Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…Circular RNAs (circRNAs) have emerged as potential biomarkers due to their stability and tissue-specific expression.MethodsIn this study, we investigated the circRNA landscape during neuroendocrine transdifferentiation (NED) of PC cells using the androgen-sensitive LNCaP and androgen-insensitive DU145 cell lines. …”
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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…The revised guidance aims to improve seizure control and quality of life for patients with LGS through personalized, evidence‐based treatment strategies while addressing the challenges of accurate diagnosis and management in a rapidly evolving therapeutic landscape. Plain Language Summary Lennox–Gastaut syndrome (LGS) is a severe type of epilepsy that usually starts in childhood but continues into adulthood. …”
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El rol de los actores sociales y sus implicancias en la configuración territorial de Moquehue, Neuquén, Argentina by Celia Viviana Torrens, Elsie Marcela Jurio, Vanesa Yanina Cappelletti, Germán Gabriel Pérez, Daiana Elcira Cara Plá, Gimena Nathalie Cuevas, María Silvina Hauw, Pablo Alejandro Leyes

“…Nature has given the region a beautiful landscape that acquires value since the 70's, when the population of nearby localities began to usufruct tourism in the region. …”
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Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…Although short in quantity, I consider it to be loaded in quality, contents, intents, intensities, and in its ability to problematize a discourse critical to our understanding of indigenous scholarship and all its epistemological implications that span the entire landscape of the humanities. Indeed, Okediji’s pedagogy is the proverbial Yoruba drum of “ògìdìgbó” which is revealed only to the wise and the prudent, and they are the only two capable of effectively dancing to its rhythm. …”
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A scoping review on the obstacles faced by beta thalassemia major patients in Pakistan- Matter of policy investment by Ali Hussain Ansari, Saqib Hussain Ansari, Mubarak Jabeen Salman, Muhammad Usman Hussain Ansari, Rawshan Jabeen

“…Additionally, we critically analyzed the current landscape of β-TM in Pakistan. The main challenges in β-TM care in Pakistan are suboptimal transfusion services and a poor complication management. …”
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Outcomes of oncologic arthroplasty in children and adolescents with malignant limb tumors: a systematic review by Vyacheslav I. Zorin, Sergei V. Vissarionov, Alexandr Y. Makarov, Timofey S. Rybinskikh, Kristina N. Rodionova

“…However, the development and refinement of chemotherapy and radiotherapy protocols, along with advances in surgical techniques and implants, have significantly altered the treatment landscape for these patients. Currently, limb-sparing oncologic arthroplasty is the preferred surgical approach for treating limb sarcomas in children. …”
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Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury by Dandan Mao, Qi Chen, Shuolan Tong, Zixia Xu, Guofeng Yu, Chuan Chang, Yao Lv

“…Additionally, relying on the immune infiltration landscape associated with cuproptosis, we carried out immune cell correlation analysis on hub genes. …”
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Digital interactive experience- and game-based fall interventions for community-dwelling healthy older adults: a cross-disciplinary systematic review by Celina Ciemer, Celina Ciemer, Lisa Kröper, Thomas Jürgen Klotzbier, Sabiha Ghellal, Nadja Schott

“…Digital, interactive interventions, incorporating experience-, and game-related aspects, offer a promising solution, making this topic inherently cross-disciplinary.ObjectiveThis review aims to assess the current landscape of digital interactive experience and game-based fall interventions for community-dwelling, healthy older adults. …”
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Sensor-controlled fertigation management for higher yield and quality in greenhouse hydroponic strawberries by George Kerrigan Hutchinson, Lan Xuan Nguyen, Zilfina Rubio Ames, Krishna Nemali, Rhuanito Soranz Ferrarezi

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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…These findings both reinforce our current understanding of prostate cancer’s molecular landscape and point to unexplored pathways that could lead to novel therapeutic strategies. …”
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Mitigation of environmental impacts in ornamental rock and limestone aggregate quarries in arid and semi-arid areas by M.A. Peñaranda Barba, V. Alarcón Martínez, I. Gómez Lucas, J. Navarro Pedreño

“…All of this has given rise to numerous active and abandoned mines, where no restoration process has been carried out, generating strong impacts on the environment.METHODS: In this study, 8 environmental impact assessments studies of ornamental rock and aggregate quarries in the Region of Murcia were analysed to identify the negative impacts on the abiotic and biotic environment, landscape, socio-economic and socio-cultural environment, and infrastructures and analysing preventive and control measures. …”
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The Mediating Role of Cognitive Reappraisal on Bedtime Procrastination and Sleep Quality in Higher Educational Context: A Three-Wave Longitudinal Study by Zhang Y, Rehman S, Addas A, Ahmad M, Khan A

“…Yuan Zhang,1 Shazia Rehman,2 Abdullah Addas,3,4 Mehmood Ahmad,5 Ayesha Khan6 1College of Art, Nanyang Vocational College of Agriculture, Nan Yang, Henan, 47300, People’s Republic of China; 2Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China; 3Department of Civil Engineering, College of Engineering, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia; 4Landscape Architecture Department, Faculty of Architecture and Planning, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan; 6Department of Applied Psychology, Faculty of Social Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, PakistanCorrespondence: Shazia Rehman, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-13308429613, Email rehmanshazia.malik@gmail.comBackground: While bedtime procrastination is commonly associated with adverse outcomes such as poor sleep quality, the mechanisms mediating these effects remain underexplored. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Principal Component Analysis (PCA) and Free Energy Landscape (FEL) results revealed the trajectories' motion and conformational energy states. …”
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Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…As the tobacco control landscape evolves, tobacco prevention efforts should focus on all tobacco products, not just cigarettes.…”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Conclusions This study provided a microecological landscape of the lower respiratory tract with advanced NSCLC to ICI interventions and presented a multidimensional perspective with favoured outcomes that may improve the predictive capacity of the localized microbiome in clinical practices. …”
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Challenges and Strategies Adopted for Remote Teaching of Biochemistry During the COVID-19 Pandemic: Protocol for a Scoping Review by Tatiane Iembo, Helena Landim Gonçalves Cristóvão, Emerson Roberto dos Santos, André Bavaresco Gonçalves Cristóvão, Nathália Bavaresco Gonçalves Cristóvão, Cíntia Canato Martins, Natália Almeida de Arnaldo Silva Rodrigues Castro, Fernando Nestor Facio Júnior, Antônio Hélio Oliani, Alba Regina de Abreu Lima, Vânia Maria Sabadoto Brienze, Doroteia Rossi Silva Souza, Júlio César André

“… BackgroundIn March 2020, the global landscape witnessed widespread upheavals in both socioeconomic and educational spheres due to the onset of the COVID-19 pandemic. …”
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Genome assembly of an endemic butterfly (Minois aurata) shed light on the genetic mechanisms underlying ecological adaptation to arid valley habitat by Wenqian Hu, Yi Wang, Xiaoxiao Chen, Jialong Huang, Jingge Kuang, Lei Wang, Kangshan Mao, Liang Dou

“…Abstract Background The Hengduan Mountains, one of the global biodiversity hotspots with exceptional species richness and high endemism, contains numerous arid valleys that create a distinctive geographical and ecological landscape. However, the adaptive evolutionary mechanisms of organism in the arid valley remain poorly understood. …”
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Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma by Teresa Troiani, Fabiana Napolitano, Luigi Formisano, Roberto Bianco, Daniela Russo, Daniela Esposito, Giuseppe Ercolano, Angela Ianaro, Alberto Servetto, Daniela Claudia Maresca, Marcella Scala, Annarita Amato, Stefania Belli, Claudia Maria Ascione, Angela Vallefuoco, Giovanna Attanasio, Fabio Somma, Silvia Varricchio, Massimo Mascolo, Claudia Costa, Alessia Villani, Massimiliano Scalvenzi, Gianfranco Orlandino

“…However, reliable biomarkers for patient selection are still lacking.Experimental design In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate the association between sustained objective responses and transcriptional profiles, immune cell dynamics in tumor tissue and peripheral blood samples, as well as circulating cytokine levels.Results First, we investigated the baseline characteristics of the immune landscape of cSCC biopsies. Gene Set Enrichment Analysis showed upregulation of interleukin (IL)2/STAT5 pathways and downregulation of Interferon signatures in non-responder patients compared with responders. …”
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Ecological networks construction and optimization in the Longdong Loess Plateau: The advantages of self-organizing map and complex networks by Xueyu Huang, Lina Xiu, Zhixiang Lu, Jiahui Wang

“…The additional corridors also serve as an important reference for enhancing regional landscape connectivity and ecological security.…”
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