Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer by Liangjian Ma, Wunan Huang, Xiaolei Liang, Hongli Li, Wei Yu, Lexin Liu, Yuelin Guan, Chang Liu, Xiangjun Chen, Lidan Hu

“…In this study, we identified lanosterol synthase (LSS) as a key mediator in cholesterol metabolism associated with EC. …”
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Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors by Nafiz Öncü Can, Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Serkan Levent, Büşra Korkut, Yusuf Özkay, Zafer Asım Kaplancıklı, Ali Savaş Koparal

“…The molecular docking studies were performed to investigate the interaction modes between the compounds and active site of lanosterol 14-α-demethylase (CYP51), which is as a target enzyme for anticandidal azoles. …”
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Antimicrobial Activities of Stigmasterol from Piper crocatum In Vitro and In Silico by Seftiana Lestari, Dikdik Kurnia, Tri Mayanti, Leny Heliawati

“…The study findings indicate that the stigmasterol compound exhibits antibacterial and antifungal properties against pathogenic oral microorganisms in vitro as well as in silico against the crucial antibacterial enzymes MurA and PBP in addition to the pivotal antifungal enzyme exo-β-1,3-glucanase and lanosterol-14-α-demethylase. Therefore, it can be inferred that the stigmasterol present in Red Betel leaves could potentially function as an antimicrobial agent by impeding the spread of pathogenic oral microorganisms.…”
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Antibacterial and Antioxidant Activities of Triterpenoids Isolated from Endemic Euphorbia arbuscula Stem Latex by Zainab Al-Ansi, Mohammed Masaoud, Khaled Hussein, Bushra Moharram, Wafa M. Al-Madhagi

“…In addition, chromatographic techniques were employed to isolate two triterpenoids, lanosterol and lupeol, from the stem latex. The structures of these compounds were confirmed using IR, MS, and NMR techniques. …”
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Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis by Joydeep Karan, Aditi Kundu, Robin Gogoi, Kanchikeri Math Manjaiah, Ashutosh Kumar Singh, Koyel Mondal, Rajesh Kumar, Parshant Kaushik, Priya Saini, Virendra Singh Rana, Najam Akhtar Shakil

“…The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.…”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…In tubers, with an excess of SGA precursors, they are involved in the synthesis of lanosterol, supporting in this way the stable level of SGA. …”
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