

“…The MPFs tended to aggregate in the gut of D. magna, leading to a slow elimination compared to polystyrene microspheres. …”
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Long-term variability of extreme precipitation with WRF model at a complex terrain River Basin by Yinchi Zhang, Chao Deng, Wanling Xu, Yao Zhuang, Lizhi Jiang, Caiying Jiang, Xiaojun Guan, Jianhui Wei, Miaomiao Ma, Ying Chen, Jian Peng, Lu Gao

“…Abstract Global warming has profound effects on precipitation patterns, leading to more frequent and extreme precipitation events over the world. …”
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Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin by Anke H. Hautmann, Josef Schroeder, Peter Wild, Matthias G. Hautmann, Elisabeth Huber, Patrick Hoffstetter, Martin Fleck, Christiane Girlich

“…FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). …”
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Psychological Health Factors in Young and Elderly People by T.N. Reznikova, I.V. Chikhachev, S.E. Abbasova, N.A. Seliverstova

“…It was found that in a stressful situation, elderly people with MCI have a more differentiated reaction to stress compared to young people, and indicators of self-esteem and cognitive functions remain at the same level, while young people in a stressful situation demonstrate an undifferentiated reaction leading to personal maladaptation, deterioration of cognitive functions and greater severity of negative emotions (anxiety, fear, aggression, depression). …”
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Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells by Bingxue Nie, Daoqiang Zhang, Xin Liu, Chengying Lei, Zhiruo Li, Nan Zhang, Shuping Zhang, Yiju Wei, Jie Zhang

“…Notably, the use of radical scavengers like vitamin C and coumarin decreased the OP of PM2.5 effectively, thereby leading to a decrease in its cytotoxic effects. Furthermore, the reduction of OP reversed redox imbalance and alleviated lung damage in vivo. …”
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Artificial intelligence in healthcare: transforming patient safety with intelligent systems—A systematic review by Francesco De Micco, Francesco De Micco, Gianmarco Di Palma, Gianmarco Di Palma, Davide Ferorelli, Anna De Benedictis, Anna De Benedictis, Luca Tomassini, Vittoradolfo Tambone, Mariano Cingolani, Roberto Scendoni, Roberto Scendoni

“…IntroductionAdverse events in hospitals significantly compromise patient safety and trust in healthcare systems, with medical errors being a leading cause of death globally. Despite efforts to reduce these errors, reporting remains low, and effective system changes are rare. …”
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Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

“…Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. …”
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Microplastic-enhanced chromium toxicity in Scenedesmus obliquus: Synergistic effects on algal growth and biochemical responses by Luoxin Li, Jiani Yu, Yonghua Ma, Hui Tan, Fengxia Tan, Yi Chai, Hui Zhang

“…As emerging contaminants in aquatic ecosystems, MPs have been shown to intensify the toxicity of Cr6+, leading to a more significant impact on algal growth and biochemical responses than either stressor alone. …”
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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…Human β-cells lacking SPOCK2 presented elevated MMP2 expression and activity, leading to β-integrin-FAK-c-JUN pathway activation. …”
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Endobronchial One-Way Valve Therapy Facilitates Weaning from Extracorporeal Membrane Oxygenation in a Patient with ARDS and Persistent Air Leak by Alessandro Ghiani, Matthias Hansen, Konstantinos Tsitouras, Claus Neurohr

“…After bronchoscopic localisation of the fistula, two endobronchial valves were inserted into the left upper lobe, leading to an immediate decrease in the air flow and reexpansion of the left lung. …”
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Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs by Jinshuang Bo, Shiya Xie, Yi Guo, Chunli Zhang, Yanming Guan, Chunmei Li, Jianxin Lu, Qing H. Meng

“…High levels of ROS can damage β-cells directly via JNK/P38 upregulation and through activation of UCP2 resulting in reduced MMP and ATP production, leading to β-cell dysfunction and impairment of insulin production.…”
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А quantitative estimate of uncertainty of the random scattering of the average clearance and interference in mating by N. N. Chigrik

“…The error of the shape of the real surface affects the probabilistic estimate of the results of sorting parts, leads to uncertainty in the size of the maximum of the material, a random scattering of the average clearance and interference in the mating and, as a consequence — the uncertainty to use all that come in for assembly of parts. …”
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Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia by Jacqueline E. Taudien, Diana Bracht, Heike Olbrich, Sebastian Swirski, Fulvio D’Abrusco, Bert Van der Zwaag, Maike Möller, Thomas Lücke, Norbert Teig, Ulrika Lindberg, Kai Wohlgemuth, Julia Wallmeier, Anja Blanque, Christos Gatsogiannis, Sebastian George, Christoph Jüschke, Marta Owczarek-Lipska, Dorothee Veer, Hester Y. Kroes, Enza Maria Valente, G. Christoph Korenke, Heymut Omran, John Neidhardt

“…We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway disease. …”
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