Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats’ Disease by Qingshan Chen, Saying Liang, Xizhen Wang, Chenli Hu, Jieting She, Zi Li

“…The patients were divided into two groups according to the application of dexamethasone implant as a DEX (+) group and DEX (−) group. Laser photocoagulation, anti-VEGF agents, and vitrectomy were performed if necessary. …”
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Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…In those found to have stage 2 and 3 ROP in zone II with plus disease (n = 6), intravitreal anti-VEGF injections and/or retinal laser treatments were performed. Notably, no cases of ROP-related blindness were recorded. …”
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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Investigation of functionally graded triply periodic minimal surfaces with graphene-reinforced AlSi10Mg powder: Design, fabrication and impact resistance by Mengyuan Hu, Xueqing Wu, Yangyang Xu, Xin Huang, Da Lu, Baoqing Pei

“…The samples prepared with optimized parameters of the laser powder of 370 W and scanning speed of 1500 mm/s exhibited significant characteristics with relative density of 99.6 %. …”
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Failure Mechanism and Kinematics of the Deadly September 28th 2016 Sucun Landslide, Suichang, Zhejiang, China by Hai Tian, Jianjun Gan, Hui Jiang, Chun Tang, Changtai Luo, Chenghui Wan, Bin Xu, Faliang Gui, Chengyi Liu, Nian Liu

“…Detail field surveys, 3D laser scanning, and high-density electrical methods were used to collect the geotechnical information of the complex landslide, to identify the discontinuity between the landslide material and the bedrock, and to investigate the deformation characterization and dynamic process of the rockslide. …”
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Field intercomparison of ice nucleation measurements: the Fifth International Workshop on Ice Nucleation Phase 3 (FIN-03) by P. J. DeMott, J. A. Mirrielees, J. A. Mirrielees, S. S. Petters, S. S. Petters, S. S. Petters, D. J. Cziczo, D. J. Cziczo, M. D. Petters, M. D. Petters, M. D. Petters, H. G. Bingemer, T. C. J. Hill, K. Froyd, K. Froyd, K. Froyd, S. Garimella, S. Garimella, A. G. Hallar, A. G. Hallar, E. J. T. Levin, E. J. T. Levin, I. B. McCubbin, I. B. McCubbin, A. E. Perring, A. E. Perring, A. E. Perring, C. N. Rapp, T. Schiebel, T. Schiebel, J. Schrod, K. J. Suski, K. J. Suski, D. Weber, D. Weber, M. J. Wolf, M. J. Wolf, M. Zawadowicz, M. Zawadowicz, J. Zenker, J. Zenker, O. Möhler, S. D. Brooks

“…The composition of the total aerosols was characterized using the Particle Analysis by Laser Mass Spectrometry (PALMS) and Wideband Integrated Bioaerosol Sensor (WIBS) instruments, and aerosol size distributions were measured by a laser aerosol spectrometer (LAS). …”
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Gas-phase Formation of Large, Astronomically Relevant Polycyclic Aromatic Hydrocarbon Clusters by Yanan Ge, Congcong Zhang, Xiaoyi Hu, Jia Liu, Liping Qin, Junfeng Zhen

“…., [(C _17 H _12 ) _6 C _48 H _14 ] ^+ , 236 atoms, and [(C _17 H _12 ) _5 C _48 ] ^+ , 193 atoms) are efficiently formed by gas-phase condensation under laser irradiation conditions. With theoretical calculations, the structure of newly formed DC/2, 3-benzofluorene cluster cations and the bonding energy for these formation reactions are obtained. …”
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Free-Space Optical (FSO) Satellite Networks Performance Analysis: Transmission Power, Latency, and Outage Probability by Jintao Liang, Aizaz U. Chaudhry, Eylem Erdogan, Halim Yanikomeroglu, Gunes Karabulut Kurt, Peng Hu, Khaled Ahmed, Stephane Martel

“…In free-space optical satellite networks (FSOSNs), satellites can have different laser inter-satellite link (LISL) ranges for connectivity. …”
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Fluid Inclusions and H-O-C-S Isotopes of the Wushan Copper Polymetallic Deposit in the Suizao Area, Hubei Province: Implications for Ore Genesis by Pan-Pan Niu, Shao-Yong Jiang, Suo-Fei Xiong, Qi-Sheng Hu, Tian-liang Xu

“…The daughter mineral-bearing multiphase fluid inclusions (S) are further divided into three subclasses according to their different solid mineral assemblages, including (1) S1: L+V+Hal, (2) S2: L+V+CO2+S (chalcopyrite), and (3) S3: L+V+S (calcite, chalcopyrite, and hematite)±Hal. A laser Raman spectroscopic analysis shows that the main components of fluid inclusions are water and carbon dioxide. …”
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Retinoblastoma. Part 2.&nbsp; Treatment strategies for intraocular retinoblastoma by S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva

“…</i> </p> <p> <i><b>Keywords</b>: children, retinoblastoma, enucleation, polychemotherapy, selective intra-arterial chemotherapy, intravitreal chemotherapy, laser photocoagulation, transpupillary thermotherapy, cryotherapy, brachytherapy, monitoring.…”
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MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy by Lihua Chen, Jiaying Yang, Lingyu Jia, Xiaolu Wei, Huijun Wang, Zhuo Liu, Shan Jiang, Pengyue Li, Yanyan Zhou, Hongjie Wang, Nan Si, Baolin Bian, Qinghe Zhao, Haiyu Zhao

“…ZIAMH nanoparticles can release ArBu in the tumor microenvironment for chemtherapy, and ICG enables photothermal therapy under near-infrared laser irradiation. In vitro and in vivo mechanism studies revealed that the ZIAMH nanoplatform downregulated glucose metabolism related genes, resulting in the reduction of energy substances and metabolites in tumors. …”
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Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure by Jiayi Tang, Okkyun Seo, Jaemyung Kim, Ibrahima Gueye, L.S.R. Kumara, Ho Jun Oh, Wan-Gil Jung, Won-Jin Moon, Yong Tae Kim, Satoshi Yasuno, Tappei Nishihara, Akifumi Matsuda, Osami Sakata

“…Thin films are generally prepared by pulsed laser deposition under high temperatures, but it is challenging to obtain a smooth surface. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…The histopathological evaluations were conducted in the cortex and hippocampus regions. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) was used to assess metabolite changes in various brain regions. …”
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…Methods Genomic DNA of three laser micro-dissected tumor regions, including digestive tract surface, central bulk, and invasive front, was extracted from formalin-fixed paraffin-embedded sections of colorectal cancer patients. …”
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The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense by Shuangzhi Zhao, Ming Lei, Hui Xu, Hailun He, Alexander Suvorov, Junhua Wang, Jiying Qiu, Qingxin Zhou, Jinyu Yang, Leilei Chen

“…The results showed that the GAMPS was composed of glucose, mannose, and galactose at a molar ratio of 67.62:14.07:7.50, and the weight-average molecular weights were 5.439 × 106 and 1.704 × 105 g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter (HPGPC-MALS) analysis. GAMPS (0.2 μg/μL) showed the strongest proliferation ability to THP-1 cells, with cell survival rate of 178.7%. …”
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Target Detection Using Fused Unidentical Photonics-Based LFM Sub-Band Radar Signals With an Adaptive Feed Forward Network Equalizer by Bikash Nakarmi, S. M. Rezwanul Islam, Hum Nath Parajuli, Ikechi Augustine Ukaegbu, Aigerim Ashimbayeva, Carlo Molardi, T. D. Subash, Xiangchuan Wang, Shilong Pan

“…We demonstrate this using optical injection in a semiconductor laser to generate Ph-LFM signals at different IEEE X-KA radar sub-bands: 19.25&#x2013;23.94 GHz and 24.06&#x2013;28.31 GHz (bandgap 0.12 GHz), 19.69&#x2013;23.06 GHz and 23.625&#x2013;27 GHz (bandgap 0.56 GHz), and 8&#x2013;11.5 GHz and 12.75&#x2013;17 GHz (bandgap 1.25 GHz). …”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…In situ metabolomics through matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased glutamine levels in cornea following MSC + Tβ4 combined therapy. …”
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Analysis of the efficacy of MALDI-TOF MS technology in identifying microorganisms in cancer patients and oncology hospital environment by Grażyna Czeszewska-Rosiak, Iwona Adamczyk, Agnieszka Ludwiczak, Piotr Fijałkowski, Paweł Fijałkowski, Magdalena Twarużek, Michał Złoch, Dorota Gabryś, Wioletta Miśta, Andrzej Tretyn, Paweł Piotr Pomastowski

“…The study was conducted to evaluate the effectiveness of the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS) technology in the microbial profiling of hospital environments and patient samples. …”
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MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…The nuclear and cytoplasm translocation of HMGB1 and NF-κB p65 were detected by Western blot and laser confocal microscopy. After siHMGB1 transfection, the expression levels of HMGB1, inflammatory mediators, p-IKK, IKK, p-IκBα, IκBα and NF-κB p65 were assessed using Western blot, qRT-PCR and ELISA. …”
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Characterization of microplastics in human follicular fluid and assessment of their potential impact on mouse oocyte maturation in vitro by Danyu Ni, Kaidi Yu, Nan Yan, Xiaojiao Chen, Qijun Xie, Yuqin Yang, Wei Jiang, Ye Yang, Junqiang Zhang, Xiufeng Ling

“…This study aims to evaluate the presence of MPs in human follicular fluid (hFF) and their potential impact on oocyte maturation. Laser direct infrared spectroscopy of 19 hFF samples identified 7956 particles, including 1739 microplastics (21.9 %) from 30 types. …”
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