Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…Conclusion The lessons from these case studies include that technical teams can and should engage in Political Economy Analysis (PEA) thinking and strategizing, including being aware of and adaptable to the changing PEA landscape and prepared to take advantage of windows of opportunity, including, but not limited to, those emerging from crisis. …”
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Russian business in the context of the growth of cybercrime: changes in economic behavior and protective mechanisms by S. G. Simonov, I. V. Lysenko

“…It is found out how the domestic business has changed its attitude to the security of information and information systems of the company. The sectoral landscape of cybercrimes in the Russian Federation for 2023 is presented. …”
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Heterogeneous occurrence of evergreen broad-leaved forests in East Asia: Evidence from plant fossils by Jiagang Zhao, Shufeng Li, Jian Huang, Wenna Ding, Mengxiao Wu, Tao Su, Alexander Farnsworth, Paul J. Valdes, Linlin Chen, Yaowu Xing, Zhekun Zhou

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Interactive and unimodal relationships between plant biomass, abiotic factors, and plant diversity in global grasslands by Marie Spohn, Sumanta Bagchi, Jonathan D. Bakker, Elizabeth T. Borer, Clinton Carbutt, Jane A. Catford, Christopher R. Dickman, Nico Eisenhauer, Anu Eskelinen, Nicole Hagenah, Yann Hautier, Sally E. Koerner, Kimberly J. Komatsu, Lauri Laanisto, Ylva Lekberg, Jason P. Martina, Holly Martinson, Meelis Pärtel, Pablo L. Peri, Anita C. Risch, Nicholas G. Smith, Carly Stevens, G. F. Ciska Veen, Risto Virtanen, Laura Yahdjian, Alyssa L. Young, Hillary S. Young, Eric W. Seabloom

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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…By advancing our understanding of the clinical and molecular landscape of early-onset breast cancer and very early-onset breast cancer, this study lays the groundwork for improving outcomes in these underserved patients through tailored therapeutic approaches.…”
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Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer by Xingsheng Liu, Kun Qian, Lei Su, Xiaoru Tian, Xin Zhao, Tengteng Wang, Li Han, Zhenzhen Li, Peilong Zhang, Ruotian Wang, Baodong Liu, Yuanbo Li, Xiaogang Tan, Yi Zhang

“…However, a comprehensive understanding of the somatic mutation landscape and transcriptome heterogeneity is lacking. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…This study systematically analyzes the current research landscape, challenges, and opportunities for BT in securing the OT critical to food and agriculture CI. …”
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Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children by Thomas C. Seijbel, BSc, Levi Hoste, MD, Corinne M. P. Buysse, MD, PhD, Karolijn Dulfer, PhD, Filomeen Haerynck, MD, PhD, Matthijs de Hoog, MD, PhD, Naomi Ketharanathan, MD, PhD

“…The COVID-19 pandemic gave rise to uncertainty concerning potential sequelae related to a severe acute respiratory syndrome coronavirus 2 infection. This landscape is currently unfolding with studies reporting sequelae on various domains (physical, cognitive, and psychosocial), although most studies focus on adults or only one domain. …”
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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy by Yu Chen, Xuan Wang, Jie Dai, Li Zhou, Xuefeng Xia, Jun Guo, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xuan Gao, Lirui Tang, Linzi Sun, Zhonghui Qi, Zelong Xu

“…Genomic sequencing analysis revealed that the genomic aberration landscape of PMME predominated in classical cancer driver genes, with approximately half of PMME cases harboring mutations in BRAF, N/KRAS, and NF1. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…Patients with partial clinical responses had more diverse T and B cell receptor repertoires prior to therapy initiation.Conclusion Ibrutinib monotherapy skewed the immune landscape both in the circulation and TME towards activated T cells, monocytes and DCs. …”
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Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer by Riqing Huang, Anqi Hu, Qixiang Rong, Ditian Shu, Meiting Chen, Wei Yang, Yue Zhang, Qiufan Zheng, Xin An, Cong Xue, Haifeng Li, Yanxia Shi

“…Abstract Background HER2-targeted antibody–drug conjugates (ADCs) have revolutionized the treatment landscape of metastatic breast cancer. However, the efficacy of these therapies may be compromised by genomic alterations. …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…These findings offer novel insights into the surrogate immunomolecular subtyping landscape of DCIS, potentially refining risk stratification and therapeutic approaches. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Further analytical procedures involved functional enrichment analysis, evaluation of immune infiltration, and examination of the mutation landscape.PTGES3 was identified as a pivotal gene associated with lipid metabolism. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…To identify in-hospital barriers to organ donation and gain a better understanding of the paediatric donor landscape. Methods. A retrospective descriptive study of consecutive deceased-donor referrals at Red Cross War Memorial Children’s Hospital over a 14-year period, from 1 January 2007 to 31 December 2020. …”
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Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia by Anmut Endalkachew Bezie, Girum Tareke Zewude, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Asmare Asrat Yirdaw, Alebachew Bitew Abie, Giziew Abere

“…To address this issue, interventions focused at reducing work–family conflicts, increasing job satisfaction, and improving the school environment are necessary to support teachers’ well-being, benefiting both young students and the broader educational landscape.…”
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Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas by Junhao Zhang, Lingbo Li, Aiwei Tang, Chucheng Wang, Yupeng Wang, Yongqi Hu, Guangting He, Guangting He, Wangjun Liao, Wangjun Liao, Wangjun Liao, Rui Zhou

“…However, systematic characterization of the transcriptomic landscape and clinical relevance of HATs and HDACs in pan-cancer contexts remains lacking.MethodsTranscriptome and clinical data of 9,483 patients across 31 tumor types from The Cancer Genome Atlas were collected for systematic pan-cancer analysis. …”
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Spatio-temporal dynamics of speleothem growth and glaciation in the British Isles by S. Panitz, S. Panitz, M. Rogerson, J. Longman, N. Scroxton, T. J. Lawson, T. C. Atkinson, V. Ersek, J. Baldini, L. Baldini, S. Umbo, M. A. Lone, G. M. Henderson, S. F. M. Breitenbach

“…Further study of leads and lags in speleothem growth compared to surface deposition may provide new insights into landscape-scale dynamics during ice sheet growth and retreat.…”
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Annotated Checklist of Poroid Hymenochaetoid Fungi in Central Asia: Taxonomic Diversity, Ecological Roles, and Potential Distribution Patterns by Yusufjon Gafforov, Manzura Yarasheva, Xue-Wei Wang, Milena Rašeta, Yelena Rakhimova, Lyazzat Kyzmetova, Kanaim Bavlankulova, Sylvie Rapior, Jia-Jia Chen, Ewald Langer, Burkhon Munnavarov, Zafar Aslonov, Bobozoda Bakokhoja, Li-Wei Zhou

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The regulation of tobacco growth under preceding crop planting: insights from soil quality, microbial communities, and metabolic profiling by Peiyan Zhao, Houfa Zhou, Xiaolin Liao, Leifeng Zhao, Yuanxian Zheng, Tiane Xiong, Gaorun Zhang, Sirong Jiang, Jiming Wang, Yuansheng He, Jiangtao Li, Jieying Zhu, Yongjun Zhang, Yanrun Li, Fuzhao Nian, Di Liu

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Implementation of Compensation-Sensitive Shot-Style-Feedback of Aiming Point Training Data at the Swiss Shooting Federation by Dino Tartaruga, Ralf Kredel

“…In our view, this project serves as a good example of how challenging real-world problems brought up by coaches and embedded scientists can be jointly structured and solved at federation and university level, and how their solution can ultimately lead to practical tools reshaping and improving a federation’s process landscape. References Tartaruga, D., & Kredel, R. (2021). …”
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